当前位置： SCI文献检索 > SCANDINAVIAN JOURNAL OF IMMUNOLOGY期刊下所有文献 > Ex vivo responses for interferon-gamma and proinflammatory cytokine secretion to low-molecular-weight antigen MTB12 of Mycobacterium tuberculosis during human tuberculosis.

Ex vivo responses for interferon-gamma and proinflammatory cytokine secretion to low-molecular-weight antigen MTB12 of Mycobacterium tuberculosis during human tuberculosis.

Abstract：

:MTB12 protein, also called CFP-2, is a major and early secreted component of Mycobacterium tuberculosis. However, its role during mycobacterial infection has been poorly characterized. In this study, we purified the native MTB12 protein and investigated the profile of MTB12-induced cytokines [interferon (IFN)-gamma, tumour necrosis factor (TNF)-alpha and interleukin (IL)-6], in early tuberculosis (TB) patients (n = 20) and healthy controls (n = 35). The cytokine profiles were compared with those induced by the 30-kDa antigen (Ag). In healthy controls, MTB12-induced IFN-gamma production was markedly decreased in peripheral blood mononuclear cells compared with 30-kDa Ag-induced IFN-gamma. In TB patients, the mean IFN-gamma level induced by MTB12 was lower than that induced by the 30-kDa Ag, albeit the difference was not significant. After 2 months of anti-TB therapy, both the MTB12- and 30-kDa-induced IFN-gamma levels were significantly increased in TB patients. MTB12-induced TNF-alpha and IL-6 levels were prominently upregulated in monocyte-derived macrophages from TB patients, but they were not significantly different from those induced by the 30-kDa Ag. Further, the activation of p38 mitogen-activated protein kinase and extracellular signal-regulated kinase was required for the induction of TNF-alpha and IL-6 by MTB12, as well as by the 30-kDa Ag. Collectively, these data suggest that the MTB12 protein plays an essential role for proinflammatory responses through the MAPK pathway during the early stages of human TB, even though its T-cell immunoreactivity is weaker than that of the 30-kDa Ag.

journal_name

Scand J Immunol

journal_title

Scandinavian journal of immunology

authors

Lee JS,Son JW,Jung SB,Kwon YM,Yang CS,Oh JH,Song CH,Kim HJ,Park JK,Paik TH,Jo EK

doi

10.1111/j.1365-3083.2006.01784.x

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

145-54

issue

2

eissn

0300-9475

issn

1365-3083

pii

SJI1784

journal_volume

64

pub_type

杂志文章

相关文献

SCANDINAVIAN JOURNAL OF IMMUNOLOGY文献大全
  • Identification of a gliadin T-cell epitope in coeliac disease: general importance of gliadin deamidation for intestinal T-cell recognition.

    abstract：:Coeliac disease probably results from a T-cell response to wheat gliadin and is associated to HLA-DQ2. No gliadin epitopes recognized by intestinal T cells have yet been identified, limiting our understanding of the pathogenesis. Gut-lesion-derived DQ2-restricted T cells from coeliac disease patients were used to iden...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-3083.1998.00397.x

    authors： Sjöström H,Lundin KE,Molberg O,Körner R,McAdam SN,Anthonsen D,Quarsten H,Norén O,Roepstorff P,Thorsby E,Sollid LM

    更新日期：1998-08-01 00:00:00

  • Spontaneous IgA synthesis by blood mononuclear cells in alcoholic liver disease.

    abstract：:Changes in the concentration and composition of serum immunoglobulin A (IgA) and deposits of IgA in tissues are well-known characteristics of alcoholic liver disease. We investigated whether these changes also accompany IgA synthesis by peripheral blood mononuclear cells (MNC), by counting immunoglobulin-producing cel...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1987.tb01062.x

    authors： Van de Wiel A,Seifert WF,Van der Linden JA,Gmelig-Meyling FH,Kater L,Schuurman HJ

    更新日期：1987-02-01 00:00:00

  • CD28nullCD4+ T cells--characterization of an effector memory T-cell population in patients with rheumatoid arthritis.

