Direct and indirect regulatory mechanisms in TH17 cell differentiation and functions.

abstract：:Dendritic cells (DCs) are specific antigen-presenting cells that play critical roles in the initiation and polarization of immune responses. DCs residing in the lungs might be detected in the bronchoalveolar lavage fluid (BALF). We analysed DC compartment in the peripheral blood and BALF of patients with allergy and i...

journal_title：Scandinavian journal of immunology

authors： Kayserova J,Zentsova-Jaresova I,Budinsky V,Rozkova D,Kopecka J,Vernerova E,Pohunek P,Skalicka V,Spisek R,Sediva A

更新日期：2012-03-01 00:00:00

abstract：:Monoclonal anti-HLA-DR antibodies inhibited the production of interleukin-2 (IL-2) when added from the initiation of autologous (AMLR) and allogeneic (MLR) mixed lymphocyte reactions, but not 60 h later. The inhibitory activity of the anti-DR sera became apparent 8 h after initiation of the cultures and was maintained...

journal_title：Scandinavian journal of immunology

authors： Palacios R

更新日期：1981-09-01 00:00:00

abstract：:Glomerular complement receptors (GCR) were demonstrated by the adsorption of C3 coated sheep erythrocytes to cryostat sections of human kidneys. An epithelial localization of the GCR is implied by the binding pattern of the indicator cells. The GCR activity was reduced in all glomeruli where in vivo deposition of immu...

journal_title：Scandinavian journal of immunology

authors： Matre R,Iversen BM,Thunold S,Tønder O

更新日期：1978-01-01 00:00:00

abstract：:The cellular and humoral natural immune response induced by hepatitis C virus (HCV) is commonly unable to eradicate the virus. HCV is a highly mutable, hepatotropic RNA virus that causes acute and chronic hepatitis, an infection that involves the production of various cytokines. The aim of the study is to analyse the ...

journal_title：Scandinavian journal of immunology

authors： Gutierrez-Reyes G,Lopez-Ortal P,Sixtos S,Cruz S,Ramirez-Iglesias MT,Gutierrez-Ruiz MC,Sanchez-Avila F,Roldan E,Vargas-Vorackova F,Kershenobich D

更新日期：2006-06-01 00:00:00

abstract：:C57BL/6 mice treated with intranasal instillation of 100 micrograms of Aspergillus antigen three times a week developed a pulmonary eosinophilia, observed in the bronchoalveolar lavage (BAL) and on histopathological examination. At week 3, the instillation of Aspergillus antigen provoked a 10-fold increase in the BAL ...

journal_title：Scandinavian journal of immunology

authors： Wang JM,Denis M,Fournier M,Laviolette M

更新日期：1994-01-01 00:00:00

abstract：:The role of HLA class I subunits in class II-restricted immune responses was investigated by means of a panel of monoclonal antibodies (MoAb) recognizing HLA-A,B,C heavy chain and different beta 2 microglobulin (beta 2m) epitopes. MoAb against either class I subunit strongly inhibited mixed lymphocyte cultures, genera...

journal_title：Scandinavian journal of immunology

authors： Spagnoli GC,Ausiello CM,Cassone A,Casciani CU,Bellone G,Malavasi F

更新日期：1987-06-01 00:00:00

abstract：:Coeliac disease probably results from a T-cell response to wheat gliadin and is associated to HLA-DQ2. No gliadin epitopes recognized by intestinal T cells have yet been identified, limiting our understanding of the pathogenesis. Gut-lesion-derived DQ2-restricted T cells from coeliac disease patients were used to iden...

journal_title：Scandinavian journal of immunology

authors： Sjöström H,Lundin KE,Molberg O,Körner R,McAdam SN,Anthonsen D,Quarsten H,Norén O,Roepstorff P,Thorsby E,Sollid LM

更新日期：1998-08-01 00:00:00

abstract：:We have examined the frequencies of T gamma delta cells in blood, synovial fluids, and synovial membranes of patients with rheumatoid arthritis (RA) and in blood from age-matched controls. Immunocytochemical and immunohistochemical techniques were used with monoclonal antibodies BB3 and A13 to define a major and minor...

journal_title：Scandinavian journal of immunology

authors： Smith MD,Bröker B,Moretta L,Ciccone E,Grossi CE,Edwards JC,Yüksel F,Colaco B,Worman C,Mackenzie L

更新日期：1990-12-01 00:00:00

abstract：:MCP-1/IL-6 in vitro monocyte secretion upon coculture with autologous fragment spheroids was studied in relation to patient 5- and 10-year overall survival rates in head and neck squamous cell carcinoma (HNSCC) patients (n = 65) diagnosed between 1998 and 2005, nine of whom had an human papilloma virus (HPV) tumour in...

journal_title：Scandinavian journal of immunology

authors： Aarstad HJ,Aarstad HH,Vintermyr OK,Kross KW,Lybak S,Heimdal JH

更新日期：2017-03-01 00:00:00

abstract：:Using rocket immunoelectrophoresis and indirect haemagglutination tests, antibodies to nicotinic acetylcholine receptor (n-AChR) from Torpedo marmorata were detected in sera from rabbits with experimental myasthenia but not in sera from patients with myasthenia gravis or in rabbit antisera to a partly purified skeleta...

