Independent duplications of Bf and C3 complement genes in the zebrafish.

abstract：:Propagermanium is an organic germanium compound with immunopotentiating activity. We examined the hepatoprotective effect of propagermanium and its mechanism in an experimental animal model of acute liver injury induced with Corynebacterium parvum (C. parvum) and lipopolysaccharide (LPS) injection. Oral pretreatment w...

journal_title：Scandinavian journal of immunology

authors： Yokochi S,Ishiwata Y,Hashimoto H,Ninomiya F,Suzuki T

更新日期：1998-08-01 00:00:00

abstract：:In order to understand why most strains of Biozzi mice are unexpectedly either arthritis-resistant, or susceptible, we investigate the autoantibody reactivity against matrix-embedded collagen molecules. We show a close correlation between these tissular and the free collagen antibodies, irrespective of arthritis susce...

journal_title：Scandinavian journal of immunology

authors： Bouvet JP,Franc B,Zyad A,Couderc J

更新日期：1992-06-01 00:00:00

abstract：:Monoclonal anti-HLA-DR antibodies inhibited the production of interleukin-2 (IL-2) when added from the initiation of autologous (AMLR) and allogeneic (MLR) mixed lymphocyte reactions, but not 60 h later. The inhibitory activity of the anti-DR sera became apparent 8 h after initiation of the cultures and was maintained...

journal_title：Scandinavian journal of immunology

authors： Palacios R

更新日期：1981-09-01 00:00:00

abstract：:Human CD26 has dipeptidyl peptidase-4 (DPP IV) enzyme activity and binds to adenosine deaminase (ADA). CD26 is costimulatory for lymphocytes and has a circulating soluble form (sCD26). DPP IV enzyme inhibition is a new successful type 2 diabetes therapy. We examined whether the ADA binding and catalytic functions of s...

journal_title：Scandinavian journal of immunology

authors： Yu DM,Slaitini L,Gysbers V,Riekhoff AG,Kähne T,Knott HM,De Meester I,Abbott CA,McCaughan GW,Gorrell MD

更新日期：2011-02-01 00:00:00

abstract：:Fenugreek is a legume mostly used as a spice in Indian-style cooking. Although it has been used since ancient times, its allergenicity has only been reported in the last two decades. It poses special problems as an emerging and often hidden allergen. Fenugreek exposure may have serious implications also for individual...

journal_title：Scandinavian journal of immunology

authors： Vinje NE,Namork E,Løvik M

更新日期：2011-10-01 00:00:00

abstract：:The average frequency of cytotoxic precursor cells in DBA/2 lymph node cell preparations reactive to the syngeneic tumour P815 has been determined as 1 in 2000. This frequency is similar to the precursor frequency for an allogeneic tumour EL-4. The normal lack of response of DBA/2 lymph node cells to the syngeneic tum...

journal_title：Scandinavian journal of immunology

authors： Warren HS,Lafferty KJ

更新日期：1979-01-01 00:00:00

abstract：:Peripheral blood lymphocytes from 43 patients with systemic lupus erythematosus (SLE) and from age- and sex-matched normal controls were cultured with lipopolysaccharide (LPS) to examine the response to the polyclonal B-cell activator. Lymphocytes from active SLE patients incorporated 4840 +/- 471 (mean +/- SE) cpm in...

journal_title：Scandinavian journal of immunology

authors： Abe T,Toguchi T,Takeuchi T,Kiyotaki M,Homma M

更新日期：1981-05-01 00:00:00

abstract：:Screening for B-cell-specific antibodies in unabsorbed pregnancy sera preselected for weak reactivity in regular HLA-A, -B, and -C screening yielded a relatively high proportion (35/81) of B-cell-specific antibodies. Most B-cell-specific antibodies react broadly, showing inclusion phenomena suggesting 'cross-reactivit...

journal_title：Scandinavian journal of immunology

authors： Albert ED,Andreas A,McNicholas A,Scholtz S,Kuntz B

更新日期：1977-01-01 00:00:00

abstract：:Around 20 susceptibility loci for type 1 diabetes mellitus (T1DM) have been mapped. One of these loci, IDDM10, was found on chromosome 10p11-q11. Here, we investigated whether the IDDM10 locus contributes in the susceptibility to T1DM in a Russian family dataset. One hundred and fourteen simplex Russian families, each...

journal_title：Scandinavian journal of immunology

authors： Chistiakov DA,Seryogin Y,Savost'anov KV,Zilberman LI,Titovich EV,Kuraeva TL,Dedov II,Nosikov VV

更新日期：2004-09-01 00:00:00

abstract：:γδ T cells are characterized by recognizing conserved endogenous and stress-induced antigens without antigen presentation. It has been show that γδ T cells play an important role in anti-tumour/microbe responses, but their function in autoimmune diseases is yet not clear. Here, we reported the quantity and phenotype o...

