当前位置： SCI文献检索 > SCANDINAVIAN JOURNAL OF IMMUNOLOGY期刊下所有文献 > Respiratory and allergic disorders in children with severe and partial immunoglobulin A immunodeficiency.

Respiratory and allergic disorders in children with severe and partial immunoglobulin A immunodeficiency.

Abstract：

BACKGROUND:Immunoglobulin A deficiency (IgAD) is the most common primary immunodeficiency. Although most people with selective IgAD (sIgAD) are asymptomatic, many patients often suffer from recurrent respiratory infections and different allergic disorders. Our aim was to investigate connection between subtypes of sIgAD and incidence of respiratory and allergic disorders, as well as connection with lung function changes in children. METHODS:Children with IgAD where divided into two groups; severe IgAD in patients was defined as serum IgA level <7 mg/dL, while partial IgA deficiency diagnosis was made when serum IgA levels was higher than 7 mg/dL but at least two standard deviations (SD) below mean normal concentrations for their age. All patients were evaluated by their clinical and laboratory investigation parameters and compared to control group of children. RESULTS:Group of children with IgAD, severe as well as partial, showed higher prevalence of allergic diseases and total number of infections, compared to controls. There was a statistically significant difference in lung function for peak expiratory flow (PEF), the maximal expiratory flow at 50% of the forced vital capacity (MEF50) and fraction of exhaled nitric oxide (FENO) between group of patients with severe as well as partial IgAD and control group, where children with IgAD showed reduced lung function. CONCLUSIONS:Children with sIgAD are at increased risk for higher number of respiratory infections and developing allergic diseases, resulting in significantly lower pulmonary function which is related with the severity of sIgAD.

journal_name

Scand J Immunol

journal_title

Scandinavian journal of immunology

authors

Živković J,Lipej M,Banić I,Bulat Lokas S,Nogalo B,Lulić Jurjević R,Turkalj M

doi

10.1111/sji.12828

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

e12828

issue

6

eissn

0300-9475

issn

1365-3083

journal_volume

90

pub_type

杂志文章

相关文献

SCANDINAVIAN JOURNAL OF IMMUNOLOGY文献大全
  • T-cell receptor V-gene usage in synovial fluid and synovial tissue from RA patients.

    abstract：:The question of whether there is a preferential use of certain V genes in T cells entering an inflamed joint has hitherto been studied mainly using unfractionated cells from synovial fluid and tissue respectively, and no clear answer to the question has yet been provided. Concomitantly, evidence has been provided that...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1992.tb03128.x

    authors： Gudmundsson S,Rönnelid J,Karlsson-Parra A,Lysholm J,Gudbjörnsson B,Widenfalk B,Janson CH,Klareskog L

    更新日期：1992-11-01 00:00:00

  • D-D recombination diversifies the CDR 3 region of chicken immunoglobulin heavy chains.

    abstract：:The occurrence of D-D recombination during the embryonic differentiation of chicken B cells was studied. Ig heavy (H) chains were amplified by polymerase chain reaction from day-12 bursal cDNA, and 30 random V-D-J regions were analysed by DNA sequencing. No gene conversion events were observed in any of the V regions,...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1991.tb02524.x

    authors： Mansikka A,Toivanen P

    更新日期：1991-05-01 00:00:00

  • The biological activity of serum IgE changes over the course of a primary response.

    abstract：:Mast-cell degranulation is triggered by the bridging of Fc receptor-bound antigen-specific immunoglobulin IgE on the cell surface. In vitro experiments suggest that antibody affinity and nonspecific IgE may affect the mast-cell function, however, their importance in vivo is unclear. Investigations of the effects of th...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-3083.2002.01012.x

    authors： Mitchell AJ,Moss ND,Collins AM

    更新日期：2002-01-01 00:00:00

  • Different glycosylation pattern of human IgG1 and IgG3 antibodies isolated from transiently as well as permanently transfected cell lines.

