B-cell mitogenic effects on human lymphocytes of rabbit anti-human beta 2-microglobulin.

abstract：:Here we analyse the ability of soluble immune complexes (IC) prepared with cationized antibodies to induce cytotoxic responses mediated by neutrophils. While cationized IC induced high levels of cytotoxicity, control IC induced very low levels of response. Inhibition of cytotoxicity by catalase but not by three haemen...

journal_title：Scandinavian journal of immunology

authors： Geffner JR,Trevani AS,Malchiodi E,Serebrinsky GP,Isturiz MA

更新日期：1993-02-01 00:00:00

abstract：:Foot-and-mouth disease (FMD) caused by FMD virus (FMDV) is a major health and economic problem in the farming industry. Vaccination of livestock against this highly infectious viral disease is crucial, and inactivated FMD vaccine has been effective at controlling infection. However, accumulated data show that the inac...

journal_title：Scandinavian journal of immunology

authors： Kang J,Zuo Y,Guo Q,Wang H,Liu Q,Liu Q,Xia G,Kang Y

更新日期：2015-11-01 00:00:00

abstract：:Human monocytes activated with lymphokines after 3-7 days of in vitro maturation released stable cytostatic factor(s) (CF), as determined by reduction of [methyl-3H]thymidine incorporation and cell counts in target cell cultures. Lipopolysaccharide from Escherichia coli slightly enhanced the release of CF. The CF rele...

journal_title：Scandinavian journal of immunology

authors： Hammestrøm J

更新日期：1982-03-01 00:00:00

abstract：:The authors have recently shown that the ability of immune complexes (IC) to trigger Fc gamma R-dependent cell responses can be dramatically enhanced when the isoelectric point (pI) of normal IgG antibodies is increased from 5.8-8.5 to 8.5-9.8 by treatment with 1-ethyl-3-2(3-dimethylaminopropyl) carbodiimide HCl and e...

journal_title：Scandinavian journal of immunology

authors： Trevani AS,Andonegui G,Kempfer C,Malchiodi E,Geffner JR

更新日期：1996-03-01 00:00:00

abstract：:The c-Met oncoprotein is a cell-surface receptor for hepatocyte growth factor (HGF). Signals through HGF and c-Met have been appreciated for their crucial roles in the development of many cell types, including liver cells. The present study examined whether c-Met is expressed in the thymus and whether c-Met/HGF signal...

journal_title：Scandinavian journal of immunology

authors： Tamura S,Sugawara T,Tokoro Y,Taniguchi H,Fukao K,Nakauchi H,Takahama Y

更新日期：1998-04-01 00:00:00

abstract：:There is convincing evidence that certain combinations of alleles within the human leucocyte antigen (HLA) complex, particularly within HLA-DQ, are associated with either resistance or susceptibility to insulin-dependent diabetes mellitus (IDDM). A previous study conducted on a large, well-defined group of patients de...

journal_title：Scandinavian journal of immunology

authors： Baisch JM,Capra JD

更新日期：1992-08-01 00:00:00

abstract：:An antiserum to unstimulated rat peritoneal macrophages was produced in rabbits. The antibodies were directed against an acidic protein with a molecular weight of 35,000 and with an isoelectric point at 4.6. The macrophage acidic protein (MAP) was purified by gel filtration of rat lung soluble proteins, followed by pr...

journal_title：Scandinavian journal of immunology

authors： Persson LI,Hansson E,Rönnbäck L

更新日期：1981-10-01 00:00:00

abstract：:Granulocyte-monocyte colony-stimulating factor (GM-CSF) regulates the function of antigen-presenting cells (APCs) and has been broadly used as the adjuvant. Here, we tested whether intranasal delivery of GM-CSF can improve the contraception of mouse zona pellucida 3 (mZP3) DNA vaccine. Our results showed that co-admin...

journal_title：Scandinavian journal of immunology

authors： Ma X,Li J,Zhang F

更新日期：2012-12-01 00:00:00

abstract：:Vitamin D, an immunomodulator of macrophage function, can activate human antimycobacterial activity. Vitamin D deficiency (VDD) is associated with an impaired mycobacterial immunity and susceptibility to tuberculosis. It has been found that vitamin D and its receptor may be essential for immune function. In this study...

journal_title：Scandinavian journal of immunology

authors： Joshi L,Ponnana M,Penmetsa SR,Nallari P,Valluri V,Gaddam S

更新日期：2014-02-01 00:00:00

abstract：:By using PCR, we have found previously that differences in T cell receptor alpha/beta chain variable region (TCR alpha/beta) gene expression in lymph nodes (LN) existed between susceptible and resistant mice following anterior chamber (AC) inoculation with herpes simplex virus (HSV). We now report and compare the immu...

