Abstract：
:Physiological ageing is accompanied by decline in immune system function and immune alteration during ageing increases susceptibility to infections. We retrospectively analysed the data for complete blood count (CBC) and lymphocyte subsets from infant to elderly age groups to determine changes during ageing. Data from dual-platform flow cytometry and CBC were analysed to determine the percentage (%) and absolute cell counts (Abs) of peripheral blood lymphocyte subsets (CD3, CD4, CD8, CD19 and CD56+16+ cells) in infants (1 month to 1 year), children (1 year to 6 years), adolescents (12 years to 18 years), adults (21 years to 50) and elderly (70 years to 92 years). Differences in plasma cytokine levels in adults and elderly were also analysed using Randox system. Comparisons among age groups from infants through adults revealed progressive declines in the percentage of total lymphocytes and absolute numbers of T and B cells. The NK cells declined from infancy to adulthood but increased in elderly participants. The percentages of T cells increased with age from infant to adulthood and then declined. Pro-inflammatory cytokines, TNF-α and IL-6, were higher in elderly people compared to adults. The elderly group had significantly higher levels of monocyte chemoattractant protein-1 (MCP-1) and lower levels of epidermal growth factor (EGF) compared to adults. Our findings confirm and extend earlier reports on age-related changes in lymphocyte subpopulations and data generated from this study is useful for clinicians and researchers, patient management in various age groups for the interpretation of disease-related changes, as well as therapy-dependent alterations.
journal_name
Scand J Immunoljournal_title
Scandinavian journal of immunologyauthors
Valiathan R,Ashman M,Asthana Ddoi
10.1111/sji.12413subject
Has Abstractpub_date
2016-04-01 00:00:00pages
255-66issue
4eissn
0300-9475issn
1365-3083journal_volume
83pub_type
杂志文章abstract：:In subjects not developing allergy, inhalation of nonpathogenic protein antigens causes no harm and is associated with tolerance induction. Repeated exposure to aerosolized ovalbumin (OVA) likewise does not evoke airway inflammation and induces inhalation tolerance in experimental animals. The present study explored t...
journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3083.2005.01682.x
更新日期：2005-11-01 00:00:00
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3083.2012.02689.x
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3083.1992.tb02874.x
更新日期：1992-04-01 00:00:00
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3083.2005.01560.x
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3083.1992.tb03106.x
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
doi：10.1111/sji.12696
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3083.1980.tb00230.x
更新日期：1980-01-01 00:00:00
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3083.1997.d01-130.x
更新日期：1997-09-01 00:00:00
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
doi：10.1111/sji.12205
更新日期：2014-10-01 00:00:00
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
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更新日期：2011-10-01 00:00:00
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3083.1986.tb02065.x
更新日期：1986-07-01 00:00:00
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3083.1985.tb01877.x
更新日期：1985-09-01 00:00:00
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3083.1989.tb01222.x
更新日期：1989-09-01 00:00:00
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3083.2007.02053.x
更新日期：2008-02-01 00:00:00
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3083.1991.tb02532.x
更新日期：1991-05-01 00:00:00
abstract：:The role of elevated intracellular calcium concentration [Ca2+]i in the LPS-induced activation of interleukin-1 beta (IL-1 beta) production was examined in cells representing different stages of myeloid differentiation (undifferentiated monocytic leukaemia cell line THP-1, THP-1 cells induced to adherent, macrophage-l...
journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3083.1992.tb02966.x
更新日期：1992-09-01 00:00:00
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3083.1998.00291.x
更新日期：1998-03-01 00:00:00
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章,评审
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更新日期：2015-11-01 00:00:00
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3083.2011.02522.x
更新日期：2011-05-01 00:00:00
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
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更新日期：1999-08-01 00:00:00
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3083.1979.tb01329.x
更新日期：1979-01-01 00:00:00
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3083.1989.tb01184.x
更新日期：1989-07-01 00:00:00
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章,评审
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更新日期：2011-05-01 00:00:00
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3083.1986.tb02078.x
更新日期：1986-08-01 00:00:00
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章,评审
doi：10.1111/sji.12921
更新日期：2020-10-01 00:00:00
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3083.2008.02103.x
更新日期：2008-06-01 00:00:00
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3083.2001.01020.x
更新日期：2001-12-01 00:00:00
abstract：:MLC-T cells from two different donors were cultured after limiting dilution (0.3 cells/well) in medium containing T-cell growth factor. Clones showing lytic activity against K-562 in a preliminary screening were expanded and tested against various NK-sensitive target-cell lines (Chang, T-24, Daudi, and Molt-4) and phy...
journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3083.1983.tb00770.x
更新日期：1983-01-01 00:00:00
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3083.1983.tb01805.x
更新日期：1983-10-01 00:00:00
abstract：:Ebola viruses (EBOVs) have been identified as an emerging threat in recent year as it causes severe haemorrhagic fever in human. Epitope-based vaccine design for EBOVs remains a top priority because a mere progress has been made in this regard. Another reason is the lack of antiviral drug and licensed vaccine although...
journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
doi：10.1111/sji.12302
更新日期：2015-07-01 00:00:00
