Heterogeneity in the specificities of an alloreactive T helper cell line.

Abstract:

:Heterogeneity in antigen recognition of an alloreactive helper T-cell line was studied by repeated limiting dilution cloning. Analysis of the fine specificities of these clones showed that the gain of reactivity to new antigens by the T-cell line included the generation of non-cross-reactive T cells specific to new major histocompatibility (MHC) antigens. Analysis of function revealed that all the T-cell clones studied had similar cell surface antigens and secreted interleukin 4 (IL-4) and IL-5/IL-3 but not IL-2 or gamma interferon (IFN-gamma). The T-cell clones served as helper cells for B cells expressing the appropriate MHC antigens to both clonal proliferation and differentiation into antibody-producing cells.

journal_name

Scand J Immunol

authors

Rajasekar R,Andersson J,Leanderson T

doi

10.1111/j.1365-3083.1988.tb02398.x

subject

Has Abstract

pub_date

1988-06-01 00:00:00

pages

653-60

issue

6

eissn

0300-9475

issn

1365-3083

journal_volume

27

pub_type

杂志文章
  • Fibronectin binds to complement-coated agarose beads and increases their association to mouse macrophages.

    abstract::We have studied the binding of fibronectin to complement (C3b, C3bi, C3d)-coated agarose beads and its effect on cell association of such beads to mouse macrophages. Fibronectin bound to agarose beads preincubated in human serum, whereas no binding occurred after preincubation of the beads with complement-inactivated ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1985.tb01886.x

    authors: Johnson E,Gauperaa T,Eskeland T

    更新日期:1985-09-01 00:00:00

  • Increased N-linked glycosylation leading to oversialylation of monomeric immunoglobulin A1 from patients with Sjögren's syndrome.

    abstract::Increased serum immunoglobulin A (IgA) level is a common finding in primary Sjögren's syndrome (pSS). IgA might not be properly eliminated because of an abnormal glycosylation. We reported previously that IgA1 from patients with pSS was oversialylated. We extend this finding by showing that monomeric IgA1 contains mor...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-3083.2000.00685.x

    authors: Basset C,Durand V,Jamin C,Clément J,Pennec Y,Youinou P,Dueymes M,Roitt IM

    更新日期:2000-03-01 00:00:00

  • Peripheral immune response in pulmonary tuberculosis.

    abstract::Cellular immune response and delayed-type hypersensitivity reactions are considered to play a major role in the immunopathogenesis of pulmonary tuberculosis (PTB). But the exact mechanism is still to be clarified. Th1 cells are mainly involved in cellular immune responses in PTB and provide a normal healing process wi...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.2009.02294.x

    authors: Aktas E,Ciftci F,Bilgic S,Sezer O,Bozkanat E,Deniz O,Citici U,Deniz G

    更新日期:2009-09-01 00:00:00

  • Mitogen-induced differentiation of human CLL lymphocytes to antibody-secreting cells.

    abstract::Peripheral blood lymphocytes from nine patients with chronic lymphatic leukaemia (CLL) have been stimulated by photohaemagglutinin, pokeweed mitogen and Epstein-Barr virus. Our results provide proof that the leukaemic B cells in CLL are capable of responding to mitogenic signals by producing and secreting antibodies, ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1979.tb01374.x

    authors: Robèrt KH,Bird AG,Möller E

    更新日期:1979-01-01 00:00:00

  • Inhibition of neutrophil chemotaxis by elastase-generated IgG fragments.

    abstract::IgG1 is cleaved in vitro by granulocyte elastase into Fc and Fab fragments. The elastase-specific Fc fragment has been previously detected in vivo. Biological activity of the fragments has been described in modulating neutrophil oxidative metabolism and enzyme release. To investigate further effects granulocyte chemot...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1991.tb01557.x

    authors: Eckle I,Kolb G,Havemann K

    更新日期:1991-09-01 00:00:00

  • Induction of cellular immune reactions by A36, an antigen complex of Mycobacterium paratuberculosis: comparison of A36 and johnin components.

    abstract::Paratuberculosis (Johne's disease) is a chronic enteritis syndrome of ruminants, which is due to infection by Mycobacterium paratuberculosis. Cutaneous testing with proteins extracted from a mycobacterial culture fluid (johnin-PPD) is currently used to evaluate the cellular immune status. We have compared the componen...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1992.tb03143.x

    authors: Gilot P,De Kesel M,Coene M,Cocito C

    更新日期:1992-12-01 00:00:00

  • Detection of tumour-associated transplantation antigens by syngeneic cytotoxic T lymphocytes after fusion of tumour cell membrane vesicles to recipient cells.

