Isolation and identification of the naturally occurring, newborn spleen-associated suppressor cells. A mixed monocyte/mast cell population with separable suppressor activities.

abstract：:Mouse monoclonal antibodies against ED sequence-containing cellular fibronectin (cFn) were used to show that Fn in the inflamed synovium is distinct from the major form of plasma Fn (pFn). An accumulation of cFn was seen at sites of hyperplasia of the rheumatoid synovial membrane and in the walls of small vessels in t...

journal_title：Scandinavian journal of immunology

authors： Walle TK,Vartio T,Helve T,Virtanen I,Kurki P

更新日期：1990-04-01 00:00:00

abstract：:The virulence of the pathogenic Yersinia species depends on a plasmid-encoded type III secretion system (T3SS) that injects six Yersinia outer protein (Yop) effector proteins into the cytosol of macrophages, leading to disruption of host defence mechanisms. Here, we report that a T3SS structural protein YscW of Yersin...

journal_title：Scandinavian journal of immunology

authors： Bi Y,Du Z,Yang H,Guo Z,Tan Y,Zhu Z,Yang R

更新日期：2009-10-01 00:00:00

abstract：:In this article we present methods for the purification and fractionation of human blood lymphocytes, which have been used in our laboratory to characterize antibody-dependent cytotoxic effector cells (K cells). The assay system consists of highly purified lymphocytes, 51Cr-labelled chicken erythrocytes (Ec) and IgG r...

journal_title：Scandinavian journal of immunology

authors： Perlmann H,Perlmann P,Pape GR,Halldén G

更新日期：1976-06-01 00:00:00

abstract：:Rat monoclonal antibodies directed against the BALB/c myeloma protein M315 (alpha,lambda 2) are described. 9A8 (IgG1) binds the V domain of lambda 2 and cross-reacts with lambda 1 and lambda 3 chains. 2B6 (IgG2a) is directed to the C domain of lambda 2 and cross-reacts with C lambda 3. The antibodies bind isolated cha...

journal_title：Scandinavian journal of immunology

authors： Bogen B

更新日期：1989-03-01 00:00:00

abstract：:Colon cancer (CC) is one of the most common malignancies in the Western world. Although surgical resection is the first choice worldwide, at this point an effective approach for the treatment of patients with metastasis and cancer recurrence post-operation has not yet been found. The aim of this study was to investiga...

journal_title：Scandinavian journal of immunology

authors： Xu F,Ye YJ,Cui ZR,Wang S

更新日期：2005-04-01 00:00:00

abstract：:Blood levels of regulators of the complement system in preterm babies were reported in few studies only. The aim of this study was to set up a complement profile in premature and term babies focusing on the development of blood levels of MBL, key regulatory proteins and on classical pathway activity, which may allow a...

journal_title：Scandinavian journal of immunology

authors： Grumach AS,Ceccon ME,Rutz R,Fertig A,Kirschfink M

更新日期：2014-04-01 00:00:00

abstract：:Human peripheral lymphocytes were cultivated in soft agar or agarose, containing 3H-thymidine or bromodeoxyuridine (BrdU), which is an analogue of thymidine readily incorporated into deoxyribonucleic acid by lymphocytes. Colonies were isolated and analysed by autoradiography or stained with the fluorescence-plus-Giems...

journal_title：Scandinavian journal of immunology

authors： Lindahl-Kiessling K,Karlberg I

更新日期：1981-05-01 00:00:00

abstract：:Serum exerts several effects in lymphocyte cultures, one of them being manifested very early. The presence of fetal calf serum (FCS) results in a markedly higher thymidine uptake within a few minutes, as compared with serum-free cultures. On the other hand, the uptake of uridine and other purine bases seem to be littl...

journal_title：Scandinavian journal of immunology

authors： Kristensen F,Joncourt F,de Weck AL

更新日期：1981-08-01 00:00:00

abstract：:This paper describes the generation, detection and characterization of cytotoxic t lymphocyte activity in vitro and the application of this assay system to various immunological problems. ...

journal_title：Scandinavian journal of immunology

authors： Engers HD,Macdonald HR

更新日期：1976-06-01 00:00:00

abstract：:Sera from 20 species of mammals were tested for their ability to lyse erythrocytes from 18 species of mammals and birds by the alternative complement pathway. Erythrocytes were not lysed by homologous complement, with one minor exception, but all erythrocytes tested were lysed by at least one complement source, and al...

journal_title：Scandinavian journal of immunology

authors： Ish C,Ong GL,Desai N,Mattes MJ

更新日期：1993-08-01 00:00:00

abstract：:Congenital heart block (CHB) is a conduction abnormality that affects hearts of foetuses and/or newborn to mothers with autoantibodies reactive with the intracellular soluble ribonucleoproteins 48-kD La, 52-kD Ro and 60-kD Ro. CHB carries substantial mortality and morbidity, with more than 60% of affected children req...

