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Mitogenic responses to lipopolysaccharide by B lymphocytes from patients with systemic lupus erythematosus.

Abstract：

:Peripheral blood lymphocytes from 43 patients with systemic lupus erythematosus (SLE) and from age- and sex-matched normal controls were cultured with lipopolysaccharide (LPS) to examine the response to the polyclonal B-cell activator. Lymphocytes from active SLE patients incorporated 4840 +/- 471 (mean +/- SE) cpm in response to LPS, whereas lymphocytes from inactive SLE patients incorporated 6906 +/- 897 cpm. In contrast, lymphocytes from normal individuals incorporated 7452 +/- 1126 cpm. Ig synthesis of lymphocytes from active SLE in response to LPS stimulation was also less than that of normal individuals. The helper T-cell function of active SLE, as examined by co-culturing irradiated SLE lymphocytes with unirradiated normal lymphocytes, was normal. These results thus suggested that a defect of B lymphocytes exists in active SLE patients. This B-cell defect and T suppressor cells apparently play an important role in the pathogenesis of SLE.

journal_name

Scand J Immunol

journal_title

Scandinavian journal of immunology

authors

Abe T,Toguchi T,Takeuchi T,Kiyotaki M,Homma M

doi

10.1111/j.1365-3083.1982.tb00673.x

subject

Has Abstract

pub_date

1981-05-01 00:00:00

pages

475-82

issue

5

eissn

0300-9475

issn

1365-3083

journal_volume

15

pub_type

杂志文章

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