当前位置： SCI文献检索 > SCANDINAVIAN JOURNAL OF IMMUNOLOGY期刊下所有文献 > Levels of interleukin-15-expressing blood mononuclear cells are elevated in multiple sclerosis.

Levels of interleukin-15-expressing blood mononuclear cells are elevated in multiple sclerosis.

Abstract：

:Interleukin-15 (IL-15) is a novel IL-2-like cytokine expressed by cells of the monocyte/macrophage and epithelial lineages. Cytokines might be involved in the pathogenesis of multiple sclerosis (MS). Using immunocytochemistry, we analysed spontaneous expression of IL-15 by peripheral blood (PB) and cerebrospinal fluid (CSF) mononuclear cells (MNC) from patients with MS, other neurological diseases (OND) and healthy controls. IL-15- positive peripheral blood mononuclear cells (PBMNC) were elevated in patients with MS compared to healthy controls (P < 0.05). The elevation of IL-15- positive PBMNC was restricted to patients with chronic progressive MS and not observed in patients studied during the relapsing-remitting phase of MS. The numbers of IL-15- expressing PBMNC correlated with the duration and disability of MS (r = 0.45, P < 0.001, and r = 0.39, P < 0.01, respectively). IL-15 was undetectable in CSF MNC, and ELISA showed low CSF levels of IL-15 in occasional patients with MS and OND. IL-15 is a potent growth factor for gammadelta T cells, but there was no correlation between IL-15 expression by PBMNC and percentage of gammadelta T cells in blood from the MS patients. Together, these data demonstrate that IL-15 expression by PBMNC is upregulated in the chronic stage of MS.

journal_name

Scand J Immunol

journal_title

Scandinavian journal of immunology

authors

Pashenkov M,Mustafa M,Kivisäkk P,Link H

doi

10.1046/j.1365-3083.1999.00598.x

keywords:

subject

Has Abstract

pub_date

1999-09-01 00:00:00

pages

302-8

issue

3

eissn

0300-9475

issn

1365-3083

pii

sji598

journal_volume

50

pub_type

杂志文章

相关文献

SCANDINAVIAN JOURNAL OF IMMUNOLOGY文献大全
  • B- and T-cell-specific alloantigens in man.

    abstract：:Screening for B-cell-specific antibodies in unabsorbed pregnancy sera preselected for weak reactivity in regular HLA-A, -B, and -C screening yielded a relatively high proportion (35/81) of B-cell-specific antibodies. Most B-cell-specific antibodies react broadly, showing inclusion phenomena suggesting 'cross-reactivit...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1977.tb02099.x

    authors： Albert ED,Andreas A,McNicholas A,Scholtz S,Kuntz B

    更新日期：1977-01-01 00:00:00

  • Cytokine genes are down-regulated when attachment of Entamoeba histolytica to HT-29 colon epithelial cells is prevented.

    abstract：:Entamoeba histolytica can cause invasive disease by disruption of the intestinal barriers and subsequent lysis of the intestinal cells. Adherence to and contact dependent killing of host cells requires the galactose inhibitable lectin. To elucidate the mechanism whereby E. histolytica influences host defence, the auth...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-3083.1997.d01-442.x

    authors： Kim JM,Jung HC,Jin DZ,Im KI,Song IS,Kim CY

    更新日期：1997-06-01 00:00:00

  • Antibiotic treatment of pregnant non-obese diabetic mice leads to altered gut microbiota and intestinal immunological changes in the offspring.

    abstract：:The intestinal microbiota is important for tolerance induction through mucosal immunological responses. The composition of the gut microbiota of an infant is affected by environmental factors such as diet, disease and antibiotic treatment. However, already in utero, these environmental factors can affect the immunolog...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/sji.12205

    authors： Tormo-Badia N,Håkansson Å,Vasudevan K,Molin G,Ahrné S,Cilio CM

    更新日期：2014-10-01 00:00:00

  • Leucocyte-associated plasma proteins. I. Plasma proteins in supernatants and cell pellets during successive washings of human blood cells.

