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The IgA-binding lectin jacalin induces complement activation by inhibition of C-1-inactivator function.

Abstract：

:Jacalin, a D-galactose-specific lectin from jackfruit, interacts with human IgA and one or two other serum proteins. Incubation of jacalin with fresh human serum was shown to result in activation of the complement system. Therefore the mechanism of complement activation by jacalin was studied. Jacalin was extracted from jackfruit seeds (crude preparation) and purified to homogeneity by affinity chromatography on IgA-Sepharose to yield a pure preparation of jacalin. Both crude and pure jacalin were able to activate complement, accompanied by conversion of C3. Consumption of C1, C4 and C-1-inactivator (C-1-In) indicated involvement of the classical pathway. Aggregated IgG (AIgG) caused partial (38%) and jacalin induced complete consumption of C1-In functional activity. It was found upon Ouchterlony analysis that jacalin forms a precipitation line with purified C-1-In. In addition binding of 125I-C-1-In to jacalin-Sepharose was observed, and this binding was inhibitable by either secretory IgA or D-galactose. Next to binding of jacalin to C-1-In, jacalin was also shown to inhibit the functional activity of C-1-In. These results indicate that jacalin induces complement activation by inhibition of C-1-In function and thereby facilitates the activation of precursor C1 in either the absence or presence of low amounts of C1 activators.

journal_name

Scand J Immunol

journal_title

Scandinavian journal of immunology

authors

Hiemstra PS,Gorter A,Stuurman ME,Van Es LA,Daha MR

doi

10.1111/j.1365-3083.1987.tb02243.x

subject

Has Abstract

pub_date

1987-08-01 00:00:00

pages

111-7

issue

2

eissn

0300-9475

issn

1365-3083

journal_volume

26

pub_type

杂志文章

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