Histamine modulates the interleukin-6-regulated acute phase protein synthesis in cultured murine hepatocytes.

Abstract:

:Murine hepatocytes cultured in the presence of human recombinant interleukin-6 (IL-6) show increased synthesis of fibrinogen and complement component C3 by the addition of histamine. No similar effect was achieved when murine hepatocytes were treated with histamine alone or with histamine and interleukin-1 alpha together. Using histamine-1 (H1) and H2 receptor antagonists a prevalence of histamine H1 receptor in the enhancement of IL-6-induced effect is suggested.

journal_name

Scand J Immunol

authors

Rokita H,Falus A,Biró J,Smolen J,Kordula T,Stalinska K

doi

10.1111/j.1365-3083.1992.tb02975.x

keywords:

subject

Has Abstract

pub_date

1992-06-01 00:00:00

pages

681-5

issue

6

eissn

0300-9475

issn

1365-3083

journal_volume

35

pub_type

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