Wallaby serum amyloid A protein: cDNA cloning, sequence and evolutionary analysis.


:A serum amyloid A (SAA) clone was isolated from a Tammar wallaby cDNA library, the most distantly related mammalian species for which an SAA has been described to date. The clone predicts a premolecule of 127 amino acids with good homology to other mammalian SAAs, and consists of an 18 residue leader peptide and a mature protein of 109 amino acids. Evolutionary analysis at both the protein and nucleotide level indicate that the wallaby SAA clone clusters with the acute phase SAAs. However, as the SAA superfamily has undergone concerted evolution it is not possible to determine at this point which acute phase SAA it is most like. The grouping of wallaby SAA inside the acute phase SAA cluster demonstrates that at least some of the duplication events giving rise to multiple acute phase genes occurred prior to the divergence of the eutherian and metatherian mammals.


Scand J Immunol


Uhlar CM,Black IL,Shields DC,Brack CM,Schreiber G,Whitehead AS




Has Abstract


1996-03-01 00:00:00












  • Increased expression of leucocyte adherence-related glycoproteins by polymorphonuclear leucocytes during phagocytosis of staphylococci on an endothelial surface.

    abstract::Phagocytosis of Staphylococcus aureus by human polymorphonuclear leucocytes (PMN) on the surface of endothelial cells is accompanied by adherence of the PMN to the endothelial surface and detachment of the endothelial cells from the culture monolayer. We studied the role of the leucocyte adherence-related glycoprotein...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Vandenbroucke-Grauls CM,Thijssen HM,Tetteroo PA,Rozemuller E,Verhoef J

    更新日期:1989-07-01 00:00:00

  • Regulation of fatty acid synthesis in immune cells.

    abstract::Metabolic reprogramming plays a critical role in the important cellular metabolic alterations that occur during the activation of immune cells to enable them to adapt to the extracellular environment. Here, we review recent studies on how substrate availability and metabolites mediate the signalling pathways that regu...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章,评审


    authors: Qian X,Yang Z,Mao E,Chen E

    更新日期:2018-11-01 00:00:00

  • NK1.1 cells downregulate murine endotoxin-induced uveitis following intraocular administration of interleukin-12.

    abstract::To evaluate the role of IFN-gamma (interferon gamma) in IL-12- (interleukin-12)-induced inhibition of the inflammatory response in the eye during endotoxin-induced uveitis (EIU). C57BL/6 wild type mice and IFN-gamma-deficient (GKO) mice were injected with 250 microg of Salmonella typhymurium endotoxin as a model for E...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Figueiredo F,Commodaro AG,de Camargo MM,Rizzo LV,Belfort R Jr

    更新日期:2007-08-01 00:00:00

  • Rabbit anti-human beta 2 microglobulin antibodies: a T-cell mitogen.

    abstract::Rabbit anti-beta 2 microglobulin antibodies have been described as a potent mitogen for human B lymphocytes. However, when fractionated after activation, only the T-cell enriched population is actively dividing. The induction of proliferation in purified T cells requires the presence of non-T cells. Daudi cells (which...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Hammarström L,Smith CI

    更新日期:1985-12-01 00:00:00

  • The immunomodulatory potentials of interleukin-27 in airway allergies.

    abstract::Allergic airway disorders such as asthma and allergic rhinitis are mainly caused by inhaled allergen-induced improper activation and responses of immune and non-immune cells. One important response is the production of IL-27 by macrophages and dendritic cells (DCs) during the early stage of airway allergies. IL-27 exe...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章,评审


    authors: Jafarzadeh A,Nemati M,Jafarzadeh S,Chauhan P,Saha B

    更新日期:2021-02-01 00:00:00

  • CD80(B7.1) and CD86(B7.2) do not have distinct roles in setting the Th1/Th2 balance in autoimmunity in rats.

    abstract::Some data suggest that the interaction between CD28 and CD80 (B7.1) stimulates Th1-responses and that CD28 and CD86 (B7.2) stimulates Th2-responses, however this is controversial. We addressed this issue by using mercuric chloride (HgCl2)-induced autoimmunity in Brown Norway (BN) rats as a highly polarized Th2 model a...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: MacPhee IA,Turner DR,Yagita H,Oliveira DB

    更新日期:2001-11-01 00:00:00

  • In search of the origin of the thymus: the thymus and GALT may be evolutionarily related.

