A polyclonal T cell repertoire of V-alpha and V-beta T cell receptor gene families in intrathyroidal T lymphocytes of Graves' disease patients.

abstract：:Central events in the host defence system and immune-mediated damage are tightly regulated by cell adhesion molecules. Sera from 28 human immunodeficiency virus (HIV)-1 infected children divided into groups according to disease severity, six seroreverting (SR) children and 25 healthy controls were studied to detect th...

journal_title：Scandinavian journal of immunology

authors： Gaddi E,Laucella S,Balbaryski J,Cantisano C,Barboni G,Candi M,Giraudi V

更新日期：2000-12-01 00:00:00

abstract：:Toll-like receptor 4 (TLR4) participates in innate immunity by detecting lipopolysaccharides (LPS) of Gram-negative bacterial cell walls. TLR4 macrophage expression in mice is modulated by LPS. This fact constitutes, at least partially, the molecular basis for LPS tolerance. Very recently, the effect of interferon-gam...

journal_title：Scandinavian journal of immunology

authors： Moreno C,Merino J,Vázquez B,Ramírez N,Echeverría A,Pastor F,Sánchez-Ibarrola A

更新日期：2004-06-01 00:00:00

abstract：:Systemic sclerosis (SSc) is a heterogeneous autoimmune disease associated with several antinuclear autoantibodies useful to diagnosis and prognosis. The aim of the present multicentric study was to determine the clinical relevance of antifibrillarin autoantibodies (AFA) in patients with SSc. The clinical features of 3...

journal_title：Scandinavian journal of immunology

authors： Tall F,Dechomet M,Riviere S,Cottin V,Ballot E,Tiev KP,Montin R,Morin C,Chantran Y,Grange C,Jullien D,Ninet J,Chretien P,Cabane J,Fabien N,Johanet C

更新日期：2017-01-01 00:00:00

abstract：:We have recently shown that a heat treatment of a murine target cell line, WEHI 164, induces resistance to lysis mediated by tumour necrosis factors alpha (TNF-alpha) and beta (TNF-beta). In the present study the effect of the heat shock of target cells on cytotoxicity mediated by natural killer cells (NK cells), lymp...

journal_title：Scandinavian journal of immunology

authors： Jäättelä M

更新日期：1990-02-01 00:00:00

abstract：:Native agarose beads (diameter 5-10 micron), activators of the alternative complement pathway, are slowly phagocytosed when incubated with human monocytes cultured under serum-free conditions. Agarose beads preincubated with monocyte cultures and then transferred to new cultures are more easily phagocytosed than nativ...

journal_title：Scandinavian journal of immunology

authors： Hetland G,Eskeland T

更新日期：1986-03-01 00:00:00

abstract：:Schizophrenia is one of the most debilitating diseases among psychiatric disorders. Recent studies suggest the existence of effective immunological changes in the pathophysiology of this disease. The purpose of the current study was to determine the changes in serum levels of Brain Derived Neurotrophic Factor (BDNF) a...

journal_title：Scandinavian journal of immunology

authors： Ajami A,Hosseini SH,Taghipour M,Khalilian A

更新日期：2014-07-01 00:00:00

abstract：:Gαq, the alpha subunit of Gq, a member of the Gq/11 sub-family, was reported to inhibit phosphatidylinositol-3-Kinase (PI3K) activation and prevent the activation of Akt. Previous studies demonstrated that mice losing Gαq in their immune system could spontaneously develop inflammatory arthritis. In this study, we show...

journal_title：Scandinavian journal of immunology

authors： Wang Y,Li Y,He Y,Sun Y,Sun W,Xie Q,Yin G,Du Y,Wang L,Shi G

更新日期：2012-02-01 00:00:00

abstract：:The murine primed lymphocyte typing (mPLT) assay, based on the sequential reactivation of specific immunocompetent, alloantigen-reactive T blast cells in secondary mixed leucocyte culture (MLC), has been utilized to define the class II I-EC-subregion-associated lymphocyte-stimulating (LS) determinants of the major his...

journal_title：Scandinavian journal of immunology

authors： Peck AB

更新日期：1980-01-01 00:00:00

abstract：:Chronic inflammatory diseases are now treated with a range of different biopharmaceuticals, often requiring lifelong parenteral administrations. This exposure to drugs is unnatural and can trigger the immune system and result in the formation of antidrug antibodies. Drug-specific antibodies will, if of sufficiently hi...

journal_title：Scandinavian journal of immunology

authors： Fogdell-Hahn A

更新日期：2015-09-01 00:00:00

abstract：:Fc gamma receptors (FcγRs) for IgG regulate adaptive immune responses by modulating activating and inhibitory signalling pathways within immune cells. Data from a haemophilia A mouse model demonstrate that genetic deletion or blockade of the inhibitory FcγR (CD32) suppresses the formation of antibody-secreting cells (...

