Role of calcium channels in congenital heart block.

Abstract:

:Congenital heart block (CHB) is a conduction abnormality that affects hearts of foetuses and/or newborn to mothers with autoantibodies reactive with the intracellular soluble ribonucleoproteins 48-kD La, 52-kD Ro and 60-kD Ro. CHB carries substantial mortality and morbidity, with more than 60% of affected children requiring lifelong pacemakers. Several hypotheses have been proposed to explain the pathogenesis of CHB. These can be grouped under three main hypotheses: Apoptosis, Serotoninergic and Ca channel hypothesis. Here, we discuss these hypotheses and provide recent scientific thinking that will most likely dominate the future of this field of research.

journal_name

Scand J Immunol

authors

Karnabi E,Boutjdir M

doi

10.1111/j.1365-3083.2010.02439.x

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

226-34

issue

3

eissn

0300-9475

issn

1365-3083

pii

SJI2439

journal_volume

72

pub_type

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