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Ia-expressing cells and T lymphocytes of different subsets in peripheral nerve tissue during experimental allergic neuritis in Lewis rats.

Abstract：

:Inflammatory infiltrates in sciatic nerves during the acute phase of experimental allergic neuritis in the Lewis rat have been characterized with regard to occurrence and distribution of Ia-expressing cells and T-lymphocyte subsets by the help of an immunohistochemical double-staining technique, enabling the simultaneous visualization of T lymphocytes and Ia-expressing non-T cells. Large numbers of Ia-expressing irregular macrophage-like/dendritic cells were seen both within inflammatory infiltrates and within afflicted nervous tissue. Many W3/13-reactive T lymphocytes of both 'helper' and 'suppressor/cytoxic' phenotypes appeared in close contact with these Ia-expressing non-T cells, particularly within the infiltrates. B lymphocytes and plasma cells were relatively few and mainly found close to endoneurial vessels.

journal_name

Scand J Immunol

journal_title

Scandinavian journal of immunology

authors

Olsson T,Holmdahl R,Klareskog L,Forsum U

doi

10.1111/j.1365-3083.1983.tb01805.x

subject

Has Abstract

pub_date

1983-10-01 00:00:00

pages

339-43

issue

4

eissn

0300-9475

issn

1365-3083

journal_volume

18

pub_type

杂志文章

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