Intranasal co-delivery with the mouse zona pellucida 3 and GM-CSF expressing constructs enhances humoral immune responses and contraception in mice.

abstract：:Rat popliteal and the iliac lymph nodes were examined after foot-pad injections of colloidal carbon and ferritin-tetramethylrhodamine isothiocyanate. Carbon rapidly entered medullary sinuses, but the entry of carbon into the interstitium was prohibited by avid phagocytosis, by sinus macrophages and by the lymphoendoth...

journal_title：Scandinavian journal of immunology

authors： Fossum S

更新日期：1980-01-01 00:00:00

abstract：:As part of an ongoing project aimed at the characterization of the MHC system in bony fishes, we have attempted to identify the class III region in the zebrafish (a teleost), a region that in higher vertebrates contains genes coding for complement proteins C2, Bf and C4. We obtained several genomic PAC clones by hybri...

journal_title：Scandinavian journal of immunology

authors： Gongora R,Figueroa F,Klein J

更新日期：1998-12-01 00:00:00

abstract：:Rabbit Ig against human beta2-microglobulin was found to be mitogenic for human peripheral lymphocytes, tonsil lymphocytes, and appendix and spleen cells. Anti-beta2-m gave increased DNA synthesis, with peak responses on day 3 or 4 and showed a dose-response effect when diluted. The effect was seen in both serum-free ...

journal_title：Scandinavian journal of immunology

authors： Ringeén O,Möller E

更新日期：1975-01-01 00:00:00

abstract：:This study is to investigate the regulation of Toll-like receptor (TLR) expression in systemic immune reactions in different arthritis rat models, which will provide evidence to understand the mechanisms of rheumatoid arthritis further. Arthritis-susceptible DA rats were used to induce arthritis by pristane or collage...

journal_title：Scandinavian journal of immunology

authors： Zhu W,Meng L,Jiang C,Xu J,Wang B,Han Y,Lu S

更新日期：2012-09-01 00:00:00

abstract：:Subclasses of lymphocytes can be separated on gradients of non-toxic polyvinylpyrrolidone-coated colloidal silica (Percoll) by virtue of differential densities. Such gradients can yield functionally active lymphocyte populations after brief centrifugation. Gradients can be generated in a discontinuous step fashion and...

journal_title：Scandinavian journal of immunology

authors： Kurnick JT,Ostberg L,Stegagno M,Kimura AK,Orn A,Sjöberg O

更新日期：1979-01-01 00:00:00

abstract：:The aim of this study was to investigate the epitope recognition pattern of La(SS-B) autoantibodies in sera from patients with Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE) using overlapping synthetic decapeptides on solid phase. Eighty different decapeptides with five amino acids overlap from the hum...

journal_title：Scandinavian journal of immunology

authors： Haaheim LR,Halse AK,Kvakestad R,Stern B,Normann O,Jonsson R

更新日期：1996-01-01 00:00:00

abstract：:The currently used vaccine against tuberculosis, Bacille Calmette-Guérin (BCG), has variable efficacy, so new vaccine development is crucial. In this study, we evaluated a recombinant vaccine prepared from non-pathogenic Mycobacterium smegmatis (rMS) that expresses a fusion of early secreted antigenic target 6-kDa ant...

journal_title：Scandinavian journal of immunology

authors： Zhang H,Peng P,Miao S,Zhao Y,Mao F,Wang L,Bai Y,Xu Z,Wei S,Shi C

更新日期：2010-10-01 00:00:00

abstract：:T helper 17 (TH17) cells have well-described roles in autoimmune diseases. The immune modulations of development and function of TH17 have become a key issue. In this review, we summarize the recent findings regarding the direct and indirect signalling regulatory mechanisms of TH17 cells in the general mouse model of ...

journal_title：Scandinavian journal of immunology

authors： Bi Y,Yang R

更新日期：2012-06-01 00:00:00

abstract：:Using rocket immunoelectrophoresis and indirect haemagglutination tests, antibodies to nicotinic acetylcholine receptor (n-AChR) from Torpedo marmorata were detected in sera from rabbits with experimental myasthenia but not in sera from patients with myasthenia gravis or in rabbit antisera to a partly purified skeleta...

journal_title：Scandinavian journal of immunology

authors： Aarli JA,Mattsson C,Heilbronn E

更新日期：1975-01-01 00:00:00

abstract：:The CD45 molecule is a transmembrane tyrosine phosphatase that may be associated with the T-cell receptor (TCR). This has led to the suggestion that CD45 may be important for the regulation of signal transduction in T cells. This idea is supported by the finding that antibodies against CD45 are comitogenic in prolifer...

journal_title：Scandinavian journal of immunology

authors： Wolff H,Janeway C Jr

更新日期：1994-07-01 00:00:00

abstract：:The homogenates of amyloid-laden spleens prepared from CBA mice were analysed by SDS-PAGE and immunoblotting employing rat anti-murine monoclonal antibody, MSA 4-26. The results showed that the precursor of amyloid A protein (AA), serum amyloid A protein 2 (SAA2), and SAA intermediates with molecular weights of 10,000...

