当前位置： SCI文献检索 > SCANDINAVIAN JOURNAL OF IMMUNOLOGY期刊下所有文献 > Evidence for the involvement of galectin-3 in mesenchymal stem cell suppression of allogeneic T-cell proliferation.

Evidence for the involvement of galectin-3 in mesenchymal stem cell suppression of allogeneic T-cell proliferation.

Abstract：

:Human bone marrow-derived mesenchymal stem cells (MSC) are multipotent non-hematopoietic progenitors that have regulatory activity on immune cells. NOD- and Toll-like receptors (NLR, TLR) have several roles in immunity, including those relevant to pathogen recognition and shaping the course of immune responses by controlling gene expression. We have shown that these innate immune receptors are expressed by hematopoietic CD34+ progenitors and MSC. To uncover genes critical in MSC function, first we have used microarray to screen for potential transcripts whose levels are altered in response to NOD-1 and TLR-2 activation, and second we validated some candidate genes using real-time RT-PCR, Western blots and cellular assays. Amongst the altered genes, galectin-3 was upregulated at both mRNA and protein levels in response to TLR-2 activation. Interestingly, MSC secreted galectin-3, a protein known to modulate T-cell proliferation, gene expression, cell adhesion and migration. Knockdown of galectin-3 in MSC using small interfering RNA (siRNA) reduced the immunosuppressive effect of MSC on mixed lymphocyte cultures when compared to cells treated with an irrelevant siRNA (P < 0.05). Collectively, the data emphasize a new role of galectin-3 in the immunomodulatory function of MSC and indicate that NOD signalling pathway is also functional in these cells.

journal_name

Scand J Immunol

journal_title

Scandinavian journal of immunology

authors

Sioud M,Mobergslien A,Boudabous A,Fløisand Y

doi

10.1111/j.1365-3083.2010.02378.x

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

267-74

issue

4

eissn

0300-9475

issn

1365-3083

pii

SJI2378

journal_volume

71

pub_type

杂志文章

相关文献

SCANDINAVIAN JOURNAL OF IMMUNOLOGY文献大全
  • Coexistence of protein AA and immunoglobulin light-chain fragments in amyloid fibrils.

    abstract：:Coexistence of amyloid fibril protein AA and homogeneous immunoglobulin light-chain fragments was found in the isolated amyloid fibrils of two patients with amyloidosis secondary to rheumatoid arthritis. The light-chain amyloid fibril protein showed antigenic identity with a light-chain amyloid from a patient with pri...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1976.tb02989.x

    authors： Westermark P,Natvig JB,Anders RF,Sletten K,Husby G

    更新日期：1976-01-01 00:00:00

  • The sheep erythrocyte receptor and both alpha and beta chains of the human T-lymphocyte antigen receptor bind the mitogenic lectin (phytohaemagglutinin) from Phaseolus vulgaris.

    abstract：:We have studied the interaction of mitogenic lectins such as phytohaemagglutinin (PHA) and concanavalin A (Con A) with both surface molecules which, by the use of monoclonal antibodies, are known to trigger T-cell mitogenesis. Monoclonal antibodies recognizing the T-lymphocyte receptor for antigen (Ti) and/or its asso...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1986.tb01985.x

    authors： Leca G,Boumsell L,Fabbi M,Reinherz EL,Kanellopoulos JM

    更新日期：1986-05-01 00:00:00

  • T-cell cross-reactivity may explain the large variation in how cancer patients respond to checkpoint inhibitors.

    abstract：:The therapeutic use of the immune system to specifically attack tumours has been a long-standing vision among tumour immunologists. Recently, the use of checkpoint inhibitors to turn-off immunosuppressive signals has proven to be effective in enhancing T-cell reactivity against patient-specific neoantigens, resulting ...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章,评审

    doi：10.1111/sji.12643

    authors： Sioud M

    更新日期：2018-03-01 00:00:00

  • The pathogenesis of cutaneous lupus erythematosus: The aberrant distribution and function of different cell types in skin lesions.

