The double role of the endoplasmic reticulum chaperone tapasin in peptide optimization of HLA class I molecules.

abstract：:Polymorphonuclear cell function tests were performed in 340 patients with recurrent unexplained infections. Serum-dependent defects in phagocytosis and intracellular killing of Candida albicans (Candida opsonin and procidin defects) were specifically associated with susceptibility to recurrent pyogenic infections, Can...

journal_title：Scandinavian journal of immunology

authors： Parkin JM,Bridges J,Sloper KS,Warner JO,Pinching AJ

更新日期：1991-01-01 00:00:00

abstract：:Extracts of the leaves and roots from the tree Artocarpus tonkinensis A Cheval (family Moraceae) are used in traditional Vietnamese medicine in order to treat backache as well as rheumatic joint diseases. We prepared an ethyl acetate (EtOAc) extract from this plant and tested its anti-inflammatory properties in an exp...

journal_title：Scandinavian journal of immunology

authors： Ngoc DD,Catrina AI,Lundberg K,Harris HE,Ha NT,Anh PT,Larsson P

更新日期：2005-03-01 00:00:00

abstract：:ESAT-6 is a protein produced by virulent Mycobacterium tuberculosis but absent in Mycobacterium bovis bacillus Calmette-Guerin (BCG) and is considered as a promising vaccine subunit against tuberculosis. The protective efficacy of a new strategy based on the combination of DNA vaccine encoding ESAT-6 (DNA-E6) and BCG ...

journal_title：Scandinavian journal of immunology

authors： Fan X,Gao Q,Fu R

更新日期：2007-11-01 00:00:00

abstract：:Immune complexes of horseradish peroxidase (HRP) and rabbit IgG antibodies to HRP were used to study the Fcgamma receptors in normal human placenta. Cryostat sections of placental tissue were incubated with the complexes, and the peroxidase activity was revealed histochemically. The bound complexes were localized to t...

journal_title：Scandinavian journal of immunology

authors： Matre R,Haugen A

更新日期：1978-01-01 00:00:00

abstract：:Interleukin-17 (IL-17) plays an important role in several autoimmune diseases. IL-17 can induce the expression of vascular cell adhesion molecule (VCAM-1) in aortic vascular smooth muscle cells (SMCs), which is important for the development of atherosclerosis. However, the signalling pathway of IL-17-induced VCAM-1 ex...

journal_title：Scandinavian journal of immunology

authors： Zhang H,Chen J,Liu X,Awar L,McMickle A,Bai F,Nagarajan S,Yu S

更新日期：2013-04-01 00:00:00

abstract：:A computer search was carried out for homologies between HLA-A and HLA-B antigen sequences and the sequences of constant and variable regions of immunoglobulins and of all other sequenced proteins. Searches were made both with relatively short peptide sequences from the HLA antigens and with those longer peptide seque...

journal_title：Scandinavian journal of immunology

authors： Strominger JL,Orr HT,Parham P,Ploegh HL,Mann DL,Bilofsky H,Saroff HA,Wu TT,Kabat EA

更新日期：1980-01-01 00:00:00

abstract：:Fresh human T lymphocytes from the blood of healthy individuals exhibited few motile forms, i.e. nonspherical shape and lamellar surface activity, when allowed to settle on a plastic surface. This poor motility of 'normal' blood T lymphocytes is most likely physiological, since under the same conditions more than 75% ...

journal_title：Scandinavian journal of immunology

authors： Sundqvist KG,Otteskog P,Mellstedt H

更新日期：1986-06-01 00:00:00

abstract：:Human T lymphocytes, upon phytohaemagglutinin stimulation, are able to form colonies in semisolid media. Peripheral T cell bearing Fc receptors (TG) were studied for their possible regulatory activity on lymphoid colony development. Although no substantial differences were observed between the cloning efficiency of un...

journal_title：Scandinavian journal of immunology

authors： Canonica GW,Pistoia V,Ghio R,Mingari MC,Moretta L

更新日期：1980-01-01 00:00:00

abstract：:In order to study the pathogenic potential of IgG rheumatoid factor (IgG-RF) we generated a human monoclonal IgG4-RF-producing cell line, OR-1, by Epstein-Barr virus transformation of B cells derived from a healthy donor. Characterization of OR-1 RF specificity demonstrated that this RF binds only to IgG and not to ds...

journal_title：Scandinavian journal of immunology

authors： Otten HG,Daha MR,De Rooy HH,Breedveld FC

更新日期：1992-07-01 00:00:00

abstract：:Multifactorial involvement in the pathogenesis of autoimmune NZB/W F1 mice has been well documented. To further elucidate the role of cytokines in the disease development of murine lupus, single spleen cells isolated from NZB/W F1 and non-autoimmune C57BL/6 mice were stimulated with T cell mitogens or anti-CD3 antibod...

