V and C gene contribution in creating anti-alpha-1,3 dextran antibodies in mice. II. Characteristics of Ig-lb to e prototype responses.


:The light (L) and heavy (H) chain and the idiotypic (Id) composition of the antibody (Ab) plaque-forming cells (PFC) and serum Ab specific for alpha-1,3 dextran have been characterized in murine strains exhibiting the CH-Ig-lb to e allotypes and in their F1 hybrids with Ig-la1, BALB/c prototypes. The Ab response of the Ig-lb to e mice to the alpha-1,3 dextran was low in the kappa (kappa) L chain class with only a minor, sporadic Ab in the lambda (lambda) L chain class discernible after prolonged immunization. Two of a total of sixty-eight C57Bl/6 Ig-lb mice, in a total of 318 Ig-lb to e mice tested, exhibited, in late responses, a significantly elevated Ab in the lambda L class at both serum and PFC levels, equalling at the PFC level the total non-specific lambda PFC values. An Id analysis showed this lambda Ab and the kappa Ab to lack the Id relatedness to the three BALB/c alpha-1,3 dextran-binding myeloma proteins (MP) Ab prototypes, J-558, 104 E, and UPC-102, exhibited by the lambda Id+ Ab of the Ig-la1 BALB/c prototypes and their F1 hybrids with the Ig-lb to e prototypes. Furthermore, affinity differences could be detected by alpha-1,3 nigerodextrans, PFC inhibition analysis, between the late C57Bl/6 anti-alpha-1,3 dextran lambda Id--Ab PFC and the lambda Id+ Ab PFC of the BALB/c and their F1 progeny.


Scand J Immunol


Bell C




Has Abstract


1979-03-01 00:00:00












  • Mononuclear cell factors that inhibit fibroblast collagen synthesis. II. Properties of the factors.

    abstract::Supernatants harvested from peripheral blood mononuclear cells (PBMC) incubated either with the non-specific mitogen phytohaemagglutinin-P (PHA) or with the specific antigen tuberculin purified protein derivative for 72 h decreased collagen synthesis by dermal fibroblasts. PHA-induced mononuclear cell factors (PHA-MCF...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Hart PH,Powell LW,Cooksley WG,Halliday JW

    更新日期:1983-07-01 00:00:00

  • Possible role of the plasminogen receptor as a site of interaction of the human immunodeficiency virus p24 immunosuppressive heptapeptide Ch7 with the host immune system.

    abstract::Previous work from our laboratory demonstrated that a synthetic heptapeptide (Ch7: RGSDIAG), corresponding to a conserved sequence of human immunodeficiency virus (HIV) core protein p24 (amino acids 232- 238), was able to specifically abrogate antigen-induced responses in cultures of normal human peripheral blood mono...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Giacomini E,Chersi A,Giordani L,Luzzati AL

    更新日期:2000-02-01 00:00:00

  • Specific and non-specific T-cell activation in high and low antibody-producing mice (selection IV-A).

    abstract::The T-cell regulatory function has been evaluated in lines of mice genetically selected according to the High (H) and Low (L) antibody responsiveness to heterologous erythrocytes. The inhibition of antibody production following CD4+ subset depletion was stronger in L than in H mice. The dose of CD4-specific monoclonal...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Cabrera WH,Siqueira M,Takahashi NS,Ribeiro OG,Araujo LM,Mouton D,Ibanez OM

    更新日期:1995-03-01 00:00:00

  • H-2 class I Ld antigen positively selects different TCR V beta gene products in CD8+ and CD4+ T cells.

    abstract::Expression of CD4+ or CD8+ determinants and ten different TCR V beta genes was analysed by two-colour flow cytometry in lymph node cells (LNC) of BALB/c and dm2 (a BALB/c Ld loss mutant) mice. TCR V beta 14 expression of CD8+ T cells and TCR V beta 7 and 14 of CD4+ T Cells were significantly more frequent in BALB/c th...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Tscherning T,Reimann J,Claesson MH

    更新日期:1992-10-01 00:00:00

  • Prethymic progenitors from the avian para-aortic mesoderm express GATA-3 and distinct chTcf isoforms but still lack T-cell receptor-gamma rearrangements.

    abstract::Haematopoietic precursors first colonizing the avian embryonic thymus are derived from the intraembryonic sites located around the dorsal aortae. These intraembryonic precursors have previously been demonstrated to include cells that harbour T-cell progenitor capacity and express the Ikaros transcription factor, known...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Liippo J,Koskela K,Lassila O

