当前位置： SCI文献检索 > SCANDINAVIAN JOURNAL OF IMMUNOLOGY期刊下所有文献 > HLA DQ and DP locus mismatches and their effect on MLC in HLA class I- and DRB1-matched unrelated patient/donor pairs waiting for allogeneic bone-marrow transplantation.

HLA DQ and DP locus mismatches and their effect on MLC in HLA class I- and DRB1-matched unrelated patient/donor pairs waiting for allogeneic bone-marrow transplantation.

Abstract：

:The frequency of HLA DQA1, DQB1, and DPB1 mismatches was evaluated in 110 HLA class I- and DRB1-matched, unrelated pairs who were tested in mixed lymphocyte culture (MLC) in connection with a potential allogeneic bone-marrow transplantation between unrelated persons. After typing of the DQA1, DQB1, and DPB1 genes retrospectively, it was found that only 22% of the pairs were matched for all the loci tested. However, the frequency of this fully matched group was higher (37%) in pairs where both individuals were of Finnish origin as compared to those where the donor originated from a foreign registry. This suggests that the variety of haplotypes may be limited in small populations and justifies local national registries. The overall correlation between class-II match and stimulation in MLC was clear: better matches gave lower responses. However, the correlation was not definitive; for example, no response was observed in some cases with mismatches only in DPB1.

journal_name

Scand J Immunol

journal_title

Scandinavian journal of immunology

authors

Partanen J,Koskimies S

doi

10.1111/j.1365-3083.1994.tb03375.x

subject

Has Abstract

pub_date

1994-03-01 00:00:00

pages

301-4

issue

3

eissn

0300-9475

issn

1365-3083

journal_volume

39

pub_type

杂志文章

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