journal_title：Scandinavian journal of immunology

authors： Lin LC,Chen YC,Chou CC,Hsieh KH,Chiang BL

更新日期：1995-10-01 00:00:00

abstract：:The build-up of long-term immunological memory in the gut mucosal immune system may explain long-lasting protection against new attacks of cholera in convalescents from natural disease. We have looked for gut mucosal antitoxin immunological memory and memory cells in mice after oral immunization with cholera toxin. Ou...

journal_title：Scandinavian journal of immunology

authors： Lycke N,Holmgren J

更新日期：1986-05-01 00:00:00

abstract：:Modified C-reactive protein (mCRP) has been reported to non-specifically bind to immunoglobulins; notwithstanding, the nature of these interactions is not clear. The aim of this study was to investigate the binding of antibodies directed against HSA and IgG to mCRP, fibrinogen (Fg), IgG, fibronectin (Fn) and C1q and i...

journal_title：Scandinavian journal of immunology

authors： Boncler M,Dudzińska D,Nowak J,Watała C

更新日期：2012-07-01 00:00:00

abstract：:Around 20 susceptibility loci for type 1 diabetes mellitus (T1DM) have been mapped. One of these loci, IDDM10, was found on chromosome 10p11-q11. Here, we investigated whether the IDDM10 locus contributes in the susceptibility to T1DM in a Russian family dataset. One hundred and fourteen simplex Russian families, each...

journal_title：Scandinavian journal of immunology

authors： Chistiakov DA,Seryogin Y,Savost'anov KV,Zilberman LI,Titovich EV,Kuraeva TL,Dedov II,Nosikov VV

更新日期：2004-09-01 00:00:00

abstract：:Neural transplantation may become an important treatment alternative for focal brain disorders. To date, the most successful grafts have been obtained in patients with Parkinson's disease. Completely normalized dopamine production and reduction of Parkinsonian symptoms have been demonstrated 10 years after grafting. H...

journal_title：Scandinavian journal of immunology

authors： Larsson LC,Widner H

更新日期：2000-09-01 00:00:00

abstract：:BALB/c mice were injected with an affinity-chromatography-purified placental transferrin receptor preparation. Spleen cells were fused with NS-1 myeloma cells. Sixteen hybrids producing monoclonal antibodies specific for the transferrin receptor and two hybrids specific for transferrin were identified by radioimmunoas...

journal_title：Scandinavian journal of immunology

authors： Nikinmaa B,Enns CA,Tonik SE,Sussman HH,Schröder J

更新日期：1984-11-01 00:00:00

abstract：:Regulation of acute-phase serum amyloid A (A-SAA) synthesis by proinflammatory cytokines and steroid hormones in human aortic smooth muscle cells (HASMCs) is distinct from that in HepG2 cells. To study the cis- and trans-activating promoter element involved in the SAA1 gene expression by HASMCs and HepG2 cells, we con...

journal_title：Scandinavian journal of immunology

authors： Kumon Y,Suehiro T,Faulkes DJ,Hosakawa T,Ikeda Y,Woo P,Sipe JD,Hashimoto K

更新日期：2002-11-01 00:00:00

abstract：:We studied the T-cell reactivity to overlapping peptides of B. garinii OspA, in order to locate possible immunodominant T-cell epitopes in neuroborreliosis. Cells from cerebrospinal fluid (CSF) and blood from 39 patients with neuroborreliosis and 31 controls were stimulated with 31 overlapping peptides, and interferon...

journal_title：Scandinavian journal of immunology

authors： Widhe M,Ekerfelt C,Jarefors S,Skogman BH,Peterson EM,Bergström S,Forsberg P,Ernerudh J

更新日期：2009-08-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) infection is a risk factor for thrombotic microangiopathy (TMA). We sought whether a severe deficiency in ADAMTS13, the enzyme specifically involved in the cleavage of von Willebrand factor, was associated with specific presenting features and outcome in HIV-associated TMA. In this p...

journal_title：Scandinavian journal of immunology

authors： Malak S,Wolf M,Millot GA,Mariotte E,Veyradier A,Meynard JL,Korach JM,Malot S,Bussel A,Azoulay E,Boulanger E,Galicier L,Devaux E,Eschwège V,Gallien S,Adrie C,Schlemmer B,Rondeau E,Coppo P,Réseau d'Etude des Microangi

更新日期：2008-09-01 00:00:00

abstract：:The results reported here suggest that there exist two T-cell-mitogenic responsive populations in the spleen--one that is responsive to concanavalin A (Con A) and a second one that is responsive to Con A and phytohemagglutinin (PHA). Using an in vitro restimulation system, we have found that a primary in vivo activati...

journal_title：Scandinavian journal of immunology

authors： Waterfield JD,Ekstedt RD,Möller G

更新日期：1977-01-01 00:00:00

abstract：:High-grade glioma is a malignant tumour; the pathogenesis is to be further investigated. Interleukin (IL)-17 is an inflammatory cytokine. Chronic inflammation is a pathological feature of cancer. This study aimed to characterize the glioma-derived IL-17(+) regulatory T cells (Treg). In this study, single cells were is...