    abstract：:Sixteen plasma proteins were studied in the supernatants from 20 successive washings of human leucocytes by a new sensitive immunoelectrophoretic method. In the first few supernatants a fast and parallel decrease in concentration of all proteins took place, but for 11 proteins this was followed by a phase of slow decr...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1982.tb00664.x

    authors： Andersen MM

    更新日期：1982-04-01 00:00:00

  • The plasma cell differentiation antigen PC.1 is absent in CH3/Tif and present in C3H/HeJ.

    abstract：:(C3H/TifxDBA/2)F1 mice, immunized with viable BALB/c plasmacytoma MOPC315 cells, produce antibodies directed against a cell-surface antigen. The strain and tissue distribution of this antigen was identical to that of the plasma cell differentiation alloantigen PC.1. The antigen is absent in the mouse strain C3H/Tif bu...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1979.tb03176.x

    authors： Gaudernack G,Hannestad K

    更新日期：1979-01-01 00:00:00

  • Humoral and Cellular Responses to a Single Dose of Fendrix in Renal Transplant Recipients with Non-response to Previous Hepatitis B Vaccination.

    abstract：:Approximately 70% of kidney transplant recipients are non-responders to conventional hepatitis B virus (HBV) vaccines. We examined whether Fendrix™, an HBV vaccine containing 3-O-desacyl-4'-monophosphoryl lipid A (MPL) as adjuvant, could induce HBV immunity in these patients and compared their vaccination efficacy wit...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/sji.12497

    authors： Lindemann M,Zaslavskaya M,Fiedler M,Wilde B,Heinemann FM,Heinold A,Horn PA,Witzke O

    更新日期：2017-01-01 00:00:00

  • Milk-derived GM(3) and GD(3) differentially inhibit dendritic cell maturation and effector functionalities.

    abstract：:Gangliosides are complex glycosphingolipids, which exert immune-modulating effects on various cell types. Ganglioside GD(3) and GM(3) are the predominant gangliosides of human breast milk but during the early phase of lactation, the content of GD(3) decreases while GM(3) increases. The biological value of gangliosides...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.2005.01566.x

    authors： Brønnum H,Seested T,Hellgren LI,Brix S,Frøkiaer H

    更新日期：2005-06-01 00:00:00

  • Direct and indirect regulatory mechanisms in TH17 cell differentiation and functions.

    abstract：:T helper 17 (TH17) cells have well-described roles in autoimmune diseases. The immune modulations of development and function of TH17 have become a key issue. In this review, we summarize the recent findings regarding the direct and indirect signalling regulatory mechanisms of TH17 cells in the general mouse model of ...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-3083.2012.02686.x

    authors： Bi Y,Yang R

    更新日期：2012-06-01 00:00:00

  • Selective response of dermal Th-1 cells to 20-50 kDa streptococcal cell-wall proteins in chronic plaque psoriasis.

    abstract：:We have recently described a dermal Th-1 subset in skin lesions of psoriasis which recognizes cell-wall extract isolated from group A streptococci (GAS). As a first step in the identification of the streptococcal proteins involved, dermal T-cell lines (TCL) cultured from the lesional skin of 12 human leucocyte antigen...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-3083.2003.01309.x

    authors： Baker BS,Ovigne JM,Fischetti VA,Powles A,Fry L

    更新日期：2003-09-01 00:00:00

  • Characterization of a lectin in human plasma analogous to bovine conglutinin.

    abstract：:The structural characteristics of a human plasma protein analogous to bovine conglutinin were studied. The protein was previously found to bind to complement-reacted IgG in a calcium-dependent and N-acetyl-D-glucosamine-inhibitable manner and it further shows cross-reactivity with anti-bovine conglutinin antibody. By ...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1987.tb02279.x

    authors： Thiel S,Baatrup G,Friis-Christiansen P,Svehag SE,Jensenius JC

    更新日期：1987-11-01 00:00:00

  • Maternal-Foetal Diabetes Modifies Neonatal Fc Receptor Expression on Human Leucocytes.

