Abstract:
:The demonstration in the 1960s that T cells collaborated with B cells in enabling antibody responses to simple protein antigens opened up the challenge of how to investigate the interactions of two rare antigen-specific lymphocytes within a vast population. One idea was that T cells made soluble factors that could activate B cells at a distance; the other was that rare T cells and B cells came into contact. Using limiting dilution analysis, we asked the question 'How many B cells could a single T cell collaborate with in the short term?' Unequivocally, the answer was just one. This implied a need for cell contact, and coupled with the observation for genetic restriction in T-cell/B-cell co-operation, seemed to make a watertight case for direct coupling. Claims of diffusible antigen-specific factors undermined the importance of our findings at that time. Remarkably, those claims have not yet been retracted and our original findings that collaborating T cells and B cells must come into contact have never achieved the recognition that they deserved.
journal_name
Scand J Immunoljournal_title
Scandinavian journal of immunologyauthors
Waldmann Hdoi
10.1111/j.1365-3083.2005.01604.xkeywords:
subject
Has Abstractpub_date
2005-07-01 00:00:00pages
30-2eissn
0300-9475issn
1365-3083pii
SJI1604journal_volume
62 Suppl 1pub_type
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