journal_title：Scandinavian journal of immunology

authors： Aarli JA,Mattsson C,Heilbronn E

更新日期：1975-01-01 00:00:00

abstract：:Antigen 60 (A60), a member of the thermostable macromolecular antigen family (TMA) and main component of old tuberculin and purified protein derivative (PPD), has been purified from the cytoplasm of Mycobacterium bovis BCG; its structure and metabolism have already been described. In the present paper, the action of A...

journal_title：Scandinavian journal of immunology

authors： Cocito C,Baelden MC,Benoit C

更新日期：1987-06-01 00:00:00

abstract：:Gangliosides are complex glycosphingolipids, which exert immune-modulating effects on various cell types. Ganglioside GD(3) and GM(3) are the predominant gangliosides of human breast milk but during the early phase of lactation, the content of GD(3) decreases while GM(3) increases. The biological value of gangliosides...

journal_title：Scandinavian journal of immunology

authors： Brønnum H,Seested T,Hellgren LI,Brix S,Frøkiaer H

更新日期：2005-06-01 00:00:00

abstract：:The objective of the study was to investigate the antigen specificity and occurrence of individual autoantibodies in mothers of children diagnosed with atrioventricular (AV) block in a nation-wide setting. Patients with AV block detected before 15 years of age were identified using national quality registries as well ...

journal_title：Scandinavian journal of immunology

authors： Salomonsson S,Dzikaite V,Zeffer E,Eliasson H,Ambrosi A,Bergman G,Fernlund E,Theander E,Ohman A,Rydberg A,Skogh T,Wållberg-Jonsson S,Elfving A,Fored M,Ekbom A,Lundström U,Mellander M,Winqvist O,Sonesson SE,Gadler F,

更新日期：2011-11-01 00:00:00

abstract：:T cell immunoglobulin and mucin domain-3 (Tim-3), an immune checkpoint molecule, plays critical roles in maintaining innate immune homeostasis; however, the mechanisms underlying these roles remain to be determined. Here, we determined that Tim-3 controls glycolysis in macrophages and thus contributes to phenotype shi...

journal_title：Scandinavian journal of immunology

authors： Zhang J,Hou C,Dou S,Li G,Wang Z,Liu Y,Zhang Y,Wang R,Shen B,Han G

更新日期：2021-02-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a group of idiopathic, chronic and relapsing inflammatory conditions of the gastrointestinal tract, caused by an aberrant and exaggerated immunological response in the gut. Supplementation of vitamin D3 in patients with IBD exerts both direct and indirect regulatory roles on the naï...

journal_title：Scandinavian journal of immunology

authors： Alhassan Mohammed H,Mirshafiey A,Vahedi H,Hemmasi G,Moussavi Nasl Khameneh A,Parastouei K,Saboor-Yaraghi AA

更新日期：2017-06-01 00:00:00

abstract：:Medial histocompatibility (H) antigens are weak H antigens, recognized by unrestricted T cells; they differ thus from both major and minor H antigens. An example, Qed-1, is described in detail, and other known medial H antigens of the mouse are reviewed. The structural and genetic relationships of major and medial H a...

journal_title：Scandinavian journal of immunology

authors： Lindahl KF,Langhorne J

更新日期：1981-12-01 00:00:00

abstract：:X-irradiated (250 rad), cyclophosphamide-treated or ATx A mice injected with syngeneic trinitrophenylated spleen cells (TNP-SC) and footpad challenged with syngeneic lymphoblasts generated delayed-type hypersensitivity (DTH) responses 24, 48 and 72 h after challenge. The syngeneic-DTH (syn-DTH) response was mediated b...

journal_title：Scandinavian journal of immunology

authors： Tarcic N,Baler R,Naor D

更新日期：1984-11-01 00:00:00

abstract：:Primary immunodeficiency diseases represent many natural mutant models for the analysis of many aspects of immunology. Examples dealing with T- and B-cell receptors are herein discussed. They also represent privileged models in medicine, because well characterized monogenic inherited diseases can in some instances be ...

journal_title：Scandinavian journal of immunology

authors： Fischer A

更新日期：2002-03-01 00:00:00

abstract：:TIM-3 is a member of the TIM (T-cell immunoglobulin domain and mucin domain) family, which plays an important role in TH1 responses and autoimmune diseases. In this study, we cloned and characterized the porcine TIM-3 gene. Real-time PCR showed little expression of porcine TIM-3 in muscle and stomach, low expression i...

journal_title：Scandinavian journal of immunology

authors： Zhao W,Li Y,Wang Z,Li K,Yang S

更新日期：2011-01-01 00:00:00

abstract：:We investigated interferon (IFN) production by peripheral blood mononuclear cells from four patients with chronic OKT4 T-lymphocytic leukaemia and three patients with abnormal expansions of granular lymphocytes. No spontaneous production of IFN-gamma was found in supernatants of cultures from both patients and normal ...

