Highly increased natural killer cell number and lytic activity in the murine peripheral blood and lungs after interferon induction in vivo.

abstract：:In this study we analysed the potential of highly purified polyclonal TcR alpha beta+, TcR gamma delta + and CD3- NK cells, to produce lymphokines in response to mitogenic stimulation. RNA hybridizations were performed to detect with high sensitivity the induction of multiple lymphokine genes. Upon stimulation with le...

journal_title：Scandinavian journal of immunology

authors： Biassoni R,Ferrini S,Prigione I,Pelak VS,Sekaly RP,Long EO

更新日期：1991-03-01 00:00:00

abstract：:Tumour necrosis factor-α-induced protein-8 like-2 (TIPE2) is a newly identified immune negative regulator. The abnormal expression of TIPE2 has been found in several human inflammatory diseases. However, the expression level and clinical significance of TIPE2 in childhood asthma remain unclear. In this study, we detec...

journal_title：Scandinavian journal of immunology

authors： Ma Y,Liu X,Wei Z,Wang X,Wang Z,Zhong W,Li Y,Zhu F,Guo C,Zhang L,Wang X

更新日期：2013-12-01 00:00:00

abstract：:Macrophages obtained from animals treated with beta-1,3-D-glucan-derivatized plastic beads were greatly stimulated, as judged by morphology, esterase release, and cytostatic effect on L-929 tumour cells in vitro. The pretreatment of mice with such beads conferred an apparent absolute local resistance to an otherwise l...

journal_title：Scandinavian journal of immunology

authors： Seljelid R,Bøgwald J,Rasmussen LT,Larm O,Hoffman J,Berge A,Ugelstad J

更新日期：1985-06-01 00:00:00

abstract：:HLA class II determinants were analysed for their role in monocyte-T-cell interactions in the proliferative response to purified protein derivative (PPD). Allogeneic cell combinations of monocytes and T cells were tested with a range of suboptimal PPD concentrations. For each cell combination tested, a summary measure...

journal_title：Scandinavian journal of immunology

authors： van Eden W,Elferink BG,Hermans J,de Vries RR,van Rood JJ

更新日期：1984-12-01 00:00:00

abstract：:Inflammatory cytokines appear to be involved in damage to Schwann cells, myelin and axons, although the exact role of the different cytokines is uncertain. The direct injection model offers a new and simplified way of examining the mechanisms of early inflammation in the peripheral nervous system. The present study wa...

journal_title：Scandinavian journal of immunology

authors： Pelidou SH,Deretzi G,Zou LP,Quiding C,Zhu J

更新日期：1999-07-01 00:00:00

abstract：:A method of separating neutrophils from the peripheral blood of rats with 95% purity is described. To determine the role of antigenic stimulation in neutrophil function, neutrophils from germ-free (GF) rats were compared with those of conventional (CV) rats. Neutrophil counts were lower in GF rats but the total number...

journal_title：Scandinavian journal of immunology

authors： Ohkubo T,Tsuda M,Tamura M,Yamamura M

更新日期：1990-12-01 00:00:00

abstract：:The heavy (H) chains of three anti-streptococcal group A carbohydrate antibodies (anti-SACHO) of restricted heterogeneity, elicited in inbred Sprague-Dawley rats, were subjected to 40 cycles of automated Edman degradation. All three antibody H-chain preparations had an identical amino acid sequence and were classified...

journal_title：Scandinavian journal of immunology

authors： Klapper DG,Stankus RP,Leslie GA,Capra JD

更新日期：1976-01-01 00:00:00

abstract：:In 10 blood samples from mothers who were studied after the delivery of a male infant and who had Y-body-containing cells in their circulations (mean value, 0.06%) the proportions of surface-Ig- and Y-body-positive lymphocytes were determined after passage through nylon wool. In each case one part of the sample was tr...

journal_title：Scandinavian journal of immunology

authors： Schröder J

更新日期：1975-01-01 00:00:00

abstract：:We have studied the binding of fibronectin to complement (C3b, C3bi, C3d)-coated agarose beads and its effect on cell association of such beads to mouse macrophages. Fibronectin bound to agarose beads preincubated in human serum, whereas no binding occurred after preincubation of the beads with complement-inactivated ...

journal_title：Scandinavian journal of immunology

authors： Johnson E,Gauperaa T,Eskeland T

更新日期：1985-09-01 00:00:00

abstract：:Histamine was shown to suppress the in vitro generation of secondary syngeneic tumour-specific Ly-2+, L3T4- cytotoxic T cells from Ly-2+, L3T4- precursor cells. The sensitivity of the spleen cells from P815X2 mastocytoma-bearing DBA/2 mice to histamine-induced suppression changed during tumour progression; by the time...

