V and C gene contribution in creating anti-alpha-1,3 dextran antibodies in mice. II. Characteristics of Ig-lb to e prototype responses.


:The light (L) and heavy (H) chain and the idiotypic (Id) composition of the antibody (Ab) plaque-forming cells (PFC) and serum Ab specific for alpha-1,3 dextran have been characterized in murine strains exhibiting the CH-Ig-lb to e allotypes and in their F1 hybrids with Ig-la1, BALB/c prototypes. The Ab response of the Ig-lb to e mice to the alpha-1,3 dextran was low in the kappa (kappa) L chain class with only a minor, sporadic Ab in the lambda (lambda) L chain class discernible after prolonged immunization. Two of a total of sixty-eight C57Bl/6 Ig-lb mice, in a total of 318 Ig-lb to e mice tested, exhibited, in late responses, a significantly elevated Ab in the lambda L class at both serum and PFC levels, equalling at the PFC level the total non-specific lambda PFC values. An Id analysis showed this lambda Ab and the kappa Ab to lack the Id relatedness to the three BALB/c alpha-1,3 dextran-binding myeloma proteins (MP) Ab prototypes, J-558, 104 E, and UPC-102, exhibited by the lambda Id+ Ab of the Ig-la1 BALB/c prototypes and their F1 hybrids with the Ig-lb to e prototypes. Furthermore, affinity differences could be detected by alpha-1,3 nigerodextrans, PFC inhibition analysis, between the late C57Bl/6 anti-alpha-1,3 dextran lambda Id--Ab PFC and the lambda Id+ Ab PFC of the BALB/c and their F1 progeny.


Scand J Immunol


Bell C




Has Abstract


1979-03-01 00:00:00












  • Circulating T cells of patients with active psoriasis respond to streptococcal M-peptides sharing sequences with human epidermal keratins.

    abstract::Psoriasis is a T-cell mediated inflammatory skin disease which has been associated with group A, beta-haemolytic streptococcal infections. Four 20 a.a. long M6-peptides sharing 5-6 a.a. sequences with human epidermal keratins were identified. To investigate the role of potentially cross-reactive T cells in the pathoge...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Sigmundsdottir H,Sigurgeirsson B,Troye-Blomberg M,Good MF,Valdimarsson H,Jonsdottir I

    更新日期:1997-06-01 00:00:00

  • Application of chimerism-based drug-induced tolerance to rat into mouse xenotransplantation.

    abstract::The current critical shortage of human donor organs has stimulated the feasibility of the xenogenic transplantation, such as swine to primate. We have previously reported the induction of donor-specific tolerance in MHC-disparated recipient mice by using our cyclophosphamide (CP)-induced tolerance conditioning. In thi...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Tomita Y,Shimizu I,Iwai T,Zhang QW,Okano S,Kajiwara T,Onzuka T,Tominaga R

    更新日期:2006-10-01 00:00:00

  • Induction of cellular immune reactions by A36, an antigen complex of Mycobacterium paratuberculosis: comparison of A36 and johnin components.

    abstract::Paratuberculosis (Johne's disease) is a chronic enteritis syndrome of ruminants, which is due to infection by Mycobacterium paratuberculosis. Cutaneous testing with proteins extracted from a mycobacterial culture fluid (johnin-PPD) is currently used to evaluate the cellular immune status. We have compared the componen...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Gilot P,De Kesel M,Coene M,Cocito C

    更新日期:1992-12-01 00:00:00

  • T-cell stimulation induced by idiotypes on monoclonal immunoglobulins in patients with monoclonal gammopathies.

    abstract::The stimulation of peripheral blood mononuclear cells by purified autologous and/or allogeneic monoclonal IgG was studied in five patients with multiple myeloma (MM), nine patients with monoclonal gammopathy of undetermined significance (MGUS) and six healthy individuals. Single cells secreting IFN-gamma or IL-2 were ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Yi Q,Bergenbrant S,Osterborg A,Osby E,Ostman R,Björkholm M,Holm G,Lefvert AK

    更新日期:1993-12-01 00:00:00

  • Characterization of amyloid protein AA and its serum precursor SAA in the horse.

    abstract::Amyloid was extracted from the liver of a horse that had developed amyloidosis after being used for several years for the production of antibodies to bacterial antigens. The amyloid fibrils were shown to be of the AA type. Two AA proteins with molecular weights of 9000 and 11,000 and with identical partial N-terminal ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Husebekk A,Husby G,Sletten K,Marhaug G,Nordstoga K

    更新日期:1986-06-01 00:00:00

  • Altered natural killer and natural cytotoxic cellular activities in lpr mice.