journal_title：Scandinavian journal of immunology

authors： Pandolfi F,Capobianchi M,Matricardi P,Facchini J,Bonomo G,De Rossi G,Semenzato G,Fiorilli M,Dianzani F,Aiuti F

更新日期：1985-04-01 00:00:00

abstract：:The mechanisms by which glucocorticoids suppress immune responses have not yet been clearly defined. In steroid-sensitive pathological conditions, an increase in gamma delta T cells can occur in certain untreated systemic autoimmune disorders and seems to be a peristent feature in most cases of systemic lupus erythema...

journal_title：Scandinavian journal of immunology

authors： Spinozzi F,Agea E,Bistoni O,Travetti A,Migliorati G,Moraca R,Nicoletti I,Riccardi C,Paoletti FP,Vaccaro R

更新日期：1995-05-01 00:00:00

abstract：:Experimental autoimmune neuritis (EAN), an animal model of human Guillain-Barré syndrome, has long been considered as a T helper (Th) 1 cell-mediated autoimmune disorder. However, deficiency of IFN-γ, a signature Th1 cytokine, aggravated EAN, with features of elevated production of IL-17A, despite an alleviated system...

journal_title：Scandinavian journal of immunology

authors： Wang X,Zheng XY,Ma C,Wang XK,Wu J,Adem A,Zhu J,Zhang HL

更新日期：2014-09-01 00:00:00

abstract：:Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract that leads to substantial suffering for millions of patients. In some patients, the chronic inflammation leads to remodelling of the extracellular matrix and fibrosis. Fibrosis, in combination with expansion of smooth muscle layers, l...

journal_title：Scandinavian journal of immunology

authors： Alfredsson J,Wick MJ

更新日期：2020-12-01 00:00:00

abstract：:In subjects not developing allergy, inhalation of nonpathogenic protein antigens causes no harm and is associated with tolerance induction. Repeated exposure to aerosolized ovalbumin (OVA) likewise does not evoke airway inflammation and induces inhalation tolerance in experimental animals. The present study explored t...

journal_title：Scandinavian journal of immunology

authors： Alenmyr L,Matheu V,Uller L,Greiff L,Malm-Erjefält M,Ljunggren HG,Persson CG,Korsgren M

更新日期：2005-11-01 00:00:00

abstract：:In 10 blood samples from mothers who were studied after the delivery of a male infant and who had Y-body-containing cells in their circulations (mean value, 0.06%) the proportions of surface-Ig- and Y-body-positive lymphocytes were determined after passage through nylon wool. In each case one part of the sample was tr...

journal_title：Scandinavian journal of immunology

authors： Schröder J

更新日期：1975-01-01 00:00:00

abstract：:The J-chain content of 3 IgM and 24 IgA preparations was quantitated by an immunochemical technique after reduction with 20mM dithiothreitol. The amounts released ranged from undetectable (less than 0.1 mg) to 7.3 mg per 100 mg of Ig. Most of the J-chain-deficient proteins were monomeric, but four polymeric IgA prepar...

journal_title：Scandinavian journal of immunology

authors： Brandtzaeg P

更新日期：1976-01-01 00:00:00

abstract：:Expression of CD4+ or CD8+ determinants and ten different TCR V beta genes was analysed by two-colour flow cytometry in lymph node cells (LNC) of BALB/c and dm2 (a BALB/c Ld loss mutant) mice. TCR V beta 14 expression of CD8+ T cells and TCR V beta 7 and 14 of CD4+ T Cells were significantly more frequent in BALB/c th...

journal_title：Scandinavian journal of immunology

authors： Tscherning T,Reimann J,Claesson MH

更新日期：1992-10-01 00:00:00

abstract：:The occurrence of D-D recombination during the embryonic differentiation of chicken B cells was studied. Ig heavy (H) chains were amplified by polymerase chain reaction from day-12 bursal cDNA, and 30 random V-D-J regions were analysed by DNA sequencing. No gene conversion events were observed in any of the V regions,...

journal_title：Scandinavian journal of immunology

authors： Mansikka A,Toivanen P

更新日期：1991-05-01 00:00:00

abstract：:The most frequent pathogen in haematogenously acquired kidney infections in humans in Staphylococcus aureus. In order to characterize in situ the immunological patterns of septic nephritis we developed a murine model of this disease. A single intravenous injection of S. aureus producing toxic shock syndrome toxin-1 re...

journal_title：Scandinavian journal of immunology

authors： Verba V,Tarkowski A

更新日期：1996-09-01 00:00:00

abstract：:Exogenously added beta 2-microglobulin (beta 2m) binds to a variety of murine cell types. The 'receptor' for beta 2m has been isolated. The purified 'receptor' comprised a 48,000-dalton chain and occasionally a 25,000-dalton component. Direct crosslinking of beta 2m to the receptor on intact cells gave rise to a singl...

journal_title：Scandinavian journal of immunology

authors： Sege K,Peterson PA

更新日期：1980-01-01 00:00:00