Analysis of the T-cell receptor V beta usage in monozygotic and dizygotic twins living in a Plasmodium falciparum endemic area in west Africa.

Abstract:

:To investigate the influence of genetic and/or environmental factors in the development and shaping of the human peripheral T cell repertoire the authors studied the T-cell receptor (TCR) V beta usage in 10 adult monozygous (Mz) and nine dizygous (Dz) twin pairs living in a Plasmodium falciparum endemic area in West Africa. The TCR repertoire was determined using a small panel of anti-V beta specific monoclonal antibodies (MoAbs) using conventional immunofluorescence assays. The results revealed that the V beta repertoire was similar to that recently described for a Caucasian population using a similar panel of antibodies. The frequencies of particular V beta genes tested were influenced neither by anti-malarial antibody titres nor by parasite densities, indicating that the P. falciparum parasite is not a dominating factor in determining the peripheral T cell repertoire. All donors were human leucocyte antigen (HLA) class I and II typed; no association was found between the expression of any V beta genes and MHC haplotype. The V beta usage was more concordant within the Mz than within the Dz pairs. For a group comprising four HLA class II identical individuals, the average within-pair difference was significantly greater than for the whole Mz group, but similar to that seen for the total Dz group. Thus, the data suggest that genetic, rather than environmental, factors have a profound effect on the shaping of the human circulating T cell repertoire and that the major genetic factors are encoded by non-HLA class II genes.

journal_name

Scand J Immunol

authors

Troye-Blomberg M,Fogdell A,el-Ghazali G,Larsson A,King MH,Sisay-Joof F,Olerup O,Grunewald J,Jepson A

doi

10.1046/j.1365-3083.1997.d01-421.x

subject

Has Abstract

pub_date

1997-05-01 00:00:00

pages

541-5

issue

5

eissn

0300-9475

issn

1365-3083

journal_volume

45

pub_type

杂志文章
  • Pathogenesis of autoimmune diseases: antibodies against transglutaminase, peptidylarginine deiminase and protein-bound citrulline in primary Sjögren's syndrome, multiple sclerosis and Alzheimer's disease.

    abstract::Coeliac disease (CD) is becoming a model for understanding the pathogenesis of autoimmune disorders. In CD, antibodies against transglutaminase 2 (TG2) and specific residues of gliadins have been identified. A similar situation is seen in rheumatoid arthritis (RA) with both anti-citrullinated protein antibodies (ACPA)...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.2008.02115.x

    authors: Bodil Roth E,Theander E,Londos E,Sandberg-Wollheim M,Larsson A,Sjöberg K,Stenberg P

    更新日期:2008-06-01 00:00:00

  • In vitro immunization for the production of antigen-specific lymphocyte hybridomas.

    abstract::Antigen-specific lymphocyte hybridomas have been produced by a simple in vitro immunization procedure. Non-immune spleen cells have been activated in vitro, and the B-cell blasts have subsequently been used for somatic cell hybridization. Hybrids secreting monoclonal antibodies to human myoglobin, pig insulin, and ben...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1983.tb00829.x

    authors: Borrebaeck CA

    更新日期:1983-07-01 00:00:00

  • Altered IL-1 beta and IL-2 mRNA expression in murine splenic cells after concomitant stimulation by Semliki Forest virus and lipopolysaccharide.

    abstract::Co-infection with virus and bacteria happens frequently and often results in an exacerbated clinical course of the disease, possibly due to mechanisms including altered cytokine production. In the present study, the authors investigated the combined effects of avirulent Semliki Forest virus (SFV-A7) and bacterial lipo...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-3083.1997.d01-406.x

    authors: Yang J,Hukkanen V,Seljelid R,Salmi AA

    更新日期:1997-04-01 00:00:00

  • Role of calcium channels in congenital heart block.

