Alterations during positive selection in the thymus of nackt CD4-deficient mice.

abstract：:Peripheral blood monocyte (PBM) subsets play different roles in inflammatory response and tissue remodelling. The aim of this study was to investigate how allergen challenge affects the number of circulating PBMs in Dermatophagoides pteronyssinus (Dp) allergic patients (Dp-APs). Among 34 Dp-APs challenged, in 22 patie...

journal_title：Scandinavian journal of immunology

authors： Kowal K,Moniuszko M,Dabrowska M,Bodzenta-Lukaszyk A

更新日期：2012-05-01 00:00:00

abstract：:ESAT-6 is a protein produced by virulent Mycobacterium tuberculosis but absent in Mycobacterium bovis bacillus Calmette-Guerin (BCG) and is considered as a promising vaccine subunit against tuberculosis. The protective efficacy of a new strategy based on the combination of DNA vaccine encoding ESAT-6 (DNA-E6) and BCG ...

journal_title：Scandinavian journal of immunology

authors： Fan X,Gao Q,Fu R

更新日期：2007-11-01 00:00:00

abstract：:We have analysed separately the role of B-cell receptor (BCR) stimulation and the soluble second signal in the T-cell-independent type 2 (TI-2) B-cell response. We were able to show that human B cells and macrophages (Mphi) could function together in TI-type microbial response. Interestingly, BCR cross-linking of peri...

journal_title：Scandinavian journal of immunology

authors： Mättö M,Raunio AR,Postila V,Huttunen K,Hirvonen MR,Pelkonen J

更新日期：2008-03-01 00:00:00

abstract：:The authors have recently shown that the ability of immune complexes (IC) to trigger Fc gamma R-dependent cell responses can be dramatically enhanced when the isoelectric point (pI) of normal IgG antibodies is increased from 5.8-8.5 to 8.5-9.8 by treatment with 1-ethyl-3-2(3-dimethylaminopropyl) carbodiimide HCl and e...

journal_title：Scandinavian journal of immunology

authors： Trevani AS,Andonegui G,Kempfer C,Malchiodi E,Geffner JR

更新日期：1996-03-01 00:00:00

abstract：:Some data suggest that the interaction between CD28 and CD80 (B7.1) stimulates Th1-responses and that CD28 and CD86 (B7.2) stimulates Th2-responses, however this is controversial. We addressed this issue by using mercuric chloride (HgCl2)-induced autoimmunity in Brown Norway (BN) rats as a highly polarized Th2 model a...

journal_title：Scandinavian journal of immunology

authors： MacPhee IA,Turner DR,Yagita H,Oliveira DB

更新日期：2001-11-01 00:00:00

abstract：:Chronic granulomatous disease (CGD) is a primary immunodeficiency characterized by susceptibility to bacterial and fungal infections resulting from the inadequacy of phagocytic leucocytes to produce reactive oxygen radicals. CGD is a genetically heterogeneous disease with an X-linked recessive (XR-CGD) form caused by ...

journal_title：Scandinavian journal of immunology

authors： Kutukculer N,Aykut A,Karaca NE,Durmaz A,Aksu G,Genel F,Pariltay E,Cogulu Ö,Azarsız E

更新日期：2019-02-01 00:00:00

abstract：:Prognosis in myelodysplastic syndrome (MDS) is not only correlated closely with blast cell count in bone marrow and chromosomal abnormalities but also correlated with decreased leucocyte count and function leading to acquisition of lethal infections. Recently, clinical trials in MDS have focused on the application of ...

journal_title：Scandinavian journal of immunology

authors： Zwierzina H,Holzinger I,Gaggl S,Wolf H,Schöllenberger S,Lam C,Bammer T,Geissler D,Lindley I

更新日期：1993-03-01 00:00:00

abstract：:It was reported that the expression of Toll-like receptor (TLR) 9 may be related to Th2-type allergic inflammation including allergic rhinitis (AR). However, little is known about the expression of TLR9 in the basophils in AR. In the present study, the expression of TLR9 was examined by flow cytometry analysis, and th...

journal_title：Scandinavian journal of immunology

authors： Zhong Q,Zhan M,Wang L,Chen D,Zhao N,Wang J,Huang Y,Zhang X,He S,Zhang H

更新日期：2020-11-28 00:00:00

abstract：:The Kva IgG2(k) myeloma protein showed a complete resistance to papain in the presence of cysteine at neutral pH, and a higher resistance to trypsin and alpha-chymotrypsin digestion than other IgG2 proteins. On the other hand, the Kva molecule was cleaved by pepsin at low pH to give the expected F(ab')2 fragment. When...

journal_title：Scandinavian journal of immunology

authors： Vogt RA,Michaelsen TE

更新日期：1987-07-01 00:00:00

abstract：:Spleen cells or thymocytes immune to one H-2 genotype are cytotoxic to allogeneic target cells of a third-party genotype, provided the target shares private specificities determined by either the H-2K or the H-2D locus of the H-2 complex with the H-2 genotype used for sensitization in vivo. The present results on elim...

