Human B cells and macrophages cooperate in T-cell-independent type 2 response.

abstract：:Cutaneous leishmaniasis (CL) is a self-healing skin disease which rarely for unknown reason(s) the lesion develops to a non-healing form. It seems that the initial contact of Leishmania parasites with the host innate immune system is an important step in the outcome of the disease. Recent studies suggested that toll-l...

journal_title：Scandinavian journal of immunology

authors： Tolouei S,Hejazi SH,Ghaedi K,Khamesipour A,Hasheminia SJ

更新日期：2013-11-01 00:00:00

abstract：:Human haptoglobin (Hp) is synthesized at hepatic and extrahepatic sites as an acute-phase reactant protein (APP). We investigated the effects of Hp on granulocyte function. The chemotaxis of freshly isolated human granulocytes and differentiated HL-60 cells in response to the bacterial tripeptide, f-met-leu-phe, was i...

journal_title：Scandinavian journal of immunology

authors： Rossbacher J,Wagner L,Pasternack MS

更新日期：1999-10-01 00:00:00

abstract：:Foot-and-mouth disease (FMD) caused by FMD virus (FMDV) is a major health and economic problem in the farming industry. Vaccination of livestock against this highly infectious viral disease is crucial, and inactivated FMD vaccine has been effective at controlling infection. However, accumulated data show that the inac...

journal_title：Scandinavian journal of immunology

authors： Kang J,Zuo Y,Guo Q,Wang H,Liu Q,Liu Q,Xia G,Kang Y

更新日期：2015-11-01 00:00:00

abstract：:Physical association was measured between MLV gp70, the envelope glycoprotein of Rauscher murine leukaemia virus (R-MLV), and serologically defined H-2 antigens on the surface of R-MLV transformed C57BL/6 (H-2DbKb) mouse leukaemia cells (RBL-5A). Capping and patching with antisera against H-2Db caused specific co-capp...

journal_title：Scandinavian journal of immunology

authors： Zarling DA,Keshet I,Watson A,Bach FH

更新日期：1978-01-01 00:00:00

abstract：:Prognosis in myelodysplastic syndrome (MDS) is not only correlated closely with blast cell count in bone marrow and chromosomal abnormalities but also correlated with decreased leucocyte count and function leading to acquisition of lethal infections. Recently, clinical trials in MDS have focused on the application of ...

journal_title：Scandinavian journal of immunology

authors： Zwierzina H,Holzinger I,Gaggl S,Wolf H,Schöllenberger S,Lam C,Bammer T,Geissler D,Lindley I

更新日期：1993-03-01 00:00:00

abstract：:Peripheral blood neutrophils from germ-free (GF), specific-pathogen-free (SPF) and conventional (CV) rats were compared. Besides neutropenia and impaired superoxide anion generation as previously reported, it was found that GF rats had lower phagocytic function (70%) and generated less nitric oxide than the other rats...

journal_title：Scandinavian journal of immunology

authors： Ohkubo T,Tsuda M,Suzuki S,El Borai N,Yamamura M

更新日期：1999-01-01 00:00:00

abstract：:The in vitro effect of superoxide anion and lysosomal enzyme activity on the killing of Listeria monocytogenes EGD (listeria) by peritoneal macrophages (PM) was investigated. Generation of superoxide anion by PM stimulated with phorbol myristate acetate (PMA) was significantly increased by intraperitoneal injection of...

journal_title：Scandinavian journal of immunology

authors： Hashimoto S,Nomoto K,Yokokura T

更新日期：1986-10-01 00:00:00

abstract：:We have characterized a monoclonal antibody (AT389), produced by immunization of mice with 4-day-old avian Concanavalin A blasts, which recognizes a 38-40 kDa homodimer present on the surface of all chicken T cells. AT389 increased the spontaneous and IL-2-driven proliferation of 3-day-old T-cell blasts. This antibody...

journal_title：Scandinavian journal of immunology

authors： Kaplan MH,Alhasan S,Rosenspire A,Sundick RS

更新日期：1993-08-01 00:00:00

abstract：:The recombinant bacillus Calmette-Guérin (rBCG) secretion system utilizing an extracellular alpha antigen of Mycobacterium kansasii (alpha-K) was characterized biochemically and immunologically. The human immunodeficiency virus type 1 (HIV-1) p17gag B cell epitope fused to alpha-K was secreted in extremely large amoun...

journal_title：Scandinavian journal of immunology

authors： Wada N,Ohara N,Kameoka M,Nishino Y,Matsumoto S,Nishiyama T,Naito M,Yukitake H,Okada Y,Ikuta K,Yamada T

更新日期：1996-02-01 00:00:00

abstract：:C-reactive protein (CRP) binds to Fcγ-receptors, FcγRIIa (CD32) with high affinity and to FcγRIa (CD64) with low affinity. The binding to CD32 has been shown to be allele specific, that is, it binds to R/R131 but not to H/H131. Little is known about the cooperation of CRP and neutrophilic granulocytes (PMNs) in inflam...