    abstract::Congenital heart block (CHB) is a conduction abnormality that affects hearts of foetuses and/or newborn to mothers with autoantibodies reactive with the intracellular soluble ribonucleoproteins 48-kD La, 52-kD Ro and 60-kD Ro. CHB carries substantial mortality and morbidity, with more than 60% of affected children req...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-3083.2010.02439.x

    authors: Karnabi E,Boutjdir M

    更新日期:2010-09-01 00:00:00

  • Histamine secretion from human leucocytes stimulated by basophil-derived platelet-activating factor.

    abstract::Crude preparations of platelet-activating factors (PAF) derived by methanolic extraction of supernatants from antigen-challenged basophils generally stimulated the secretion of histamine from human peripheral blood leucocytes when co-incubated with these cells in the absence of an additional stimulator. When these cru...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1981.tb00168.x

    authors: O'Donnell MC,Fiedel BA

    更新日期:1981-01-01 00:00:00

  • Analysis of properties and proinflammatory functions of cockroach allergens Per a 1.01s.

    abstract::Cockroaches have been identified as one of the major indoor allergens inducing perennial rhinitis and asthma. Per a 1s are a group of the major allergens from American cockroach. Although Per a 1s are major allergens from American cockroach, factors contributing to the allergenicity of Per a 1s are still poorly define...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.2011.02571.x

    authors: He S,Zhang Z,Zhang H,Wei J,Yang L,Yang H,Sun W,Zeng X,Yang P

    更新日期:2011-09-01 00:00:00

  • Three-point association of HLA-A,B,Bf haplotypes deduced in 200 parents of 100 families.

    abstract::The association of HLA-A and -B antigens with Bf alleles was investigated in 200 parents from 100 unrelated families. There were significant associations between HLA-A3 and Bf-F, B7 and Bf-S, B8 and Bf-S, B12 and Bf-F, and BW 35 and Bf-F. Three-point HLA-A,B,Bf haplotype frequencies, linkage disequilibrium parameters,...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1977.tb02103.x

    authors: Albert ED,Rittner C,Scholz S,Kuntz B,Mickey MR

    更新日期:1977-01-01 00:00:00

  • Over-estimation of the number of complement receptor type 1 (CR1) on erythrocytes.

    abstract::The number of CR1 on erythrocytes, as measured by monoclonal antibodies, remains undefined because of the repetitive structure of CR1 and the presence of different types of structural CR1 alleles. We studied the number of CR1 per erythrocyte using two monoclonal antibodies, E11 and 3D9, which recognize different sites...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1992.tb02948.x

    authors: Quadri RA,Schifferli JA

    更新日期:1992-07-01 00:00:00

  • Binding, trafficking and accumulation of serum amyloid A in peritoneal macrophages.

    abstract::Murine serum amyloid A1.1 (SAA1.1) has been conjugated with the fluorophore Texas Red (TxR), and its interaction with peritoneal macrophages has been visualized by scanning confocal microscopy. Binding of TxR-SAA to cell surfaces was inhibited by an excess of unlabelled SAA indicating the involvement of saturable rece...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-3083.2001.00879.x

    authors: Kluve-Beckerman B,Manaloor J,Liepnieks JJ

    更新日期:2001-04-01 00:00:00

  • Characterization of amyloid protein AA and its serum precursor SAA in the horse.

    abstract::Amyloid was extracted from the liver of a horse that had developed amyloidosis after being used for several years for the production of antibodies to bacterial antigens. The amyloid fibrils were shown to be of the AA type. Two AA proteins with molecular weights of 9000 and 11,000 and with identical partial N-terminal ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1986.tb02007.x

    authors: Husebekk A,Husby G,Sletten K,Marhaug G,Nordstoga K

    更新日期:1986-06-01 00:00:00

  • Distribution and characterization of autoantibodies to interleukin 1 alpha in normal human sera.