    abstract::The thymus is the major primary immune tissue for the production of functional T lymphocytes in vertebrates. However, its evolutionary origin is unknown. It has recently been shown that the generation of local T cells also occurs in gut-associated lymphoid tissues (GALT). This suggests that the thymus and GALT have si...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章,评审


    authors: Matsunaga T,Rahman A

    更新日期:2001-01-01 00:00:00

  • Blockade of CTLA-4 promotes airway inflammation in naive mice exposed to aerosolized allergen but fails to prevent inhalation tolerance.

    abstract::In subjects not developing allergy, inhalation of nonpathogenic protein antigens causes no harm and is associated with tolerance induction. Repeated exposure to aerosolized ovalbumin (OVA) likewise does not evoke airway inflammation and induces inhalation tolerance in experimental animals. The present study explored t...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Alenmyr L,Matheu V,Uller L,Greiff L,Malm-Erjefält M,Ljunggren HG,Persson CG,Korsgren M

    更新日期:2005-11-01 00:00:00

  • Plaque-forming cells in man. II. Evidence of the existence of active suppressor cells in peripheral blood of normal plaque-forming cell non-responders.

    abstract::When the immunoglobulin secretion of 172 normal healthy individuals was investigated with the protein-A plaque assay, 12 persons (7%) did not develop any plaque-forming cells (PFC) in cultures of pokeweed mitogen (PWM)-activated unfractionated peripheral blood lymphocytes (PBL), incubated for 6 days. The effect of irr...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Tauris P

    更新日期:1983-09-01 00:00:00

  • Chronic granulamatous disease: Two decades of experience from a paediatric immunology unit in a country with high rate of consangineous marriages.

    abstract::Chronic granulomatous disease (CGD) is a primary immunodeficiency characterized by susceptibility to bacterial and fungal infections resulting from the inadequacy of phagocytic leucocytes to produce reactive oxygen radicals. CGD is a genetically heterogeneous disease with an X-linked recessive (XR-CGD) form caused by ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Kutukculer N,Aykut A,Karaca NE,Durmaz A,Aksu G,Genel F,Pariltay E,Cogulu Ö,Azarsız E

    更新日期:2019-02-01 00:00:00

  • Molecular characteristics of IgA in infant saliva.

    abstract::Saliva was collected from 57 infants aged 6 weeks to 2.5 years and the molecular form of IgA was studied by centrifugation on sucrose density gradients. Two distinct populations were identified. Seventy-two per cent of the children had secretory IgA in their salivary secretions, while 28% had a molecular form correspo...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Cripps AW,Gleeson M,Clancy RL

    更新日期:1989-03-01 00:00:00

  • Properties of cell subpopulations of starfish axial organ: in vitro effect of pokeweed mitogen and evidence of lymphokine-like substances.

    abstract::The in vitro effects of pokeweed mitogen (PWM) on axial organ (AO) cells of the echinoderm starfish Asteria rubens have been studied. PWM stimulates 3H-thymidine incorporation by the whole population of AO cells (index of stimulation 4-5). On the basis of surface adherence to nylon wool the AO cell population can be f...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Leclerc M,Brillouet C,Luquet G,Agogue P,Binaghi RA

    更新日期:1981-09-01 00:00:00

  • Antidrug Antibodies: B Cell Immunity Against Therapy.

    abstract::Chronic inflammatory diseases are now treated with a range of different biopharmaceuticals, often requiring lifelong parenteral administrations. This exposure to drugs is unnatural and can trigger the immune system and result in the formation of antidrug antibodies. Drug-specific antibodies will, if of sufficiently hi...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章,评审


    authors: Fogdell-Hahn A

    更新日期:2015-09-01 00:00:00

  • Inhibitory activity of soluble IL-2R in sera, ascites and culture supernatants from murine leukaemic cells.

    abstract::The effect of sera from mice bearing a T cell lymphoid leukaemia (LB) and the supernatants from short term cultures of the tumour cells were studied on cell proliferation using syngeneic and allogeneic normal and tumour cells. An inhibitory activity was demonstrated in 24-48 h supernatants of LB cells in culture and d...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Waldner C,Mongini C,Alvarez E,Roig I,Hajos SE

    更新日期:1994-09-01 00:00:00

  • Specific activation of human peripheral blood gamma/delta + lymphocytes by sonicated antigens of Mycobacterium tuberculosis: role in vitro in killing human bladder carcinoma cell lines.