journal_title：Scandinavian journal of immunology

authors： Aas V,Sand KL,Asheim HC,Benestad HB,Iversen JG

更新日期：2013-06-01 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection affects millions of people worldwide and about half a million people die every year. India represents the second largest pool of chronic HBV infections with an estimated 40 million chronically infected patients. Persistence or clearance of HBV infection mainly depends upon hos...

journal_title：Scandinavian journal of immunology

authors： Vyas AK,Jindal A,Hissar S,Ramakrishna G,Trehanpati N

更新日期：2017-07-01 00:00:00

abstract：:The authors have established a new immunodeficient mouse strain on the genetic background of the diabetes prone non-obese diabetic (NOD) mouse. A deletion mutant of the RAG-2 gene was back crossed 10 generations onto the NOD/Bom strain background. The homozygous NODrag-2-/- mice lack functionally mature B and T lympho...

journal_title：Scandinavian journal of immunology

authors： Söderstrøm I,Bergman ML,Colucci F,Lejon K,Bergqvist I,Holmberg D

更新日期：1996-05-01 00:00:00

abstract：:In this study, we demonstrate the use of oligonucleotide probes to the most VH family-specific framework, the Framework 3 (FR3) gene segment, in the analysis of germline DNA. Compared with the hybridization of restriction enzyme-digested genomic DNA to large, cloned human VH family probes, hybridization with oligonucl...

journal_title：Scandinavian journal of immunology

authors： Rubinstein DB,Symann M,Guillaume T

更新日期：1993-01-01 00:00:00

abstract：:Osteoclasts are responsible for bone destruction in rheumatoid arthritis (RA), and adipose-derived mesenchymal stromal cells (ADSCs) can inhibit experimental collagen-induced arthritis model. This study aims to determine whether ADSCs also suppresses osteoclastogenesis and bone erosion in collagen-induced arthritis (C...

journal_title：Scandinavian journal of immunology

authors： Chang Q,Li C,Lu Y,Geng R,Wei JN,Hu JZ

更新日期：2020-08-01 00:00:00

abstract：:Spleen effector cells for IgG- and IgM-induced antibody-dependent cellular cytotoxicity (ADCC) were characterized with respect to density and cell surface markers by using sheep erythrocytes (SRBC) coated with hybridoma-derived monoclonal anti-SRBC IgG or anti-SRBC IgM antibodies as targets. While basically the same e...

journal_title：Scandinavian journal of immunology

authors： Zöller M,Andrighetto GC,Heyman B,Lamon EW,Wigzell H

更新日期：1983-01-01 00:00:00

abstract：:Inflammatory mediators such as interleukin-1 beta (IL-1 beta), tumour necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) exhibit local autocrine and paracrine effects as well as distant systemic effects on target cells. Human Kupffer cells, the fixed tissue macrophages of the liver, may modulate immune and en...

journal_title：Scandinavian journal of immunology

authors： Kutteh WH,Rainey WE,Carr BR

更新日期：1991-05-01 00:00:00

abstract：:The pair of microH-chain and kappa L-chain transgenes encoding the Sp6 TNP/DNA-specific IgM was bred onto the rearrangement-deficient genetic background of RAG-2T mice, and onto the kappa L-chain expression-deficient background of iE kappa T mice. Bone marrow of Sp6 transgenic RAG-2T mice contained normal numbers of B...

journal_title：Scandinavian journal of immunology

authors： Andersson J,Melchers F,Rolink A

更新日期：1995-07-01 00:00:00

abstract：:Hypoxia is a prominent microenvironment feature in a range of disorders including cancer, rheumatoid arthritis (RA), atherosclerosis, inflammatory bowel disease (IBD), infection and obesity. Hypoxia promotes biological functions of fibroblast-like synoviocytes via regulating hypoxia-inducible factor 1α (HIF1α). Dysreg...

journal_title：Scandinavian journal of immunology

authors： Yu R,Li C,Sun L,Jian L,Ma Z,Zhao J,Liu X

更新日期：2018-04-01 00:00:00

abstract：:Psoriasis is a T-cell mediated inflammatory skin disease which has been associated with group A, beta-haemolytic streptococcal infections. Four 20 a.a. long M6-peptides sharing 5-6 a.a. sequences with human epidermal keratins were identified. To investigate the role of potentially cross-reactive T cells in the pathoge...

journal_title：Scandinavian journal of immunology

authors： Sigmundsdottir H,Sigurgeirsson B,Troye-Blomberg M,Good MF,Valdimarsson H,Jonsdottir I

更新日期：1997-06-01 00:00:00

abstract：:Rat popliteal and the iliac lymph nodes were examined after foot-pad injections of colloidal carbon and ferritin-tetramethylrhodamine isothiocyanate. Carbon rapidly entered medullary sinuses, but the entry of carbon into the interstitium was prohibited by avid phagocytosis, by sinus macrophages and by the lymphoendoth...