    abstract::Sendai virus envelope-mediated fusion was used to transfer plasma membrane vesicles of ESb lymphoma cells (H-2d) to syngeneic or allogeneic recipient cells. After fusion, ESb-specific cell surface determinants were detectable on the recipient cells, as revealed by indirect immunofluorescence and cytofluorographic anal...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1984.tb01000.x

    authors: Altevogt P

    更新日期:1984-09-01 00:00:00

  • Common peptide epitope in mumps virus nucleocapsid protein and MHC class II-associated invariant chain.

    abstract::The present study describes a 7 amino acid-long sequence (YQQQGRL) which is identical in HLA-associated invariant chain and mumps virus nucleocapsid protein and is additionally followed by one conservative amino acid pair. As such a long amino acid homology is extremely rare in two evolutionarily unrelated proteins th...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1993.tb02571.x

    authors: Hyöty H,Parkkonen P,Rode M,Bakke O,Leinikki P

    更新日期:1993-05-01 00:00:00

  • Naturally occurring, spleen-associated suppressor activity of the newborn mouse. Biochemical and functional identification of three monokines secreted by newborn suppressor-inducer monocytes.

    abstract::Immature monocytes residing in the spleens of newborn mice less than 6-7 days of age are known to suppress T-dependent and T-independent immune responses in vitro and in vivo. Suppression is mediated in part through products secreted by the newborn monocytes. In the present study, we have identified 3 monokines secret...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1986.tb01940.x

    authors: Jadus MR,Peck AB

    更新日期:1986-01-01 00:00:00

  • The relationship between maximal exercise-induced increases in serum IL-6, MPO and MMP-9 concentrations.

    abstract::The aim of this study was to test the hypothesis that exercise would induce inflammatory response characterized by increased pro-inflammatory cytokines - interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α), adhesion molecule, matrix metalloprotease-9 (MMP-9) and myeloperoxidase (MPO) levels. Additional aim was t...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.2012.02720.x

    authors: Reihmane D,Jurka A,Tretjakovs P

    更新日期:2012-08-01 00:00:00

  • A novel human anti-AXL monoclonal antibody attenuates tumour cell migration.

    abstract::TAM family members (TYRO3, AXL and MERTK) play essential roles in the resolution of inflammation and in infectious diseases and cancer. AXL, a tyrosine kinase receptor, is commonly overexpressed in several solid tumours and numerous hematopoietic malignancies including acute myeloid leukaemia, acute lymphocytic leukae...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/sji.12777

    authors: Duan Y,Luo L,Qiao C,Li X,Wang J,Liu H,Zhou T,Shen B,Lv M,Feng J

    更新日期:2019-08-01 00:00:00

  • Characterization of amyloid protein AA and its serum precursor SAA in the horse.

    abstract::Amyloid was extracted from the liver of a horse that had developed amyloidosis after being used for several years for the production of antibodies to bacterial antigens. The amyloid fibrils were shown to be of the AA type. Two AA proteins with molecular weights of 9000 and 11,000 and with identical partial N-terminal ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1986.tb02007.x

    authors: Husebekk A,Husby G,Sletten K,Marhaug G,Nordstoga K

    更新日期:1986-06-01 00:00:00

  • Down-regulation of L-selectin surface expression by various leukocyte isolation procedures.

    abstract::L-selectin, a cell surface glycoprotein expressed on lymphocytes, granulocytes, and monocytes, has been implicated in lymphocyte homing and extravasation of phagocytic leukocytes into areas of inflammation. Considerable differences of L-selectin expression among various individuals has been reported, with clinical cor...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:

    authors: Stibenz D,Bührer C

    更新日期:1994-01-01 00:00:00

  • Interaction of decidual CD56+ NK with trophoblast cells during normal pregnancy and recurrent spontaneous abortion at early term of gestation.

    abstract::The immunological paradox of pregnancy, when maternal immune system recognizes but does not reject the semiallogenic foetus, is not yet fully understood. The aim of this work was to detail the mechanisms of the interaction of decidual CD56+ NK, infiltrating the maternal part of placenta, and trophoblast cells of foeta...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/sji.12196

    authors: Sotnikova N,Voronin D,Antsiferova Y,Bukina E

    更新日期:2014-09-01 00:00:00

  • B-cell activation in duodenal mucosa after oral cholera vaccination in IgA deficient subjects with or without IgG subclass deficiency.