    更新日期:2000-11-01 00:00:00

  • Lymphocyte transformation with mitogens and antigens during normal human pregnancy: a longitudinal study.

    abstract::In a longitudinal analysis of immunological changes in normal human pregnancy, twenty-two pregnant women were studied, with blood samples taken before pregnancy, during its course, at delivery, and 3-5 months after delivery. The blood samples were frozen successively, using a cryobiological freezing system, and were s...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Birkeland SA,Kristoffersen K

    更新日期:1980-01-01 00:00:00

  • The immune response to pneumococcal polysaccharide type III is followed by increased production of an antibody antifactor.

    abstract::The study shows that serum from pneumococcal polysaccharide type III (SSSIII)-immunized and nonimmunized mice that has been absorbed until devoid of anti-SSSIII antibodies inhibits anti-SSSIII plaque-forming cells (PFC) but not antisheep red blood PFC in antibody plaque assay. A large fraction of the inhibitions activ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Pasanen VJ

    更新日期:1986-03-01 00:00:00

  • Effects of various adjuvants and a viral infection on the antibody specificity toward native or cryptic epitopes of a protein antigen.

    abstract::An immunization protocol that induces antibodies (Abs) directed to cryptic epitopes of a protein antigen (Ag) reduces the efficacy of vaccines that ideally should induce Abs against native epitopes. We have shown earlier that viral infections concomitant with immunization against a protein tend to shift the Ab specifi...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Gómez KA,Longhi SA,Marino VJ,Mathieu PA,Loureiro ME,Coutelier JP,Roguin LP,Retegui LA

    更新日期:2003-02-01 00:00:00

  • SRBC rosette formation as a human T lymphocyte marker.

    abstract::This paper describes a technique utilizing rosette formation with sheep red blood cells as a human T lymphocyte marker, and separation of T cells by rosette sedimentation. ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Jondal M

    更新日期:1976-06-01 00:00:00

  • Fc-signalling in the modulation of immune responses by passive antibody.

    abstract::Passive antibody can both suppress and augment immune responses. Until recently, there was virtual unanimity on the importance of the interaction of the Fc portion of modulating antibody with Fc-receptors (Fc-signalling), especially in experiments involving the suppression by antibody. Experiments reported in the last...

    journal_title:Scandinavian journal of immunology

    pub_type: 历史文章,杂志文章,评审


    authors: Sinclair NR

    更新日期:2001-04-01 00:00:00

  • Complement activation and interleukin response in major abdominal surgery.

    abstract::The objective of this study was to evaluate whether major abdominal surgery leads to complement activation and interleukin response and whether the kind of anaesthesia influence complement activation and the release of inflammatory interleukins. The study design was prospective and randomised. Fifty patients undergoin...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章,随机对照试验


    authors: Kvarnström AL,Sarbinowski RT,Bengtson JP,Jacobsson LM,Bengtsson AL

    更新日期:2012-05-01 00:00:00

  • The attentive focus on T cell-mediated autoimmune pathogenesis of psoriasis, lichen planus and vitiligo.

    abstract::T cell-mediated autoimmune skin diseases develop as a result of the aberrant immune response to the skin cells with T cells playing a central role. These chronic inflammatory skin diseases encompass various types including psoriasis, lichen planus and vitiligo. These diseases show similarities in their immune-pathophy...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章,评审


    authors: Aghamajidi A,Raoufi E,Parsamanesh G,Jalili A,Salehi-Shadkami M,Mehrali M,Mohsenzadegan M

    更新日期:2020-11-15 00:00:00

  • beta 2-Microglobulin is bound to streptococcal M protein.

    abstract::The presence of receptors for three human proteins (fibrinogen, IgG, and beta 2-microglobulin (beta 2m)) was studied in group A streptococcal strains. M type 1, 12 and 14, and in M protein-negative variants of these strains. Fibrinogen binding was detected in all six strains. IgG did not bind to the two type-12 strain...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Björck L,Tylewska SK,Wadström T,Kronvall G

    更新日期:1981-01-01 00:00:00

  • The absence of a human thymus lymphocyte antigen (HTLA) on basophils and mast cells.

    abstract::Basophilic granulocytes and mast cells of different species have been reported to originate from thymocytes and other lymphocytes. These observations were recently confirmed when evidence was given that thymic antigen is present on rabbit basophilic granulocytes. In the study reported here, human leukocytes were teste...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Stallman PJ,Van Elven EH,Feltkamp-Vroom TM,Brutel de la Rivière A

