In vitro experiments demonstrate that monocytes and dendritic cells are rendered apoptotic by extracorporeal photochemotherapy, but exhibit unaffected surviving and maturing capacity after 30 Gy gamma irradiation.

abstract：:Peripheral blood lymphocytes from nine patients with chronic lymphatic leukaemia (CLL) have been stimulated by photohaemagglutinin, pokeweed mitogen and Epstein-Barr virus. Our results provide proof that the leukaemic B cells in CLL are capable of responding to mitogenic signals by producing and secreting antibodies, ...

journal_title：Scandinavian journal of immunology

authors： Robèrt KH,Bird AG,Möller E

更新日期：1979-01-01 00:00:00

abstract：:A serum amyloid A (SAA) clone was isolated from a Tammar wallaby cDNA library, the most distantly related mammalian species for which an SAA has been described to date. The clone predicts a premolecule of 127 amino acids with good homology to other mammalian SAAs, and consists of an 18 residue leader peptide and a mat...

journal_title：Scandinavian journal of immunology

authors： Uhlar CM,Black IL,Shields DC,Brack CM,Schreiber G,Whitehead AS

更新日期：1996-03-01 00:00:00

abstract：:Increased serum immunoglobulin A (IgA) level is a common finding in primary Sjögren's syndrome (pSS). IgA might not be properly eliminated because of an abnormal glycosylation. We reported previously that IgA1 from patients with pSS was oversialylated. We extend this finding by showing that monomeric IgA1 contains mor...

journal_title：Scandinavian journal of immunology

authors： Basset C,Durand V,Jamin C,Clément J,Pennec Y,Youinou P,Dueymes M,Roitt IM

更新日期：2000-03-01 00:00:00

abstract：:CD27 has been found to be expressed on somatically mutated B cells and is thus a positive marker for memory B cells in peripheral blood (PB). Since abnormal immunogloblin (Ig) production is characteristic of the autoimmune diseases primary Sjögren's syndrome (pSS) and rheumatoid arthritis (RA), we have analyzed in det...

journal_title：Scandinavian journal of immunology

authors： Bohnhorst JO,Thoen JE,Natvig JB,Thompson KM

更新日期：2001-10-01 00:00:00

abstract：:We have developed a new assay for quantitative detection of all helper T cells that can induce normal B lymphocytes to proliferation and Ig secretion. To establish the optimal assay conditions, we have used cloned T helper cells of defined specificities that had previously been shown to activate normal B lymphocytes e...

journal_title：Scandinavian journal of immunology

authors： Pobor G,Bandeira A,Pettersson S,Coutinho A

更新日期：1984-09-01 00:00:00

abstract：:Recent studies performed in Seattle, USA have suggested that pretransplant assignment of high or low donor alloreactivity may predict acute graft-versus-host disease (aGvHD) after allogeneic HLA identical marrow transplantation for acute leukaemia. The effect of such pretransplant assignment was studied in a Scandinav...

journal_title：Scandinavian journal of immunology

authors： Johnsen HE,Bostrom L,Moller J,Jorgensen JA,Jensen L,Ringden O

更新日期：1992-03-01 00:00:00

abstract：:To investigate autologous antigen recognition, we developed two autoreactive CD4+ T-cell clones, A2 and A10, maintained with non-T cells and IL-2. Autologous non-T-cell stimulation of the T-cell clones resulted in a decrease in cell surface expression of CD4, whereas the expression of CD2, CD3, and WT31 was unchanged....

journal_title：Scandinavian journal of immunology

authors： Hara M,Kitani A,Harigai M,Suzuki K,Hirose T,Kawakami M,Kawagae M,Nakamura H

更新日期：1991-02-01 00:00:00

abstract：:Histoplasma capsulatum is a fungus found intracellularly in neutrophils and peripheral blood mononuclear cells (PBMCs), suggesting that it is capable of evading damage and survives inside these cells. In this study, we report that neutrophils from H. capsulatum-infected mice, and human neutrophils and mononuclear cell...

journal_title：Scandinavian journal of immunology

authors： Medeiros AI,Bonato VL,Malheiro A,Dias AR,Silva CL,Faccioli LH

更新日期：2002-10-01 00:00:00

abstract：:Persistent humoral immunity depends on the follicular B cell response and on the generation of somatically mutated high-affinity plasma cells and memory B cells. Upon activation by an antigen, cognately activated follicular B cells and follicular T helper (TFH ) cells initiate germinal centre (GC) reaction during whic...

journal_title：Scandinavian journal of immunology

authors： Nera KP,Kyläniemi MK,Lassila O

更新日期：2015-09-01 00:00:00

abstract：:Thymopentin (TP-5) is a synthetic pentapeptide that corresponds to the active 32-36 amino acid sequence of the thymic hormone thymopoietin, of which it retains all the immunomodulatory properties. In this study, we have evaluated the effects of long term prophylactic treatment with TP-5 on the clinical, immunological ...

journal_title：Scandinavian journal of immunology

authors： Nicoletti F,Zaccone P,Magro G,Barcellini W,Cavallaro V,Belli G,Cocuzza C,di Marco R,Meroni PL