journal_title：Scandinavian journal of immunology

authors： Laatikainen A

更新日期：1989-10-01 00:00:00

abstract：:We studied the inhibitory effect of a fraction of bovine seminal plasma on in vitro lymphocyte responses to specific and nonspecific ligands. Seminal plasma was fractionated by Sephadex G-100 chromatography, and the inhibitory component was found to have a molecular weight of above 100,000 daltons. This fraction was d...

journal_title：Scandinavian journal of immunology

authors： Prakash C,Coutinho A,Möller G

更新日期：1976-01-01 00:00:00

abstract：:Cutaneous lupus erythematosus (CLE) is an autoimmune disease with a broad range of cutaneous manifestations. In skin lesions of CLE, keratinocytes primarily undergo apoptosis. Interferon-κ(IFN-κ) is belonged to type I interferons (type I IFNs) and is selectively produced by keratinocytes. Recently, keratinocytes selec...

journal_title：Scandinavian journal of immunology

authors： Zhou X,Yan J,Lu Q,Zhou H,Fan L

更新日期：2021-01-01 00:00:00

abstract：:Several vaccination studies have been performed in monkeys and humans testing the feasibility of prophylactic and therapeutic immunizations against Helicobacter pylori. The monkey studies showed that immune responses were induced by oral vaccination with the mucosal adjuvant LT (Escherichia coli heat-labile enterotoxi...

journal_title：Scandinavian journal of immunology

authors： Lee CK

更新日期：2001-05-01 00:00:00

abstract：:Subclasses of lymphocytes can be separated on gradients of non-toxic polyvinylpyrrolidone-coated colloidal silica (Percoll) by virtue of differential densities. Such gradients can yield functionally active lymphocyte populations after brief centrifugation. Gradients can be generated in a discontinuous step fashion and...

journal_title：Scandinavian journal of immunology

authors： Kurnick JT,Ostberg L,Stegagno M,Kimura AK,Orn A,Sjöberg O

更新日期：1979-01-01 00:00:00

abstract：:When the immunoglobulin secretion of 172 normal healthy individuals was investigated with the protein-A plaque assay, 12 persons (7%) did not develop any plaque-forming cells (PFC) in cultures of pokeweed mitogen (PWM)-activated unfractionated peripheral blood lymphocytes (PBL), incubated for 6 days. The effect of irr...

journal_title：Scandinavian journal of immunology

authors： Tauris P

更新日期：1983-09-01 00:00:00

abstract：:To further investigate the interaction between human mononuclear leucocytes [peripheral blood mononuclear cells (PBMC)] and enterocytes, the effect of a confluent layer of differentiated CACO-2 cells on cytokine kinetics during challenge with bacteria in a compartmentalized coculture model was investigated. Nonpathoge...

journal_title：Scandinavian journal of immunology

authors： Parlesak A,Haller D,Brinz S,Baeuerlein A,Bode C

更新日期：2004-11-01 00:00:00

abstract：:To compare the receptor patterns for mitogenic and non-mitogenic substances, surface glycoproteins of human lymphocytes were labelled with the lactoperioxidase-catalysed iodination technique and with a galactose oxidase-tritiated sodium borohydride technique. Labelled cells were detergent-solubilized, and the lysates ...

journal_title：Scandinavian journal of immunology

authors： Skoog VT,Nilsson SF,Weber TH

更新日期：1980-01-01 00:00:00

abstract：:We have previously shown that various benign and malignant natural killer (NK)-resistant monolayer cells inhibit endogenous human NK activity, probably by reducing the secretion of cytotoxic factors from the effector cells. The nature of the molecules responsible for the inhibition has been unclear. In this study we s...

journal_title：Scandinavian journal of immunology

authors： Heiskala MK,Stenman UH,Koivunen E,Carpén O,Saksela E,Timonen T

更新日期：1988-07-01 00:00:00

abstract：:Secretory component (SC) acts as a receptor for polymeric IgA (pIgA) and pIgM on the basolateral face of secretory epithelia. This study showed that both the production and surface membrane expression of SC were additively up-regulated by tumour necrosis factor-alpha (TNF) and gamma interferon (IFN-gamma) in a human c...

journal_title：Scandinavian journal of immunology

authors： Kvale D,Brandtzaeg P,Løvhaug D

更新日期：1988-09-01 00:00:00

abstract：:Assessment of cytokine expression has become crucial to understand host responses to infections as well as autoimmunity. Several approaches including Northern blot, RNase protection assay and enzyme-linked immunosorbent assay have been used for this purpose, but they are time consuming, labour intense, and relatively ...

journal_title：Scandinavian journal of immunology

authors： Ramos-Payán R,Aguilar-Medina M,Estrada-Parra S,González-Y-Merchand JA,Favila-Castillo L,Monroy-Ostria A,Estrada-Garcia IC