journal_title：Scandinavian journal of immunology

authors： Shiroo M,Kawahara E,Nakanishi I,Migita S

更新日期：1987-12-01 00:00:00

abstract：:To determine whether the genetic background of the insulin-producing beta cells of the pancreas contributes to autoimmune diabetes susceptibility, we have used a model of the disease based on transferring spleen cells from nonobese diabetic (NOD) <--> C57BL/6 (B6) embryo aggregation (EA) chimeras into B6 and NOD irrad...

journal_title：Scandinavian journal of immunology

authors： Colucci F,Bergman ML,Lejon K,Holmberg D

更新日期：1998-12-01 00:00:00

abstract：:The role of several adhesion molecules for lymphocyte-endothelial interactions in the synovia of rheumatoid arthritis patients was studied using the frozen section assay. Partial inhibition of lymphocyte binding to endothelium of synovial sections could be observed with antibodies against CD44, L-selectin, and beta 1-...

journal_title：Scandinavian journal of immunology

authors： Fischer C,Thiele HG,Hamann A

更新日期：1993-08-01 00:00:00

abstract：:Persistent humoral immunity depends on the follicular B cell response and on the generation of somatically mutated high-affinity plasma cells and memory B cells. Upon activation by an antigen, cognately activated follicular B cells and follicular T helper (TFH ) cells initiate germinal centre (GC) reaction during whic...

journal_title：Scandinavian journal of immunology

authors： Nera KP,Kyläniemi MK,Lassila O

更新日期：2015-09-01 00:00:00

abstract：:Two new TCRV beta coding region polymorphisms were identified: V beta 6.9a/b and V beta 21.4a/b. In both cases, a single nucleotide difference gives rise to an amino acid exchange. Genomic typing by the PCR/sequence-specific oligonucleotide probing technique was performed to study a possible contribution of these two ...

journal_title：Scandinavian journal of immunology

authors： Hansen T,Rønningen KS,Ploski R,Kimura A,Thorsby E

更新日期：1992-08-01 00:00:00

abstract：:We investigated interferon (IFN) production by peripheral blood mononuclear cells from four patients with chronic OKT4 T-lymphocytic leukaemia and three patients with abnormal expansions of granular lymphocytes. No spontaneous production of IFN-gamma was found in supernatants of cultures from both patients and normal ...

journal_title：Scandinavian journal of immunology

authors： Pandolfi F,Capobianchi M,Matricardi P,Facchini J,Bonomo G,De Rossi G,Semenzato G,Fiorilli M,Dianzani F,Aiuti F

更新日期：1985-04-01 00:00:00

abstract：:Contagious bovine pleuropneumonia, caused by Mycoplasma mycoides ssp. mycoides biotype small colony (MmmSC), is one of the most serious cattle diseases in Africa. Several observations suggested that MmmSC had evolved an efficient way to escape the bovine immune responses by triggering host-cell cytotoxicity. This stud...

journal_title：Scandinavian journal of immunology

authors： Dedieu L,Chapey E,Balcer-Rodrigues V

更新日期：2005-12-01 00:00:00

abstract：:C-reactive protein (CRP) binds to Fcγ-receptors, FcγRIIa (CD32) with high affinity and to FcγRIa (CD64) with low affinity. The binding to CD32 has been shown to be allele specific, that is, it binds to R/R131 but not to H/H131. Little is known about the cooperation of CRP and neutrophilic granulocytes (PMNs) in inflam...

journal_title：Scandinavian journal of immunology

authors： Aas V,Sand KL,Asheim HC,Benestad HB,Iversen JG

更新日期：2013-06-01 00:00:00

abstract：:(NZB x NZW)F1 (B/W) mice spontaneously develop a disease which is remarkably similar to systemic lupus erythematosus (SLE) in humans. This disease is characterized by the appearance of autoantibodies to double-stranded (ds)DNA and the subsequent development of fatal glomerulonephritis. The prophylactic treatment of B/...

journal_title：Scandinavian journal of immunology

authors： Lin RH,Wang LF

更新日期：1994-05-01 00:00:00

abstract：:The activation of complement and the release of TNF-alpha, IL-6 and IL-8 are important pathogenic factors behind organ dysfunction in sepsis. The aim of this study was to determine whether infusion of anti-TNF antibodies alters complement activation and plasma concentrations of pro-inflammatory cytokines at high doses...

journal_title：Scandinavian journal of immunology

authors： Bengtsson A,Redl H,Schlag G,Högåsen K,Götze O,Mollnes TE

更新日期：1998-11-01 00:00:00

abstract：:Mast-cell degranulation is triggered by the bridging of Fc receptor-bound antigen-specific immunoglobulin IgE on the cell surface. In vitro experiments suggest that antibody affinity and nonspecific IgE may affect the mast-cell function, however, their importance in vivo is unclear. Investigations of the effects of th...

