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IgM and IgG subclass distribution of human anti-Ro/SSA 60 kDa autoantibodies.

Abstract：

:The Ro/SSA and La/SSB antigens are common targets for autoantibodies found in the sera of patients with Sjögren's syndrome and SLE. The anti-Ro/SSA and anti-La/SSB antibodies often appear together but are not cross-reactive. This paper describes the humoral autoimmune response to the Ro/SSA 60 kDa protein moiety with respect to the presence of IgM and IgG1-4 antibodies. IgM antibodies to the Ro 60 kDa protein coexisted with IgG anti-Ro 60 kDa antibodies in nearly half of the sera. A similar fraction also contained IgM anti-La/SSB antibodies. The frequency of sera with IgM antibodies of both specificities was that expected from random overlap. A predominating IgG1 anti-Ro 60 kDa response was found in all patients, but anti-Ro 60 kDa antibodies of the other IgG subclasses were present also in a high number of sera. This is in contrast to the reported IgG subclass distribution of anti-La/SSB antibodies. Mapping of IgM and IgG1-4 antibody recognition of different parts of the Ro 60 kDa protein was also performed. IgM and IgG1-4 antibodies of all sera reacted with the central part of the Ro 60 kDa protein, encompassing amino acid residues 181-320.

journal_name

Scand J Immunol

journal_title

Scandinavian journal of immunology

authors

Wahren M,Ringertz NR,Pettersson I

doi

10.1111/j.1365-3083.1994.tb03357.x

subject

Has Abstract

pub_date

1994-02-01 00:00:00

pages

179-83

issue

2

eissn

0300-9475

issn

1365-3083

journal_volume

39

pub_type

杂志文章

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