Altered natural killer and natural cytotoxic cellular activities in lpr mice.

abstract：:The currently used vaccine against tuberculosis, Bacille Calmette-Guérin (BCG), has variable efficacy, so new vaccine development is crucial. In this study, we evaluated a recombinant vaccine prepared from non-pathogenic Mycobacterium smegmatis (rMS) that expresses a fusion of early secreted antigenic target 6-kDa ant...

journal_title：Scandinavian journal of immunology

authors： Zhang H,Peng P,Miao S,Zhao Y,Mao F,Wang L,Bai Y,Xu Z,Wei S,Shi C

更新日期：2010-10-01 00:00:00

abstract：:The virulence of the pathogenic Yersinia species depends on a plasmid-encoded type III secretion system (T3SS) that injects six Yersinia outer protein (Yop) effector proteins into the cytosol of macrophages, leading to disruption of host defence mechanisms. Here, we report that a T3SS structural protein YscW of Yersin...

journal_title：Scandinavian journal of immunology

authors： Bi Y,Du Z,Yang H,Guo Z,Tan Y,Zhu Z,Yang R

更新日期：2009-10-01 00:00:00

abstract：:γδ T cells are characterized by recognizing conserved endogenous and stress-induced antigens without antigen presentation. It has been show that γδ T cells play an important role in anti-tumour/microbe responses, but their function in autoimmune diseases is yet not clear. Here, we reported the quantity and phenotype o...

journal_title：Scandinavian journal of immunology

authors： Wang L,Kang N,Zhou J,Guo Y,Zhang X,Cui L,Ba D,He W

更新日期：2012-07-01 00:00:00

abstract：:We have previously shown that various benign and malignant natural killer (NK)-resistant monolayer cells inhibit endogenous human NK activity, probably by reducing the secretion of cytotoxic factors from the effector cells. The nature of the molecules responsible for the inhibition has been unclear. In this study we s...

journal_title：Scandinavian journal of immunology

authors： Heiskala MK,Stenman UH,Koivunen E,Carpén O,Saksela E,Timonen T

更新日期：1988-07-01 00:00:00

abstract：:In this study, we demonstrate the use of oligonucleotide probes to the most VH family-specific framework, the Framework 3 (FR3) gene segment, in the analysis of germline DNA. Compared with the hybridization of restriction enzyme-digested genomic DNA to large, cloned human VH family probes, hybridization with oligonucl...

journal_title：Scandinavian journal of immunology

authors： Rubinstein DB,Symann M,Guillaume T

更新日期：1993-01-01 00:00:00

abstract：:Severe hypercholesterolaemia is associated with decreased levels of immunoglobulin G2a (IgG2a) antibodies [T-helper 1 (Th1) response] to modified malondialdehyde-modified low-density lipoprotein (MDA-LDL) and increased levels of Th2-dependent IgG1 antibodies in apolipoprotein E-deficient (apoE(-/-)) mice. To investiga...

journal_title：Scandinavian journal of immunology

authors： Robertson AK,Zhou X,Strandvik B,Hansson GK

更新日期：2004-03-01 00:00:00

abstract：:We have evaluated phagocytosis, C3-binding and cytotoxicity of human leukocytes simultaneously, using IgM-sensitized C3-fragment-bearing sheep erythrocytes (EAC3b, EAC3bi) as targets. In this method, 51Cr-labelled EAC3b or EAC3bi were added to human peripheral granulocytes anchored by fibronectin onto microtitre plate...

journal_title：Scandinavian journal of immunology

authors： Kojima A,Hazeki K,Seya T

更新日期：1991-06-01 00:00:00

abstract：:Toll-like receptor 4 (TLR4) participates in innate immunity by detecting lipopolysaccharides (LPS) of Gram-negative bacterial cell walls. TLR4 macrophage expression in mice is modulated by LPS. This fact constitutes, at least partially, the molecular basis for LPS tolerance. Very recently, the effect of interferon-gam...

journal_title：Scandinavian journal of immunology

authors： Moreno C,Merino J,Vázquez B,Ramírez N,Echeverría A,Pastor F,Sánchez-Ibarrola A

更新日期：2004-06-01 00:00:00

abstract：:The demonstration in the 1960s that T cells collaborated with B cells in enabling antibody responses to simple protein antigens opened up the challenge of how to investigate the interactions of two rare antigen-specific lymphocytes within a vast population. One idea was that T cells made soluble factors that could act...

journal_title：Scandinavian journal of immunology

authors： Waldmann H

更新日期：2005-07-01 00:00:00

abstract：:Our objective was to investigate the patterns of proliferation and differentiation of infiltrating cells in inflammatory myopathies. Immunohistochemical staining was performed on muscle biopsy specimens from 18 patients with inclusion body myositis, polymyositis and dermatomyositis using monoclonal and polyclonal anti...

