Abstract:
:Peripheral blood lymphoid subsets expressing either CD45RA or CD29 antigens, were quantified in 30 children and 59 adults with Down Syndrome and appropriate age-matched controls, by dual immunofluorescence and flow cytometry. Down's patients, both adults and children, displayed a significant decrease of CD4+CD45RA+ cells in comparison with the observed in their age-matched controls, but no difference was found in the CD4+CD29+ subset. These results show clearly the imbalance of these subpopulations in the peripheral blood of individuals with Down syndrome that result in the inversion of the CD45RA/CD29 ratio, due to a major reduction of the CD45RA subset. No obvious difference was found in the CD45RA/CD29 ratio within the CD4 negative cells. Abnormalities of these subpopulations could be indicative of early senescence of the immune system, since age-related changes in Down's persons were in parallel with those observed in normal individuals and the proportion of both subpopulations were roughly similar in Down's children and normal adults.
journal_name
Scand J Immunoljournal_title
Scandinavian journal of immunologyauthors
Barrena MJ,Echaniz P,Garcia-Serrano C,Cuadrado Edoi
10.1111/j.1365-3083.1993.tb01733.xsubject
Has Abstractpub_date
1993-10-01 00:00:00pages
323-6issue
4eissn
0300-9475issn
1365-3083journal_volume
38pub_type
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journal_title:Scandinavian journal of immunology
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journal_title:Scandinavian journal of immunology
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journal_title:Scandinavian journal of immunology
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journal_title:Scandinavian journal of immunology
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journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
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journal_title:Scandinavian journal of immunology
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1990-12-01 00:00:00
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journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
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更新日期:2000-08-01 00:00:00
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pub_type: 杂志文章
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journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
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journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
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更新日期:1985-09-01 00:00:00
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journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
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更新日期:1975-01-01 00:00:00
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journal_title:Scandinavian journal of immunology
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更新日期:1976-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2005-06-01 00:00:00