    abstract::Three strains of mice bearing the autosomal recessive lpr gene (MRL, C57BL/6, and C3H) that had spontaneously developed a lupus-like disease were studied sequentially for functional natural killer (NK) and natural cytotoxic (NC) cell activity. Natural killing was impaired in spleen and bone marrow cells from all the l...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Pan LZ,Dauphinée MJ,Ansar Ahmed S,Talal N

    更新日期:1986-04-01 00:00:00

  • Selective cytotoxicity of two rodent T cell lymphomas to rat yolk sac tumours involves a retroviral envelope protein expressed by the lymphoma.

    abstract::A Gross virus induced rat T cell lymphoma G1-Tc1 and a Moloney virus induced mouse T cell lymphoma YAC-1 are shown to exert a strong cytotoxic activity against rat yolk sac tumours but not to various types of rat, mouse or human normal cells or tumour cell lines including carcinomas, sarcomas, lymphomas and gliomas. B...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Lindvall M,Eriksson H,Hedlund G,Sjögren HO

    更新日期:1997-11-01 00:00:00

  • The detection and biological activity of human antibodies to IL-2 in normal donors.

    abstract::Antibodies to interleukin-2 (IL-2) have been reported in the sera of patients under therapies involving this cytokine and in the sera of patients infected with human immunodeficiency virus (HIV). Our study proves that auto-antibodies to IL-2 are present also, at a lower titre, in healthy individuals. These antibodies ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Tiberio L,Caruso A,Pozzi A,Rivoltini L,Morelli D,Monti E,Balsari A

    更新日期:1993-11-01 00:00:00

  • Monoclonal antibodies to a purified human transferrin receptor.

    abstract::BALB/c mice were injected with an affinity-chromatography-purified placental transferrin receptor preparation. Spleen cells were fused with NS-1 myeloma cells. Sixteen hybrids producing monoclonal antibodies specific for the transferrin receptor and two hybrids specific for transferrin were identified by radioimmunoas...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Nikinmaa B,Enns CA,Tonik SE,Sussman HH,Schröder J

    更新日期:1984-11-01 00:00:00

  • T-lymphocyte recognition of the I-EC gene products (Ia) requires concomitant recognition of I-AB gene products.

    abstract::The murine primed lymphocyte typing (mPLT) assay, based on the sequential reactivation of specific immunocompetent, alloantigen-reactive T blast cells in secondary mixed leucocyte culture (MLC), has been utilized to define the class II I-EC-subregion-associated lymphocyte-stimulating (LS) determinants of the major his...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Peck AB

    更新日期:1980-01-01 00:00:00

  • Specifically decreased MLC response of lymphocytes from CBA mice injected with cells from the H-2-compatible, M-antigen-incompatible strain C3H. Lack of such effect after injection of H-2-disparate C3H-hybrid cells.

    abstract::The mixed lymphocyte culture (MLC) response of lymphocytes from CBA mice against C3H cells was studied after injection of spleen cells from C3H mice or C3H hybrids. Intravenous infusion of C3H cells resulted in a strongly suppressed specific MLC response, but this was not the case when cells from H-2-incompatible hybr...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Lilliehöök B,Jacobsson H,Blomgren H

    更新日期:1975-01-01 00:00:00

  • Interleukin-17 facilitates the immune suppressor capacity of high-grade glioma-derived CD4 (+) CD25 (+) Foxp3 (+) T cells via releasing transforming growth factor beta.

    abstract::High-grade glioma is a malignant tumour; the pathogenesis is to be further investigated. Interleukin (IL)-17 is an inflammatory cytokine. Chronic inflammation is a pathological feature of cancer. This study aimed to characterize the glioma-derived IL-17(+) regulatory T cells (Treg). In this study, single cells were is...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Liang H,Yi L,Wang X,Zhou C,Xu L

    更新日期:2014-08-01 00:00:00

  • Medial histocompatibility antigens.

    abstract::Medial histocompatibility (H) antigens are weak H antigens, recognized by unrestricted T cells; they differ thus from both major and minor H antigens. An example, Qed-1, is described in detail, and other known medial H antigens of the mouse are reviewed. The structural and genetic relationships of major and medial H a...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章,评审


    authors: Lindahl KF,Langhorne J

    更新日期:1981-12-01 00:00:00

  • The effects of thymopentin on the development of SLE-like syndrome in the MRL/lpr-lpr mouse.

    abstract::Thymopentin (TP-5) is a synthetic pentapeptide that corresponds to the active 32-36 amino acid sequence of the thymic hormone thymopoietin, of which it retains all the immunomodulatory properties. In this study, we have evaluated the effects of long term prophylactic treatment with TP-5 on the clinical, immunological ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Nicoletti F,Zaccone P,Magro G,Barcellini W,Cavallaro V,Belli G,Cocuzza C,di Marco R,Meroni PL