    abstract：:The effector functions of IgG depend on the presence of carbohydrates attached to asparagine 297 in the Fc-portion. In this report, glycosylation profiles of recombinant wild-type and mutant IgG1 and IgG3 antibodies produced from three cell lines were analysed using LC-ESI-Orbitrap. Clear differences were detected bet...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/sji.12046

    authors： Vestrheim AC,Moen A,Egge-Jacobsen W,Bratlie DB,Michaelsen TE

    更新日期：2013-05-01 00:00:00

  • Complex formation between secretory component and human immunoglobulins related to their content of J chain.

    abstract：:The J-chain content of 3 IgM and 24 IgA preparations was quantitated by an immunochemical technique after reduction with 20mM dithiothreitol. The amounts released ranged from undetectable (less than 0.1 mg) to 7.3 mg per 100 mg of Ig. Most of the J-chain-deficient proteins were monomeric, but four polymeric IgA prepar...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1976.tb00295.x

    authors： Brandtzaeg P

    更新日期：1976-01-01 00:00:00

  • Coding region polymorphisms of human T-cell receptor V beta 6.9 and V beta 21.4.

    abstract：:Two new TCRV beta coding region polymorphisms were identified: V beta 6.9a/b and V beta 21.4a/b. In both cases, a single nucleotide difference gives rise to an amino acid exchange. Genomic typing by the PCR/sequence-specific oligonucleotide probing technique was performed to study a possible contribution of these two ...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1992.tb03101.x

    authors： Hansen T,Rønningen KS,Ploski R,Kimura A,Thorsby E

    更新日期：1992-08-01 00:00:00

  • Human leukocyte migration inhibitory factor (LIF). II. Partial biochemical characterization of the substrate specificities for this lymphokine.

    abstract：:Previously reported experiments suggested that an esterase or a protease, or both, might participate in the expression of human leukocyte migration inhibitory factor (LIF). To clarify this further, a wide variety of simple ester were tested for the ability to protect LIF against inactivation by the serine esterase inh...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1977.tb00328.x

    authors： Bendtzen K

    更新日期：1977-01-01 00:00:00

  • Thalidomide prolongs experimental autoimmune neuritis in Lewis rats.

    abstract：:Thalidomide is reported to have immunomodulatory and anti-inflammatory effects, which have led to its use in the treatment of a number of immune-mediated disorders, including leprosy, discoid lupus and Behcet's disease, and to prevent immunological rejection phenomena following skin and bone marrow grafts. Experimenta...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-3083.1998.00421.x

    authors： Zhu J,Deng GM,Diab A,Zwingenberger K,Bakhiet M,Link H

    更新日期：1998-10-01 00:00:00

  • Immunological effects of D-penicillamine during experimental induced inflammation in rats.

    abstract：:Administration of D-penicillamine (50 mg/kg/day orally) to rats with adjuvant arthritis for up to 42 days significantly modified the incorporation of 3H-thymidine (3H-TdR) in concanavalin A (Con A)-stimulated lymph node cells. Treatment with D-penicillamine abolished the ability of macrophages from arthritic rats to i...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1980.tb00064.x

    authors： Binderup L,Bramm E,Arrigoni-Martelli E

    更新日期：1980-01-01 00:00:00

  • Macrophage requirement for the in vitro response to an insolubilized T-independent antigen.

    abstract：:The role of macrophages in the in vitro response of mouse spleen cells to the insolubilized, T-independent antigen trinitrophenylated polyacrylamide (TNP-PAA) is demonstrated by the following points. The response is abolished by filtration on Sephadex G-10 and can be restored by the addition of splenic adherent cells,...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1979.tb02718.x

    authors： Duclos H,Galanaud P,Maillot MC,Crevon MC,Dormont J

    更新日期：1979-01-01 00:00:00

  • Inhibition of in vitro immune responses by a fraction from seminal plasma.