    abstract：:This study investigated the expression of the neonatal Fc receptor (FcRn) in maternal blood, cord blood and placental cells and determined IgG levels in maternal blood and cord blood from diabetic mothers. Peripheral blood, cord blood and placenta samples were collected from 26 mothers with normoglycaemia (non-diabeti...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/sji.12466

    authors： de Souza EG,Hara CC,Fagundes DL,de Queiroz AA,Morceli G,Calderon IM,França EL,Honorio-França AC

    更新日期：2016-10-01 00:00:00

  • Modulation of neutrophil influx with cell adhesion molecule specific antibodies during nonspecific and immune mediated inflammatory reactions.

    abstract：:Neutrophils are essential for the host defence against infection. However, neutrophils may also mediate damage namely during immune mediated pathologies. We therefore tested whether targeting of different cell adhesion molecules with specific monoclonal antibodies might reduce immune mediated neutrophil recruitment bu...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-3083.2000.00720.x

    authors： Gonçalves AS,Appelberg R

    更新日期：2000-05-01 00:00:00

  • Progression of articular destruction and the production of tumour necrosis factor-alpha in antigen-induced arthritis in rabbits.

    abstract：:We examined the progression of articular destruction and the production of tumour necrosis factor-alpha (TNF-alpha) in antigen-induced arthritis (AIA) in rabbits, i.e. flare-ups of inflammation induced by repeated intra-articular injections (single, twice and three times) of antigen. A marked progression of articular ...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-3083.1997.d01-174.x

    authors： Idogawa H,Imamura A,Onda M,Umemura T,Ohashi M

    更新日期：1997-12-01 00:00:00

  • Increased expression of fas ligand in human tuberculosis and leprosy lesions: a potential novel mechanism of immune evasion in mycobacterial infection.

    abstract：:To study the location and mechanism of apoptosis within the human tuberculosis (TB) and leprosy lesions, parallel sections were analyzed for mycobacterial antigens (M.Ag), Fas ligand (FasL), Fas, CD68 and Mac387 by immunohistochemistry, and apoptotic cells by the terminal deoxynucleotidyl-transferase-mediated dUTP-dig...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-3083.2001.01020.x

    authors： Mustafa T,Bjune TG,Jonsson R,Pando RH,Nilsen R

    更新日期：2001-12-01 00:00:00

  • Primary immunodeficiency diseases: natural mutant models for the study of the immune system.

    abstract：:Primary immunodeficiency diseases represent many natural mutant models for the analysis of many aspects of immunology. Examples dealing with T- and B-cell receptors are herein discussed. They also represent privileged models in medicine, because well characterized monogenic inherited diseases can in some instances be ...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章,评审

    doi：10.1046/j.1365-3083.2002.01056.x

    authors： Fischer A

    更新日期：2002-03-01 00:00:00

  • Soluble cytostatic factor(s) released from human monocytes. I. Production and effect on normal and transformed human target cells.

    abstract：:Human monocytes activated with lymphokines after 3-7 days of in vitro maturation released stable cytostatic factor(s) (CF), as determined by reduction of [methyl-3H]thymidine incorporation and cell counts in target cell cultures. Lipopolysaccharide from Escherichia coli slightly enhanced the release of CF. The CF rele...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1982.tb00654.x

    authors： Hammestrøm J

    更新日期：1982-03-01 00:00:00

  • Effects of 12-O-tetradecanoyl phorbol-13-acetate (TPA) on rat thymocytes.

    abstract：:The short-term incubation of rat thymocytes with 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in a significant increase in sialyltransferase (S-T) activity and a decrease in terminal deoxyribonucleotidyl transferase (TdT) activity. The ratio of peanut agglutinin (PNA)-positive cells and of TdT-positive cells in...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1989.tb01148.x

    authors： Sasaki R,Takaku F,Miura Y

    更新日期：1989-04-01 00:00:00

  • Monoclonal antibodies to a purified human transferrin receptor.