journal_title：Scandinavian journal of immunology

authors： Jorgensen PN,Güttler F,Rubin B

更新日期：1975-01-01 00:00:00

abstract：:Foot-and-mouth disease (FMD) caused by FMD virus (FMDV) is a major health and economic problem in the farming industry. Vaccination of livestock against this highly infectious viral disease is crucial, and inactivated FMD vaccine has been effective at controlling infection. However, accumulated data show that the inac...

journal_title：Scandinavian journal of immunology

authors： Kang J,Zuo Y,Guo Q,Wang H,Liu Q,Liu Q,Xia G,Kang Y

更新日期：2015-11-01 00:00:00

abstract：:Age and gender-related variability of main lymphocyte subsets (T, B and NK cell absolute counts and percentages from Ly; T4, T8 and DN cell absolute counts and percentages from lymphocytes and from T cells; T4:T8 and T:B ratios) was studied in a large cohort of pediatric patients (2 days - 17 years) at yearly interval...

journal_title：Scandinavian journal of immunology

authors： Nikulshin S,Kundzina L,Tolstikova I,Gravele D,Prokofjeva T,Gardovska D

更新日期：2018-06-23 00:00:00

abstract：:Human lymphocytes were cultured under different conditions to determine the effects of technical variations on the response to pokeweed mitogen (PWM) and Staphylococcus aureus as measured by (a) quantitation of immunoglobulins (Ig) in the culture supernatants and (b) enumeration of Ig-secreting cells (ISC) by a revers...

journal_title：Scandinavian journal of immunology

authors： Munoz J,Pryjma J,Fudenberg HH,Virella G

更新日期：1980-01-01 00:00:00

abstract：:Recently, associations were found between several autoimmune diseases and functional variants of interleukin-23 receptor (IL23R) gene; here, we studied the possible association of nine polymorphisms of IL23R with ankylosing spondylitis (AS) and with Sjögren syndrome (SS). In our study, we genotyped groups of patients ...

journal_title：Scandinavian journal of immunology

authors： Sáfrány E,Pazár B,Csöngei V,Járomi L,Polgár N,Sipeky C,Horváth IF,Zeher M,Poór G,Melegh B

更新日期：2009-07-01 00:00:00

abstract：:Saliva was collected from 57 infants aged 6 weeks to 2.5 years and the molecular form of IgA was studied by centrifugation on sucrose density gradients. Two distinct populations were identified. Seventy-two per cent of the children had secretory IgA in their salivary secretions, while 28% had a molecular form correspo...

journal_title：Scandinavian journal of immunology

authors： Cripps AW,Gleeson M,Clancy RL

更新日期：1989-03-01 00:00:00

abstract：:We have characterized a monoclonal antibody (AT389), produced by immunization of mice with 4-day-old avian Concanavalin A blasts, which recognizes a 38-40 kDa homodimer present on the surface of all chicken T cells. AT389 increased the spontaneous and IL-2-driven proliferation of 3-day-old T-cell blasts. This antibody...

journal_title：Scandinavian journal of immunology

authors： Kaplan MH,Alhasan S,Rosenspire A,Sundick RS

更新日期：1993-08-01 00:00:00

abstract：:We have recently shown that a heat treatment of a murine target cell line, WEHI 164, induces resistance to lysis mediated by tumour necrosis factors alpha (TNF-alpha) and beta (TNF-beta). In the present study the effect of the heat shock of target cells on cytotoxicity mediated by natural killer cells (NK cells), lymp...

journal_title：Scandinavian journal of immunology

authors： Jäättelä M

更新日期：1990-02-01 00:00:00

abstract：:We have developed a new assay for quantitative detection of all helper T cells that can induce normal B lymphocytes to proliferation and Ig secretion. To establish the optimal assay conditions, we have used cloned T helper cells of defined specificities that had previously been shown to activate normal B lymphocytes e...

journal_title：Scandinavian journal of immunology

authors： Pobor G,Bandeira A,Pettersson S,Coutinho A

更新日期：1984-09-01 00:00:00

abstract：:The identification of a herd of goats with tuberculosis let us test a new treatment regimen against latent tuberculosis infection (LTBI). Using large animal experimental models allows a better approach to understanding human tuberculosis according to immunopathological parameters. Based on an initial study showing a c...

journal_title：Scandinavian journal of immunology

authors： Domingo M,Gil O,Serrano E,Guirado E,Nofrarias M,Grassa M,Cáceres N,Pérez B,Vilaplana C,Cardona PJ

更新日期：2009-06-01 00:00:00

abstract：:The human lymphokine, leucocyte migration-inhibitory factor (LIF), appears to be a serine esterase and protease by virtue of its susceptibility to the irreversible enzyme inhibitor, phenylmethylsulfonyl fluoride (PMSF), and by the ability of arginine esters and amides to protect LIF against PMSF-induced inactivation. ...