    abstract：:We studied the inhibitory effect of a fraction of bovine seminal plasma on in vitro lymphocyte responses to specific and nonspecific ligands. Seminal plasma was fractionated by Sephadex G-100 chromatography, and the inhibitory component was found to have a molecular weight of above 100,000 daltons. This fraction was d...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1976.tb02994.x

    authors： Prakash C,Coutinho A,Möller G

    更新日期：1976-01-01 00:00:00

  • Participation of V beta 4(+)-, V beta 7(+)-, and V beta 11(+)-T lymphocytes in haematogenously acquired Staphylococcus aureus nephritis.

    abstract：:The most frequent pathogen in haematogenously acquired kidney infections in humans in Staphylococcus aureus. In order to characterize in situ the immunological patterns of septic nephritis we developed a murine model of this disease. A single intravenous injection of S. aureus producing toxic shock syndrome toxin-1 re...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-3083.1996.d01-309.x

    authors： Verba V,Tarkowski A

    更新日期：1996-09-01 00:00:00

  • Peripheral circulating activated b-cell populations are associated with nephritis and disease activity in patients with systemic lupus erythematosus.

    abstract：:B-cell-dependent autoantibody production is a hallmark of systemic lupus erythematosus (SLE) which requires costimulatory molecules. The aim of the study was to analyse the expression of costimulatory molecules on B cells in patients with SLE. Twenty-six patients with SLE (four male, 22 female, mean age 46 +/- 15 year...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.2007.02008.x

    authors： Dolff S,Wilde B,Patschan S,Dürig J,Specker C,Philipp T,Kribben A,Witzke O

    更新日期：2007-11-01 00:00:00

  • Multiple sclerosis: cells secreting antibodies against myelin-associated glycoprotein are present in cerebrospinal fluid.

    abstract：:We evaluated the B-cell response in cerebrospinal fluid (CSF) and blood by enumerating cells secreting antibodies to myelin-associated glycoprotein (MAG) and, for reference, to myelin basic protein (MBP), two myelin components which may constitute targets for autoimmune attack in multiple sclerosis (MS). Among 25 untr...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1991.tb02493.x

    authors： Baig S,Olsson T,Yu-Ping J,Höjeberg B,Cruz M,Link H

    更新日期：1991-01-01 00:00:00

  • Cytokine levels in midtrimester amniotic fluid in normal pregnancy and in the prediction of pre-eclampsia.

    abstract：:Midtrimester amniotic fluid cytokines may reflect the function of the maternal immune system in the maternal-fetal interface and thus be predictive of pre-eclampsia. We determined the concentrations of interleukin (IL)-6, IL-8, IL-10, IL-11, IL-12, IL-15, tumour necrosis factor (TNF)-alpha and transforming growth fact...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-3083.2001.00872.x

    authors： Heikkinen J,Möttönen M,Pulkki K,Lassila O,Alanen A

    更新日期：2001-03-01 00:00:00

  • Utilization of the MHC class I (H-2Kb) purified molecule and its synthetic peptides for inhibition of Kb-specific suppressor T cells and their induction in vivo by the MHC peptides.

    abstract：:Six synthetic peptides of the MHC class I molecule corresponding to individual H-2Kb participants in amino acid sequences of domains alpha 1 (peptide 1 and 2) and alpha 2 (peptides 3, 4, 5, 6) were selected. Kb-specific suppressor T cells (Ts) were induced in vivo in mice, then pretreated with a set of peptides and as...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1993.tb01674.x

    authors： Brondz BD,Anfalova TV,Pavlova LS,Pankratova EV,Kojich AG,Moshnikov SA

    更新日期：1993-06-01 00:00:00

  • Natural killer-like cytotoxicity of human T-cell clones against various target cells.

    abstract：:MLC-T cells from two different donors were cultured after limiting dilution (0.3 cells/well) in medium containing T-cell growth factor. Clones showing lytic activity against K-562 in a preliminary screening were expanded and tested against various NK-sensitive target-cell lines (Chang, T-24, Daudi, and Molt-4) and phy...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1983.tb00770.x

    authors： López-Botet M,Moretta A,Moretta L

    更新日期：1983-01-01 00:00:00

  • The number of regulatory T cells correlates with hemodynamic improvement in patients with inflammatory dilated cardiomyopathy after immunoadsorption therapy.