    abstract：:Cutaneous lupus erythematosus (CLE) is an autoimmune disease with a broad range of cutaneous manifestations. In skin lesions of CLE, keratinocytes primarily undergo apoptosis. Interferon-κ(IFN-κ) is belonged to type I interferons (type I IFNs) and is selectively produced by keratinocytes. Recently, keratinocytes selec...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章,评审

    doi：10.1111/sji.12933

    authors： Zhou X,Yan J,Lu Q,Zhou H,Fan L

    更新日期：2021-01-01 00:00:00

  • Blockade of CTLA-4 promotes airway inflammation in naive mice exposed to aerosolized allergen but fails to prevent inhalation tolerance.

    abstract：:In subjects not developing allergy, inhalation of nonpathogenic protein antigens causes no harm and is associated with tolerance induction. Repeated exposure to aerosolized ovalbumin (OVA) likewise does not evoke airway inflammation and induces inhalation tolerance in experimental animals. The present study explored t...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.2005.01682.x

    authors： Alenmyr L,Matheu V,Uller L,Greiff L,Malm-Erjefält M,Ljunggren HG,Persson CG,Korsgren M

    更新日期：2005-11-01 00:00:00

  • Lymphocyte multiplication in vitro induced by mitogens and antigens.

    abstract：:A simple technique requiring only 0.2 ml whole blood for measuring the response of lymphocytes in cultures to each of various mitogens and antigens has been elaborated. The response is quantified by comparing the number of lymphocytes with and without a stimulating agent. The increment of cell numbers is given by a ce...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1978.tb00490.x

    authors： Haneberg B,Wesenberg F,Aarskog D

    更新日期：1978-01-01 00:00:00

  • Analysis of peripheral blood dendritic cell subtypes in thymomatous MG.

    abstract：:The object of this work was to measure the levels of monocyte-derived dendritic cell precursors (pDC1) and plasmacytoid dendritic cell precursors (pDC2) in peripheral blood mononuclear cells (PBMC) of patients with thymomatous MG and to assess the ratio of pDC1/pDC2 in these patients. Three-colour monoclonal antibody ...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.2010.02399.x

    authors： Zhang LY,Wang W,Feng YK,Liu YH,Wang QS

    更新日期：2010-06-01 00:00:00

  • The tuberculin skin test increases the responses measured by T cell interferon-gamma release assays.

    abstract：:RUTI is a vaccine consisting of Mycobacterium tuberculosis bacilli grown in stress conditions that is fragmented, detoxified and liposomed. RUTI was designed to shorten the treatment of latent tuberculosis infection (LTBI) with isoniazid from 9 months to just 1 month, by additional treatment with two inoculations of R...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.2008.02103.x

    authors： Vilaplana C,Ruiz-Manzano J,Gil O,Cuchillo F,Montané E,Singh M,Spallek R,Ausina V,Cardona PJ

    更新日期：2008-06-01 00:00:00

  • Short-term tissue culture of two nonsecretory human myelomas. A morphological and functional study.

    abstract：:Bone marrow cells from two patients without detectable monoclonal immunoglobulin (Ig) in serum and urine but with the clinical picture of plasma cell myeloma were cultivated in vitro. Immunofluorescence studies of cultured living and fixed bone marrow cells showed no signs of Ig production in one of the cases, whereas...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1976.tb03031.x

    authors： Nilsson K,Killander D,Killander J,Mellstedt H

    更新日期：1976-01-01 00:00:00

  • Similarities of Fcgamma receptors on trophoblasts and placental endothelial cells.

    abstract：:The trophoblastic tissue and endothelium of fetal stem vessels in cryostat sections of first-trimester and term human placentae adsorbed erythrocytes sensitized with IgG antibodies of human, rabbit, and guinea pig origin. Native and heat-aggregated human and rabbit IgG, and human IgG subclasses except IgG2 inhibited t...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1977.tb00416.x

    authors： Matre R

    更新日期：1977-01-01 00:00:00

  • Rabbit spleen B lymphocytes as helper cells in lymphocyte activation by concanavalin A and phytohaemagglutinin.