journal_title：Scandinavian journal of immunology

authors： Lindberg C,Oldfors A,Tarkowski A

更新日期：1995-05-01 00:00:00

abstract：:The present study was designed to identify a possible new class of pathogen-recognition proteins that bind single-base oligodeoxynucleotide (ODN) ligands. Binding by the teleost natural killer cell equivalent [referred to as nonspecific cytotoxic cells (NCC)] was compared with mammalian cells (mouse RAW264.7 cells and...

journal_title：Scandinavian journal of immunology

authors： Kaur H,Jaso-Friedmann L,Leary JH 3rd,Evans DL

更新日期：2004-09-01 00:00:00

abstract：:Non-specific antibody production usually accompanies the T-cell-regulated B-cell response. In this paper the mechanisms involved in non-MHC-restricted T-B-cell interaction were studied. As previously shown for NK cells, activated B cells induce IFN-gamma and TNF alpha production in non-MHC-restricted cytotoxic T lymph...

journal_title：Scandinavian journal of immunology

authors： Becker JC,Dummer R,Von Wussow P,Burg G,Schmidt RE

更新日期：1992-08-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a common respiratory condition involving the airways and characterized by airflow limitation. Gaseous and noxious particles play an important role in this process. Antioxidants are the substances that may protect cells from the damage caused by unstable molecules known a...

journal_title：Scandinavian journal of immunology

authors： Singh S,Verma SK,Kumar S,Ahmad MK,Nischal A,Singh SK,Dixit RK

更新日期：2017-02-01 00:00:00

abstract：:Allograft rejection involves T-cell activation, requiring T-cell receptor interactions with major histocompatibility complex (MHC) molecules and costimulatory signals delivered through the B7-CD28 pathway. We evaluated the effect of blocking this pathway on graft rejection and survival, in a rat experimental model of ...

journal_title：Scandinavian journal of immunology

authors： Kurlberg G,Haglind E,Schön K,Törnqvist H,Lycke N

更新日期：2000-03-01 00:00:00

abstract：:The heavy (H) chains of three anti-streptococcal group A carbohydrate antibodies (anti-SACHO) of restricted heterogeneity, elicited in inbred Sprague-Dawley rats, were subjected to 40 cycles of automated Edman degradation. All three antibody H-chain preparations had an identical amino acid sequence and were classified...

journal_title：Scandinavian journal of immunology

authors： Klapper DG,Stankus RP,Leslie GA,Capra JD

更新日期：1976-01-01 00:00:00

abstract：:The major subunit protein of amyloid fibrils (758) isolated from a patient with systemic amyloidosis and studied by N-terminal amino acid sequence analysis was found to be almost identical to the sequence of a V lambda IV Bence-Jones protein and a previously described A lambda IV amyloid protein. The two A lambda IV a...

journal_title：Scandinavian journal of immunology

authors： Natvig JB,Westermark P,Sletten K,Husby G,Michaelsen T

更新日期：1981-07-01 00:00:00

abstract：:Recently, associations were found between several autoimmune diseases and functional variants of interleukin-23 receptor (IL23R) gene; here, we studied the possible association of nine polymorphisms of IL23R with ankylosing spondylitis (AS) and with Sjögren syndrome (SS). In our study, we genotyped groups of patients ...

journal_title：Scandinavian journal of immunology

authors： Sáfrány E,Pazár B,Csöngei V,Járomi L,Polgár N,Sipeky C,Horváth IF,Zeher M,Poór G,Melegh B

更新日期：2009-07-01 00:00:00

abstract：:In a previous study we observed that after in vitro treatment with indomethacin, lymphocyte response to phytohaemagglutinin (PHA) in primary biliary cirrhosis (PBC) patients was higher than that of controls. We know that indomethacin also inhibits prostanoid production, and thus in the present work we directly measure...

journal_title：Scandinavian journal of immunology

authors： Chiricolo M,Lenzi M,Bianchi F,Franceschi C,Bartolini G,Orlandi M,Tomasi V,Licastro F

更新日期：1989-09-01 00:00:00

abstract：:Peripheral CD4 T-cell depletion has been observed in human immunodeficiency virus (HIV)-negative patients with pulmonary tuberculosis (TB). To investigate more accurately this alteration, we studied peripheral blood CD45RA(+) and CD29(high) CD4 subsets in 79 TB patients with (HIV(+)TB(+)) or without (HIV(-)TB(+)) HIV ...

journal_title：Scandinavian journal of immunology

authors： Diagbouga S,Chiron JP,Sanou O,Ledru E

更新日期：2001-01-01 00:00:00

abstract：:The epidermis has been identified as an important site for the initiation of immunological events. In addition to the macrophage-like Langerhans cells, keratinocytes within the epidermal cells have been shown to act as immunoregulatory cells through the secretion of cytokines such as epidermal cell-derived thymocyte-a...

journal_title：Scandinavian journal of immunology

authors： Luger TA,Köck A,Danner M

更新日期：1985-05-01 00:00:00

abstract：:Normal human peripheral blood and tonsil lymphocytes can be stimulated to proliferate by phytohemagglutinin (PHA). When cells cultured with this mitogen for 3 days were transferred fo fresh autologous lymphocytes in fresh medium with PHA, the mitogen response of the fresh lymphocytes was suppressed. The suppression re...