    abstract::Tumour regression induced in cancer patients by local instillation of Bacillus Calmette-Guérin (BCG) into the bladder has been considered to be mainly mediated by activated cellular immunity and inflammatory reactions. In the present study we investigated the cytotoxicity of T cells bearing gamma/delta T-cell receptor...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Wang MH,Chen YQ,Gercken J,Ernst M,Böhle A,Flad HD,Ulmer AJ

    更新日期:1993-09-01 00:00:00

  • Heterogeneity in expression of the T4 epitope in black individuals.

    abstract::The T-cell differentiation antigen T4/Leu3 has been described as a non-polymorphic molecule important in T-cell recognition of class II major histocompatibility complex antigens. We report the polymorphism of this molecule in black individuals as manifest by a heterogeneity of staining with OKT4 monoclonal antibody. N...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Stohl W,Kunkel HG

    更新日期:1984-09-01 00:00:00

  • Expression and function of c-Met, a receptor for hepatocyte growth factor, during T-cell development.

    abstract::The c-Met oncoprotein is a cell-surface receptor for hepatocyte growth factor (HGF). Signals through HGF and c-Met have been appreciated for their crucial roles in the development of many cell types, including liver cells. The present study examined whether c-Met is expressed in the thymus and whether c-Met/HGF signal...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Tamura S,Sugawara T,Tokoro Y,Taniguchi H,Fukao K,Nakauchi H,Takahama Y

    更新日期:1998-04-01 00:00:00

  • Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merozoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels.

    abstract::The immunogenicity and protective efficacy of various antigen-adjuvant formulations derived either from the merozoite-surface protein-3 (MSP-3) or the glutamate-rich protein (GLURP) of Plasmodium falciparum were evaluated in Saimiri sciureus monkeys. These proteins were selected for immunogenicity studies based primar...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Carvalho LJ,Oliveira SG,Theisen M,Alves FA,Andrade MC,Zanini GM,Brígido MC,Oeuvray C,Póvoa MM,Muniz JA,Druilhe P,Daniel-Ribeiro CT

    更新日期:2004-04-01 00:00:00

  • Specific deposition of serum amyloid A protein 2 in the mouse.

    abstract::The homogenates of amyloid-laden spleens prepared from CBA mice were analysed by SDS-PAGE and immunoblotting employing rat anti-murine monoclonal antibody, MSA 4-26. The results showed that the precursor of amyloid A protein (AA), serum amyloid A protein 2 (SAA2), and SAA intermediates with molecular weights of 10,000...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Shiroo M,Kawahara E,Nakanishi I,Migita S

    更新日期:1987-12-01 00:00:00

  • Immunoglobulin A and CD8 T-cell mucosal immune defenses protect against intranasal infection with Chlamydia pneumoniae.

    abstract::Chlamydia pneumoniae initiates infection in humans via the mucosal epithelia of the respiratory tract; therefore, immunity at this mucosal site is believed to be important to control infection with this pathogen. We compared the protective capacity of immunization in mice with two C. pneumoniae antigens, namely the ma...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Rodríguez A,Rottenberg M,Tjärnlund A,Fernández C

    更新日期:2006-03-01 00:00:00

  • Spectrum of Inborn errors of immunity in a cohort of 90 patients presenting with complications to BCG vaccination in India.

    abstract::World Health Organisation recommends the practice of BCG vaccination at birth in countries which have a high incidence of tuberculosis and/or high leprosy burden. The BCG vaccination is considered safe for a competent immune system. However, in children with weakened immune systems cause of which can be primary or sec...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Yadav RM,Dalvi A,Gupta M,Bargir UA,Shabrish S,Aluri J,Kulkarni M,Hule G,Kambli P,Setia P,Jodhawat N,Taur P,Desai M,Madkaikar MR

    更新日期:2020-12-16 00:00:00

  • Modulation of host immune responses by overexpression of immunodominant antigens of Mycobacterium tuberculosis in bacille Calmette-Guérin.

    abstract::Based on their immunodominant nature and ability to induce appropriate immune responses in the host, several antigens of Mycobacterium tuberculosis have shown promise of protection. However, most of the candidate vaccines developed by employing various strategies have afforded protection that is at best comparable wit...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Rao V,Dhar N,Tyagi AK