    更新日期:1994-11-01 00:00:00

  • IgM and IgG subclass distribution of human anti-Ro/SSA 60 kDa autoantibodies.

    abstract::The Ro/SSA and La/SSB antigens are common targets for autoantibodies found in the sera of patients with Sjögren's syndrome and SLE. The anti-Ro/SSA and anti-La/SSB antibodies often appear together but are not cross-reactive. This paper describes the humoral autoimmune response to the Ro/SSA 60 kDa protein moiety with ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Wahren M,Ringertz NR,Pettersson I

    更新日期:1994-02-01 00:00:00

  • Mitogenic responses to lipopolysaccharide by B lymphocytes from patients with systemic lupus erythematosus.

    abstract::Peripheral blood lymphocytes from 43 patients with systemic lupus erythematosus (SLE) and from age- and sex-matched normal controls were cultured with lipopolysaccharide (LPS) to examine the response to the polyclonal B-cell activator. Lymphocytes from active SLE patients incorporated 4840 +/- 471 (mean +/- SE) cpm in...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Abe T,Toguchi T,Takeuchi T,Kiyotaki M,Homma M

    更新日期:1981-05-01 00:00:00

  • Cellular fibronectin in rheumatoid synovium and synovial fluid: a possible factor contributing to lymphocytic infiltration.

    abstract::Mouse monoclonal antibodies against ED sequence-containing cellular fibronectin (cFn) were used to show that Fn in the inflamed synovium is distinct from the major form of plasma Fn (pFn). An accumulation of cFn was seen at sites of hyperplasia of the rheumatoid synovial membrane and in the walls of small vessels in t...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Walle TK,Vartio T,Helve T,Virtanen I,Kurki P

    更新日期:1990-04-01 00:00:00

  • Vitamin A supplementation reduces IL-17 and RORc gene expression in atherosclerotic patients.

    abstract::Vitamin A is a potential mediator of T helper cells in atherosclerosis. The purpose of this study was to evaluate the effect of vitamin A supplementation on expression of Th17 cells-related IL-17 and RORc genes in atherosclerotic patients. Thirty one atherosclerotic patients and 15 healthy controls were studied for 4 ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章,随机对照试验


    authors: Mottaghi A,Ebrahimof S,Angoorani P,Saboor-Yaraghi AA

    更新日期:2014-08-01 00:00:00

  • Immunoglobulin G3 and immunoglobulin M isotype plasma levels are influenced by interleukin-1alpha genotype.

    abstract::The immunoglobulin (Ig) plasma levels are known to be, at least partially, genetically regulated, but all the genes involved are not known. Interleukin-1 (IL-1) is a potent proinflammatory cytokine able to serve as an adjuvant for immune responses. IL-1alpha gene is polymorphic, and at least one of the polymorphisms h...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Kilpinen S,Laine S,Hulkkonen J,Hurme M

    更新日期:2003-03-01 00:00:00

  • Evidence of aberration of T-cell subsets in aged individuals.

    abstract::In the present study, T-cell subsets from aged individuals were examined by using anti-BAT (brain-associated thymocyte antigen) serum. Anti-BAT serum was raised against the human fetal brain at 28 weeks of gestation. After absorption wit AB erythrocytes, B-cell lines, and leukaemic cells, anti-BAT serum was T cell-spe...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Abe T,Morimoto C,Toguchi T,Kiyotaki M,Homma M

    更新日期:1981-01-01 00:00:00

  • A protocol for generation of clinical grade mRNA-transfected monocyte-derived dendritic cells for cancer vaccines.

    abstract::With the aim of producing large quantities of mRNA-transfected monocyte-derived dendritic cells (DCs) to be used as cancer vaccines, a new clinical grade procedure has been developed. Peripheral blood mononuclear cells (PBMCs) obtained by leukapheresis were enriched for monocytes by immunomagnetic depletion of CD19+ B...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Mu LJ,Gaudernack G,Saebøe-Larssen S,Hammerstad H,Tierens A,Kvalheim G

    更新日期:2003-11-01 00:00:00

  • A low serum concentration of mannan-binding protein is not associated with serogroup B or C meningococcal disease.

    abstract::The mammalian C-type serum lectin, mannan-binding protein (MBP), may induce C1q- and antibody-independent activation of the classical pathway of complement. Accordingly, MBP is considered as a member of the complement system. Complement deficiencies have been found with increased frequency in patients with meningococc...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Garred P,Michaelsen TE,Bjune G,Thiel S,Svejgaard A