    abstract::Antibodies against IL-1 alpha were detected in sera of apparently healthy individuals. The immunoglobulins belonged to the IgG class, particularly IgG1, IgG2, and IgG4. [125I]rIL-1 alpha bound to Fab fragments of IgG, and IgG immune complexes of molecular weights from 160 to 700 kDa were formed in the sera by [125I]rI...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1990.tb03212.x

    authors: Svenson M,Bagge Hansen M,Bendtzen K

    更新日期:1990-12-01 00:00:00

  • Generation of anti-tumour effector T cells from naïve T cells by stimulation with dendritic/tumour fusion cells.

    abstract::Tumour-draining lymph node T cells are an excellent source of effector T cells that can be used in adoptive tumour immunotherapy because they have already been sensitized to tumour-associated antigens in vivo. However, such tumour-specific immune cells are not readily obtained from the host due to poor immunogenicity ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.2007.02012.x

    authors: Ishida A,Tanaka H,Hiura T,Miura S,Watanabe S,Matsuyama K,Kuriyama H,Tanaka J,Kagamu H,Gejyo F,Yoshizawa H

    更新日期:2007-11-01 00:00:00

  • Trypsin does not reconstitute responsiveness to lipopolysaccharide in the strain C3H/HeJ, but is a B-cell mitogen-like lipopolysaccharide, stimulating a different subpopulation.

    abstract::The effect of trypsin on mouse spleen cells and enriched B cells, added alone or together with lipopolysaccharide (LPS), was investigated. With trypsin, proliferation in serum free spleen cell cultures was 2-6 times greater than the background using cells from LPS responder strains, and 2-4 times the background with c...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1989.tb01110.x

    authors: Cardell S,Möller G

    更新日期:1989-02-01 00:00:00

  • Epstein-Barr virus-driven B Cell Proliferation with CD4+ T Cell Expansion: A Lymphomatoid Granulomatosis-like Disease Related to Hyperinterleukin-10 Secretion of Remarkably Favourable Outcome with Rituximab.

    abstract::Granulomatous lymphomatosis is an Epstein-Barr virus (EBV)-driven B cell proliferation associated with an exuberant CD4(+) T cell reaction with usually histopathological pictures of angiocentrism. So far, the characteristics of CD4(+) T cells in granulomatous lymphomatosis and the mechanism leading to their expansion ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/sji.12370

    authors: Cervera P,Guihot A,Gorochov G,Lassoued K,Coppo P

    更新日期:2015-12-01 00:00:00

  • IgG rheumatoid factors against the four human Fc-gamma subclasses in early rheumatoid arthritis (the Swedish TIRA project).

    abstract::Rheumatoid factor (RF), i.e. a family of autoantibodies against the Fc part of IgG, is an important seromarker of rheumatoid arthritis (RA). Traditional particle agglutination without disclosing the antibody isotype remains the predominating diagnostic method in clinical routine. Although IgG-RF attracts pathogenic in...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.2011.02626.x

    authors: Kanmert D,Kastbom A,Almroth G,Skogh T,Enander K,Wetterö J

    更新日期:2012-01-01 00:00:00

  • Experimental allergic bronchopulmonary aspergillosis in the mouse: immunological and histological features.

    abstract::C57BL/6 mice treated with intranasal instillation of 100 micrograms of Aspergillus antigen three times a week developed a pulmonary eosinophilia, observed in the bronchoalveolar lavage (BAL) and on histopathological examination. At week 3, the instillation of Aspergillus antigen provoked a 10-fold increase in the BAL ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1994.tb03334.x

    authors: Wang JM,Denis M,Fournier M,Laviolette M

    更新日期:1994-01-01 00:00:00

  • CD25 blockade protects T cells from activation-induced cell death (AICD) via maintenance of TOSO expression.