    abstract：:Inflammatory DCM (iDCM) may be related to autoimmune processes. An immunoadsorption (IA) has been reported to improve cardiac hemodynamics. The benefit of IA is probably related to the removal of autoantibodies. A recent study suggests additional effects of IA on the T cell-mediated immune reactions, especially on reg...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/sji.12000

    authors： Bulut D,Creutzenberg G,Mügge A

    更新日期：2013-01-01 00:00:00

  • Human umbilical vein endothelial cells synthesize functional C3, C5, C6, C8 and C9 in vitro.

    abstract：:Human endothelial cells (EC), cultured serum-free, synthesize de novo protein which increasingly bind to agarose beads (an alternative pathway activator), until a plateau phase is reached after 24-48 h. EC synthesize functional C3, C5, C6, C8 and C9, which were detected on co-cultured agarose beads, using relevant pol...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1991.tb02539.x

    authors： Johnson E,Hetland G

    更新日期：1991-06-01 00:00:00

  • Increased expression of leucocyte adherence-related glycoproteins by polymorphonuclear leucocytes during phagocytosis of staphylococci on an endothelial surface.

    abstract：:Phagocytosis of Staphylococcus aureus by human polymorphonuclear leucocytes (PMN) on the surface of endothelial cells is accompanied by adherence of the PMN to the endothelial surface and detachment of the endothelial cells from the culture monolayer. We studied the role of the leucocyte adherence-related glycoprotein...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1989.tb01192.x

    authors： Vandenbroucke-Grauls CM,Thijssen HM,Tetteroo PA,Rozemuller E,Verhoef J

    更新日期：1989-07-01 00:00:00

  • The MHC class I associated beta 2-microglobulin (beta 2m) light chain is expressed in a molar excess over HLA-ABC and CD1 on the membrane of leukaemic B cells but not leukaemic T cells: evidence for further beta 2m-associated molecules.

    abstract：:Beta 2-microglobulin (beta 2m) constitutes the common light chain of both the MHC-encoded HLA-ABC molecules and a group of structurally related glycoproteins recognized by antibodies of the first cluster of differentiation (CD1a, CD1b and CD1c). These CD1 antigens appear similar to murine T1 and Qa molecules in terms ...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1991.tb01520.x

    authors： Jones RA,Child JA,Master PS,Scott CS

    更新日期：1991-07-01 00:00:00

  • T-cell effector function and unresponsiveness in the murine lymphocytic choriomeningitis virus infection. I. On the mechanism of a selective suppression of the virus-specific delayed-type hypersensitivity response.

    abstract：:When the virus dose is increased from 10(2) (low dose) to 10(4) LD50 (high dose) a fatal lymphocytic choriomeningitis virus (LCMV) infection is changed into a subclinical one, and a selective virus-specific delayed-type hypersensitivity (DTH) unresponsiveness is induced, while the cytotoxic T-cell response remains ess...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1986.tb02078.x

    authors： Marker O,Thomsen AR

    更新日期：1986-08-01 00:00:00

  • F1-hybrid anti-parental-strain reactivity. I. Impaired proliferation of CBA lymphocytes in the spleens of irradiated C3H X CBA mice pretreated with CBA spleen cells.

    abstract：:Previous investigations have indicated that C3H X CBA hybrid lymphocytes can neutralize lymphocytes which are reactive against the C3H-determined Mls antigen when injected into the H-2-compatible strain CBA. In this study we have inoculated C3H X CBA hybrids with CBA spleen cells and 2 weeks later lethally irradiated ...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1978.tb00514.x

    authors： Lilliehöök B,Blomgren H

    更新日期：1978-01-01 00:00:00

  • Downregulation of CD94/NKG2A inhibitory receptor on decreased γδ T cells in patients with systemic lupus erythematosus.