更新日期：1994-11-01 00:00:00

abstract：:The fluid-phase terminal complement complex (TCC), consisting of the components C5b, C6, C7, C8, C9, and the S-protein, has recently been detected in normal human plasma by using antibodies against native terminal complement components. Increased amounts of TCC were then found in several patients with in vivo activati...

journal_title：Scandinavian journal of immunology

authors： Mollnes TE,Lea T,Frøland SS,Harboe M

更新日期：1985-08-01 00:00:00

abstract：:In vitro lymphocyte stimulation was performed on peripheral blood lymphocytes from 48 leprosy patients, 15 healthy contacts of leprosy patients, and 16 normal controls who lived in a leprosy-free area and who had not been exposed to leprosy. Tuberculin PPD and an antigen fraction. MLW 1, prepared from M. leprae, were ...

journal_title：Scandinavian journal of immunology

authors： Closs O,Reitan LJ,Negassi K,Harboe M,Belehu A

更新日期：1982-08-01 00:00:00

abstract：:The presence of receptors for three human proteins (fibrinogen, IgG, and beta 2-microglobulin (beta 2m)) was studied in group A streptococcal strains. M type 1, 12 and 14, and in M protein-negative variants of these strains. Fibrinogen binding was detected in all six strains. IgG did not bind to the two type-12 strain...

journal_title：Scandinavian journal of immunology

authors： Björck L,Tylewska SK,Wadström T,Kronvall G

更新日期：1981-01-01 00:00:00

abstract：:Spleen cells or thymocytes immune to one H-2 genotype are cytotoxic to allogeneic target cells of a third-party genotype, provided the target shares private specificities determined by either the H-2K or the H-2D locus of the H-2 complex with the H-2 genotype used for sensitization in vivo. The present results on elim...

journal_title：Scandinavian journal of immunology

authors： Jorgensen PN,Güttler F,Rubin B

更新日期：1975-01-01 00:00:00

abstract：:Clonal selection in the thymus occurs mostly in the CD4+ CD8+ (double positive; DP) stage. Within DP thymocytes, cells in the CD3low subset are believed to be involved in clonal selection, and this subset is generally considered as a homogeneous population. T-cell antigen-receptor (TCR) signals on DP thymocytes are kn...

journal_title：Scandinavian journal of immunology

authors： Sheard M,Sugaya K,Furuta M,Tsuda S,Takahama Y

更新日期：1996-06-01 00:00:00

abstract：:Tumour-draining lymph node T cells are an excellent source of effector T cells that can be used in adoptive tumour immunotherapy because they have already been sensitized to tumour-associated antigens in vivo. However, such tumour-specific immune cells are not readily obtained from the host due to poor immunogenicity ...

journal_title：Scandinavian journal of immunology

authors： Ishida A,Tanaka H,Hiura T,Miura S,Watanabe S,Matsuyama K,Kuriyama H,Tanaka J,Kagamu H,Gejyo F,Yoshizawa H

更新日期：2007-11-01 00:00:00

abstract：:B-cell-dependent autoantibody production is a hallmark of systemic lupus erythematosus (SLE) which requires costimulatory molecules. The aim of the study was to analyse the expression of costimulatory molecules on B cells in patients with SLE. Twenty-six patients with SLE (four male, 22 female, mean age 46 +/- 15 year...

journal_title：Scandinavian journal of immunology

authors： Dolff S,Wilde B,Patschan S,Dürig J,Specker C,Philipp T,Kribben A,Witzke O

更新日期：2007-11-01 00:00:00

abstract：:Ebola viruses (EBOVs) have been identified as an emerging threat in recent year as it causes severe haemorrhagic fever in human. Epitope-based vaccine design for EBOVs remains a top priority because a mere progress has been made in this regard. Another reason is the lack of antiviral drug and licensed vaccine although...

journal_title：Scandinavian journal of immunology

authors： Khan MA,Hossain MU,Rakib-Uz-Zaman SM,Morshed MN

更新日期：2015-07-01 00:00:00

abstract：:In all of four human germinal centre cell-associated B lymphomas carrying sIgM + sIgD F(ab')2 fragments of rabbit antibodies to human mu-chain were accumulated intracellularly, whereas the accumulation of antibodies to delta-chain was considerably less abundant. The accumulation of antibodies to light chain was interm...

journal_title：Scandinavian journal of immunology

authors： Ruud E,Beiske K,Drack A,Steen HB,Godal T

更新日期：1984-05-01 00:00:00

abstract：:The heavy (H) chains of three anti-streptococcal group A carbohydrate antibodies (anti-SACHO) of restricted heterogeneity, elicited in inbred Sprague-Dawley rats, were subjected to 40 cycles of automated Edman degradation. All three antibody H-chain preparations had an identical amino acid sequence and were classified...