journal_title：Scandinavian journal of immunology

authors： Vollack N,Friese J,Bergmann S,Cragg MS,Tiede A,Werwitzke S

更新日期：2017-08-01 00:00:00

abstract：:Spleen cells or thymocytes immune to one H-2 genotype are cytotoxic to allogeneic target cells of a third-party genotype, provided the target shares private specificities determined by either the H-2K or the H-2D locus of the H-2 complex with the H-2 genotype used for sensitization in vivo. The present results on elim...

journal_title：Scandinavian journal of immunology

authors： Jorgensen PN,Güttler F,Rubin B

更新日期：1975-01-01 00:00:00

abstract：:Hyper-IgE syndrome (HIES) is a rare primary immunodeficiency disease characterized by eczema, recurrent staphylococcal aureus skin abscesses, pneumonia with pneumatocele formation, remarkably high serum IgE levels, eosinophilia and involvement of skeleton and connective tissues. Heterozygous signal transducer and acti...

journal_title：Scandinavian journal of immunology

authors： Zhang LY,Tian W,Shu L,Jiang LP,Zhan YZ,Liu W,Zhao XD,Cui YX,Tang XM,Wang M,Wu DQ,Yang XQ

更新日期：2013-09-01 00:00:00

abstract：:We have investigated the ability of different cells from non-immunized mice of the BALB/c strain to present antigen to two ovalbumin-specific I-Ad-restricted T hybridomas. Lipopolysaccharide-activated B-cell blasts were found to be the most efficient antigen-presenting cells. Purified small and dense splenic B cells a...

journal_title：Scandinavian journal of immunology

authors： Gontijo CM,Möller G

更新日期：1991-08-01 00:00:00

abstract：:Rat monoclonal antibodies directed against the BALB/c myeloma protein M315 (alpha,lambda 2) are described. 9A8 (IgG1) binds the V domain of lambda 2 and cross-reacts with lambda 1 and lambda 3 chains. 2B6 (IgG2a) is directed to the C domain of lambda 2 and cross-reacts with C lambda 3. The antibodies bind isolated cha...

journal_title：Scandinavian journal of immunology

authors： Bogen B

更新日期：1989-03-01 00:00:00

abstract：:Thirty-two mycobacterial components were detected by antibodies contained in leprosy patients' sera across the clinical spectrum and rabbit anti-M. leprae hyperimmune sera by western blot analysis of armadillo-derived M. leprae antigen preparations. Sera of borderline tuberculoid patients were found to contain antibod...

journal_title：Scandinavian journal of immunology

authors： Ehrenberg JP,Gebre N

更新日期：1987-12-01 00:00:00

abstract：:We have studied the interaction of mitogenic lectins such as phytohaemagglutinin (PHA) and concanavalin A (Con A) with both surface molecules which, by the use of monoclonal antibodies, are known to trigger T-cell mitogenesis. Monoclonal antibodies recognizing the T-lymphocyte receptor for antigen (Ti) and/or its asso...

journal_title：Scandinavian journal of immunology

authors： Leca G,Boumsell L,Fabbi M,Reinherz EL,Kanellopoulos JM

更新日期：1986-05-01 00:00:00

abstract：:Mycobacteria preferentially reside in resident macrophages whereas activated macrophages are presumed to eliminate the bacteria effectively. The aim of the present study was to determine the antibacterial activities of resident and activated murine peritoneal macrophages against Mycobacterium fortuitum and the intrace...

journal_title：Scandinavian journal of immunology

authors： Nibbering PH,Yoshida SI,van den Barselaar MT,van Furth R

更新日期：1994-08-01 00:00:00

abstract：:Paclitaxel (PTX) is one of the most widely used clinical antitumour drugs in chemotherapy nowadays. Its effect on immune system has become a hot spot of research in recent years. Here, we demonstrated that PTX not only decreased the percentage of CD4+Foxp3+ regulatory T (Treg) cells both in vitro and in vivo but also ...

journal_title：Scandinavian journal of immunology

authors： Zhu Y,Liu N,Xiong SD,Zheng YJ,Chu YW

更新日期：2011-04-01 00:00:00

abstract：:Immunisation of female mice with the allergen ovalbumin (OVA) during pregnancy reduces the OVA-specific IgE response in adult offspring. To approach primary prevention strategies for allergy, we investigated to what extent genetic, paternal and maternal factors influence this suppressive effect on allergic sensitisati...

journal_title：Scandinavian journal of immunology

authors： Nygaard UC,Hansen JS,Groeng EC,Melkild I,Løvik M

更新日期：2013-02-01 00:00:00

abstract：:An antigen-specific T-cell line which transforms into T-lymphoma cells in vitro but apparently not in vivo is described. Membrane markers, tumorigenicity and T-cell receptor (TcR) V alpha and V beta-gene usage of the in vitro transformed T-cell line were analysed to investigate whether the transformation event was pol...