    abstract::CD25 monoclonal antibody binding to the alpha-chain of the Interleukin-2 (IL-2) receptor, blocks high-affinity IL-2 binding, thereby preventing complete T-cell activation and being of ample importance in transplantation medicine and potentially the treatment of autoimmune disease. However, CD25 antibodies do not only ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.2009.02281.x

    authors: Richter GH,Mollweide A,Hanewinkel K,Zobywalski C,Burdach S

    更新日期:2009-09-01 00:00:00

  • Antigen binding by non-bursa-derived chicken leukocytes.

    abstract::Antigen-binding peripheral blood leukocytes (PBL) from normal and bursectomized agammaglobulinemic chickens were labeled by incubation in vitro with radioiodinated antigen at 4 degrees C in the presence of sodium azide. [125I]TGAL-binding cells could be detected by autoradiography of PBL from normal, unimmunized chick...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1975.tb02612.x

    authors: Jensenius C,Crone M,Koch C

    更新日期:1975-01-01 00:00:00

  • In vivo activation of mouse macrophages with beta-1,3-D-glucan-derivatized plastic beads.

    abstract::Macrophages obtained from animals treated with beta-1,3-D-glucan-derivatized plastic beads were greatly stimulated, as judged by morphology, esterase release, and cytostatic effect on L-929 tumour cells in vitro. The pretreatment of mice with such beads conferred an apparent absolute local resistance to an otherwise l...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1985.tb01850.x

    authors: Seljelid R,Bøgwald J,Rasmussen LT,Larm O,Hoffman J,Berge A,Ugelstad J

    更新日期:1985-06-01 00:00:00

  • Adoptive transfer of low numbers of CD4+ T cells into SCID mice chronically treated with soluble IL-4 receptor does not prevent engraftment of IL-4-producing T cells.

    abstract::After intravenous injection of 10(5) purified, lymph node (LN)-derived dm2 (H-2d/Ld-) CD4+ T cells into young C.B-17 scid/scid (severe combined immunodeficiency, SCID) mice (H-2d/Ld+), the transplanted Ld-T cells show a selective pattern of engraftment: they repopulate the spleen, the lamina propria of the small intes...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1993.tb01694.x

    authors: Rudolphi A,Enssle KH,Claesson MH,Reimann J

    更新日期:1993-07-01 00:00:00

  • Affinity purification of IgG subclasses and the distribution of thyroid auto-antibody reactivity in Hashimoto's thyroiditis.

    abstract::To delineate accurately the IgG subclass distribution of thyroid auto-antibodies, sera from nine patients with Hashimoto's thyroiditis were fractionated into IgG subclasses by complete depletion of the other IgG subclasses on affinity columns. All IgG subclass fractions contained thyroglobulin and microsomal (or thyro...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1989.tb01190.x

    authors: Weetman AP,Black CM,Cohen SB,Tomlinson R,Banga JP,Reimer CB

    更新日期:1989-07-01 00:00:00

  • Hepatic production of biliary IgM in the rat.

    abstract::Drainage of the thoracic duct resulted in a decrease in the IgA level in rat bile, but at the same time there was an increase in both the total IgM level and the specific IgM antibody activity to Escherichia coli 06 in the bile of animals immunized in the Peyer's patches with these bacteria. The increase in total IgM ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1986.tb02178.x

    authors: Dahlgren UI,Ahlstedt S,Hanson LA

    更新日期:1986-11-01 00:00:00

  • Immunological characterization of human glomerular basement membrane antigens.

    abstract::Normal human glomerular basement membrane (H-GBM) was solubilized by collagenase and subjected to crossed immunoelectrophoresis with rabbit antibodies against H-GBM. Seven precipitates appeared with the mobility of alpha, beta, and gamma globulins. Only two of these precipitates might be specific for GBM, since the ot...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1975.tb02678.x

    authors: Henriksen K,Jensen H

    更新日期:1975-01-01 00:00:00

  • Irregular cytokine pattern of CD4+ T lymphocytes in response to Staphylococcus aureus in patients with Wegener's granulomatosis.

