Monoclonal antibodies specific for Sendai virus. II. Production of monoclonal anti-idiotypic antibodies.

Abstract:

:The monoclonal antibodies A and B specific for the HN molecule of Sendai virus were used to induce polyclonal and monoclonal anti-idiotypic antibodies. No response was observed in allogeneic Lewis rats, low responses in syngeneic LOU rats, and high responses in allogeneic BN rats and xenogeneic Balb/c mice. The monoclonals A and B share a similar or identical idiotype, since polyclonal anti-idiotypic antisera to antibody A cross-reacted completely with antibody B and vice versa. The same was found with the three monoclonal anti-idiotypes 1, 2, and 3 elicited in a BN rat or in Balb/c mice. None of the polyclonal or monoclonal anti-idiotypes reacted with other monoclonal antibodies specific for Sendai virus, even when these recognized the same epitope as antibodies A and B. The monoclonal anti-idiotypic antibodies could be used to induce anti-Sendai antibodies in BN rats.

journal_name

Scand J Immunol

authors

Fenner M,Siegmann K,Binz H

doi

10.1111/j.1365-3083.1986.tb02103.x

subject

Has Abstract

pub_date

1986-09-01 00:00:00

pages

341-9

issue

3

eissn

0300-9475

issn

1365-3083

journal_volume

24

pub_type

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