A human monoclonal IgG1 lambda anti-hepatitis B surface antibody. Production, properties, and applications.

abstract：:T-cell sensitization to indirectly presented alloantigens (indirect pathway of allorecognition) plays a critical role in chronic rejection. The usual very efficient priming of such self-restricted, T helper type 1 (Th1)-deviated CD4+ T cells obviously conflicts with the fact that allogeneic MHC molecules are poorly im...

journal_title：Scandinavian journal of immunology

authors： Wallgren AC,Andersson B,Bäcker A,Karlsson-Parra A

更新日期：2005-09-01 00:00:00

abstract：:In murine schistosomiasis mansoni the worm egg-induced granulomatous inflammation is bi-phasic: an initial Th1 type is subsequently switched to a Th2 type response. Analysis of the cellular, molecular base of the Th1-associated response (5-6 weeks post infection) revealed mRNA messages for interleukin (IL)-12 p40, IL-...

journal_title：Scandinavian journal of immunology

authors： Todt JC,Whitfield JR,Ivard SR,Boros DL

更新日期：2000-10-01 00:00:00

abstract：:Sea star factor (SSF) harvested from the echinoderm Asterias forbesi celomocytes is a potent inhibitor of the primary immune response to T-dependent antigens and also suppresses concanavalin-A-induced mitogenesis. We have isolated and purified a basic protein from this source which has a molecular weight of approximat...

journal_title：Scandinavian journal of immunology

authors： Prendergast RA,Liu SH

更新日期：1976-01-01 00:00:00

abstract：:Based on their immunodominant nature and ability to induce appropriate immune responses in the host, several antigens of Mycobacterium tuberculosis have shown promise of protection. However, most of the candidate vaccines developed by employing various strategies have afforded protection that is at best comparable wit...

journal_title：Scandinavian journal of immunology

authors： Rao V,Dhar N,Tyagi AK

更新日期：2003-10-01 00:00:00

abstract：:C-reactive protein (CRP) binds to Fcγ-receptors, FcγRIIa (CD32) with high affinity and to FcγRIa (CD64) with low affinity. The binding to CD32 has been shown to be allele specific, that is, it binds to R/R131 but not to H/H131. Little is known about the cooperation of CRP and neutrophilic granulocytes (PMNs) in inflam...

journal_title：Scandinavian journal of immunology

authors： Aas V,Sand KL,Asheim HC,Benestad HB,Iversen JG

更新日期：2013-06-01 00:00:00

abstract：:Beta 2-glycoprotein I (beta 2-GPI) is a 50 kDa protein in human plasma composed of five repeating complement control protein modules thereby closely resembling complement factor H which has 20 such units. Both beta 2-GPI and factor H (150 kDa) have binding sites for negatively charged polyions. beta 2-GPI has been sho...

journal_title：Scandinavian journal of immunology

authors： Puurunen M,Jokiranta S,Vaarala O,Meri S

更新日期：1995-11-01 00:00:00

abstract：:Induced expression of the intercellular adhesion molecule 1 (ICAM-1) and of the major histocompatibility complex (MHC) class II antigens has been simultaneously observed on keratinocytes and epithelial cells in the thyroid and kidney, suggesting that ICAM-1 and HLA-DR expression might be under common regulation. We ha...

journal_title：Scandinavian journal of immunology

authors： Scheynius A,Engstrand L

更新日期：1991-02-01 00:00:00

abstract：:The authors recently reported that CD2 ligation rescues B cells from antigen-induced apoptosis by upregulation of intracellular Bcl-2 levels. However, the characterization of the early signals involved in apoptosis rescue by CD2 ligation has not been well established. In this context, CD2 does not promote either phosp...

journal_title：Scandinavian journal of immunology

authors： Baixeras E,Garcia-Lozano E,Martinez-A C

更新日期：1996-04-01 00:00:00

abstract：:Here we analyse the ability of soluble immune complexes (IC) prepared with cationized antibodies to induce cytotoxic responses mediated by neutrophils. While cationized IC induced high levels of cytotoxicity, control IC induced very low levels of response. Inhibition of cytotoxicity by catalase but not by three haemen...

journal_title：Scandinavian journal of immunology

authors： Geffner JR,Trevani AS,Malchiodi E,Serebrinsky GP,Isturiz MA

更新日期：1993-02-01 00:00:00

abstract：:In subjects not developing allergy, inhalation of nonpathogenic protein antigens causes no harm and is associated with tolerance induction. Repeated exposure to aerosolized ovalbumin (OVA) likewise does not evoke airway inflammation and induces inhalation tolerance in experimental animals. The present study explored t...

journal_title：Scandinavian journal of immunology

authors： Alenmyr L,Matheu V,Uller L,Greiff L,Malm-Erjefält M,Ljunggren HG,Persson CG,Korsgren M