journal_title：Scandinavian journal of immunology

authors： Karnabi E,Boutjdir M

更新日期：2010-09-01 00:00:00

abstract：:The in vitro effect of superoxide anion and lysosomal enzyme activity on the killing of Listeria monocytogenes EGD (listeria) by peritoneal macrophages (PM) was investigated. Generation of superoxide anion by PM stimulated with phorbol myristate acetate (PMA) was significantly increased by intraperitoneal injection of...

journal_title：Scandinavian journal of immunology

authors： Hashimoto S,Nomoto K,Yokokura T

更新日期：1986-10-01 00:00:00

abstract：:Antibodies to DNA (anti-DNA) play an important role in the pathogenesis of systemic lupus erythematosus (SLE). In blood, these antibodies may exist in a free, unbound state or as part of complexes with DNA. Furthermore, circulating DNA may be either complexed or free. Because of the central role of these immunoreactan...

journal_title：Scandinavian journal of immunology

authors： Björkman L,Reich CF,Pisetsky DS

更新日期：2003-06-01 00:00:00

abstract：:Fresh human T lymphocytes from the blood of healthy individuals exhibited few motile forms, i.e. nonspherical shape and lamellar surface activity, when allowed to settle on a plastic surface. This poor motility of 'normal' blood T lymphocytes is most likely physiological, since under the same conditions more than 75% ...

journal_title：Scandinavian journal of immunology

authors： Sundqvist KG,Otteskog P,Mellstedt H

更新日期：1986-06-01 00:00:00

abstract：:Flow cytometric analysis of splenocytes from mice infected with lymphocytic choriomeningitis virus revealed marked and long-standing up-regulation of LFA-1 expression on CD8+, but not on CD4+ T cells. Appearance of CD8+ T cells with a changed expression of adhesion molecules reflected polyclonal activation and expansi...

journal_title：Scandinavian journal of immunology

authors： Andersson EC,Christensen JP,Scheynius A,Marker O,Thomsen AR

更新日期：1995-07-01 00:00:00

abstract：:To determine whether psoriatic keratinocytes differ from normal keratinocytes in their response to gamma interferon, epidermal cell suspensions from normal and from lesional and uninvolved psoriatic skin were cultured in the presence of gamma interferon and the induction of HLA-DR expression and inhibition of cell gro...

journal_title：Scandinavian journal of immunology

authors： Baker BS,Powles AV,Valdimarsson H,Fry L

更新日期：1988-12-01 00:00:00

abstract：:The T-cell regulatory function has been evaluated in lines of mice genetically selected according to the High (H) and Low (L) antibody responsiveness to heterologous erythrocytes. The inhibition of antibody production following CD4+ subset depletion was stronger in L than in H mice. The dose of CD4-specific monoclonal...

journal_title：Scandinavian journal of immunology

authors： Cabrera WH,Siqueira M,Takahashi NS,Ribeiro OG,Araujo LM,Mouton D,Ibanez OM

更新日期：1995-03-01 00:00:00

abstract：:Human mast cell carboxypeptidase (hMC-CP) is a unique product of mast cells. Unlike tryptase and chymase, its potential function and expression in diseased conditions remain largely unknown. To develop an assay for hMC-CP, the recombinant fusion protein of hMC-CP and purified native skin hMC-CP was prepared, and two n...

journal_title：Scandinavian journal of immunology

authors： Zhou Y,Chen Z,He S

更新日期：2006-11-01 00:00:00

abstract：:Sera from patients with primary biliary cirrhosis recognize various cellular components, such as mitochondria, centromere, nuclear envelope, and multiple nuclear dot antigens. There also appears to be a novel antibody reacting with a particular protein in these sera. The presence of this antibody was investigated by d...

journal_title：Scandinavian journal of immunology

authors： Miyachi K,Matsushima H,Hankins RW,Hirakata M,Mimori T,Hosaka H,Amagasaki Y,Miyakawa H,Kako M,Shibata M,Onozuka Y,Ueno U

更新日期：1998-01-01 00:00:00

abstract：:The migration inhibition in vitro induced by measles virus material on leukocytes from 17 patients with multiple sclerosis (MS) was compared with that of 8 patients with various other central nervous system diseases and that of 12 healthy blood donors. Significant differences could not be demonstrated. The results do ...

journal_title：Scandinavian journal of immunology

authors： Nordal HJ,Froland SS,Vandvik B,Norrby E

更新日期：1976-01-01 00:00:00

abstract：:The demonstration in the 1960s that T cells collaborated with B cells in enabling antibody responses to simple protein antigens opened up the challenge of how to investigate the interactions of two rare antigen-specific lymphocytes within a vast population. One idea was that T cells made soluble factors that could act...