    abstract::Alterations in duodenal Ig-producing cells induced by two oral cholera vaccinations were studied by two-colour immunofluorescence in mucosal tissue sections from adults with selective IgA deficiency (IgAD), either with (n = 7) or without (n = 9) frequent infections, infection-prone patients with combined IgAD and IgG ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1993.tb01714.x

    authors: Nilssen DE,Friman V,Theman K,Björkander J,Kilander A,Holmgren J,Hanson LA,Brandtzaeg P

    更新日期:1993-08-01 00:00:00

  • Effects of Ageing on the Immune System: Infants to Elderly.

    abstract::Physiological ageing is accompanied by decline in immune system function and immune alteration during ageing increases susceptibility to infections. We retrospectively analysed the data for complete blood count (CBC) and lymphocyte subsets from infant to elderly age groups to determine changes during ageing. Data from...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/sji.12413

    authors: Valiathan R,Ashman M,Asthana D

    更新日期:2016-04-01 00:00:00

  • T-cell receptor V-gene usage in synovial fluid and synovial tissue from RA patients.

    abstract::The question of whether there is a preferential use of certain V genes in T cells entering an inflamed joint has hitherto been studied mainly using unfractionated cells from synovial fluid and tissue respectively, and no clear answer to the question has yet been provided. Concomitantly, evidence has been provided that...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1992.tb03128.x

    authors: Gudmundsson S,Rönnelid J,Karlsson-Parra A,Lysholm J,Gudbjörnsson B,Widenfalk B,Janson CH,Klareskog L

    更新日期:1992-11-01 00:00:00

  • Human intestinal B-cell blasts and plasma cells express the mucosal homing receptor integrin alpha 4 beta 7.

    abstract::Interactions between homing receptors on circulating leucocytes and endothelial addressins regulate tissue-specific cellular extravasation. Although integrin alpha 4 beta 7 appears to be the main receptor for gut-homing T lymphocytes, less is known about molecules mediating mucosal B cell homing. Expression of integri...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1995.tb03709.x

    authors: Farstad IN,Halstensen TS,Lazarovits AI,Norstein J,Fausa O,Brandtzaeg P

    更新日期:1995-12-01 00:00:00

  • Upregulated IL-17A secretion and CCR6 co-expression in Treg subsets are related to the imbalance of Treg/Th17 cells in active UC patients.

    abstract::Ulcerative colitis (UC) is an idiopathic, chronic inflammatory disease, which is characterized with overactive immune response. It is well established that the imbalance between Tregs and Th17 cells plays a pivotal role in pathogenesis of UC. In this study, we investigated the impact of functional changes in Treg subs...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/sji.12842

    authors: Long Y,Zhao X,Xia C,Li X,Fan C,Liu C,Wang C

    更新日期:2020-06-01 00:00:00

  • Analysis of properties and proinflammatory functions of cockroach allergens Per a 1.01s.

    abstract::Cockroaches have been identified as one of the major indoor allergens inducing perennial rhinitis and asthma. Per a 1s are a group of the major allergens from American cockroach. Although Per a 1s are major allergens from American cockroach, factors contributing to the allergenicity of Per a 1s are still poorly define...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.2011.02571.x

    authors: He S,Zhang Z,Zhang H,Wei J,Yang L,Yang H,Sun W,Zeng X,Yang P

    更新日期:2011-09-01 00:00:00

  • beta 2-Microglobulin is bound to streptococcal M protein.

    abstract::The presence of receptors for three human proteins (fibrinogen, IgG, and beta 2-microglobulin (beta 2m)) was studied in group A streptococcal strains. M type 1, 12 and 14, and in M protein-negative variants of these strains. Fibrinogen binding was detected in all six strains. IgG did not bind to the two type-12 strain...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1981.tb00149.x

    authors: Björck L,Tylewska SK,Wadström T,Kronvall G

    更新日期:1981-01-01 00:00:00

  • Suppression of allergen-specific IgE in offspring after preconceptional immunisation: maternal, paternal and genetic influences.

    abstract::Immunisation of female mice with the allergen ovalbumin (OVA) during pregnancy reduces the OVA-specific IgE response in adult offspring. To approach primary prevention strategies for allergy, we investigated to what extent genetic, paternal and maternal factors influence this suppressive effect on allergic sensitisati...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/sji.12017

    authors: Nygaard UC,Hansen JS,Groeng EC,Melkild I,Løvik M

    更新日期:2013-02-01 00:00:00

  • Anaphylactic reactions in mice with Fenugreek allergy.