    更新日期:1993-04-01 00:00:00

  • Roles of group IIA phospholipase A2 and complement in killing of bacteria by acute phase serum.

    abstract::The complement system is regarded as an important component of the innate defence system against invading bacteria. However, synergistic actions between the complement and the other components of innate immunity are incompletely known. Human group IIA phospholipase A(2) (hGIIA PLA(2)) is an effective antibacterial enz...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Grönroos JO,Salonen JH,Viander M,Nevalainen TJ,Laine VJ

    更新日期:2005-10-01 00:00:00

  • Vaccination against Helicobacter pylori in non-human primate models and humans.

    abstract::Several vaccination studies have been performed in monkeys and humans testing the feasibility of prophylactic and therapeutic immunizations against Helicobacter pylori. The monkey studies showed that immune responses were induced by oral vaccination with the mucosal adjuvant LT (Escherichia coli heat-labile enterotoxi...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章,评审


    authors: Lee CK

    更新日期:2001-05-01 00:00:00

  • Variants of the IL23R gene are associated with ankylosing spondylitis but not with Sjögren syndrome in Hungarian population samples.

    abstract::Recently, associations were found between several autoimmune diseases and functional variants of interleukin-23 receptor (IL23R) gene; here, we studied the possible association of nine polymorphisms of IL23R with ankylosing spondylitis (AS) and with Sjögren syndrome (SS). In our study, we genotyped groups of patients ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Sáfrány E,Pazár B,Csöngei V,Járomi L,Polgár N,Sipeky C,Horváth IF,Zeher M,Poór G,Melegh B

    更新日期:2009-07-01 00:00:00

  • Molecular mechanism of immunoglobulin V-region diversification regulated by transcription and RNA metabolism in antigen-driven B cells.

    abstract::The immune system produces specific antibodies (Ab) against any antigens (Ag) of exogenous and endogenous origins with a diverse repertoire of V-region specificities. The primary V-region repertoire is created by the rearrangement of immunoglobulin (Ig) V-region, D- and J-segments with the insertion of N- and P-sequen...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章,评审


    authors: Sakaguchi N,Maeda K,Kuwahara K

    更新日期:2011-06-01 00:00:00

  • Correlation of susceptibility and cytostatic factor-inducing activity of tumour cells to peritoneal macrophages. The role of concanavalin A-binding glycopeptides extracted from the tumour cell surface.

    abstract::L929, 3T12-3, B16, 3LL, and YAC1 cells with cytostatic factor (CF)-inducing activity from Lactobacillus casei-elicited murine peritoneal macrophages (LCEPM) were susceptible to the cytostatic activity of LCEPM and to LCEPM-produced CF, but L1210, P388D1, and Colon 26 cells, which have no CF-inducing activity, were res...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Hashimoto S,Nagaoka M,Yokokura T,Mutai M

    更新日期:1988-03-01 00:00:00

  • Biliary immune response to orally presented food antigen, ovomucoid, and its potentiation by cholera toxin B subunit.

    abstract::To clarify the biliary immune response against food antigen, we studied biliary antibody response to intravenous and oral primary immunization with ovomucoid (OM) and the effects of cholera toxin B subunit (CTB) on the oral response in mice. Specific antibodies against OM were induced in biliary and serum immunoglobul...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Sugita-Konishi Y,Kumagai S

    更新日期:1992-05-01 00:00:00

  • Pandemic influenza vaccination elicits influenza-specific CD4+ Th1-cell responses in hypogammaglobulinaemic patients: four case reports.

    abstract::In these case reports, we investigated pandemic influenza 2009 vaccination of primary hypogammaglobulinaemic patients. Three combined variable immunodeficiency (CVID) patients and one X-linked agammaglobulinaemia (XLA) patient were vaccinated with the pandemic vaccine A/California/7/2009 (H1N1)-like split virus (X179a...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Pedersen G,Halstensen A,Sjursen H,Naess A,Kristoffersen EK,Cox RJ

    更新日期:2011-08-01 00:00:00

  • Characterization of effector cells mediating IgG and IgM antibody-dependent cellular cytotoxicity.

    abstract::Spleen effector cells for IgG- and IgM-induced antibody-dependent cellular cytotoxicity (ADCC) were characterized with respect to density and cell surface markers by using sheep erythrocytes (SRBC) coated with hybridoma-derived monoclonal anti-SRBC IgG or anti-SRBC IgM antibodies as targets. While basically the same e...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Zöller M,Andrighetto GC,Heyman B,Lamon EW,Wigzell H

    更新日期:1983-01-01 00:00:00