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Natural immunity has significant impact on immune responses against cancer.

Abstract：

:The immune system defends the host against pathogenic attacks by micro-organisms and their products. It does not react against self-components due to the relatively efficient negative selection of developing T lymphocytes in the thymus. This process does permit T cells with low avidity against self to be present in the T cell repertoire. Such cells play an important physiological role as the host needs so-called autoimmune reactions in order to eliminate dying cells or transformed tumour cells. One of the mysteries in immunology is how the host maintains beneficial autoimmune reactions and avoids pathogenic autoimmune reactions. Activation of the adaptive T lymphocytes is mediated by the low avidity interaction between T-cell antigen receptors and antigenic peptides associated with major histocompatibility complex class I or class II molecules. This interaction is strengthened by T-cell co-receptors such as CD2, CD4, CD8, CD28 and CD154, which react with ligands expressed by cells of the innate immune system. In recent years, the importance of pre-activation of the innate immune system for initiation of adaptive T-cell immune responses has been appreciated. In the present review, I will summarize our work on how natural immunity plays an important role in determining the level of beneficial autoimmune reactions against cancer.

journal_name

Scand J Immunol

journal_title

Scandinavian journal of immunology

authors

Rubin B

doi

10.1111/j.1365-3083.2008.02220.x

subject

Has Abstract

pub_date

2009-03-01 00:00:00

pages

275-90

issue

3

eissn

0300-9475

issn

1365-3083

pii

SJI2220

journal_volume

69

pub_type

杂志文章,评审

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