Heterogeneous expression of recombination activating genes and surface CD5 in CD3low CD4+ CD8+ thymocytes.

abstract：:Metabolic reprogramming plays a critical role in the important cellular metabolic alterations that occur during the activation of immune cells to enable them to adapt to the extracellular environment. Here, we review recent studies on how substrate availability and metabolites mediate the signalling pathways that regu...

journal_title：Scandinavian journal of immunology

authors： Qian X,Yang Z,Mao E,Chen E

更新日期：2018-11-01 00:00:00

abstract：:Interleukin-12 receptor deficiency is a well-described cause of human susceptibility to infection with low-virulent mycobacteria and Salmonella species. We identified a male patient presenting in his late forties with severe gastroenteropathy because of outbred infestation by a previously unknown mycobacterium. In add...

journal_title：Scandinavian journal of immunology

authors： Schejbel L,Rasmussen EM,Kemp HB,Lundstedt AC,Nielsen KR,Obel N,Marquart H,Andersen AB

更新日期：2011-12-01 00:00:00

abstract：:Physical association was measured between MLV gp70, the envelope glycoprotein of Rauscher murine leukaemia virus (R-MLV), and serologically defined H-2 antigens on the surface of R-MLV transformed C57BL/6 (H-2DbKb) mouse leukaemia cells (RBL-5A). Capping and patching with antisera against H-2Db caused specific co-capp...

journal_title：Scandinavian journal of immunology

authors： Zarling DA,Keshet I,Watson A,Bach FH

更新日期：1978-01-01 00:00:00

abstract：:The procoagulant activities of non-elicited mouse monocytes/macrophages from four anatomical localizations were compared. These cell populations were further examined for their ability to increase their procoagulant activity on exposure to endotoxin or phytohaemagglutinin (PHA). Peritoneal macrophages exhibited the hi...

journal_title：Scandinavian journal of immunology

authors： Lyberg T,Amlie E,Kaplun A,Prydz H

更新日期：1983-09-01 00:00:00

abstract：:Dendritic cells (DCs) are specific antigen-presenting cells that play critical roles in the initiation and polarization of immune responses. DCs residing in the lungs might be detected in the bronchoalveolar lavage fluid (BALF). We analysed DC compartment in the peripheral blood and BALF of patients with allergy and i...

journal_title：Scandinavian journal of immunology

authors： Kayserova J,Zentsova-Jaresova I,Budinsky V,Rozkova D,Kopecka J,Vernerova E,Pohunek P,Skalicka V,Spisek R,Sediva A

更新日期：2012-03-01 00:00:00

abstract：:MTB12 protein, also called CFP-2, is a major and early secreted component of Mycobacterium tuberculosis. However, its role during mycobacterial infection has been poorly characterized. In this study, we purified the native MTB12 protein and investigated the profile of MTB12-induced cytokines [interferon (IFN)-gamma, t...

journal_title：Scandinavian journal of immunology

authors： Lee JS,Son JW,Jung SB,Kwon YM,Yang CS,Oh JH,Song CH,Kim HJ,Park JK,Paik TH,Jo EK

更新日期：2006-08-01 00:00:00

abstract：:Recently, associations were found between several autoimmune diseases and functional variants of interleukin-23 receptor (IL23R) gene; here, we studied the possible association of nine polymorphisms of IL23R with ankylosing spondylitis (AS) and with Sjögren syndrome (SS). In our study, we genotyped groups of patients ...

journal_title：Scandinavian journal of immunology

authors： Sáfrány E,Pazár B,Csöngei V,Járomi L,Polgár N,Sipeky C,Horváth IF,Zeher M,Poór G,Melegh B

更新日期：2009-07-01 00:00:00

abstract：:Active chloride (Cl-) secretion by intestinal crypt enterocytes is the central pathophysiological disturbance in most cases of acute diarrhoea. We examined monolayers of the human intestinal cell line T84 mounted in Ussing chambers to see whether the T-cell lymphokine gamma interferon (IFN-gamma) might affect the Cl- ...

journal_title：Scandinavian journal of immunology

authors： Holmgren J,Fryklund J,Larsson H

更新日期：1989-10-01 00:00:00

abstract：:Glomerular complement receptors (GCR) were demonstrated by the adsorption of C3 coated sheep erythrocytes to cryostat sections of human kidneys. An epithelial localization of the GCR is implied by the binding pattern of the indicator cells. The GCR activity was reduced in all glomeruli where in vivo deposition of immu...

journal_title：Scandinavian journal of immunology

authors： Matre R,Iversen BM,Thunold S,Tønder O

更新日期：1978-01-01 00:00:00

abstract：:Our data on peripheral blood T cells from Motor neuron disease (MND) patients indicate major immunological disturbances linked to this disease. Both CD4+ and CD8+ T-cell subsets display an increased fraction of cells showing activation markers compared to controls, indicating an unusually high level of activity in bot...

