In search of the origin of the thymus: the thymus and GALT may be evolutionarily related.

Abstract:

:The thymus is the major primary immune tissue for the production of functional T lymphocytes in vertebrates. However, its evolutionary origin is unknown. It has recently been shown that the generation of local T cells also occurs in gut-associated lymphoid tissues (GALT). This suggests that the thymus and GALT have similar functions and that they might be evolutionarily related. We discuss the possibility that the thymus may have evolved from mucosa-associated lymphoid tissues (MALT) located in the gill region in early vertebrates. Various facts supporting this proposal are summarized.

journal_name

Scand J Immunol

authors

Matsunaga T,Rahman A

doi

10.1046/j.1365-3083.2001.00854.x

keywords:

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

1-6

issue

1

eissn

0300-9475

issn

1365-3083

pii

sji854

journal_volume

53

pub_type

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