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H-2 private specificity of in vivo-sensitized lymphocytes studied by adsorption on fibroblast monolayers.

Abstract：

:Spleen cells or thymocytes immune to one H-2 genotype are cytotoxic to allogeneic target cells of a third-party genotype, provided the target shares private specificities determined by either the H-2K or the H-2D locus of the H-2 complex with the H-2 genotype used for sensitization in vivo. The present results on elimination of cytotoxicity to specificities determined by one of the H-2 loci after adsorption of the immune lymphoid cells onto fibroblasts bearing this specificity suggest a state of diversity among effector lymphocytes reactive to the antigens determined by either the H-2K or the H-2D locus of the H-2 complex. Thymus cells activated in vivo were less specifically adsorbable than spleen cells of tumor-allografted mice.

journal_name

Scand J Immunol

journal_title

Scandinavian journal of immunology

authors

Jorgensen PN,Güttler F,Rubin B

doi

10.1111/j.1365-3083.1975.tb02640.x

subject

Has Abstract

pub_date

1975-01-01 00:00:00

pages

383-9

issue

4

eissn

0300-9475

issn

1365-3083

journal_volume

4

pub_type

杂志文章

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