更新日期：2003-05-01 00:00:00

abstract：:In the present study evidence is presented that SAA in serum complexes to a carrier protein with a molecular weight of 100,000-200,000 daltons, with mobility in the alpha-region on electrophoresis, and with a rather low normal serum concentration. The carrier protein is apparently not albumin. SAA isolated from the ca...

journal_title：Scandinavian journal of immunology

authors： Skogen B,Natvig JB,Michaelsen TE,Anders RF

更新日期：1977-01-01 00:00:00

abstract：:HLA class II molecules may be induced on non-lymphoid cells by gamma-interferon (IFN-gamma). We investigated if HLA class II molecules induced by IFN-gamma on the HT29 colonic carcinoma cell line are functional, i.e. if they may be recognized by allogeneic T cells. We found that IFN-gamma-treated HT29 (HT29IFN) cells ...

journal_title：Scandinavian journal of immunology

authors： Lundin KE,Sollid LM,Bosnes V,Gaudernack G,Thorsby E

更新日期：1990-04-01 00:00:00

abstract：:Drainage of the thoracic duct resulted in a decrease in the IgA level in rat bile, but at the same time there was an increase in both the total IgM level and the specific IgM antibody activity to Escherichia coli 06 in the bile of animals immunized in the Peyer's patches with these bacteria. The increase in total IgM ...

journal_title：Scandinavian journal of immunology

authors： Dahlgren UI,Ahlstedt S,Hanson LA

更新日期：1986-11-01 00:00:00

abstract：:Immunoglobulin-secreting cells (ISC) in the peripheral blood of healthy individuals and in the bone marrow, peripheral blood, or plasmacytomas of patients with multiple myeloma were enumerated by a protein-A plaque-forming cell assay after treatment with anti-Ia antibody and complement. Rabbit anti-human B-cell antise...

journal_title：Scandinavian journal of immunology

authors： Nagai K,Nagai T,Takatsuki K,Uchino H

更新日期：1982-06-01 00:00:00

abstract：:Hypoxia (low oxygen tension) is a common feature of inflamed and infected tissues. The influence of hypoxia on macrophage responses to micro-organisms has only recently been studied. This study demonstrates that hypoxia induced macrophages to control Leishmania amazonensis, an intracellular parasite that causes cutane...

journal_title：Scandinavian journal of immunology

authors： Degrossoli A,Arrais-Silva WW,Colhone MC,Gadelha FR,Joazeiro PP,Giorgio S

更新日期：2011-08-01 00:00:00

abstract：:Inflammatory bowel diseases (IBD) are a group of chronic recurrent gastrointestinal inflammatory diseases, including ulcerative colitis (UC), Crohn's disease (CD) and IBD unclassified. The pathogenesis may be related to the mucosal immune dysfunction in genetically susceptible hosts affected by environmental factors. ...

journal_title：Scandinavian journal of immunology

authors： Zhang X,Wang S,Ding X,Guo J,Tian Z

更新日期：2020-09-01 00:00:00

abstract：:Heterogeneity in antigen recognition of an alloreactive helper T-cell line was studied by repeated limiting dilution cloning. Analysis of the fine specificities of these clones showed that the gain of reactivity to new antigens by the T-cell line included the generation of non-cross-reactive T cells specific to new ma...

journal_title：Scandinavian journal of immunology

authors： Rajasekar R,Andersson J,Leanderson T

更新日期：1988-06-01 00:00:00

abstract：:The ability of different subpopulations of blood mononuclear cells to serve as accessory cells in the activation of CD4+ and CD8+ T cells via Ti-CD3 or with phytohaemagglutinin (PHA) was studied. Pure CD4+ or CD8+ T cells did not respond to particle-bound anti-CD3 monoclonal antibodies (MoAb) or PHA, whereas responses...

journal_title：Scandinavian journal of immunology

authors： Halvorsen R,Leivestad T,Gaudernack G,Thorsby E

更新日期：1988-05-01 00:00:00

abstract：:Lewis rats develop arthritis after immunization with heterologous but not homologous rat type II collagen (CII). We have observed that if the rat CII is prepared by pepsin digestion without subsequent extensive purification, it is arthritogenic in Lewis rats. To address whether pepsin in the CII preparations contribut...

journal_title：Scandinavian journal of immunology

authors： Vingsbo C,Larsson P,Andersson M,Holmdahl R

更新日期：1993-03-01 00:00:00

abstract：:C57BL/6 mice treated with intranasal instillation of 100 micrograms of Aspergillus antigen three times a week developed a pulmonary eosinophilia, observed in the bronchoalveolar lavage (BAL) and on histopathological examination. At week 3, the instillation of Aspergillus antigen provoked a 10-fold increase in the BAL ...

journal_title：Scandinavian journal of immunology

authors： Wang JM,Denis M,Fournier M,Laviolette M

更新日期：1994-01-01 00:00:00