    更新日期:2003-10-01 00:00:00

  • Up-regulation of the expression of secretory component and HLA molecules in a human colonic cell line by tumour necrosis factor-alpha and gamma interferon.

    abstract::Secretory component (SC) acts as a receptor for polymeric IgA (pIgA) and pIgM on the basolateral face of secretory epithelia. This study showed that both the production and surface membrane expression of SC were additively up-regulated by tumour necrosis factor-alpha (TNF) and gamma interferon (IFN-gamma) in a human c...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Kvale D,Brandtzaeg P,Løvhaug D

    更新日期:1988-09-01 00:00:00

  • Clinical features, STAT3 gene mutations and Th17 cell analysis in nine children with hyper-IgE syndrome in mainland China.

    abstract::Hyper-IgE syndrome (HIES) is a rare primary immunodeficiency disease characterized by eczema, recurrent staphylococcal aureus skin abscesses, pneumonia with pneumatocele formation, remarkably high serum IgE levels, eosinophilia and involvement of skeleton and connective tissues. Heterozygous signal transducer and acti...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Zhang LY,Tian W,Shu L,Jiang LP,Zhan YZ,Liu W,Zhao XD,Cui YX,Tang XM,Wang M,Wu DQ,Yang XQ

    更新日期:2013-09-01 00:00:00

  • Prozone effects in indirect immunofluorescence.

    abstract::A marked prozone effect was observed in indirect immunofluorescence (IFL) with rabbit antisera against rat renal proximal tubular epithelial brush border (BB) antigens: anti-BB antibodies were not detectable if used in high concentrations but were readily demonstrated if sufficiently diluted. The prozone effect occurr...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Linder E,Miettinen A

    更新日期:1976-01-01 00:00:00

  • Abnormal kappa:lambda light chain ratio in circulating immune complexes as a marker for B cell activity in juvenile idiopathic arthritis.

    abstract::Patients with juvenile idiopathic arthritis (JIA) have been shown to have elevated levels of circulating immune complexes (CICs) which correlated with disease activity. Our aim was to assess B cell activity by measuring the amount of and the kappa:lambda chain immunoglobulin light (L) chain ratio in CICs from JIA pati...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Low JM,Chauhan AK,Moore TL

    更新日期:2007-01-01 00:00:00

  • A high frequency of cytotoxic precursor cells for a syngeneic tumour.

    abstract::The average frequency of cytotoxic precursor cells in DBA/2 lymph node cell preparations reactive to the syngeneic tumour P815 has been determined as 1 in 2000. This frequency is similar to the precursor frequency for an allogeneic tumour EL-4. The normal lack of response of DBA/2 lymph node cells to the syngeneic tum...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Warren HS,Lafferty KJ

    更新日期:1979-01-01 00:00:00

  • Isolation and partial characterization of a murine cell surface glycoprotein with affinity for exogenously added beta 2-microglubulin.

    abstract::Exogenously added beta 2-microglobulin (beta 2m) binds to a variety of murine cell types. The 'receptor' for beta 2m has been isolated. The purified 'receptor' comprised a 48,000-dalton chain and occasionally a 25,000-dalton component. Direct crosslinking of beta 2m to the receptor on intact cells gave rise to a singl...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Sege K,Peterson PA

    更新日期:1980-01-01 00:00:00

  • Presynaptic membrane receptor-reactive T lymphocytes in myasthenia gravis.

    abstract::The majority of patients with myasthenia gravis were shown to have T and B cells specific for a beta-bungarotoxin binding protein, presynaptic membrane receptor (PsmR). Such autoreactive T cells may be subdivided into different subsets according to the pattern of cytokine production. In this study the authors examined...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Yi Q,Pirskanen R,Lefvert AK

    更新日期:1996-01-01 00:00:00

  • Association of mouse major histocompatibility and Rauscher murine leukaemia virus envelope glycoprotein antigens on leukaemia cells and their recognition by syngeneic virus-immune-cytotoxic T-lymphocytes.

    abstract::Physical association was measured between MLV gp70, the envelope glycoprotein of Rauscher murine leukaemia virus (R-MLV), and serologically defined H-2 antigens on the surface of R-MLV transformed C57BL/6 (H-2DbKb) mouse leukaemia cells (RBL-5A). Capping and patching with antisera against H-2Db caused specific co-capp...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Zarling DA,Keshet I,Watson A,Bach FH

    更新日期:1978-01-01 00:00:00