journal_title：Scandinavian journal of immunology

authors： Waldmann H

更新日期：2005-07-01 00:00:00

abstract：:We studied the T-cell reactivity to overlapping peptides of B. garinii OspA, in order to locate possible immunodominant T-cell epitopes in neuroborreliosis. Cells from cerebrospinal fluid (CSF) and blood from 39 patients with neuroborreliosis and 31 controls were stimulated with 31 overlapping peptides, and interferon...

journal_title：Scandinavian journal of immunology

authors： Widhe M,Ekerfelt C,Jarefors S,Skogman BH,Peterson EM,Bergström S,Forsberg P,Ernerudh J

更新日期：2009-08-01 00:00:00

abstract：:B-Lymphocyte-activating factor (BAFF/BLyS) is a survival factor for B cells, belonging to the tumor necrosis ligand super family. Serum BAFF levels have been found to be elevated in patients with systemic lupus erythematosus (SLE). Neutralization of BAFF activity was suggested as an additional therapeutic approach in ...

journal_title：Scandinavian journal of immunology

authors： Toubi E,Kessel A,Rosner I,Rozenbaum M,Paran D,Shoenfeld Y

更新日期：2006-04-01 00:00:00

abstract：:Regulation of acute-phase serum amyloid A (A-SAA) synthesis by proinflammatory cytokines and steroid hormones in human aortic smooth muscle cells (HASMCs) is distinct from that in HepG2 cells. To study the cis- and trans-activating promoter element involved in the SAA1 gene expression by HASMCs and HepG2 cells, we con...

journal_title：Scandinavian journal of immunology

authors： Kumon Y,Suehiro T,Faulkes DJ,Hosakawa T,Ikeda Y,Woo P,Sipe JD,Hashimoto K

更新日期：2002-11-01 00:00:00

abstract：:BALB/c mice were injected with an affinity-chromatography-purified placental transferrin receptor preparation. Spleen cells were fused with NS-1 myeloma cells. Sixteen hybrids producing monoclonal antibodies specific for the transferrin receptor and two hybrids specific for transferrin were identified by radioimmunoas...

journal_title：Scandinavian journal of immunology

authors： Nikinmaa B,Enns CA,Tonik SE,Sussman HH,Schröder J

更新日期：1984-11-01 00:00:00

abstract：:This paper describes a technique utilizing rosette formation with sheep red blood cells as a human T lymphocyte marker, and separation of T cells by rosette sedimentation. ...

journal_title：Scandinavian journal of immunology

authors： Jondal M

更新日期：1976-06-01 00:00:00

abstract：:MTB12 protein, also called CFP-2, is a major and early secreted component of Mycobacterium tuberculosis. However, its role during mycobacterial infection has been poorly characterized. In this study, we purified the native MTB12 protein and investigated the profile of MTB12-induced cytokines [interferon (IFN)-gamma, t...

journal_title：Scandinavian journal of immunology

authors： Lee JS,Son JW,Jung SB,Kwon YM,Yang CS,Oh JH,Song CH,Kim HJ,Park JK,Paik TH,Jo EK

更新日期：2006-08-01 00:00:00

abstract：:Human blood lymphocytes were tested for their proliferative response to purified protein derivative (PPD) in vitro. Purified T cells showed a lower response than the orginial purified lymphocyte suspension. Purified B cells were unresponsive to PPD. Mixtures of preparations of T and B cells were stimulated to a greate...

journal_title：Scandinavian journal of immunology

authors： Blomgren H

更新日期：1975-09-01 00:00:00

abstract：:We have investigated the production of interleukin 2 (IL-2) by human T cells after their stimulation by phytohaemagglutinin (PHA). T cells isolated by rosetting with sheep erythrocytes produced high levels of IL-2. Further separation of rosette-forming cells, according to the expression of Fc receptors for IgG, showed...

journal_title：Scandinavian journal of immunology

authors： Silva AG,Alvarez JM,Bonnard GD,de Landazuri MO

更新日期：1981-09-01 00:00:00

abstract：:The frequency of HLA DQA1, DQB1, and DPB1 mismatches was evaluated in 110 HLA class I- and DRB1-matched, unrelated pairs who were tested in mixed lymphocyte culture (MLC) in connection with a potential allogeneic bone-marrow transplantation between unrelated persons. After typing of the DQA1, DQB1, and DPB1 genes retr...

journal_title：Scandinavian journal of immunology

authors： Partanen J,Koskimies S

更新日期：1994-03-01 00:00:00