    abstract：:CD4+ T cells lacking the costimulatory molecule CD28 have been described both in elderly individuals and in chronic inflammatory disorders, one being rheumatoid arthritis (RA). We, in this study, provide a comprehensive characterization of cell surface markers on and function of such CD28nullCD4+ T cells, as well as c...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.0300-9475.2004.01464.x

    authors： Fasth AE,Cao D,van Vollenhoven R,Trollmo C,Malmström V

    更新日期：2004-07-01 00:00:00

  • Naturally occurring, spleen-associated suppressor activity of the newborn mouse. Biochemical and functional identification of three monokines secreted by newborn suppressor-inducer monocytes.

    abstract：:Immature monocytes residing in the spleens of newborn mice less than 6-7 days of age are known to suppress T-dependent and T-independent immune responses in vitro and in vivo. Suppression is mediated in part through products secreted by the newborn monocytes. In the present study, we have identified 3 monokines secret...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1986.tb01940.x

    authors： Jadus MR,Peck AB

    更新日期：1986-01-01 00:00:00

  • Mice deficient for the complement factor B develop and reproduce normally.

    abstract：:Factor B is an essential component of the complement cascade which forms the C3 and C5 convertase of the alternative pathway. Factor B cleavage products also function as cofactors in antibody-independent monocyte-mediated cytotoxicity, macrophage spreading, plasminogen activation and proliferation of B lymphocytes. Se...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-3083.1998.00313.x

    authors： Pekna M,Hietala MA,Landin A,Nilsson AK,Lagerberg C,Betsholtz C,Pekny M

    更新日期：1998-04-01 00:00:00

  • D-D recombination diversifies the CDR 3 region of chicken immunoglobulin heavy chains.

    abstract：:The occurrence of D-D recombination during the embryonic differentiation of chicken B cells was studied. Ig heavy (H) chains were amplified by polymerase chain reaction from day-12 bursal cDNA, and 30 random V-D-J regions were analysed by DNA sequencing. No gene conversion events were observed in any of the V regions,...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1991.tb02524.x

    authors： Mansikka A,Toivanen P

    更新日期：1991-05-01 00:00:00

  • Quantification of cytokine gene expression using an economical real-time polymerase chain reaction method based on SYBR Green I.

    abstract：:Assessment of cytokine expression has become crucial to understand host responses to infections as well as autoimmunity. Several approaches including Northern blot, RNase protection assay and enzyme-linked immunosorbent assay have been used for this purpose, but they are time consuming, labour intense, and relatively ...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-3083.2003.01250.x

    authors： Ramos-Payán R,Aguilar-Medina M,Estrada-Parra S,González-Y-Merchand JA,Favila-Castillo L,Monroy-Ostria A,Estrada-Garcia IC

    更新日期：2003-05-01 00:00:00

  • Analysis of peripheral blood dendritic cell subtypes in thymomatous MG.

    abstract：:The object of this work was to measure the levels of monocyte-derived dendritic cell precursors (pDC1) and plasmacytoid dendritic cell precursors (pDC2) in peripheral blood mononuclear cells (PBMC) of patients with thymomatous MG and to assess the ratio of pDC1/pDC2 in these patients. Three-colour monoclonal antibody ...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.2010.02399.x

    authors： Zhang LY,Wang W,Feng YK,Liu YH,Wang QS

    更新日期：2010-06-01 00:00:00

  • Comparison between the specificity of primary and secondary killer cells against alloantigens and hapten-modified syngeneic lymphoid cells.

    abstract：:Cytotoxic responses of lymphoid cells from different mouse strains against syngeneic cells modified with the haptens fluorescein isothiocyanate and trinitrophenyl were investigated. Mic of the H-2k strain demonstrated strong primary in vitro hapten-specific cytotoxicity reactions, which were H-2 restricted and involve...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1981.tb00119.x

    authors： Möller E,Ramos T

    更新日期：1981-01-01 00:00:00

  • Histoplasma capsulatum inhibits apoptosis and Mac-1 expression in leucocytes.

