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Idiotypic multireactivity of 'natural' antibodies. 'Natural' anti-idiotypes also inhibit helper cells with cross-reactive clonotypes.

Abstract：

:One hundred and twenty IgM-secreting hybridomas derived from unmanipulated 6-day-old BALB/c mice were screened for reactivity with the prototype idiotypic and anti-idiotypic monoclonal antibodies, defining three well established systems, namely TEPC 15:10/13-15, J558:CD3.2, and MOPC 460:F 6(51). Up to 25% of all IgM antibodies reacted with at least one of the six specific ligands, half of the latter being 'monospecific', the others reacting with two or more antibodies. A detailed analysis of the four most multi-reactive clones showed individually specific patterns of reactivity and revealed reactions of the same IgM molecule in idiotypic systems previously studied independently. Furthermore, when tested for functional interactions with syngeneic helper T cells expressing MOPC 460-like clonotypes, one of these antibodies was found to inhibit effector helper activity. The results show the existence of 'natural antibodies' with idiotypic reactivities related to recurrent clonotypes in the strain. They may be either 'specific' or 'multireactive', and might connect idiotypes on T and B cells and on antigenic systems so far studied independently.

journal_name

Scand J Immunol

journal_title

Scandinavian journal of immunology

authors

Araujo PM,Holmberg D,Martinez-A C,Coutinho A

doi

10.1111/j.1365-3083.1987.tb02221.x

subject

Has Abstract

pub_date

1987-05-01 00:00:00

pages

497-505

issue

5

eissn

0300-9475

issn

1365-3083

journal_volume

25

pub_type

杂志文章

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