Abstract:
:The short-term incubation of rat thymocytes with 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in a significant increase in sialyltransferase (S-T) activity and a decrease in terminal deoxyribonucleotidyl transferase (TdT) activity. The ratio of peanut agglutinin (PNA)-positive cells and of TdT-positive cells in TPA-treated cells also decreased. However, TPA had no significant effects on the viability, morphology, DNA synthesis, and DNA polymerase alpha activity of the cells. More marked changes were observed by incubating a non-T, non-B human lymphoid leukaemia cell line with TPA. Similar findings were also noted in TPA-treated mouse thymocytes. These changes may represent an aspect of TPA-induced differentiation of murine thymocytes.
journal_name
Scand J Immunoljournal_title
Scandinavian journal of immunologyauthors
Sasaki R,Takaku F,Miura Ydoi
10.1111/j.1365-3083.1989.tb01148.xsubject
Has Abstractpub_date
1989-04-01 00:00:00pages
485-8issue
4eissn
0300-9475issn
1365-3083journal_volume
29pub_type
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