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T-cell enforced invariance of the antibody repertoire in the immune response against a bacterial carbohydrate antigen.

Abstract：

:The humoral response against the bacterial polysaccharide antigen alpha(1-->3) dextran (Dex) is controlled by J558 idiotype-(Id) specific T cells. These T cells of which the cell clone 178-4 Ts is a representative by all relevant criteria, recognize J558 Id-bearing B cells in an I-Ed-restricted manner. Costimulation via CD28/B7-1 but not via CD40/CD40L leads to T-cell activation. These T cells do not only suppress B cells producing the immunoglobulin (Ig)G3 isotype but also support the survival and clonal expansion of J558 Id positive B cells both in vivo and in vitro. This T-cell mediated dominance of the J558 idiotype limits the appearance of antibodies carrying other more diverse idiotypes which appear in immunized BALB/c nu/nu mice where no regulatory T cells occur. This T-cell mediated antibody invariance could be a strategy of the immune system responding to highly conserved antigens like polysaccharides, different from those against protein antigens, where diversity is assumed to be the basis for a successful response.

journal_name

Scand J Immunol

journal_title

Scandinavian journal of immunology

authors

Rademaekers A,Specht C,Kölsch E

doi

10.1046/j.1365-3083.2001.00864.x

keywords:

subject

Has Abstract

pub_date

2001-03-01 00:00:00

pages

240-4

issue

3

eissn

0300-9475

issn

1365-3083

pii

sji864

journal_volume

53

pub_type

杂志文章

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