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Macrophage requirement for the in vitro response to an insolubilized T-independent antigen.

Abstract：

:The role of macrophages in the in vitro response of mouse spleen cells to the insolubilized, T-independent antigen trinitrophenylated polyacrylamide (TNP-PAA) is demonstrated by the following points. The response is abolished by filtration on Sephadex G-10 and can be restored by the addition of splenic adherent cells, deficient in either B or T cells, or by 2-mercaptoethanol (2ME). It is suppressed upon elimination of phagocytic cells by silica, and restored by 2-ME. 2-ME can restore a normal response from zero, in cultures depleted of both adherent and phagocytic cells, and is efficient in the absence of mature T cells. Experiments in microcultures show that large numbers of macrophages can stimulate a supra-optimal response from B cells. This response is only obtained in the presence of the antigen, and is specific for TNP. These results show that microphages, probably by their polyclonal B-cell activator (PBA) property, play a role in the specific response to TNP-PAA. This prompts us to discuss the respective roles in the B-cell response of this PBA activity and of the interaction of the antigen with the specific B-cell receptors.

journal_name

Scand J Immunol

journal_title

Scandinavian journal of immunology

authors

Duclos H,Galanaud P,Maillot MC,Crevon MC,Dormont J

doi

10.1111/j.1365-3083.1979.tb02718.x

subject

Has Abstract

pub_date

1979-01-01 00:00:00

pages

159-66

issue

2

eissn

0300-9475

issn

1365-3083

journal_volume

9

pub_type

杂志文章

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