journal_title：Scandinavian journal of immunology

authors： Bendtzen K

更新日期：1979-01-01 00:00:00

abstract：:This study investigated the expression of the neonatal Fc receptor (FcRn) in maternal blood, cord blood and placental cells and determined IgG levels in maternal blood and cord blood from diabetic mothers. Peripheral blood, cord blood and placenta samples were collected from 26 mothers with normoglycaemia (non-diabeti...

journal_title：Scandinavian journal of immunology

authors： de Souza EG,Hara CC,Fagundes DL,de Queiroz AA,Morceli G,Calderon IM,França EL,Honorio-França AC

更新日期：2016-10-01 00:00:00

abstract：:The role of HLA class I subunits in class II-restricted immune responses was investigated by means of a panel of monoclonal antibodies (MoAb) recognizing HLA-A,B,C heavy chain and different beta 2 microglobulin (beta 2m) epitopes. MoAb against either class I subunit strongly inhibited mixed lymphocyte cultures, genera...

journal_title：Scandinavian journal of immunology

authors： Spagnoli GC,Ausiello CM,Cassone A,Casciani CU,Bellone G,Malavasi F

更新日期：1987-06-01 00:00:00

abstract：:Thymocytes that bind with high affinity to peptides displayed by MHC class II (pMHC-II) are deleted while low-affinity binders differentiate into naive CD4+ T cells. However, Foxp3+ regulatory T cells (Tregs) seem to defy this binary choice as their precursors require high-affinity interaction with pMHC-II for maturat...

journal_title：Scandinavian journal of immunology

authors： Usharauli D,Kamala T

更新日期：2021-01-01 00:00:00

abstract：:Immunoglobulin D (IgD) is the least studied of immunoglobulin classes. This study sought to investigate the potential relationship between demographic, metabolic, lifestyle and immunological factors, and serum IgD concentrations in a general adult population. We measured serum IgD concentrations by means of a commerci...

journal_title：Scandinavian journal of immunology

authors： Carballo I,Rabuñal N,Alvela L,Pérez LF,Vidal C,Alonso M,Sopeña B,Gude F,Gonzalez-Quintela A

更新日期：2017-04-01 00:00:00

abstract：:The activation of resting T cells to interleukin 2 (IL-2) production and DNA synthesis via Ti-CD3 is dependent on accessory cells (AC). Using positively selected, resting T cells activated with particle-bound anti-CD3, we investigated the ability of various cell lines to function as AC. We found that cell lines able t...

journal_title：Scandinavian journal of immunology

authors： Halvorsen R,Leivestad T,Gaudernack G,Thorsby E

更新日期：1988-09-01 00:00:00

abstract：:The homogenates of amyloid-laden spleens prepared from CBA mice were analysed by SDS-PAGE and immunoblotting employing rat anti-murine monoclonal antibody, MSA 4-26. The results showed that the precursor of amyloid A protein (AA), serum amyloid A protein 2 (SAA2), and SAA intermediates with molecular weights of 10,000...

journal_title：Scandinavian journal of immunology

authors： Shiroo M,Kawahara E,Nakanishi I,Migita S

更新日期：1987-12-01 00:00:00

abstract：:The function of the Fc and C3 receptors on the free surface of normal and endotoxin activated mouse peritoneal macrophages seeded on glass bound antibody--antigen (AbAg) complexes or complement was examined. We found that the glass bound AbAg complexes interfered with attachment and internalization of particles recogn...

journal_title：Scandinavian journal of immunology

authors： Kaplan G,Eskeland T,Seljelid R

更新日期：1978-01-01 00:00:00

abstract：:Ulcerative colitis (UC) is an idiopathic, chronic inflammatory disease, which is characterized with overactive immune response. It is well established that the imbalance between Tregs and Th17 cells plays a pivotal role in pathogenesis of UC. In this study, we investigated the impact of functional changes in Treg subs...

journal_title：Scandinavian journal of immunology

authors： Long Y,Zhao X,Xia C,Li X,Fan C,Liu C,Wang C

更新日期：2020-06-01 00:00:00

abstract：:The immune system of a healthy individual responds vigorously to foreign microbial antigens. However, all potentially immunogenic regions (determinants) within an antigen are not functionally of equal relevance in mediating host immunity against the pathogen. Moreover, some of these antigenic determinants are well pro...

journal_title：Scandinavian journal of immunology

authors： Sinha P,Snyder JA,Kim EY,Moudgil KD

更新日期：2007-02-01 00:00:00

abstract：:Cytokines produced by tumour and immune cells may play a significant role in a modulation of immune cells response against tumour. We investigated an ability of peripheral blood mononuclear cells (PBMC) of patients with early and advanced stages of ovarian cancer and from non-cancer patients to produce various cytokin...

journal_title：Scandinavian journal of immunology

authors： Nowak M,Klink M,Glowacka E,Sulowska Z,Kulig A,Szpakowski M,Szyllo K,Tchorzewski H

更新日期：2010-02-01 00:00:00