journal_title：Scandinavian journal of immunology

authors： Wegener AM,Holm B,Geisler C,Rubin B

更新日期：1990-05-01 00:00:00

abstract：:Understanding the specificity of antibody response to Neisseria meningitidis serogroup B (Men B) is a key requirement for the development of an effective vaccine. This study was designed to investigate the antigen specificity of murine IgG1 and IgG2b antibodies induced by different primary immunization schedules and t...

journal_title：Scandinavian journal of immunology

authors： Silva Junior FC,Gioia CA,Oliveira JM,Cruz SC,Frasch CE,Milagres LG

更新日期：2007-01-01 00:00:00

abstract：:The fibril in primary amyloidosis (AL) is composed of a monoclonal light chain or portions thereof. No unique primary structure has been identified that predisposes certain light chains to form amyloid fibrils. Currently, classification of amyloidosis is based on the biochemistry of the amyloid fibril. We determined t...

journal_title：Scandinavian journal of immunology

authors： Gertz MA,Skinner M,Cohen AS,Connors LH,Kyle RA

更新日期：1985-09-01 00:00:00

abstract：:The majority of patients with myasthenia gravis were shown to have T and B cells specific for a beta-bungarotoxin binding protein, presynaptic membrane receptor (PsmR). Such autoreactive T cells may be subdivided into different subsets according to the pattern of cytokine production. In this study the authors examined...

journal_title：Scandinavian journal of immunology

authors： Yi Q,Pirskanen R,Lefvert AK

更新日期：1996-01-01 00:00:00

abstract：:Psoriasis is a T-cell mediated inflammatory skin disease which has been associated with group A, beta-haemolytic streptococcal infections. Four 20 a.a. long M6-peptides sharing 5-6 a.a. sequences with human epidermal keratins were identified. To investigate the role of potentially cross-reactive T cells in the pathoge...

journal_title：Scandinavian journal of immunology

authors： Sigmundsdottir H,Sigurgeirsson B,Troye-Blomberg M,Good MF,Valdimarsson H,Jonsdottir I

更新日期：1997-06-01 00:00:00

abstract：:CD8+ T cells are thought to play an important role in protective immunity against tuberculosis. We report the identification of three peptides derived from Rv1818c, Rv3812 and Rv3018c proteins of Mycobacterium tuberculosis that bound to HLA-A*0201 molecules and their ability to induce in vitro T-cell response in perip...

journal_title：Scandinavian journal of immunology

authors： Chaitra MG,Shaila MS,Chandra NR,Nayak R

更新日期：2008-04-01 00:00:00

abstract：:Autologous and allogeneic mixed lymphocyte cultures (AMC and MLC) were assayed for blastogenesis, generation of cytotoxic potential, and the effect of interferon (IFN-alpha) on these features. The cells of the mixed cultures lysed K562, Daudi, and autologous and allogeneic phytohaemagglutinin blasts. Stimulator-specif...

journal_title：Scandinavian journal of immunology

authors： Argov S,Klein E

更新日期：1983-03-01 00:00:00

abstract：:Several enveloped viruses, particularly some RNA viruses, have high rates of mutation or replication, which can make them virulent pathogens in humans and other mammals. A proposed treatment could use synthesized proteins to mask pathogenic viral surface proteins to quickly induce an immune attack on specific envelope...

journal_title：Scandinavian journal of immunology

authors： Roe K

更新日期：2020-09-01 00:00:00

abstract：:We have examined the frequencies of T gamma delta cells in blood, synovial fluids, and synovial membranes of patients with rheumatoid arthritis (RA) and in blood from age-matched controls. Immunocytochemical and immunohistochemical techniques were used with monoclonal antibodies BB3 and A13 to define a major and minor...

journal_title：Scandinavian journal of immunology

authors： Smith MD,Bröker B,Moretta L,Ciccone E,Grossi CE,Edwards JC,Yüksel F,Colaco B,Worman C,Mackenzie L

更新日期：1990-12-01 00:00:00

abstract：:Pneumocystis carinii is an opportunistic pathogen that causes pneumonia in immunocompromised hosts. In the normal host, P. carinii is susceptible to an array of first line host defense mechanisms that are operative in the lung. Alveolar macrophages play a central role in the clearance of inhaled organisms. The macroph...

journal_title：Scandinavian journal of immunology

authors： Stehle SE,Rogers RA,Harmsen AG,Ezekowitz RA

更新日期：2000-08-01 00:00:00

abstract：:Neuraminidase-treated lymphocytes from the peripheral blood of normal human donors were fractionated on columns charged with Helix pomatia haemagglutinin (HP) coupled to Sepharose 4B. While lymphocytes lacking HP receptors (HP-) passed directly through the column (fraction I), lymphocytes with HP receptors (HP+) were ...

journal_title：Scandinavian journal of immunology

authors： Pape GR,Troye M,Perlmann P

更新日期：1979-01-01 00:00:00