journal_title：Scandinavian journal of immunology

authors： Mitchell AJ,Moss ND,Collins AM

更新日期：2002-01-01 00:00:00

abstract：:The restriction fragment length polymorphism of the human tumour necrosis factor (TNF alpha) region was investigated by means of 20 different restriction enzymes and a human TNF alpha cDNA probe. Only one of the enzymes, NcoI, revealed a polymorphic pattern consisting of fragments of 10.5 and 5.5 kb, which behaved as ...

journal_title：Scandinavian journal of immunology

authors： Fugger L,Morling N,Ryder LP,Platz P,Georgsen J,Jakobsen BK,Svejgaard A,Dalhoff K,Ranek L

更新日期：1989-08-01 00:00:00

abstract：:We have compared antibody-dependent cell-mediated cytotoxicity (ADCMC) of human peripheral blood leukocytes (PBL) in three model systems. target cells were 51Cr-labeled mouse mastocytoma cells, chicken erythrocytes (CRBC), and human erythrocytes (HRBC) coated with appropriate heterologous or isologous antisera. Effect...

journal_title：Scandinavian journal of immunology

authors： MacDonald HR,Bonnard GD,Sordat B,Zawodnik SA

更新日期：1975-09-01 00:00:00

abstract：:MLC-T cells from two different donors were cultured after limiting dilution (0.3 cells/well) in medium containing T-cell growth factor. Clones showing lytic activity against K-562 in a preliminary screening were expanded and tested against various NK-sensitive target-cell lines (Chang, T-24, Daudi, and Molt-4) and phy...

journal_title：Scandinavian journal of immunology

authors： López-Botet M,Moretta A,Moretta L

更新日期：1983-01-01 00:00:00

abstract：:To determine whether psoriatic keratinocytes differ from normal keratinocytes in their response to gamma interferon, epidermal cell suspensions from normal and from lesional and uninvolved psoriatic skin were cultured in the presence of gamma interferon and the induction of HLA-DR expression and inhibition of cell gro...

journal_title：Scandinavian journal of immunology

authors： Baker BS,Powles AV,Valdimarsson H,Fry L

更新日期：1988-12-01 00:00:00

abstract：:The objective of the study was to investigate the antigen specificity and occurrence of individual autoantibodies in mothers of children diagnosed with atrioventricular (AV) block in a nation-wide setting. Patients with AV block detected before 15 years of age were identified using national quality registries as well ...

journal_title：Scandinavian journal of immunology

authors： Salomonsson S,Dzikaite V,Zeffer E,Eliasson H,Ambrosi A,Bergman G,Fernlund E,Theander E,Ohman A,Rydberg A,Skogh T,Wållberg-Jonsson S,Elfving A,Fored M,Ekbom A,Lundström U,Mellander M,Winqvist O,Sonesson SE,Gadler F,

更新日期：2011-11-01 00:00:00

abstract：:Human endothelial cells (EC), cultured serum-free, synthesize de novo protein which increasingly bind to agarose beads (an alternative pathway activator), until a plateau phase is reached after 24-48 h. EC synthesize functional C3, C5, C6, C8 and C9, which were detected on co-cultured agarose beads, using relevant pol...

journal_title：Scandinavian journal of immunology

authors： Johnson E,Hetland G

更新日期：1991-06-01 00:00:00

abstract：:There is strong evidence from animal models that placental and/or breast milk-mediated transfer of maternal allergen-specific IgG prevents allergic immune responses in the progeny. Both human and animal data also point to IgA as having an important regulatory role. In contrast, little is known about maternal transfer ...

journal_title：Scandinavian journal of immunology

authors： Macchiaverni P,Arslanian C,Frazão JB,Palmeira P,Russo M,Verhasselt V,Condino-Neto A

更新日期：2011-12-01 00:00:00

abstract：:Immunoglobulin-secreting cells (ISC) in the peripheral blood of healthy individuals and in the bone marrow, peripheral blood, or plasmacytomas of patients with multiple myeloma were enumerated by a protein-A plaque-forming cell assay after treatment with anti-Ia antibody and complement. Rabbit anti-human B-cell antise...

journal_title：Scandinavian journal of immunology

authors： Nagai K,Nagai T,Takatsuki K,Uchino H

更新日期：1982-06-01 00:00:00

abstract：:TIM-3 is a member of the TIM (T-cell immunoglobulin domain and mucin domain) family, which plays an important role in TH1 responses and autoimmune diseases. In this study, we cloned and characterized the porcine TIM-3 gene. Real-time PCR showed little expression of porcine TIM-3 in muscle and stomach, low expression i...

journal_title：Scandinavian journal of immunology

authors： Zhao W,Li Y,Wang Z,Li K,Yang S

更新日期：2011-01-01 00:00:00