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CD4+Foxp3+ regulatory T-cell impairment by paclitaxel is independent of toll-like receptor 4.

Abstract：

:Paclitaxel (PTX) is one of the most widely used clinical antitumour drugs in chemotherapy nowadays. Its effect on immune system has become a hot spot of research in recent years. Here, we demonstrated that PTX not only decreased the percentage of CD4+Foxp3+ regulatory T (Treg) cells both in vitro and in vivo but also impaired cell viability and cytokine production of Treg cells rather than CD4+Foxp3- effector T (Teff) cells. As PTX has been reported to mimic the activity of LPS to trigger the toll-like receptor 4 (TLR4) signalling pathway in macrophages, we investigated the possible role of TLR4 in the effect of PTX. However, although TLR4 expression on Treg cells was higher than that on Teff cells, the expression level remained unaltered in both Treg and Teff cells after PTX treatment. Surface molecules and activation markers in Treg and Teff cells did not change, either. Further study showed that the effect of PTX on TLR4-/- mice deficient in TLR4 signalling was similar to that on C57BL/6 mice both in vivo and in vitro. These data indicate that the selective impairment of Treg cells by PTX is independent of TLR4.

journal_name

Scand J Immunol

journal_title

Scandinavian journal of immunology

authors

Zhu Y,Liu N,Xiong SD,Zheng YJ,Chu YW

doi

10.1111/j.1365-3083.2011.02514.x

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

301-8

issue

4

eissn

0300-9475

issn

1365-3083

journal_volume

73

pub_type

杂志文章

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