    abstract：:Histoplasma capsulatum is a fungus found intracellularly in neutrophils and peripheral blood mononuclear cells (PBMCs), suggesting that it is capable of evading damage and survives inside these cells. In this study, we report that neutrophils from H. capsulatum-infected mice, and human neutrophils and mononuclear cell...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-3083.2002.01142.x

    authors： Medeiros AI,Bonato VL,Malheiro A,Dias AR,Silva CL,Faccioli LH

    更新日期：2002-10-01 00:00:00

  • Granulocyte-dependent extracellular cytotoxicity is enhanced by complement C3bi and independent of phagocytosis.

    abstract：:We have evaluated phagocytosis, C3-binding and cytotoxicity of human leukocytes simultaneously, using IgM-sensitized C3-fragment-bearing sheep erythrocytes (EAC3b, EAC3bi) as targets. In this method, 51Cr-labelled EAC3b or EAC3bi were added to human peripheral granulocytes anchored by fibronectin onto microtitre plate...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1991.tb02544.x

    authors： Kojima A,Hazeki K,Seya T

    更新日期：1991-06-01 00:00:00

  • Extensive CDR3H length heterogeneity exists in bovine foetal VDJ rearrangements.

    abstract：:Analysis of seven variable-diversity-joining (VDJ) gene rearrangements in B splenocytes from a 125-day-old bovine foetus revealed an extensive heavy-chain complementarity-determining region 3 (CDR3H) length variation (9-56 codons). Indeed, the global CDR3H size spectratyping of foetal VDJ rearrangements substantiated ...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-3083.2002.01028.x

    authors： Saini SS,Kaushik A

    更新日期：2002-02-01 00:00:00

  • Significantly depressed percentage of CD27+ (memory) B cells among peripheral blood B cells in patients with primary Sjögren's syndrome.

    abstract：:CD27 has been found to be expressed on somatically mutated B cells and is thus a positive marker for memory B cells in peripheral blood (PB). Since abnormal immunogloblin (Ig) production is characteristic of the autoimmune diseases primary Sjögren's syndrome (pSS) and rheumatoid arthritis (RA), we have analyzed in det...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-3083.2001.00989.x

    authors： Bohnhorst JO,Thoen JE,Natvig JB,Thompson KM

    更新日期：2001-10-01 00:00:00

  • Chimeric Epitope Vaccine from Multistage Antigens for Lymphatic Filariasis.

    abstract：:Lymphatic filariasis, a mosquito-borne parasitic disease, affects more than 120 million people worldwide. Vaccination for filariasis by targeting different stages of the parasite will be a boon to the existing MDA efforts of WHO which required repeated administration of the drug to reduce the infection level and susta...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/sji.12340

    authors： Anugraha G,Madhumathi J,Prince PR,Prita PJ,Khatri VK,Amdare NP,Reddy MV,Kaliraj P

    更新日期：2015-10-01 00:00:00

  • The relation between cutaneous blood flow and cell content in the tuberculin reaction.

    abstract：:The relationship of velocity of blood flow to density and microanatomical distribution of inflammatory cells in the dermis was studied in 20 human tuberculin tests. Most positive reactions showed maximal blood flow velocities (measured as red blood cell (RBC) flux) at the centre of the reaction, but the two most inten...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1989.tb01096.x

    authors： Swanson Beck J,Gibbs JH,Potts RC,Jawad ES,Kardjito T,Spence VA,Grange JM

    更新日期：1989-01-01 00:00:00

  • Histamine modulates the interleukin-6-regulated acute phase protein synthesis in cultured murine hepatocytes.

    abstract：:Murine hepatocytes cultured in the presence of human recombinant interleukin-6 (IL-6) show increased synthesis of fibrinogen and complement component C3 by the addition of histamine. No similar effect was achieved when murine hepatocytes were treated with histamine alone or with histamine and interleukin-1 alpha toget...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1992.tb02975.x

    authors： Rokita H,Falus A,Biró J,Smolen J,Kordula T,Stalinska K

    更新日期：1992-06-01 00:00:00

  • Immunological characterization of human glomerular basement membrane antigens.