journal_title：Scandinavian journal of immunology

authors： Arrunategui-Correa VR,Dutt JE,Foster CS

更新日期：1995-09-01 00:00:00

abstract：:A solid-phase radioimmunoassay for detection of circulating C1q-binding immune complexes (IC) or heat-aggregated IgG (delta IgG) is described. Purified human C1q protein was adsorbed to a fixed area of polystyrene tube surface for 1 hr at 22 degrees C, pH 7.3, mu 0.15. Binding of delta IgG or IC to solid-phase C1q at ...

journal_title：Scandinavian journal of immunology

authors： Svehag SE

更新日期：1975-01-01 00:00:00

abstract：:Human bone marrow-derived mesenchymal stem cells (MSC) are multipotent non-hematopoietic progenitors that have regulatory activity on immune cells. NOD- and Toll-like receptors (NLR, TLR) have several roles in immunity, including those relevant to pathogen recognition and shaping the course of immune responses by cont...

journal_title：Scandinavian journal of immunology

authors： Sioud M,Mobergslien A,Boudabous A,Fløisand Y

更新日期：2010-04-01 00:00:00

abstract：:Discontinuous Percoll gradients have been used to obtain selected human peripheral blood T lymphocytes without having to resort to interactions with immune complexes in the fractionation of Tm, Tg and Ta cells. Here, we could show that Ta cells represent a heterogeneous population with no distinct density profile, in ...

journal_title：Scandinavian journal of immunology

authors： Canonica GW,Kabelitz D,Sjöberg O,Aigrain Y,Wigzell H

更新日期：1982-09-01 00:00:00

abstract：:The human serum amyloid A (SAA) gene family consists of two acute phase genes, SAA1 and SAA2; a pseudogene, SAA3 and a fourth gene, SAA4. The existence of SAA4 was first described in this laboratory. Subsequently, Sack & Talbot isolated a clone, designated GSAA4, which had homology to SAA3. The clone was described as ...

journal_title：Scandinavian journal of immunology

authors： Watson G,Faulkes DJ,Woo P

更新日期：1994-08-01 00:00:00

abstract：:Guinea pig alpha 1-microglobulin (alpha 1-m) was found to exert mitogenic effects on guinea pig lymphocytes, i.e. peritoneal exudate lymphocytes (PEL) or T lymphocytes from regional or mesenteric lymph nodes (LNL). On the other hand, spleen T lymphocytes did not respond to alpha 1-m. Stimulation of LNL required the pr...

journal_title：Scandinavian journal of immunology

authors： Lögdberg L,Akerström B,Shevach EM

更新日期：1986-11-01 00:00:00

abstract：:Sea star factor (SSF) harvested from the echinoderm Asterias forbesi celomocytes is a potent inhibitor of the primary immune response to T-dependent antigens and also suppresses concanavalin-A-induced mitogenesis. We have isolated and purified a basic protein from this source which has a molecular weight of approximat...

journal_title：Scandinavian journal of immunology

authors： Prendergast RA,Liu SH

更新日期：1976-01-01 00:00:00

abstract：:The question of whether there is a preferential use of certain V genes in T cells entering an inflamed joint has hitherto been studied mainly using unfractionated cells from synovial fluid and tissue respectively, and no clear answer to the question has yet been provided. Concomitantly, evidence has been provided that...

journal_title：Scandinavian journal of immunology

authors： Gudmundsson S,Rönnelid J,Karlsson-Parra A,Lysholm J,Gudbjörnsson B,Widenfalk B,Janson CH,Klareskog L

更新日期：1992-11-01 00:00:00

abstract：:The aim of this study was to investigate T-T cell interactions that may be involved in the pathogenesis of chronic synovitis. Two CD4+ T-cell clones, termed N16 and N18, sharing similar cytokine profiles were isolated from the synovial tissue of a patient with rheumatoid arthritis. Activated N16 cells induced prolifer...

journal_title：Scandinavian journal of immunology

authors： Van Laar JM,Miltenburg AM,De Kuiper P,Daha MR,De Vries RR,Breedveld FC

更新日期：1993-06-01 00:00:00

abstract：:The ability of macrophage subpopulations, separated by virtue of differences in size, to liberate soluble factors able to reconstitute antibody and cell-mediated immune responses in macrophage-depleted lymphoid cultures has been investigated. Evidence is presented to show that all macrophages release trypsin- and peps...

journal_title：Scandinavian journal of immunology

authors： Gorczynski RM

更新日期：1977-01-01 00:00:00

abstract：:Assessment of cytokine expression has become crucial to understand host responses to infections as well as autoimmunity. Several approaches including Northern blot, RNase protection assay and enzyme-linked immunosorbent assay have been used for this purpose, but they are time consuming, labour intense, and relatively ...

journal_title：Scandinavian journal of immunology

authors： Ramos-Payán R,Aguilar-Medina M,Estrada-Parra S,González-Y-Merchand JA,Favila-Castillo L,Monroy-Ostria A,Estrada-Garcia IC

