The immunomodulatory potentials of interleukin-27 in airway allergies.

Abstract:

:Allergic airway disorders such as asthma and allergic rhinitis are mainly caused by inhaled allergen-induced improper activation and responses of immune and non-immune cells. One important response is the production of IL-27 by macrophages and dendritic cells (DCs) during the early stage of airway allergies. IL-27 exerts powerful modulatory influences on the cells of innate immunity [eg neutrophils, eosinophils, mast cells, monocytes, macrophages, dendritic cells (DCs), innate lymphoid cells (ILCs), natural killer (NK) cells and NKT cells)] and adaptive immunity (eg Th1, Th2, Th9, Th17, regulatory T, CD8+ cytotoxic T and B cells). The IL-27-mediated signalling pathways may be modulated to attenuate asthma and allergic rhinitis. In this review, a comprehensive discussion concerning the roles carried out by IL-27 in asthma and allergic rhinitis was provided, while evidences are presented favouring the use of IL-27 in the treatment of airway allergies.

journal_name

Scand J Immunol

authors

Jafarzadeh A,Nemati M,Jafarzadeh S,Chauhan P,Saha B

doi

10.1111/sji.12959

subject

Has Abstract

pub_date

2021-02-01 00:00:00

pages

e12959

issue

2

eissn

0300-9475

issn

1365-3083

journal_volume

93

pub_type

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