    abstract：:γδ T cells are characterized by recognizing conserved endogenous and stress-induced antigens without antigen presentation. It has been show that γδ T cells play an important role in anti-tumour/microbe responses, but their function in autoimmune diseases is yet not clear. Here, we reported the quantity and phenotype o...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.2012.02705.x

    authors： Wang L,Kang N,Zhou J,Guo Y,Zhang X,Cui L,Ba D,He W

    更新日期：2012-07-01 00:00:00

  • Wallaby serum amyloid A protein: cDNA cloning, sequence and evolutionary analysis.

    abstract：:A serum amyloid A (SAA) clone was isolated from a Tammar wallaby cDNA library, the most distantly related mammalian species for which an SAA has been described to date. The clone predicts a premolecule of 127 amino acids with good homology to other mammalian SAAs, and consists of an 18 residue leader peptide and a mat...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-3083.1996.d01-34.x

    authors： Uhlar CM,Black IL,Shields DC,Brack CM,Schreiber G,Whitehead AS

    更新日期：1996-03-01 00:00:00

  • Molecular mechanism of immunoglobulin V-region diversification regulated by transcription and RNA metabolism in antigen-driven B cells.

    abstract：:The immune system produces specific antibodies (Ab) against any antigens (Ag) of exogenous and endogenous origins with a diverse repertoire of V-region specificities. The primary V-region repertoire is created by the rearrangement of immunoglobulin (Ig) V-region, D- and J-segments with the insertion of N- and P-sequen...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-3083.2011.02557.x

    authors： Sakaguchi N,Maeda K,Kuwahara K

    更新日期：2011-06-01 00:00:00

  • Upregulated microRNA-132 in T helper 17 cells activates hepatic stellate cells to promote hepatocellular carcinoma cell migration in vitro.

    abstract：:MicroRNAs play an important role in the modulation of the immune system. T helper 17 (Th17) cells are involved in the modulation of the tumour microenvironment. However, the function of miRNA in Th17 cells in the tumour microenvironment is unclear. In this study, we analysed miR-132 expression in Th17 cells and assess...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/sji.13007

    authors： Feng R,Cui Z,Liu Z,Zhang Y

    更新日期：2020-12-02 00:00:00

  • Coexistence of protein AA and immunoglobulin light-chain fragments in amyloid fibrils.

    abstract：:Coexistence of amyloid fibril protein AA and homogeneous immunoglobulin light-chain fragments was found in the isolated amyloid fibrils of two patients with amyloidosis secondary to rheumatoid arthritis. The light-chain amyloid fibril protein showed antigenic identity with a light-chain amyloid from a patient with pri...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1976.tb02989.x

    authors： Westermark P,Natvig JB,Anders RF,Sletten K,Husby G

    更新日期：1976-01-01 00:00:00

  • Evidence of aberration of T-cell subsets in aged individuals.

    abstract：:In the present study, T-cell subsets from aged individuals were examined by using anti-BAT (brain-associated thymocyte antigen) serum. Anti-BAT serum was raised against the human fetal brain at 28 weeks of gestation. After absorption wit AB erythrocytes, B-cell lines, and leukaemic cells, anti-BAT serum was T cell-spe...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1981.tb00121.x

    authors： Abe T,Morimoto C,Toguchi T,Kiyotaki M,Homma M

    更新日期：1981-01-01 00:00:00

  • Diabetes induction in C57BL/6 mice reconstituted with lymphocytes of nonobese diabetic C57BL/6 mouse embryo aggregation chimeras.

    abstract：:To determine whether the genetic background of the insulin-producing beta cells of the pancreas contributes to autoimmune diabetes susceptibility, we have used a model of the disease based on transferring spleen cells from nonobese diabetic (NOD) <--> C57BL/6 (B6) embryo aggregation (EA) chimeras into B6 and NOD irrad...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-3083.1998.00479.x

    authors： Colucci F,Bergman ML,Lejon K,Holmberg D

    更新日期：1998-12-01 00:00:00