Abstract:
:The lectins from Datura stramonium, Lycopersicon esculentum, and Solanum tuberosum are structurally related and possess a similar carbohydrate specificity, yet the Datura lectin is mitogenic for human lymphocytes while the other two are not. However, the Datura lectin was found to antagonize blast transformation induced by purified protein derivative (PPD), even within the concentration range at which it was optimally mitogenic on its own. The presence of a submitogenic concentration of the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) enormously enhanced the mitogenic activity of Datura lectin. No such synergy was observed, however, between tomato lectin or S. tuberosum agglutinin (STA) and TPA, nor between Datura lectin and the calcium ionophore A 23187.
journal_name
Scand J Immunoljournal_title
Scandinavian journal of immunologyauthors
McCurrach PM,Kilpatrick DCdoi
10.1111/j.1365-3083.1988.tb02320.xsubject
Has Abstractpub_date
1988-01-01 00:00:00pages
31-4issue
1eissn
0300-9475issn
1365-3083journal_volume
27pub_type
杂志文章abstract::The advent of advanced molecular biological techniques in the last two decades has allowed the study of genetic factors in inflammatory bowel disease (IBD). A variety of techniques have been employed to elucidate the effects of genes, starting with the clinical observations that IBD is more common in the relatives of ...
journal_title:Scandinavian journal of immunology
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journal_title:Scandinavian journal of immunology
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journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
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journal_title:Scandinavian journal of immunology
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journal_title:Scandinavian journal of immunology
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journal_title:Scandinavian journal of immunology
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journal_title:Scandinavian journal of immunology
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journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
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更新日期:2000-07-01 00:00:00
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journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
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