    abstract：:Using rosetting methods, we have purified rabbit B cells and studied their interactions with T cells purified by passage over an anti-immunoglobulin-coated Degalan beads column. B cells enhance the response of T cells to concanavalin A (Con A) and phytohaemagglutinin. In regulation of the response to Con A, an adheren...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1982.tb00620.x

    authors： Cavaillon JM,Udupa TN,Chou CT,Cinader B,Dubiski S

    更新日期：1982-01-01 00:00:00

  • A novel human anti-AXL monoclonal antibody attenuates tumour cell migration.

    abstract：:TAM family members (TYRO3, AXL and MERTK) play essential roles in the resolution of inflammation and in infectious diseases and cancer. AXL, a tyrosine kinase receptor, is commonly overexpressed in several solid tumours and numerous hematopoietic malignancies including acute myeloid leukaemia, acute lymphocytic leukae...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/sji.12777

    authors： Duan Y,Luo L,Qiao C,Li X,Wang J,Liu H,Zhou T,Shen B,Lv M,Feng J

    更新日期：2019-08-01 00:00:00

  • T-cell recognition of HLA class II molecules induced by gamma-interferon on a colonic adenocarcinoma cell line (HT29).

    abstract：:HLA class II molecules may be induced on non-lymphoid cells by gamma-interferon (IFN-gamma). We investigated if HLA class II molecules induced by IFN-gamma on the HT29 colonic carcinoma cell line are functional, i.e. if they may be recognized by allogeneic T cells. We found that IFN-gamma-treated HT29 (HT29IFN) cells ...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1990.tb02794.x

    authors： Lundin KE,Sollid LM,Bosnes V,Gaudernack G,Thorsby E

    更新日期：1990-04-01 00:00:00

  • CD25 blockade protects T cells from activation-induced cell death (AICD) via maintenance of TOSO expression.

    abstract：:CD25 monoclonal antibody binding to the alpha-chain of the Interleukin-2 (IL-2) receptor, blocks high-affinity IL-2 binding, thereby preventing complete T-cell activation and being of ample importance in transplantation medicine and potentially the treatment of autoimmune disease. However, CD25 antibodies do not only ...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.2009.02281.x

    authors： Richter GH,Mollweide A,Hanewinkel K,Zobywalski C,Burdach S

    更新日期：2009-09-01 00:00:00

  • Cell-mediated immune response in the diseased joints in patients with reactive arthritis.

    abstract：:To evaluate the level of lymphocyte activation in reactive and rheumatoid arthritis, density gradient-isolated, synovial fluid mononuclear cells were stained with a panel of antisera directed at lymphocyte activation markers using an avidin-biotin-peroxidase complex (ABC) method. More specifically, we studied the expr...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1986.tb02005.x

    authors： Konttinen YT,Nordström D,Bergroth V,Leirisalo-Repo M,Skrifvars B

    更新日期：1986-06-01 00:00:00

  • Differential regulation of MHC class-I-restricted and unrestricted cytotoxicity by the Us3 protein kinase of herpes simplex virus-1.

    abstract：:Modulation of cytotoxic responses by viral immunoevasins plays an important role in the establishment of latent and persistent viral infections. Together with MHC class-I-restricted CD8T-lymphocytes, non-MHC-restricted natural killer (NK) and lymphokine-activated killer (LAK) cells participate in this anti-viral contr...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.0300-9475.2004.01523.x

    authors： Cartier A,Masucci MG

    更新日期：2004-12-01 00:00:00

  • Activated CD3- CD16+ natural killer cells express a subset of the lymphokine genes induced in activated alpha beta + and gamma delta + T cells.

