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Intestinal mucosal memory and presence of memory cells in lamina propria and Peyer's patches in mice 2 years after oral immunization with cholera toxin.

Abstract：

:The build-up of long-term immunological memory in the gut mucosal immune system may explain long-lasting protection against new attacks of cholera in convalescents from natural disease. We have looked for gut mucosal antitoxin immunological memory and memory cells in mice after oral immunization with cholera toxin. Our results show that mice that were orally primed with cholera toxin and then boosted 2 years later with a single oral antigen dose mounted a rapid and vigorous IgA antitoxin response in the intestinal lamina propria. A specific secondary antitoxin response could also be elicited without any in-vivo boosting by in-vitro stimulation of isolated lymphocytes from the lamina propria, Peyer's patches, mesenteric lymph nodes, and spleen. The results provide evidence for the almost life-long persistence of anti-cholera toxin memory B cells (and perhaps also T cells) in the intestine and probably also recirculating cells, after oral immunization with cholera toxin. A functional antitoxic immune response may be boosted rapidly on renewed enteral exposure to cholera toxin by the stimulation of memory cells both in the lamina propria and in the Peyer's patches.

journal_name

Scand J Immunol

journal_title

Scandinavian journal of immunology

authors

Lycke N,Holmgren J

doi

10.1111/j.1365-3083.1986.tb01995.x

subject

Has Abstract

pub_date

1986-05-01 00:00:00

pages

611-6

issue

5

eissn

0300-9475

issn

1365-3083

journal_volume

23

pub_type

杂志文章

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