journal_title：Scandinavian journal of immunology

authors： Kurnick JT,Bell C,Grey HM

更新日期：1976-01-01 00:00:00

abstract：:In the present study we describe the production and characterization of a panel of monoclonal antibodies (MoAbs) directed against cruzipain (Crz), the major cysteine proteinase from Trypanosoma cruzi. The five MoAbs, BD6, BF2, CG2, CH8, and DC10 were analysed with respect to affinity and specificity. None of the MoAbs...

journal_title：Scandinavian journal of immunology

authors： Gonzalez G,Orn A,Cazzulo JJ,Grönvik KO

更新日期：1994-10-01 00:00:00

abstract：:Mouse monoclonal antibodies against ED sequence-containing cellular fibronectin (cFn) were used to show that Fn in the inflamed synovium is distinct from the major form of plasma Fn (pFn). An accumulation of cFn was seen at sites of hyperplasia of the rheumatoid synovial membrane and in the walls of small vessels in t...

journal_title：Scandinavian journal of immunology

authors： Walle TK,Vartio T,Helve T,Virtanen I,Kurki P

更新日期：1990-04-01 00:00:00

abstract：:Immune complexes were isolated by ultracentrifugation in sucrose gradients (20-65% (w/w]. the centrifugation procedure was demonstrated to be isopycnic. The banding density of the complexes was influenced by the chemical nature and molecular size of the antigen and by the antigen to antibody ratio. The method was appl...

journal_title：Scandinavian journal of immunology

authors： Rødahl E,Iversen OJ,Dalen AB

更新日期：1984-07-01 00:00:00

abstract：:Colon cancer (CC) is one of the most common malignancies in the Western world. Although surgical resection is the first choice worldwide, at this point an effective approach for the treatment of patients with metastasis and cancer recurrence post-operation has not yet been found. The aim of this study was to investiga...

journal_title：Scandinavian journal of immunology

authors： Xu F,Ye YJ,Cui ZR,Wang S

更新日期：2005-04-01 00:00:00

abstract：:The immunogenicity and protective efficacy of various antigen-adjuvant formulations derived either from the merozoite-surface protein-3 (MSP-3) or the glutamate-rich protein (GLURP) of Plasmodium falciparum were evaluated in Saimiri sciureus monkeys. These proteins were selected for immunogenicity studies based primar...

journal_title：Scandinavian journal of immunology

authors： Carvalho LJ,Oliveira SG,Theisen M,Alves FA,Andrade MC,Zanini GM,Brígido MC,Oeuvray C,Póvoa MM,Muniz JA,Druilhe P,Daniel-Ribeiro CT

更新日期：2004-04-01 00:00:00

abstract：:Midtrimester amniotic fluid cytokines may reflect the function of the maternal immune system in the maternal-fetal interface and thus be predictive of pre-eclampsia. We determined the concentrations of interleukin (IL)-6, IL-8, IL-10, IL-11, IL-12, IL-15, tumour necrosis factor (TNF)-alpha and transforming growth fact...

journal_title：Scandinavian journal of immunology

authors： Heikkinen J,Möttönen M,Pulkki K,Lassila O,Alanen A

更新日期：2001-03-01 00:00:00

abstract：:To study the location and mechanism of apoptosis within the human tuberculosis (TB) and leprosy lesions, parallel sections were analyzed for mycobacterial antigens (M.Ag), Fas ligand (FasL), Fas, CD68 and Mac387 by immunohistochemistry, and apoptotic cells by the terminal deoxynucleotidyl-transferase-mediated dUTP-dig...

journal_title：Scandinavian journal of immunology

authors： Mustafa T,Bjune TG,Jonsson R,Pando RH,Nilsen R

更新日期：2001-12-01 00:00:00

abstract：:We have investigated the production of interleukin 2 (IL-2) by human T cells after their stimulation by phytohaemagglutinin (PHA). T cells isolated by rosetting with sheep erythrocytes produced high levels of IL-2. Further separation of rosette-forming cells, according to the expression of Fc receptors for IgG, showed...

journal_title：Scandinavian journal of immunology

authors： Silva AG,Alvarez JM,Bonnard GD,de Landazuri MO

更新日期：1981-09-01 00:00:00

abstract：:Experimental autoimmune neuritis (EAN), an animal model of human Guillain-Barré syndrome, has long been considered as a T helper (Th) 1 cell-mediated autoimmune disorder. However, deficiency of IFN-γ, a signature Th1 cytokine, aggravated EAN, with features of elevated production of IL-17A, despite an alleviated system...

journal_title：Scandinavian journal of immunology

authors： Wang X,Zheng XY,Ma C,Wang XK,Wu J,Adem A,Zhu J,Zhang HL

更新日期：2014-09-01 00:00:00