    abstract：:Normal human glomerular basement membrane (H-GBM) was solubilized by collagenase and subjected to crossed immunoelectrophoresis with rabbit antibodies against H-GBM. Seven precipitates appeared with the mobility of alpha, beta, and gamma globulins. Only two of these precipitates might be specific for GBM, since the ot...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1975.tb02678.x

    authors： Henriksen K,Jensen H

    更新日期：1975-01-01 00:00:00

  • Effects of various adjuvants and a viral infection on the antibody specificity toward native or cryptic epitopes of a protein antigen.

    abstract：:An immunization protocol that induces antibodies (Abs) directed to cryptic epitopes of a protein antigen (Ag) reduces the efficacy of vaccines that ideally should induce Abs against native epitopes. We have shown earlier that viral infections concomitant with immunization against a protein tend to shift the Ab specifi...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-3083.2003.01208.x

    authors： Gómez KA,Longhi SA,Marino VJ,Mathieu PA,Loureiro ME,Coutelier JP,Roguin LP,Retegui LA

    更新日期：2003-02-01 00:00:00

  • Increased N-linked glycosylation leading to oversialylation of monomeric immunoglobulin A1 from patients with Sjögren's syndrome.

    abstract：:Increased serum immunoglobulin A (IgA) level is a common finding in primary Sjögren's syndrome (pSS). IgA might not be properly eliminated because of an abnormal glycosylation. We reported previously that IgA1 from patients with pSS was oversialylated. We extend this finding by showing that monomeric IgA1 contains mor...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-3083.2000.00685.x

    authors： Basset C,Durand V,Jamin C,Clément J,Pennec Y,Youinou P,Dueymes M,Roitt IM

    更新日期：2000-03-01 00:00:00

  • Characterization of a susceptibility locus for SLE, SLEB5, on chromosome 4p14-13.

    abstract：:Systemic lupus erythematosus is a systemic autoimmune disorder of unknown aetiology but is most likely caused by an interaction between several genetic factors and the environment. In a previously published genome scan we presented linkage to a marker on chromosome 4p13 in Icelandic families. Fine mapping of the regio...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.2006.01810.x

    authors： Johansson CM,Kristjánsdottir H,Gröndal G,Steinsson K,Alarcón-Riquelme ME

    更新日期：2006-09-01 00:00:00

  • Serum antibodies from patients with primary Sjögren's syndrome and systemic lupus erythematosus recognize multiple epitopes on the La(SS-B) autoantigen resembling viral protein sequences.

    abstract：:The aim of this study was to investigate the epitope recognition pattern of La(SS-B) autoantibodies in sera from patients with Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE) using overlapping synthetic decapeptides on solid phase. Eighty different decapeptides with five amino acids overlap from the hum...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-3083.1996.d01-2.x

    authors： Haaheim LR,Halse AK,Kvakestad R,Stern B,Normann O,Jonsson R

    更新日期：1996-01-01 00:00:00

  • Genetics of inflammatory bowel disease: a reappraisal.

    abstract：:The advent of advanced molecular biological techniques in the last two decades has allowed the study of genetic factors in inflammatory bowel disease (IBD). A variety of techniques have been employed to elucidate the effects of genes, starting with the clinical observations that IBD is more common in the relatives of ...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章,评审

    doi：10.1046/j.1365-3083.2000.00656.x

    authors： Orchard TR,Satsangi J,Van Heel D,Jewell DP

    更新日期：2000-01-01 00:00:00

  • High-density lipoprotein has different binding capacity for different apoproteins. The amyloidogenic apoproteins are easier to displace from high-density lipoprotein.

    abstract：:Purified human amyloid protein A (AA) or serum amyloid protein A (SAA) was incubated with normal human high-density lipoprotein (HDL). After ultracentrifugation the amount of AA or SAA associated with HDL was measured. It was found that the binding capacity of HDL for SAA was higher than that for AA. Incubation of the...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1988.tb01498.x

    authors： Husebekk A,Skogen B,Husby G

    更新日期：1988-12-01 00:00:00

  • Heterologous B-cell antisera may detect non-Ig, non-HLA-DR antigens.