    更新日期:1977-01-01 00:00:00

  • Complex formation between secretory component and human immunoglobulins related to their content of J chain.

    abstract::The J-chain content of 3 IgM and 24 IgA preparations was quantitated by an immunochemical technique after reduction with 20mM dithiothreitol. The amounts released ranged from undetectable (less than 0.1 mg) to 7.3 mg per 100 mg of Ig. Most of the J-chain-deficient proteins were monomeric, but four polymeric IgA prepar...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Brandtzaeg P

    更新日期:1976-01-01 00:00:00

  • Structural studies of induced antibodies with defined idiotypic specificities. IV. The heavy chains of anti-streptococcal group A carbohydrate antibodies from Sprague-Dawley rats carrying a cross-reacting idiotype.

    abstract::The heavy (H) chains of three anti-streptococcal group A carbohydrate antibodies (anti-SACHO) of restricted heterogeneity, elicited in inbred Sprague-Dawley rats, were subjected to 40 cycles of automated Edman degradation. All three antibody H-chain preparations had an identical amino acid sequence and were classified...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Klapper DG,Stankus RP,Leslie GA,Capra JD

    更新日期:1976-01-01 00:00:00

  • Mitigated Tregs and augmented Th17 cells and cytokines are associated with severity of experimental autoimmune neuritis.

    abstract::Experimental autoimmune neuritis (EAN), an animal model of human Guillain-Barré syndrome, has long been considered as a T helper (Th) 1 cell-mediated autoimmune disorder. However, deficiency of IFN-γ, a signature Th1 cytokine, aggravated EAN, with features of elevated production of IL-17A, despite an alleviated system...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Wang X,Zheng XY,Ma C,Wang XK,Wu J,Adem A,Zhu J,Zhang HL

    更新日期:2014-09-01 00:00:00

  • Methylated CpG-containing plasmid activates the immune system.

    abstract::Bacterial DNA differs from mammalian DNA by the presence of unmethylated cytosine-phosphate-guanosine (CpG) motifs. The immunostimulatory properties of a DNA vaccine have been suspected to be associated with these motifs. The aim of this study was to assess the inactivation of the immunostimulatory potential of a plas...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Cornélie S,Poulain-Godefroy O,Lund C,Vendeville C,Ban E,Capron M,Riveau G

    更新日期:2004-02-01 00:00:00

  • Chronic lymphocytic leukaemia cells activated in vitro reveal cellular changes that characterize B-prolymphocytic leukaemia and immunocytoma.

    abstract::Leukaemic blood lymphocytes from a patient in the terminal stage of chronic lymphocytic leukaemia (CLL) according to the Kiel classification were stimulated by lipopolysaccharide from Escherichia coli. During progression to blast transformation, stimulated cells lost receptors for mouse erythrocytes (MRBC), accumulate...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Robèrt KH,Juliusson G,Biberfeld P

    更新日期:1983-05-01 00:00:00

  • IFNγ and perforin cooperate to control infection and prevent fatal pathology during persistent gammaherpesvirus infection in mice.

    abstract::Infection with murine gammaherpesvirus 68 has become an accepted model for studying the virus/host interactions with regard to gammaherpesvirus infections. Previous studies using gene-deficient mice have revealed that neither IFNγ nor perforin is essential in controlling the outcome of infection or the virus load duri...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Bartholdy C,Høgh-Petersen M,Storm P,Holst PJ,Orskov C,Christensen JP,Thomsen AR

    更新日期:2014-06-01 00:00:00

  • Diabetes induction in C57BL/6 mice reconstituted with lymphocytes of nonobese diabetic C57BL/6 mouse embryo aggregation chimeras.

    abstract::To determine whether the genetic background of the insulin-producing beta cells of the pancreas contributes to autoimmune diabetes susceptibility, we have used a model of the disease based on transferring spleen cells from nonobese diabetic (NOD) <--> C57BL/6 (B6) embryo aggregation (EA) chimeras into B6 and NOD irrad...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Colucci F,Bergman ML,Lejon K,Holmberg D

    更新日期:1998-12-01 00:00:00

  • A routine source of human peritoneal macrophages.

    abstract::The routine availability of nucleated human cells for experimental use in limited in the absence of venipuncture. In this paper we have demonstrated that macrophages may be harvested routinely from the waste dialysis bags of patients undergoing continuous ambulatory peritoneal dialysis. These cells were identified as ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Maddox Y,Foegh M,Zeligs B,Zmudka M,Bellanti J,Ramwell P

