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Primed B cells present type-II collagen to T cells.

Abstract：

:Development of type-II collagen (CII)-induced arthritis (CIA) is dependent on a T-cell mediated activation of autoreactive B cells. However, it is still unclear if B cells can present CII to T cells. To investigate the role of B cells as antigen-presenting cells (APCs) for CII, we purified B cells from lymph nodes of immunized and nonimmunized mice. These B cells were used as APC for antigen-specific T-cell hybridomas. B cells from naïve mice did present native, triple-helical, CII (nCII) but also ovalbumin (OVA) and denatured CII (dCII) to antigen-specific T-cell hybridomas. In addition, B cells primed with nCII or OVA, but not dCII, activated the antigen-specific T-cell hybridomas two to three times better than naïve B cells. We conclude that antigen-primed B cells have the capacity to process and present CII to primed T cells, and antigen-primed antigen-specific B cells are more efficient as APC than naïve B cells. We further conclude that B cells have the potential to play an important role as APC in the development of CIA.

journal_name

Scand J Immunol

journal_title

Scandinavian journal of immunology

authors

Holmdahl M,Vestberg M,Holmdahl R

doi

10.1046/j.1365-3083.2002.01071.x

keywords:

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

382-9

issue

4

eissn

0300-9475

issn

1365-3083

pii

1071

journal_volume

55

pub_type

杂志文章

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