journal_title：Scandinavian journal of immunology

authors： Liang H,Yi L,Wang X,Zhou C,Xu L

更新日期：2014-08-01 00:00:00

abstract：:Non-specific antibody production usually accompanies the T-cell-regulated B-cell response. In this paper the mechanisms involved in non-MHC-restricted T-B-cell interaction were studied. As previously shown for NK cells, activated B cells induce IFN-gamma and TNF alpha production in non-MHC-restricted cytotoxic T lymph...

journal_title：Scandinavian journal of immunology

authors： Becker JC,Dummer R,Von Wussow P,Burg G,Schmidt RE

更新日期：1992-08-01 00:00:00

abstract：:The Ro/SSA and La/SSB antigens are common targets for autoantibodies found in the sera of patients with Sjögren's syndrome and SLE. The anti-Ro/SSA and anti-La/SSB antibodies often appear together but are not cross-reactive. This paper describes the humoral autoimmune response to the Ro/SSA 60 kDa protein moiety with ...

journal_title：Scandinavian journal of immunology

authors： Wahren M,Ringertz NR,Pettersson I

更新日期：1994-02-01 00:00:00

abstract：:A simple technique requiring only 0.2 ml whole blood for measuring the response of lymphocytes in cultures to each of various mitogens and antigens has been elaborated. The response is quantified by comparing the number of lymphocytes with and without a stimulating agent. The increment of cell numbers is given by a ce...

journal_title：Scandinavian journal of immunology

authors： Haneberg B,Wesenberg F,Aarskog D

更新日期：1978-01-01 00:00:00

abstract：:Antibodies to DNA (anti-DNA) play an important role in the pathogenesis of systemic lupus erythematosus (SLE). In blood, these antibodies may exist in a free, unbound state or as part of complexes with DNA. Furthermore, circulating DNA may be either complexed or free. Because of the central role of these immunoreactan...

journal_title：Scandinavian journal of immunology

authors： Björkman L,Reich CF,Pisetsky DS

更新日期：2003-06-01 00:00:00

abstract：:To delineate accurately the IgG subclass distribution of thyroid auto-antibodies, sera from nine patients with Hashimoto's thyroiditis were fractionated into IgG subclasses by complete depletion of the other IgG subclasses on affinity columns. All IgG subclass fractions contained thyroglobulin and microsomal (or thyro...

journal_title：Scandinavian journal of immunology

authors： Weetman AP,Black CM,Cohen SB,Tomlinson R,Banga JP,Reimer CB

更新日期：1989-07-01 00:00:00

abstract：:Peripheral blood mononuclear cells (PBM) from four patients with IgG myeloma and four patients with benign monoclonal gammopathy (BMG) were stimulated with pokeweed mitogen (PWM), and the in vitro immunoglobulin production over 7 days was measured with an enzyme-linked immunosorbent assay. All myeloma patients were su...

journal_title：Scandinavian journal of immunology

authors： Peest D,Brunkhorst U,Schedel I,Deicher H

更新日期：1984-02-01 00:00:00

abstract：:Using a recently developed murine model of haematogenously induced Staphylococcus aureus, the authors have characterized the phenotypes and functional properties of inflammatory cells present in the synovium of arthritic mice. The results show that large numbers of granulocytes and macrophages were observed in the inf...

journal_title：Scandinavian journal of immunology

authors： Abdelnour A,Bremell T,Holmdahl R,Tarkowski A

更新日期：1994-04-01 00:00:00

abstract：:Peripheral blood neutrophils from germ-free (GF), specific-pathogen-free (SPF) and conventional (CV) rats were compared. Besides neutropenia and impaired superoxide anion generation as previously reported, it was found that GF rats had lower phagocytic function (70%) and generated less nitric oxide than the other rats...

journal_title：Scandinavian journal of immunology

authors： Ohkubo T,Tsuda M,Suzuki S,El Borai N,Yamamura M

更新日期：1999-01-01 00:00:00

abstract：:Histamine was shown to suppress the in vitro generation of secondary syngeneic tumour-specific Ly-2+, L3T4- cytotoxic T cells from Ly-2+, L3T4- precursor cells. The sensitivity of the spleen cells from P815X2 mastocytoma-bearing DBA/2 mice to histamine-induced suppression changed during tumour progression; by the time...

journal_title：Scandinavian journal of immunology

authors： Laatikainen A

更新日期：1989-10-01 00:00:00

abstract：:Normal human B lymphocytes and Epstein-Barr virus-transformed B-cell lines can produce reactive oxygen species such as superoxide if treated with phorbol myristate acetate (PMA) or with the surface immunoglobulin cross-linking agents protein A and anti-immunoglobulin. Here, we investigated under which conditions speci...

journal_title：Scandinavian journal of immunology

authors： Maly FE,Urwyler A,Tengler R,Steinitz M,Golding B,de Weck AL

更新日期：1990-12-01 00:00:00