    abstract::Fenugreek is a legume mostly used as a spice in Indian-style cooking. Although it has been used since ancient times, its allergenicity has only been reported in the last two decades. It poses special problems as an emerging and often hidden allergen. Fenugreek exposure may have serious implications also for individual...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.2011.02587.x

    authors: Vinje NE,Namork E,Løvik M

    更新日期:2011-10-01 00:00:00

  • Monoclonal antibodies to a purified human transferrin receptor.

    abstract::BALB/c mice were injected with an affinity-chromatography-purified placental transferrin receptor preparation. Spleen cells were fused with NS-1 myeloma cells. Sixteen hybrids producing monoclonal antibodies specific for the transferrin receptor and two hybrids specific for transferrin were identified by radioimmunoas...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1984.tb01023.x

    authors: Nikinmaa B,Enns CA,Tonik SE,Sussman HH,Schröder J

    更新日期:1984-11-01 00:00:00

  • Isolation and identification of the naturally occurring, newborn spleen-associated suppressor cells. A mixed monocyte/mast cell population with separable suppressor activities.

    abstract::Spleens from newborn mice less than 6-7 days of age contain 'naturally occurring' suppressor cell populations that are able to inhibit nonspecifically immune responses of third-party adult spleen cells and alloreactivity in the newborn spleen per se. Isolation of the effectors of this suppressor activity reveals that ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1983.tb00811.x

    authors: Peeler K,Wigzell H,Peck AB

    更新日期:1983-05-01 00:00:00

  • Alteration in CD29(high) CD4(+) lymphocyte subset is a common feature of early HIV disease and of active tuberculosis.

    abstract::Peripheral CD4 T-cell depletion has been observed in human immunodeficiency virus (HIV)-negative patients with pulmonary tuberculosis (TB). To investigate more accurately this alteration, we studied peripheral blood CD45RA(+) and CD29(high) CD4 subsets in 79 TB patients with (HIV(+)TB(+)) or without (HIV(-)TB(+)) HIV ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-3083.2001.00832.x

    authors: Diagbouga S,Chiron JP,Sanou O,Ledru E

    更新日期:2001-01-01 00:00:00

  • A quantitative assay detecting small numbers of effector helper T cells, regardless of clonal specificity.

    abstract::We have developed a new assay for quantitative detection of all helper T cells that can induce normal B lymphocytes to proliferation and Ig secretion. To establish the optimal assay conditions, we have used cloned T helper cells of defined specificities that had previously been shown to activate normal B lymphocytes e...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1984.tb00992.x

    authors: Pobor G,Bandeira A,Pettersson S,Coutinho A

    更新日期:1984-09-01 00:00:00

  • In vitro stimulation of lymphocytes in leprosy patients, healthy contacts of leprosy patients, and subjects not exposed to leprosy. Comparison of an antigen fraction prepared from Mycobacterium leprae and tuberculin-purified protein derivative.

    abstract::In vitro lymphocyte stimulation was performed on peripheral blood lymphocytes from 48 leprosy patients, 15 healthy contacts of leprosy patients, and 16 normal controls who lived in a leprosy-free area and who had not been exposed to leprosy. Tuberculin PPD and an antigen fraction. MLW 1, prepared from M. leprae, were ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1982.tb00704.x

    authors: Closs O,Reitan LJ,Negassi K,Harboe M,Belehu A

    更新日期:1982-08-01 00:00:00

  • Accessory cell-dependent T-cell activation via Ti-CD3. Involvement of CD2-LFA-3 interactions.

    abstract::The activation of resting T cells to interleukin 2 (IL-2) production and DNA synthesis via Ti-CD3 is dependent on accessory cells (AC). Using positively selected, resting T cells activated with particle-bound anti-CD3, we investigated the ability of various cell lines to function as AC. We found that cell lines able t...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1988.tb01449.x

    authors: Halvorsen R,Leivestad T,Gaudernack G,Thorsby E

    更新日期:1988-09-01 00:00:00

  • Development of tuberculosis vaccines in clinical trials: Current status.

    abstract::Tuberculosis (TB) is an important infectious disease worldwide. Currently, Bacillus Calmette-Guérin (BCG) remains the only TB vaccine licensed for human use. This TB vaccine is effective in protecting children against severe military TB but offers variable protective efficacy in adults. Therefore, new vaccines against...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章,评审

    doi:10.1111/sji.12710

    authors: Méndez-Samperio P

    更新日期:2018-10-01 00:00:00