更新日期：2005-11-01 00:00:00

abstract：:Immunoprecipitation of radioiodinated hairy cell leukaemia (HCL) cell lysates with monoclonal antibody (MoAb) HML-1, originally reported to recognize intraepithelial T cells, and with MoAb B-ly7, originally reported to react with HCL, led to identical biochemical characteristics. In SDS-PAGE under reducing conditions,...

journal_title：Scandinavian journal of immunology

authors： Moldenhauer G,Mielke B,Dörken B,Schwartz-Albiez R,Möller P

更新日期：1990-08-01 00:00:00

abstract：:Screening for B-cell-specific antibodies in unabsorbed pregnancy sera preselected for weak reactivity in regular HLA-A, -B, and -C screening yielded a relatively high proportion (35/81) of B-cell-specific antibodies. Most B-cell-specific antibodies react broadly, showing inclusion phenomena suggesting 'cross-reactivit...

journal_title：Scandinavian journal of immunology

authors： Albert ED,Andreas A,McNicholas A,Scholtz S,Kuntz B

更新日期：1977-01-01 00:00:00

abstract：:Several enveloped viruses, particularly some RNA viruses, have high rates of mutation or replication, which can make them virulent pathogens in humans and other mammals. A proposed treatment could use synthesized proteins to mask pathogenic viral surface proteins to quickly induce an immune attack on specific envelope...

journal_title：Scandinavian journal of immunology

authors： Roe K

更新日期：2020-09-01 00:00:00

abstract：:Interleukin (IL)-12 has dominated the field of cell-mediated immunity since its discovery more than 10 years ago, and clearly plays an essential role in the development of Th1 cells under a variety of conditions. Recent studies now indicate that the importance of IL-12 is not limited to initiating an immune response, ...

journal_title：Scandinavian journal of immunology

authors： Park AY,Scott P

更新日期：2001-06-01 00:00:00

abstract：:The autologous mixed lymphocyte reaction (AMLR) and T-cell subsets defined with monoclonal antibodies were examined in the peripheral blood of six patients with chronic mucocutaneous candidiasis (CMC). The AMLR was deficient in four of six patients when compared with simultaneously studied healthy controls. These pati...

journal_title：Scandinavian journal of immunology

authors： Gupta S

更新日期：1985-06-01 00:00:00

abstract：:The major subunit protein of amyloid fibrils (758) isolated from a patient with systemic amyloidosis and studied by N-terminal amino acid sequence analysis was found to be almost identical to the sequence of a V lambda IV Bence-Jones protein and a previously described A lambda IV amyloid protein. The two A lambda IV a...

journal_title：Scandinavian journal of immunology

authors： Natvig JB,Westermark P,Sletten K,Husby G,Michaelsen T

更新日期：1981-07-01 00:00:00

abstract：:Immunoglobulin G (IgG) is important in clearance and recognition of previously presented antigens and after activation, IgGs can interact with the Fc gamma receptors (FcγRs) on haematopoietic cells, including bone-resorbing osteoclasts. The pathogenicity of IgG, that is the ability to elicit stimulatory effects via Fc...

journal_title：Scandinavian journal of immunology

authors： Sehic E,Westerlund A,Lagerquist MK,Lerner UH,Carlsten H,Henning P,Engdahl C

更新日期：2020-12-15 00:00:00

abstract：:γδ T cells are characterized by recognizing conserved endogenous and stress-induced antigens without antigen presentation. It has been show that γδ T cells play an important role in anti-tumour/microbe responses, but their function in autoimmune diseases is yet not clear. Here, we reported the quantity and phenotype o...

journal_title：Scandinavian journal of immunology

authors： Wang L,Kang N,Zhou J,Guo Y,Zhang X,Cui L,Ba D,He W

更新日期：2012-07-01 00:00:00

abstract：:Murine serum amyloid A1.1 (SAA1.1) has been conjugated with the fluorophore Texas Red (TxR), and its interaction with peritoneal macrophages has been visualized by scanning confocal microscopy. Binding of TxR-SAA to cell surfaces was inhibited by an excess of unlabelled SAA indicating the involvement of saturable rece...

journal_title：Scandinavian journal of immunology

authors： Kluve-Beckerman B,Manaloor J,Liepnieks JJ

更新日期：2001-04-01 00:00:00

abstract：:Co-infection with virus and bacteria happens frequently and often results in an exacerbated clinical course of the disease, possibly due to mechanisms including altered cytokine production. In the present study, the authors investigated the combined effects of avirulent Semliki Forest virus (SFV-A7) and bacterial lipo...

journal_title：Scandinavian journal of immunology

authors： Yang J,Hukkanen V,Seljelid R,Salmi AA

更新日期：1997-04-01 00:00:00

abstract：:In the present study we describe the production and characterization of a panel of monoclonal antibodies (MoAbs) directed against cruzipain (Crz), the major cysteine proteinase from Trypanosoma cruzi. The five MoAbs, BD6, BF2, CG2, CH8, and DC10 were analysed with respect to affinity and specificity. None of the MoAbs...