journal_title：Scandinavian journal of immunology

authors： Fossum S

更新日期：1980-01-01 00:00:00

abstract：:Modulation of cytotoxic responses by viral immunoevasins plays an important role in the establishment of latent and persistent viral infections. Together with MHC class-I-restricted CD8T-lymphocytes, non-MHC-restricted natural killer (NK) and lymphokine-activated killer (LAK) cells participate in this anti-viral contr...

journal_title：Scandinavian journal of immunology

authors： Cartier A,Masucci MG

更新日期：2004-12-01 00:00:00

abstract：:Analysis of seven variable-diversity-joining (VDJ) gene rearrangements in B splenocytes from a 125-day-old bovine foetus revealed an extensive heavy-chain complementarity-determining region 3 (CDR3H) length variation (9-56 codons). Indeed, the global CDR3H size spectratyping of foetal VDJ rearrangements substantiated ...

journal_title：Scandinavian journal of immunology

authors： Saini SS,Kaushik A

更新日期：2002-02-01 00:00:00

abstract：:The lymphokine secretion patterns of seven independent 91-101.lambda 2(315)/I-Ed specific, CD4+ T-cell clones have been investigated. Six of the clones are of the Th1 type as they secrete IL2 and IFN gamma, but not IL4. Some of these six Th1 clones produce TNF alpha/beta, and some produce minor amounts of IL5 and IL6....

journal_title：Scandinavian journal of immunology

authors： Lauritzsen GF,Bogen B

更新日期：1991-06-01 00:00:00

abstract：:The occurrence of D-D recombination during the embryonic differentiation of chicken B cells was studied. Ig heavy (H) chains were amplified by polymerase chain reaction from day-12 bursal cDNA, and 30 random V-D-J regions were analysed by DNA sequencing. No gene conversion events were observed in any of the V regions,...

journal_title：Scandinavian journal of immunology

authors： Mansikka A,Toivanen P

更新日期：1991-05-01 00:00:00

abstract：:The routine availability of nucleated human cells for experimental use in limited in the absence of venipuncture. In this paper we have demonstrated that macrophages may be harvested routinely from the waste dialysis bags of patients undergoing continuous ambulatory peritoneal dialysis. These cells were identified as ...

journal_title：Scandinavian journal of immunology

authors： Maddox Y,Foegh M,Zeligs B,Zmudka M,Bellanti J,Ramwell P

更新日期：1984-01-01 00:00:00

abstract：:Spleens from newborn mice less than 6-7 days of age contain 'naturally occurring' suppressor cell populations that are able to inhibit nonspecifically immune responses of third-party adult spleen cells and alloreactivity in the newborn spleen per se. Isolation of the effectors of this suppressor activity reveals that ...

journal_title：Scandinavian journal of immunology

authors： Peeler K,Wigzell H,Peck AB

更新日期：1983-05-01 00:00:00

abstract：:We investigated interferon (IFN) production by peripheral blood mononuclear cells from four patients with chronic OKT4 T-lymphocytic leukaemia and three patients with abnormal expansions of granular lymphocytes. No spontaneous production of IFN-gamma was found in supernatants of cultures from both patients and normal ...

journal_title：Scandinavian journal of immunology

authors： Pandolfi F,Capobianchi M,Matricardi P,Facchini J,Bonomo G,De Rossi G,Semenzato G,Fiorilli M,Dianzani F,Aiuti F

更新日期：1985-04-01 00:00:00

abstract：:The authors recently reported that CD2 ligation rescues B cells from antigen-induced apoptosis by upregulation of intracellular Bcl-2 levels. However, the characterization of the early signals involved in apoptosis rescue by CD2 ligation has not been well established. In this context, CD2 does not promote either phosp...

journal_title：Scandinavian journal of immunology

authors： Baixeras E,Garcia-Lozano E,Martinez-A C

更新日期：1996-04-01 00:00:00

abstract：:Hypoxia (low oxygen tension) is a common feature of inflamed and infected tissues. The influence of hypoxia on macrophage responses to micro-organisms has only recently been studied. This study demonstrates that hypoxia induced macrophages to control Leishmania amazonensis, an intracellular parasite that causes cutane...

journal_title：Scandinavian journal of immunology

authors： Degrossoli A,Arrais-Silva WW,Colhone MC,Gadelha FR,Joazeiro PP,Giorgio S

更新日期：2011-08-01 00:00:00

abstract：:Mast-cell degranulation is triggered by the bridging of Fc receptor-bound antigen-specific immunoglobulin IgE on the cell surface. In vitro experiments suggest that antibody affinity and nonspecific IgE may affect the mast-cell function, however, their importance in vivo is unclear. Investigations of the effects of th...

journal_title：Scandinavian journal of immunology

authors： Mitchell AJ,Moss ND,Collins AM

更新日期：2002-01-01 00:00:00