journal_title：Scandinavian journal of immunology

authors： Klapper DG,Stankus RP,Leslie GA,Capra JD

更新日期：1976-01-01 00:00:00

abstract：:Normal human B lymphocytes and Epstein-Barr virus-transformed B-cell lines can produce reactive oxygen species such as superoxide if treated with phorbol myristate acetate (PMA) or with the surface immunoglobulin cross-linking agents protein A and anti-immunoglobulin. Here, we investigated under which conditions speci...

journal_title：Scandinavian journal of immunology

authors： Maly FE,Urwyler A,Tengler R,Steinitz M,Golding B,de Weck AL

更新日期：1990-12-01 00:00:00

abstract：:Collagen-induced arthritis (CIA) is a well studied mouse model of the human disease rheumatoid arthritis (RA). Both CIA and RA are complex diseases affected by multiple genes as well as environmental factors. Identifying the genes that determine susceptibility to arthritis would give invaluable clues to the largely un...

journal_title：Scandinavian journal of immunology

authors： Popovic M,Ahlqvist E,Rockenbauer E,Bockermann R,Holmdahl R

更新日期：2008-10-01 00:00:00

abstract：:The production of antibody by human colostral cells was assayed by the hemolysis in-gel technique. When sheep erythrocytes coated with O antigens from frequently encountered Escherichia coli bacteria were used as detector cells and anti-IgA serum was added for development, numerous plaque-forming cells (PFC) were demo...

journal_title：Scandinavian journal of immunology

authors： Ahlstedt S,Carlsson B,Hanson LA,Goldblum RM

更新日期：1975-09-01 00:00:00

abstract：:Cutaneous lupus erythematosus (CLE) is an autoimmune disease with a broad range of cutaneous manifestations. In skin lesions of CLE, keratinocytes primarily undergo apoptosis. Interferon-κ(IFN-κ) is belonged to type I interferons (type I IFNs) and is selectively produced by keratinocytes. Recently, keratinocytes selec...

journal_title：Scandinavian journal of immunology

authors： Zhou X,Yan J,Lu Q,Zhou H,Fan L

更新日期：2021-01-01 00:00:00

abstract：:The expression and function of neural cell adhesion molecule (NCAM, CD56, Leu19) on leukaemic blasts was investigated. The expression of NCAM was frequent (64%) in 14 studied cases of acute myeloid leukaemia (AML) but not in chronic lymphocytic leukaemia (CLL: 1/3 cases positive) or immunocytoma (IC: no positivity). N...

journal_title：Scandinavian journal of immunology

authors： Palucka AK,Porwit A,Reizenstein P

更新日期：1992-04-01 00:00:00

abstract：:Prolonged antigenic stimulation results in lymphocyte shedding of CD27, a member of the tumour necrosis factor receptor (TNFR) family, and transformation to a stable phenotype capable of synthesizing interleukin-4 (IL-4). Co-expression of alpha4beta7 identifies those cells with gut-homing potential. We have investigat...

journal_title：Scandinavian journal of immunology

authors： Meenan J,Spaans J,Grool TA,Lammers K,Pals S,Tytgat GN,van Deventer SJ

更新日期：1998-09-01 00:00:00

abstract：:Interactions between homing receptors on circulating leucocytes and endothelial addressins regulate tissue-specific cellular extravasation. Although integrin alpha 4 beta 7 appears to be the main receptor for gut-homing T lymphocytes, less is known about molecules mediating mucosal B cell homing. Expression of integri...

journal_title：Scandinavian journal of immunology

authors： Farstad IN,Halstensen TS,Lazarovits AI,Norstein J,Fausa O,Brandtzaeg P

更新日期：1995-12-01 00:00:00

abstract：:The avidity of breast milk IgA antibody was studied with the aid of thiocyanate elution of antibody from solid-phase bound E.coli polysaccharides and diphtheria toxoid. The relative avidity index for each sample was determined by the molarity of thiocyanate required to elute 50% of the bound IgA antibody under conditi...

journal_title：Scandinavian journal of immunology

authors： Roberton DM,Carlsson B,Coffman K,Hahn-Zoric M,Jalil F,Jones C,Hanson LA

更新日期：1988-12-01 00:00:00

abstract：:We have evaluated phagocytosis, C3-binding and cytotoxicity of human leukocytes simultaneously, using IgM-sensitized C3-fragment-bearing sheep erythrocytes (EAC3b, EAC3bi) as targets. In this method, 51Cr-labelled EAC3b or EAC3bi were added to human peripheral granulocytes anchored by fibronectin onto microtitre plate...

journal_title：Scandinavian journal of immunology

authors： Kojima A,Hazeki K,Seya T

更新日期：1991-06-01 00:00:00

abstract：:IgE antibodies against trinitrophenylated ovalbumin (TNP-OVA) were raised in Brown Norway rats by a highly reproducible immunization procedure. With these rats, the kinetics of the IgE response was studied, both for free circulating and cell-bound IgE. Cell-bound IgE was dissociated from peritoneal cell suspensions at...

journal_title：Scandinavian journal of immunology

authors： van Toorenenbergen AW,van Swieten P,Aalberse RC

更新日期：1983-01-01 00:00:00