    abstract：:In this study we analysed the potential of highly purified polyclonal TcR alpha beta+, TcR gamma delta + and CD3- NK cells, to produce lymphokines in response to mitogenic stimulation. RNA hybridizations were performed to detect with high sensitivity the induction of multiple lymphokine genes. Upon stimulation with le...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1991.tb01769.x

    authors： Biassoni R,Ferrini S,Prigione I,Pelak VS,Sekaly RP,Long EO

    更新日期：1991-03-01 00:00:00

  • A proposed treatment for pathogenic enveloped viruses having high rates of mutation or replication.

    abstract：:Several enveloped viruses, particularly some RNA viruses, have high rates of mutation or replication, which can make them virulent pathogens in humans and other mammals. A proposed treatment could use synthesized proteins to mask pathogenic viral surface proteins to quickly induce an immune attack on specific envelope...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/sji.12928

    authors： Roe K

    更新日期：2020-09-01 00:00:00

  • Characterization of human lymphocyte surface receptors for mitogenic and non-mitogenic substances.

    abstract：:To compare the receptor patterns for mitogenic and non-mitogenic substances, surface glycoproteins of human lymphocytes were labelled with the lactoperioxidase-catalysed iodination technique and with a galactose oxidase-tritiated sodium borohydride technique. Labelled cells were detergent-solubilized, and the lysates ...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1980.tb00002.x

    authors： Skoog VT,Nilsson SF,Weber TH

    更新日期：1980-01-01 00:00:00

  • A solid-phase radioimmunoassay for C1q-binding immune complexes. I. Delta IgG as indicator molecule.

    abstract：:A solid-phase radioimmunoassay for detection of circulating C1q-binding immune complexes (IC) or heat-aggregated IgG (delta IgG) is described. Purified human C1q protein was adsorbed to a fixed area of polystyrene tube surface for 1 hr at 22 degrees C, pH 7.3, mu 0.15. Binding of delta IgG or IC to solid-phase C1q at ...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1975.tb02677.x

    authors： Svehag SE

    更新日期：1975-01-01 00:00:00

  • In vitro immunization for the production of antigen-specific lymphocyte hybridomas.

    abstract：:Antigen-specific lymphocyte hybridomas have been produced by a simple in vitro immunization procedure. Non-immune spleen cells have been activated in vitro, and the B-cell blasts have subsequently been used for somatic cell hybridization. Hybrids secreting monoclonal antibodies to human myoglobin, pig insulin, and ben...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1983.tb00829.x

    authors： Borrebaeck CA

    更新日期：1983-07-01 00:00:00

  • A soluble mannose receptor immunoadhesin enhances phagocytosis of Pneumocystis carinii by human polymorphonuclear leukocytes in vitro.

    abstract：:Pneumocystis carinii is an opportunistic pathogen that causes pneumonia in immunocompromised hosts. In the normal host, P. carinii is susceptible to an array of first line host defense mechanisms that are operative in the lung. Alveolar macrophages play a central role in the clearance of inhaled organisms. The macroph...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-3083.2000.00755.x

    authors： Stehle SE,Rogers RA,Harmsen AG,Ezekowitz RA

    更新日期：2000-08-01 00:00:00

  • The reduction of serum B-lymphocyte activating factor levels following quinacrine add-on therapy in systemic lupus erythematosus.

    abstract：:B-Lymphocyte-activating factor (BAFF/BLyS) is a survival factor for B cells, belonging to the tumor necrosis ligand super family. Serum BAFF levels have been found to be elevated in patients with systemic lupus erythematosus (SLE). Neutralization of BAFF activity was suggested as an additional therapeutic approach in ...

    journal_title：Scandinavian journal of immunology

    pub_type： 临床试验,杂志文章

    doi：10.1111/j.1365-3083.2006.01737.x

    authors： Toubi E,Kessel A,Rosner I,Rozenbaum M,Paran D,Shoenfeld Y

    更新日期：2006-04-01 00:00:00

  • T lymphocytes bearing the gamma delta T cell receptor are susceptible to steroid-induced programmed cell death.