journal_title：Scandinavian journal of immunology

authors： Katchar K,Osorio L,Conradi S,Wigzell H,Gigliotti D

更新日期：2001-07-01 00:00:00

abstract：:The cause of ankylosing spondylitis (AS) remains unelucidated. Both genetic and environmental factors are suspected playing an important role in AS development. Peptidyl arginine deiminase type IV (PADI4) is a member of gene family that encodes enzymes responsible for the conversion of arginine to citrulline residues....

journal_title：Scandinavian journal of immunology

authors： Chen R,Wei Y,Cai Q,Duan S,Lin J,Fang M,Lv K,Cheng N,Sun S

更新日期：2010-11-01 00:00:00

abstract：:Age and gender-related variability of main lymphocyte subsets (T, B and NK cell absolute counts and percentages from Ly; T4, T8 and DN cell absolute counts and percentages from lymphocytes and from T cells; T4:T8 and T:B ratios) was studied in a large cohort of pediatric patients (2 days - 17 years) at yearly interval...

journal_title：Scandinavian journal of immunology

authors： Nikulshin S,Kundzina L,Tolstikova I,Gravele D,Prokofjeva T,Gardovska D

更新日期：2018-06-23 00:00:00

abstract：:The superantigen SEA binds to MHC class II molecules and activates a large fraction of T cells as a result of interaction with particular TCR-V beta sequences. MHC class II transfected CHO cells induce a marginal CD4+ T-cell proliferation in the presence of SEA. CHO cells transfected with both MHC class II and LFA-3 (...

journal_title：Scandinavian journal of immunology

authors： Gjörloff A,Hedlund G,Kalland T,Sansom D,Fischer H,Trowsdale J,Sjögren HO,Dohlsten M

更新日期：1992-08-01 00:00:00

abstract：:The aim of this study was to examine whether the unresponsiveness of MHC class I-negative subclones of the EL4 thymoma to CD3 cross-linking can be restored by transfection of class I genes into the H-2-negative cells. Cell activation experiments with selected MHC class I-negative subclones and H-2b- and H-2Ld-positive...

journal_title：Scandinavian journal of immunology

authors： Claesson MH,Dissing S,Plesner T,Sturmhöfel K,Brams P

更新日期：1990-07-01 00:00:00

abstract：:Chronic inflammatory synovitis is characterized by both lymphocytic infiltrates and persistent polymorph exudates. Activated polymorphs release reactive oxygen species (ROS) during inflammation, but the contribution that these make to the lymphocyte abnormalities associated with RA has been little studied. We therefor...

journal_title：Scandinavian journal of immunology

authors： Allan IM,Lunec J,Salmon M,Bacon PA

更新日期：1987-07-01 00:00:00

abstract：:Amyloid was extracted from the liver of a horse that had developed amyloidosis after being used for several years for the production of antibodies to bacterial antigens. The amyloid fibrils were shown to be of the AA type. Two AA proteins with molecular weights of 9000 and 11,000 and with identical partial N-terminal ...

journal_title：Scandinavian journal of immunology

authors： Husebekk A,Husby G,Sletten K,Marhaug G,Nordstoga K

更新日期：1986-06-01 00:00:00

abstract：:Thalidomide is reported to have immunomodulatory and anti-inflammatory effects, which have led to its use in the treatment of a number of immune-mediated disorders, including leprosy, discoid lupus and Behcet's disease, and to prevent immunological rejection phenomena following skin and bone marrow grafts. Experimenta...

journal_title：Scandinavian journal of immunology

authors： Zhu J,Deng GM,Diab A,Zwingenberger K,Bakhiet M,Link H

更新日期：1998-10-01 00:00:00

abstract：:The intestinal microbiota is important for tolerance induction through mucosal immunological responses. The composition of the gut microbiota of an infant is affected by environmental factors such as diet, disease and antibiotic treatment. However, already in utero, these environmental factors can affect the immunolog...

journal_title：Scandinavian journal of immunology

authors： Tormo-Badia N,Håkansson Å,Vasudevan K,Molin G,Ahrné S,Cilio CM

更新日期：2014-10-01 00:00:00

abstract：:The T-cell repertoire is shaped by the positive and negative selection of immature CD4(+) CD8(+) double positive (DP) thymocytes. Positive selection of DP T cells to the CD4(+) CD8(-) and CD4(-) CD8(+) simple positive (SP) lineages is a multistep process which involves cellular interactions between thymocytes and stro...

journal_title：Scandinavian journal of immunology

authors： Nepomnaschy I,Lombardi G,Bekinschtein P,Berguer P,Francisco V,de Almeida J,Buggiano V,Pasqualini CD,Piazzon I

更新日期：2000-12-01 00:00:00

abstract：:Patients with juvenile idiopathic arthritis (JIA) have been shown to have elevated levels of circulating immune complexes (CICs) which correlated with disease activity. Our aim was to assess B cell activity by measuring the amount of and the kappa:lambda chain immunoglobulin light (L) chain ratio in CICs from JIA pati...