journal_title：Scandinavian journal of immunology

authors： Wang L,Kang N,Zhou J,Guo Y,Zhang X,Cui L,Ba D,He W

更新日期：2012-07-01 00:00:00

abstract：:Some data suggest that the interaction between CD28 and CD80 (B7.1) stimulates Th1-responses and that CD28 and CD86 (B7.2) stimulates Th2-responses, however this is controversial. We addressed this issue by using mercuric chloride (HgCl2)-induced autoimmunity in Brown Norway (BN) rats as a highly polarized Th2 model a...

journal_title：Scandinavian journal of immunology

authors： MacPhee IA,Turner DR,Yagita H,Oliveira DB

更新日期：2001-11-01 00:00:00

abstract：:The immunoglobulin (Ig) plasma levels are known to be, at least partially, genetically regulated, but all the genes involved are not known. Interleukin-1 (IL-1) is a potent proinflammatory cytokine able to serve as an adjuvant for immune responses. IL-1alpha gene is polymorphic, and at least one of the polymorphisms h...

journal_title：Scandinavian journal of immunology

authors： Kilpinen S,Laine S,Hulkkonen J,Hurme M

更新日期：2003-03-01 00:00:00

abstract：:Mouse monoclonal antibodies against ED sequence-containing cellular fibronectin (cFn) were used to show that Fn in the inflamed synovium is distinct from the major form of plasma Fn (pFn). An accumulation of cFn was seen at sites of hyperplasia of the rheumatoid synovial membrane and in the walls of small vessels in t...

journal_title：Scandinavian journal of immunology

authors： Walle TK,Vartio T,Helve T,Virtanen I,Kurki P

更新日期：1990-04-01 00:00:00

abstract：:The relationship of velocity of blood flow to density and microanatomical distribution of inflammatory cells in the dermis was studied in 20 human tuberculin tests. Most positive reactions showed maximal blood flow velocities (measured as red blood cell (RBC) flux) at the centre of the reaction, but the two most inten...

journal_title：Scandinavian journal of immunology

authors： Swanson Beck J,Gibbs JH,Potts RC,Jawad ES,Kardjito T,Spence VA,Grange JM

更新日期：1989-01-01 00:00:00

abstract：:A Gross virus induced rat T cell lymphoma G1-Tc1 and a Moloney virus induced mouse T cell lymphoma YAC-1 are shown to exert a strong cytotoxic activity against rat yolk sac tumours but not to various types of rat, mouse or human normal cells or tumour cell lines including carcinomas, sarcomas, lymphomas and gliomas. B...

journal_title：Scandinavian journal of immunology

authors： Lindvall M,Eriksson H,Hedlund G,Sjögren HO

更新日期：1997-11-01 00:00:00

abstract：:Immunisation of female mice with the allergen ovalbumin (OVA) during pregnancy reduces the OVA-specific IgE response in adult offspring. To approach primary prevention strategies for allergy, we investigated to what extent genetic, paternal and maternal factors influence this suppressive effect on allergic sensitisati...

journal_title：Scandinavian journal of immunology

authors： Nygaard UC,Hansen JS,Groeng EC,Melkild I,Løvik M

更新日期：2013-02-01 00:00:00

abstract：:RadLV-Rs infection induces a murine immunodeficiency syndrome associated with a dramatic enlargement of spleen and lymph nodes. Surprisingly, the lymphoproliferation excludes thymus and Peyer's patches (PP). To understand the cellular interactions underlying lymphoproliferation further, the authors investigated the fa...

journal_title：Scandinavian journal of immunology

authors： Colombi S,Moutschen M,de Leval L,Demoitié MA,Trebak M,Martin MT,Boniver J

更新日期：1997-02-01 00:00:00

abstract：:Persistent humoral immunity depends on the follicular B cell response and on the generation of somatically mutated high-affinity plasma cells and memory B cells. Upon activation by an antigen, cognately activated follicular B cells and follicular T helper (TFH ) cells initiate germinal centre (GC) reaction during whic...

journal_title：Scandinavian journal of immunology

authors： Nera KP,Kyläniemi MK,Lassila O

更新日期：2015-09-01 00:00:00

abstract：:The pair of microH-chain and kappa L-chain transgenes encoding the Sp6 TNP/DNA-specific IgM was bred onto the rearrangement-deficient genetic background of RAG-2T mice, and onto the kappa L-chain expression-deficient background of iE kappa T mice. Bone marrow of Sp6 transgenic RAG-2T mice contained normal numbers of B...

journal_title：Scandinavian journal of immunology

authors： Andersson J,Melchers F,Rolink A

更新日期：1995-07-01 00:00:00

abstract：:Renal dysfunctions are major predictors of co-morbidities and mortality in HIV-infected individuals. Unconventional T cells have been shown to regulate kidney functions. However, there is dearth of information on the effect of HIV-associated nephropathies on γδ and DN T cells. It is also not clear whether γδ T cell pe...