journal_title：Scandinavian journal of immunology

authors： Gonzalez G,Orn A,Cazzulo JJ,Grönvik KO

更新日期：1994-10-01 00:00:00

abstract：:Beta 2-microglobulin (beta 2m) constitutes the common light chain of both the MHC-encoded HLA-ABC molecules and a group of structurally related glycoproteins recognized by antibodies of the first cluster of differentiation (CD1a, CD1b and CD1c). These CD1 antigens appear similar to murine T1 and Qa molecules in terms ...

journal_title：Scandinavian journal of immunology

authors： Jones RA,Child JA,Master PS,Scott CS

更新日期：1991-07-01 00:00:00

abstract：:An antigen-specific T-cell line which transforms into T-lymphoma cells in vitro but apparently not in vivo is described. Membrane markers, tumorigenicity and T-cell receptor (TcR) V alpha and V beta-gene usage of the in vitro transformed T-cell line were analysed to investigate whether the transformation event was pol...

journal_title：Scandinavian journal of immunology

authors： Wegener AM,Holm B,Geisler C,Rubin B

更新日期：1990-05-01 00:00:00

abstract：:Serum and salivary concentrations of immunoglobulin A1 (IgA1) and IgA2 were studied in 105 Icelandic children aged 0-12 years. Serum concentrations of both IgA1 and IgA2 increased slightly (P < 0.001) during childhood. The salivary IgA1/IgA2 ratio tended to decrease during the same period; this trend is less apparent ...

journal_title：Scandinavian journal of immunology

authors： Weemaes C,Klasen I,Göertz J,Beldhuis-Valkis M,Olafsson O,Haraldsson A

更新日期：2003-12-01 00:00:00

abstract：:Rabbit Ig against human beta2-microglobulin was found to be mitogenic for human peripheral lymphocytes, tonsil lymphocytes, and appendix and spleen cells. Anti-beta2-m gave increased DNA synthesis, with peak responses on day 3 or 4 and showed a dose-response effect when diluted. The effect was seen in both serum-free ...

journal_title：Scandinavian journal of immunology

authors： Ringeén O,Möller E

更新日期：1975-01-01 00:00:00

abstract：:Fc gamma receptors (FcγRs) for IgG regulate adaptive immune responses by modulating activating and inhibitory signalling pathways within immune cells. Data from a haemophilia A mouse model demonstrate that genetic deletion or blockade of the inhibitory FcγR (CD32) suppresses the formation of antibody-secreting cells (...

journal_title：Scandinavian journal of immunology

authors： Vollack N,Friese J,Bergmann S,Cragg MS,Tiede A,Werwitzke S

更新日期：2017-08-01 00:00:00

abstract：:TIM-3 is a member of the TIM (T-cell immunoglobulin domain and mucin domain) family, which plays an important role in TH1 responses and autoimmune diseases. In this study, we cloned and characterized the porcine TIM-3 gene. Real-time PCR showed little expression of porcine TIM-3 in muscle and stomach, low expression i...

journal_title：Scandinavian journal of immunology

authors： Zhao W,Li Y,Wang Z,Li K,Yang S

更新日期：2011-01-01 00:00:00

abstract：:Hypomorphic mutations in the gene encoding Bruton tyrosine kinase (BTK) may result in milder phenotypes and delayed diagnosis of B-cell related immunodeficiencies due to residual BTK function. Newborn screening for kappa-deleting-recombination-excision circles (KRECs) reliably identifies classical X-linked agammaglobu...

journal_title：Scandinavian journal of immunology

authors： Krüger R,Baumann U,Borte S,Kölsch U,Lorenz MR,Keller B,Harder I,Warnatz K,Ehl S,Schwarz K,Wahn V,von Bernuth H

更新日期：2020-01-01 00:00:00

abstract：:B cells are in analogy with T cells capable of expressing functional IL-2 receptors. IL-2R alpha-chain (CD25) positive T cells have been studied in detail but not much is known about CD25 positive B cells. The aim of this study was to examine the phenotypic properties of the CD25 expressing B cells collected from diff...

journal_title：Scandinavian journal of immunology

authors： Amu S,Gjertsson I,Tarkowski A,Brisslert M

更新日期：2006-11-01 00:00:00

abstract：:L-selectin, a cell surface glycoprotein expressed on lymphocytes, granulocytes, and monocytes, has been implicated in lymphocyte homing and extravasation of phagocytic leukocytes into areas of inflammation. Considerable differences of L-selectin expression among various individuals has been reported, with clinical cor...

journal_title：Scandinavian journal of immunology

authors： Stibenz D,Bührer C

更新日期：1994-01-01 00:00:00