    abstract::The initial stage of Wegener's Granulomatosis (WG) is often marked by symptoms of infection and it has been postulated that a bacterial infection could be the aetiologic factor of this disease. The objective of our work was to investigate T-cell-mediated immunity in WG by testing proliferative responses on bacterial a...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-3083.1999.00544.x

    authors: Mayet WJ,Märker-Hermann E,Schlaak J,Meyer Zum Büschenfelde KH

    更新日期:1999-06-01 00:00:00

  • Induction of histamine release and desensitization in human leukocytes.

    abstract::Histamine release from normal human leukocytes can be induced by anti-IgE or protein A from Staphylococcus aureus. After incubation in buffer at 37 degrees C for various time intervals or repeated washings with buffer, or both procedures, the leukocytes lose most of their reactivity to protein A, whereas the reactivit...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1975.tb03717.x

    authors: Petersson BA

    更新日期:1975-01-01 00:00:00

  • Appearance of anti-HLA-DR-reactive cells in normal and rheumatoid synovial tissue.

    abstract::The reactivity of rabbit anti-HLA-DR antigen antibodies with cells in normal and rheumatoid synovial tissue was investigated by indirect immunofluorescence on frozen sections of tissue. The antibodies reacted with a significant proportion of the synovial lining cells of both normal and rheumatoid synovial tissue, with...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1981.tb00198.x

    authors: Klareskog L,Forsum U,Malmnäs Tjernlund UK,Kabelitz D,Wigren A

    更新日期:1981-08-01 00:00:00

  • H-2 private specificity of in vivo-sensitized lymphocytes studied by adsorption on fibroblast monolayers.

    abstract::Spleen cells or thymocytes immune to one H-2 genotype are cytotoxic to allogeneic target cells of a third-party genotype, provided the target shares private specificities determined by either the H-2K or the H-2D locus of the H-2 complex with the H-2 genotype used for sensitization in vivo. The present results on elim...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1975.tb02640.x

    authors: Jorgensen PN,Güttler F,Rubin B

    更新日期:1975-01-01 00:00:00

  • Immunomodulatory effects of Lactobacillus casei administration in a mouse model of gliadin-sensitive enteropathy.

    abstract::Coeliac disease (CD) is a very common food-sensitive enteropathy, which is triggered by gluten ingestion and is mediated by CD4(+) T cells. In addition, alterations in the intestinal microbiota that is normally involved in the homeostasis of GALT (gut-associated lymphoid tissue) seem to play a role in CD. In accordanc...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.2011.02582.x

    authors: D'Arienzo R,Stefanile R,Maurano F,Mazzarella G,Ricca E,Troncone R,Auricchio S,Rossi M

    更新日期:2011-10-01 00:00:00

  • Fine specificity and cytolytic activity of continuously growing alloreactive cytotoxic T lymphocyte clones.

    abstract::The role of Lyt 1+ T-cell-derived secondard CTL inducing factor allowed the cloning of alloreactive cytotoxic T lymphocytes (CTL) by the limiting dilution approach. Several monoclonal cell lines were established in vitro. The lytic activity of some of the cell lines exceeded that of CTL from bulk cultures; that is, 50...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1980.tb00012.x

    authors: Schawaller R,Röllinghoff M,Wagner H

    更新日期:1980-01-01 00:00:00

  • Upregulated IL-17A secretion and CCR6 co-expression in Treg subsets are related to the imbalance of Treg/Th17 cells in active UC patients.

    abstract::Ulcerative colitis (UC) is an idiopathic, chronic inflammatory disease, which is characterized with overactive immune response. It is well established that the imbalance between Tregs and Th17 cells plays a pivotal role in pathogenesis of UC. In this study, we investigated the impact of functional changes in Treg subs...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/sji.12842

    authors: Long Y,Zhao X,Xia C,Li X,Fan C,Liu C,Wang C

    更新日期:2020-06-01 00:00:00