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Inhibition of in vitro immune responses by a fraction from seminal plasma.

Abstract：

:We studied the inhibitory effect of a fraction of bovine seminal plasma on in vitro lymphocyte responses to specific and nonspecific ligands. Seminal plasma was fractionated by Sephadex G-100 chromatography, and the inhibitory component was found to have a molecular weight of above 100,000 daltons. This fraction was devoid of lymphocytotoxicity and could inhibit, in a dose-dependent mode, both the primary antibody response of normal mouse spleen cells to the thymus-dependent antigen sheep erythrocytes and the one-way mixed lymphocyte reactions. Concanavalin A-induced proliferative T-cell responses were also inhibited by the same fraction. The inhibition of the T-lymphocyte responses to Con A was complete at suboptimal concentrations of the mitogen and could only partially be overcome at supraoptimal concentrations. Four other fractions in seminal plasma were also studied in this particular system, three being without effect and one being stimulatory. The inhibitory fraction was also found to inhibit the polyclonal B-cell responses induced by fetal calf serum. The importance of the present findings for the immunophysiology of reproduction are discussed.

journal_name

Scand J Immunol

journal_title

Scandinavian journal of immunology

authors

Prakash C,Coutinho A,Möller G

doi

10.1111/j.1365-3083.1976.tb02994.x

keywords:

subject

Has Abstract

pub_date

1976-01-01 00:00:00

pages

77-85

issue

1-2

eissn

0300-9475

issn

1365-3083

journal_volume

5

pub_type

杂志文章

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