Abstract:
:The thymus is the major primary immune tissue for the production of functional T lymphocytes in vertebrates. However, its evolutionary origin is unknown. It has recently been shown that the generation of local T cells also occurs in gut-associated lymphoid tissues (GALT). This suggests that the thymus and GALT have similar functions and that they might be evolutionarily related. We discuss the possibility that the thymus may have evolved from mucosa-associated lymphoid tissues (MALT) located in the gill region in early vertebrates. Various facts supporting this proposal are summarized.
journal_name
Scand J Immunoljournal_title
Scandinavian journal of immunologyauthors
Matsunaga T,Rahman Adoi
10.1046/j.1365-3083.2001.00854.xkeywords:
subject
Has Abstractpub_date
2001-01-01 00:00:00pages
1-6issue
1eissn
0300-9475issn
1365-3083pii
sji854journal_volume
53pub_type
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