    更新日期:1984-01-01 00:00:00

  • Experimental allergic bronchopulmonary aspergillosis in the mouse: immunological and histological features.

    abstract::C57BL/6 mice treated with intranasal instillation of 100 micrograms of Aspergillus antigen three times a week developed a pulmonary eosinophilia, observed in the bronchoalveolar lavage (BAL) and on histopathological examination. At week 3, the instillation of Aspergillus antigen provoked a 10-fold increase in the BAL ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Wang JM,Denis M,Fournier M,Laviolette M

    更新日期:1994-01-01 00:00:00

  • Antigenic phenotype of early intra-embryonic lymphoid progenitors in the chicken.

    abstract::The stem cells for the definitive haematopoiesis are derived from intra-embryonic sources originally described in an avian model and later also in mammals. However, the molecular make-up of the early embryonic haematopoietic progenitors is not yet clearly defined. We have recently characterized the phenotype of prethy...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Lampisuo M,Katevuo K,Lassila O

    更新日期:1998-07-01 00:00:00

  • Studies on mouse auto-reactive cells. II. Cytotoxicity exerted by mouse lymphocytes against syngeneic erythrocytes.

    abstract::In mice, an in vitro cell-mediated cytotoxicity is directed towards syngeneic erythrocytes used as targets. This phenomenon occurs in lymphoid organs of normal, non-immunized mice. Its intensity is greater in the thymus than in spleen or lymph nodes. The study of the nature of the cell responsible for this spontaneous...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Charreire J,Bach JF

    更新日期:1982-07-01 00:00:00

  • Membrane expression and function of complement receptors CR1 and CR3 on neutrophils from HIV-infected subjects: modulation by rTNF-alpha and rGM-CSF.

    abstract::We evaluated membrane expression and function of complement receptors CR1 and CR3 on neutrophils from 27 HIV-positive (HIV+) subjects (14 in the CDC class III and 13 class IV) as well as their modulation in vitro by recombinant tumour necrosis factor-alpha (rTNF-alpha) and granulocyte-macrophage colony stimulating fac...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Capsoni F,Minonzio F,Colombo G,Ongari AM,Bonara P,Rizzardi GP,Lazzarin A,Zanussi C

    更新日期:1992-10-01 00:00:00

  • Sequential antibody affinity chromatography of human leukocyte interferon.

    abstract::Antibodies to crude leukocyte interferon (CIF) were bound to Sepharose 4B, and CIF was chromatographed. A relationship between recovered interferon and percentage binding of the antibodies to Sepharose 4B was observed. Highest recovery was obtained when only 50%-85% of th- antibodies were bound. When CIF was subjected...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Berg K

    更新日期:1977-01-01 00:00:00

  • A two-signal mechanism for the induction of cytotoxic T lymphocytes.

    abstract::Depletion of adherent cells from stimulator and responder lymphocytes by a single filtration through nylon wool columns led to complete abrogation of the cytotoxic response to the stimulating alloantigen. Cytotoxic responses were restored by adding anti-Thy-1 + complement-greated normal peritoneal exudate cells (PEC) ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Symington FW,Teh HS

    更新日期:1980-01-01 00:00:00

  • Cellular fibronectin in rheumatoid synovium and synovial fluid: a possible factor contributing to lymphocytic infiltration.

    abstract::Mouse monoclonal antibodies against ED sequence-containing cellular fibronectin (cFn) were used to show that Fn in the inflamed synovium is distinct from the major form of plasma Fn (pFn). An accumulation of cFn was seen at sites of hyperplasia of the rheumatoid synovial membrane and in the walls of small vessels in t...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Walle TK,Vartio T,Helve T,Virtanen I,Kurki P

    更新日期:1990-04-01 00:00:00

  • Behçet disease (BD) and BD-like clinical phenotypes: NF-κB pathway in mucosal ulcerating diseases.

    abstract::Behçet's disease (BD) is a heterogeneous multi-organ disorder in search of a unified pathophysiological theory and classification. The disease frequently has overlapping features resembling other disease clusters, such as vasculitides, spondyloarthritides and thrombophilias with similar genetic risk variants, namely H...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章,评审


    authors: Perazzio SF,Allenspach EJ,Eklund KK,Varjosalo M,Shinohara MM,Torgerson TR,Seppänen MRJ

    更新日期:2020-11-01 00:00:00