    abstract：:The mechanisms by which glucocorticoids suppress immune responses have not yet been clearly defined. In steroid-sensitive pathological conditions, an increase in gamma delta T cells can occur in certain untreated systemic autoimmune disorders and seems to be a peristent feature in most cases of systemic lupus erythema...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1995.tb03599.x

    authors： Spinozzi F,Agea E,Bistoni O,Travetti A,Migliorati G,Moraca R,Nicoletti I,Riccardi C,Paoletti FP,Vaccaro R

    更新日期：1995-05-01 00:00:00

  • Purification, biochemical characterization and immunogenicity of SA5K, a secretion antigen of Mycobacterium tuberculosis.

    abstract：:Mycobacterium tuberculosis (MTB) secretory proteins are generally considered important antigens for immune protection against tuberculosis (TB). An 8.3-kDa secretory antigen of MTB and Mycobacterium bovis bacillus Calmette-Guérin (BCG), called SA5K, was recently identified and cloned in our laboratory. In this report,...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-3083.2002.01104.x

    authors： Batoni G,Bottai D,Esin S,Florio W,Pardini M,Maisetta G,Freer G,Senesi S,Campa M

    更新日期：2002-07-01 00:00:00

  • Vitamin A supplementation reduces IL-17 and RORc gene expression in atherosclerotic patients.

    abstract：:Vitamin A is a potential mediator of T helper cells in atherosclerosis. The purpose of this study was to evaluate the effect of vitamin A supplementation on expression of Th17 cells-related IL-17 and RORc genes in atherosclerotic patients. Thirty one atherosclerotic patients and 15 healthy controls were studied for 4 ...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/sji.12190

    authors： Mottaghi A,Ebrahimof S,Angoorani P,Saboor-Yaraghi AA

    更新日期：2014-08-01 00:00:00

  • Factors Influencing Serum Concentrations of Immunoglobulin D in the Adult Population: An Observational Study in Spain.

    abstract：:Immunoglobulin D (IgD) is the least studied of immunoglobulin classes. This study sought to investigate the potential relationship between demographic, metabolic, lifestyle and immunological factors, and serum IgD concentrations in a general adult population. We measured serum IgD concentrations by means of a commerci...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/sji.12529

    authors： Carballo I,Rabuñal N,Alvela L,Pérez LF,Vidal C,Alonso M,Sopeña B,Gude F,Gonzalez-Quintela A

    更新日期：2017-04-01 00:00:00

  • The biological activity of serum IgE changes over the course of a primary response.

    abstract：:Mast-cell degranulation is triggered by the bridging of Fc receptor-bound antigen-specific immunoglobulin IgE on the cell surface. In vitro experiments suggest that antibody affinity and nonspecific IgE may affect the mast-cell function, however, their importance in vivo is unclear. Investigations of the effects of th...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-3083.2002.01012.x

    authors： Mitchell AJ,Moss ND,Collins AM

    更新日期：2002-01-01 00:00:00

  • Natural immunity has significant impact on immune responses against cancer.

    abstract：:The immune system defends the host against pathogenic attacks by micro-organisms and their products. It does not react against self-components due to the relatively efficient negative selection of developing T lymphocytes in the thymus. This process does permit T cells with low avidity against self to be present in th...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-3083.2008.02220.x

    authors： Rubin B

    更新日期：2009-03-01 00:00:00

  • Binding, trafficking and accumulation of serum amyloid A in peritoneal macrophages.

    abstract：:Murine serum amyloid A1.1 (SAA1.1) has been conjugated with the fluorophore Texas Red (TxR), and its interaction with peritoneal macrophages has been visualized by scanning confocal microscopy. Binding of TxR-SAA to cell surfaces was inhibited by an excess of unlabelled SAA indicating the involvement of saturable rece...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-3083.2001.00879.x

    authors： Kluve-Beckerman B,Manaloor J,Liepnieks JJ

    更新日期：2001-04-01 00:00:00