更新日期：2003-05-01 00:00:00

abstract：:Drainage of the thoracic duct resulted in a decrease in the IgA level in rat bile, but at the same time there was an increase in both the total IgM level and the specific IgM antibody activity to Escherichia coli 06 in the bile of animals immunized in the Peyer's patches with these bacteria. The increase in total IgM ...

journal_title：Scandinavian journal of immunology

authors： Dahlgren UI,Ahlstedt S,Hanson LA

更新日期：1986-11-01 00:00:00

abstract：:Fc gamma receptors (FcγRs) for IgG regulate adaptive immune responses by modulating activating and inhibitory signalling pathways within immune cells. Data from a haemophilia A mouse model demonstrate that genetic deletion or blockade of the inhibitory FcγR (CD32) suppresses the formation of antibody-secreting cells (...

journal_title：Scandinavian journal of immunology

authors： Vollack N,Friese J,Bergmann S,Cragg MS,Tiede A,Werwitzke S

更新日期：2017-08-01 00:00:00

abstract：:The development of B-cell lymphomas is an intricate interplay among various pathogenic factors, leading to a multi-step process, encompassing various stages of B-cell maturation. Besides genetic abnormalities, a variety of environmental and microbial factors, as well as disproportional immune-regulatory processes lead...

journal_title：Scandinavian journal of immunology

authors： Illes A,Varoczy L,Papp G,Wilson PC,Alex P,Jonsson R,Kovacs T,Konttinen YT,Zeher M,Nakken B,Szodoray P

更新日期：2009-05-01 00:00:00

abstract：:Peripheral blood neutrophils from germ-free (GF), specific-pathogen-free (SPF) and conventional (CV) rats were compared. Besides neutropenia and impaired superoxide anion generation as previously reported, it was found that GF rats had lower phagocytic function (70%) and generated less nitric oxide than the other rats...

journal_title：Scandinavian journal of immunology

authors： Ohkubo T,Tsuda M,Suzuki S,El Borai N,Yamamura M

更新日期：1999-01-01 00:00:00

abstract：:The natural tolerance to alpha-fetoprotein (AFP) was broken in rabbits by immunizations with purified AFP from different species and homologous AFP chemically modified by haptenation. Some of the rabbits were boostered with rabbit AFP. The highest titers were obtained with human AFP, which shows a strong cross-reactio...

journal_title：Scandinavian journal of immunology

authors： Pihko H

更新日期：1976-01-01 00:00:00

abstract：:The Ro/SSA and La/SSB antigens are common targets for autoantibodies found in the sera of patients with Sjögren's syndrome and SLE. The anti-Ro/SSA and anti-La/SSB antibodies often appear together but are not cross-reactive. This paper describes the humoral autoimmune response to the Ro/SSA 60 kDa protein moiety with ...

journal_title：Scandinavian journal of immunology

authors： Wahren M,Ringertz NR,Pettersson I

更新日期：1994-02-01 00:00:00

abstract：:The major rheumatoid factor cross-reactive idiotype, which was defined by prototypic monoclonal IgM rheumatoid factors from Waldenstrom's macroglobulinaemia patient Wa, is present on 60% of all monoclonal IgM RF paraproteins. One-third of patients with juvenile rheumatoid arthritis (JRA), who are seronegative for clas...

journal_title：Scandinavian journal of immunology

authors： Ilowite NT,Wedgwood JF,Moore TL,Ramakrishnan T,Bonagura VR

更新日期：1991-10-01 00:00:00

abstract：:The in vitro anti-trinitrophenyl (TNP) response induced by TNP-lipopolysaccharide (TNP-LPs) in mouse spleen cells was eliminated by passage through Sephadex G10 columns. Conditioned medium obtained from peritoneal macrophages restored the response, indicating the supportive role of such cells in the response. Converse...

journal_title：Scandinavian journal of immunology

authors： Martinez-Alonso C,Bernabe RR,Diaz-Espada F

更新日期：1980-01-01 00:00:00

abstract：:The intestinal microbiota is important for tolerance induction through mucosal immunological responses. The composition of the gut microbiota of an infant is affected by environmental factors such as diet, disease and antibiotic treatment. However, already in utero, these environmental factors can affect the immunolog...

journal_title：Scandinavian journal of immunology

authors： Tormo-Badia N,Håkansson Å,Vasudevan K,Molin G,Ahrné S,Cilio CM

更新日期：2014-10-01 00:00:00

abstract：:The addition of a small proportion (10%) of in vivo concanavalin-A (Con-A)-activated spleen cells to normal spleen cell cultures suppressed the primary immune response to sheep erythrocytes (SRBC) but had no effect on the thymus-independent primary immune response to 3,5-dinitro-4-hydroxy-phenacetyl-conjugated lipopol...

journal_title：Scandinavian journal of immunology

authors： Ekstedt RD,Waterfield JD,Nespoli L,Möller G

更新日期：1977-01-01 00:00:00