journal_title：Scandinavian journal of immunology

authors： Low JM,Chauhan AK,Moore TL

更新日期：2007-01-01 00:00:00

abstract：:A method of isolation has been developed to purify mast cells from human lung tissue. The purification steps are: (1) dispersion of human lung tissue in single-cell suspensions by enzymatic digestion, (2) partial purification by counterflow centrifugal elutriation, (3) Percoll gradient centrifugation, and (4) enrichme...

journal_title：Scandinavian journal of immunology

authors： van Overveld FJ,Terpstra GK,Bruijnzeel PL,Raaijmakers JA,Kreukniet J

更新日期：1988-01-01 00:00:00

abstract：:The present study describes a 7 amino acid-long sequence (YQQQGRL) which is identical in HLA-associated invariant chain and mumps virus nucleocapsid protein and is additionally followed by one conservative amino acid pair. As such a long amino acid homology is extremely rare in two evolutionarily unrelated proteins th...

journal_title：Scandinavian journal of immunology

authors： Hyöty H,Parkkonen P,Rode M,Bakke O,Leinikki P

更新日期：1993-05-01 00:00:00

abstract：:Spleen cells from mice exposed to 500 rad sublethal whole-body irradiation before immunization with 100 x 10(6) allogeneic spleen cells exhibited an enhanced cytolytic T-lymphocyte (CTL) activity. In contrast, this treatment completely abrogated the humoral alloantibody response, as measured by complement-mediated lys...

journal_title：Scandinavian journal of immunology

authors： Engers HD,Louis J

更新日期：1979-01-01 00:00:00

abstract：:Recent studies performed in Seattle, USA have suggested that pretransplant assignment of high or low donor alloreactivity may predict acute graft-versus-host disease (aGvHD) after allogeneic HLA identical marrow transplantation for acute leukaemia. The effect of such pretransplant assignment was studied in a Scandinav...

journal_title：Scandinavian journal of immunology

authors： Johnsen HE,Bostrom L,Moller J,Jorgensen JA,Jensen L,Ringden O

更新日期：1992-03-01 00:00:00

abstract：:The binding of 125I-labelled bovine serum albumin (BSA)-anti-BSA immune complexes (IC) to Raji cells and polymorphonuclear (PMN) cells in vitro was studied. The IC were reacted for 1 h at 37 degrees C with normal human serum (NHS) diluted 1:2 in the presence or absence of human erythrocytes (E) before presentation for...

journal_title：Scandinavian journal of immunology

authors： Rasmussen JM,Jepsen HH,Svehag SE

更新日期：1987-10-01 00:00:00

abstract：:Serum and salivary concentrations of immunoglobulin A1 (IgA1) and IgA2 were studied in 105 Icelandic children aged 0-12 years. Serum concentrations of both IgA1 and IgA2 increased slightly (P < 0.001) during childhood. The salivary IgA1/IgA2 ratio tended to decrease during the same period; this trend is less apparent ...

journal_title：Scandinavian journal of immunology

authors： Weemaes C,Klasen I,Göertz J,Beldhuis-Valkis M,Olafsson O,Haraldsson A

更新日期：2003-12-01 00:00:00

abstract：:There is an increasing need for novel biomarkers that enable better diagnostic and prognostic stratification of patients with suspected infection. A proprotein convertase enzyme FURIN is upregulated upon immune cell activation, and it promotes infectivity by cleaving and activating pathogens. In this study, we determi...

journal_title：Scandinavian journal of immunology

authors： Ranta N,Turpeinen H,Oksanen A,Hämäläinen S,Huttunen R,Uusitalo-Seppälä R,Rintala E,Aittoniemi J,Pesu M

更新日期：2015-12-01 00:00:00

abstract：:Antigen-binding peripheral blood leukocytes (PBL) from normal and bursectomized agammaglobulinemic chickens were labeled by incubation in vitro with radioiodinated antigen at 4 degrees C in the presence of sodium azide. [125I]TGAL-binding cells could be detected by autoradiography of PBL from normal, unimmunized chick...

journal_title：Scandinavian journal of immunology

authors： Jensenius C,Crone M,Koch C

更新日期：1975-01-01 00:00:00

abstract：:The activation of resting T cells to interleukin 2 (IL-2) production and DNA synthesis via Ti-CD3 is dependent on accessory cells (AC). Using positively selected, resting T cells activated with particle-bound anti-CD3, we investigated the ability of various cell lines to function as AC. We found that cell lines able t...

journal_title：Scandinavian journal of immunology

authors： Halvorsen R,Leivestad T,Gaudernack G,Thorsby E

更新日期：1988-09-01 00:00:00

abstract：:BTK and ITK are cytoplasmic tyrosine kinases of crucial importance for B and T cell development, with loss-of-function mutations causing X-linked agammaglobulinemia and susceptibility to severe, frequently lethal, Epstein-Barr virus infection, respectively. Over the last few years, considerable efforts have been made ...

journal_title：Scandinavian journal of immunology

authors： Vargas L,Hamasy A,Nore BF,Smith CI

更新日期：2013-08-01 00:00:00