journal_title：Scandinavian journal of immunology

authors： Olusola BA,Kabelitz D,Olaleye DO,Odaibo GN

更新日期：2020-05-01 00:00:00

abstract：:Thalidomide is well documented to be an effective treatment for erythema nodosum leprosum (ENL) occurring in lepromatous leprosy. To be beneficial, thalidomide must interfere with one or more of the several essential steps in the pathogenesis of this syndrome, which is presumed to be a clinical manifestation of an Art...

journal_title：Scandinavian journal of immunology

authors： Shannon EJ,Miranda RO,Morales MJ,Hastings RC

更新日期：1981-01-01 00:00:00

abstract：:In this review, we summarize and discuss some key findings from the study of naturally occurring autoantibodies. The B-cell compartment of the immune system appears to recognize almost all endogenous and environmental antigens. This ability is accomplished principally through autopolyreactive humoral and cellular immu...

journal_title：Scandinavian journal of immunology

authors： Avrameas S

更新日期：2016-04-01 00:00:00

abstract：:Experimental amyloidosis was induced in mice by intraperitoneal injections of endotoxin (lipopolysaccharide (LPS)). In addition to LPS, a group of mice received high-density lipoprotein (HDL)-SAA complexes isolated from human acute-phase serum, whereas a group of control mice received saline in addition to LPS. Isolat...

journal_title：Scandinavian journal of immunology

authors： Husebekk A,Skogen B,Husby G,Marhaug G

更新日期：1985-03-01 00:00:00

abstract：:Interleukin-17 (IL-17) plays an important role in several autoimmune diseases. IL-17 can induce the expression of vascular cell adhesion molecule (VCAM-1) in aortic vascular smooth muscle cells (SMCs), which is important for the development of atherosclerosis. However, the signalling pathway of IL-17-induced VCAM-1 ex...

journal_title：Scandinavian journal of immunology

authors： Zhang H,Chen J,Liu X,Awar L,McMickle A,Bai F,Nagarajan S,Yu S

更新日期：2013-04-01 00:00:00

abstract：:MicroRNAs play an important role in the modulation of the immune system. T helper 17 (Th17) cells are involved in the modulation of the tumour microenvironment. However, the function of miRNA in Th17 cells in the tumour microenvironment is unclear. In this study, we analysed miR-132 expression in Th17 cells and assess...

journal_title：Scandinavian journal of immunology

authors： Feng R,Cui Z,Liu Z,Zhang Y

更新日期：2020-12-02 00:00:00

abstract：:The authors have established a new immunodeficient mouse strain on the genetic background of the diabetes prone non-obese diabetic (NOD) mouse. A deletion mutant of the RAG-2 gene was back crossed 10 generations onto the NOD/Bom strain background. The homozygous NODrag-2-/- mice lack functionally mature B and T lympho...

journal_title：Scandinavian journal of immunology

authors： Söderstrøm I,Bergman ML,Colucci F,Lejon K,Bergqvist I,Holmberg D

更新日期：1996-05-01 00:00:00

abstract：:The superantigen SEA binds to MHC class II molecules and activates a large fraction of T cells as a result of interaction with particular TCR-V beta sequences. MHC class II transfected CHO cells induce a marginal CD4+ T-cell proliferation in the presence of SEA. CHO cells transfected with both MHC class II and LFA-3 (...

journal_title：Scandinavian journal of immunology

authors： Gjörloff A,Hedlund G,Kalland T,Sansom D,Fischer H,Trowsdale J,Sjögren HO,Dohlsten M

更新日期：1992-08-01 00:00:00

abstract：:CD8+ T cells are thought to play an important role in protective immunity against tuberculosis. We report the identification of three peptides derived from Rv1818c, Rv3812 and Rv3018c proteins of Mycobacterium tuberculosis that bound to HLA-A*0201 molecules and their ability to induce in vitro T-cell response in perip...

journal_title：Scandinavian journal of immunology

authors： Chaitra MG,Shaila MS,Chandra NR,Nayak R

更新日期：2008-04-01 00:00:00

abstract：:RUTI is a vaccine consisting of Mycobacterium tuberculosis bacilli grown in stress conditions that is fragmented, detoxified and liposomed. RUTI was designed to shorten the treatment of latent tuberculosis infection (LTBI) with isoniazid from 9 months to just 1 month, by additional treatment with two inoculations of R...

journal_title：Scandinavian journal of immunology

authors： Vilaplana C,Ruiz-Manzano J,Gil O,Cuchillo F,Montané E,Singh M,Spallek R,Ausina V,Cardona PJ

更新日期：2008-06-01 00:00:00

abstract：:Flow cytometric analysis of splenocytes from mice infected with lymphocytic choriomeningitis virus revealed marked and long-standing up-regulation of LFA-1 expression on CD8+, but not on CD4+ T cells. Appearance of CD8+ T cells with a changed expression of adhesion molecules reflected polyclonal activation and expansi...

journal_title：Scandinavian journal of immunology

authors： Andersson EC,Christensen JP,Scheynius A,Marker O,Thomsen AR

更新日期：1995-07-01 00:00:00