    abstract：:A heterologous antiserum (antiserum 7420) against B-lymphocyte antigen(s) was raised in a rabbit by immunization with peripheral blood lymphocytes from a patient with chronic lymphocytic leukaemia (CLL). After absorptions with pooled normal human serum, IgA, IgD, and IgM M-components, the fluorescein isothiocyanate-co...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1979.tb01329.x

    authors： Berntorp E,Turesson I,Zettervall O

    更新日期：1979-01-01 00:00:00

  • Effectiveness and safety of a treatment regimen based on isoniazid plus vaccination with Mycobacterium tuberculosis cells' fragments: field-study with naturally Mycobacterium caprae-infected goats.

    abstract：:The identification of a herd of goats with tuberculosis let us test a new treatment regimen against latent tuberculosis infection (LTBI). Using large animal experimental models allows a better approach to understanding human tuberculosis according to immunopathological parameters. Based on an initial study showing a c...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.2009.02251.x

    authors： Domingo M,Gil O,Serrano E,Guirado E,Nofrarias M,Grassa M,Cáceres N,Pérez B,Vilaplana C,Cardona PJ

    更新日期：2009-06-01 00:00:00

  • Binding of a bacterial acylpoly(1,3)galactoside to human blood leucocytes.

    abstract：:The binding of a 34-kDa (mol. wt.) acylpoly(1,3)galactoside (APG) extracted from a membrane proteoglycan of Klebsiella pneumoniae to human blood leucocytes was investigated. APG is made of a long poly(1,3)galactose chain, a core-like region and a lipid moiety which comprises two glucosamine residues bound to a phospha...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1992.tb02935.x

    authors： Hmama Z,Kouassi E,Panaye G,Delassan S,Normier G,Binz H,Revillard JP

    更新日期：1992-07-01 00:00:00

  • Peripheral blood CD14high CD16+ monocytes are main producers of IL-10.

    abstract：:Based on CD14 and CD16 expression, human peripheral blood monocytes (MO) can be divided into a major CD14(high) CD16(-) population and two minor CD14(high) CD16(+) and CD14(dim) CD16(+) subpopulations. CD14(dim) CD16(+) MO are well characterized and regarded as pro-inflammatory because upon stimulation produce TNF-alp...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.2007.02051.x

    authors： Skrzeczyńska-Moncznik J,Bzowska M,Loseke S,Grage-Griebenow E,Zembala M,Pryjma J

    更新日期：2008-02-01 00:00:00

  • Upregulation of HO-1 with Haemin Alleviates LPS-Stimulated Pro-inflammatory Responses Through Downregulation of p38 Signalling Pathways in Rat Liver.

    abstract：:Haem oxygenase-1 (HO-1) plays an important role in inflammatory disease development and progression. Whether it has an anti-inflammatory role in lipopolysaccharide (LPS)-induced liver injury remains unclear. To investigate the functional role of HO-1 in protecting liver tissue against inflammatory response stimulated ...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/sji.12352

    authors： Tang J,Li L,Li CM,Wu J,Sun Y,Wang GL

    更新日期：2015-11-01 00:00:00

  • Measles virus-induced migration inhibition in vitro of leukocytes from patients with multiple sclerosis.

    abstract：:The migration inhibition in vitro induced by measles virus material on leukocytes from 17 patients with multiple sclerosis (MS) was compared with that of 8 patients with various other central nervous system diseases and that of 12 healthy blood donors. Significant differences could not be demonstrated. The results do ...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1976.tb00314.x

    authors： Nordal HJ,Froland SS,Vandvik B,Norrby E

    更新日期：1976-01-01 00:00:00

  • Human anti-F(ab')2 antibodies and pepsin agglutinators react with Fv determinants.

    abstract：:Affinity-purified human IgG anti-tetanus antibody was subjected to papain and then pepsin digestion, and residual fragments retaining antibody activity were re-isolated by adsorption and elution from Sepharose-tetanus toxoid columns. Both Fab' and Fv fragments isolated by gel filtration showed strong reactivity with a...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1986.tb03082.x

    authors： Silvestris F,Williams RC Jr,Searles RP

    更新日期：1986-04-01 00:00:00