    abstract：:BALB/c mice were injected with an affinity-chromatography-purified placental transferrin receptor preparation. Spleen cells were fused with NS-1 myeloma cells. Sixteen hybrids producing monoclonal antibodies specific for the transferrin receptor and two hybrids specific for transferrin were identified by radioimmunoas...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1984.tb01023.x

    authors： Nikinmaa B,Enns CA,Tonik SE,Sussman HH,Schröder J

    更新日期：1984-11-01 00:00:00

  • Disturbances in the peripheral T-cell repertoire of patients with motor neuron disease: high levels of activation and indirect evidence of superantigen.

    abstract：:Our data on peripheral blood T cells from Motor neuron disease (MND) patients indicate major immunological disturbances linked to this disease. Both CD4+ and CD8+ T-cell subsets display an increased fraction of cells showing activation markers compared to controls, indicating an unusually high level of activity in bot...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-3083.2001.00923.x

    authors： Katchar K,Osorio L,Conradi S,Wigzell H,Gigliotti D

    更新日期：2001-07-01 00:00:00

  • The absence of a human thymus lymphocyte antigen (HTLA) on basophils and mast cells.

    abstract：:Basophilic granulocytes and mast cells of different species have been reported to originate from thymocytes and other lymphocytes. These observations were recently confirmed when evidence was given that thymic antigen is present on rabbit basophilic granulocytes. In the study reported here, human leukocytes were teste...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：

    authors： Stallman PJ,Van Elven EH,Feltkamp-Vroom TM,Brutel de la Rivière A

    更新日期：1977-01-01 00:00:00

  • Mother to child transfer of IgG and IgA antibodies against Dermatophagoides pteronyssinus.

    abstract：:There is strong evidence from animal models that placental and/or breast milk-mediated transfer of maternal allergen-specific IgG prevents allergic immune responses in the progeny. Both human and animal data also point to IgA as having an important regulatory role. In contrast, little is known about maternal transfer ...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.2011.02615.x

    authors： Macchiaverni P,Arslanian C,Frazão JB,Palmeira P,Russo M,Verhasselt V,Condino-Neto A

    更新日期：2011-12-01 00:00:00

  • Distribution and characterization of autoantibodies to interleukin 1 alpha in normal human sera.

    abstract：:Antibodies against IL-1 alpha were detected in sera of apparently healthy individuals. The immunoglobulins belonged to the IgG class, particularly IgG1, IgG2, and IgG4. [125I]rIL-1 alpha bound to Fab fragments of IgG, and IgG immune complexes of molecular weights from 160 to 700 kDa were formed in the sera by [125I]rI...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1990.tb03212.x

    authors： Svenson M,Bagge Hansen M,Bendtzen K

    更新日期：1990-12-01 00:00:00

  • Specifically decreased MLC response of lymphocytes from CBA mice injected with cells from the H-2-compatible, M-antigen-incompatible strain C3H. Lack of such effect after injection of H-2-disparate C3H-hybrid cells.

    abstract：:The mixed lymphocyte culture (MLC) response of lymphocytes from CBA mice against C3H cells was studied after injection of spleen cells from C3H mice or C3H hybrids. Intravenous infusion of C3H cells resulted in a strongly suppressed specific MLC response, but this was not the case when cells from H-2-incompatible hybr...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1975.tb02619.x

    authors： Lilliehöök B,Jacobsson H,Blomgren H

    更新日期：1975-01-01 00:00:00

  • Polyclonal lymphocyte responses to murine Trypanosoma cruzi infection. II. Cytotoxic T lymphocytes.

    abstract：:Intraperitoneal infection of young adult C57BL/6 males with 10(5) blood or cloned culture forms of Trypanosoma cruzi (CL strain) induced the appearance in spleen, blood, and lymph nodes of cytotoxic effector cells detectable in a lectin-dependent 51Cr-release assay. The effector cells were conventional cytotoxic T lym...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1986.tb02186.x

    authors： Minoprio PM,Coutinho A,Joskowicz M,D'Imperio Lima MR,Eisen H

    更新日期：1986-12-01 00:00:00

  • The effect of antifibrotic drug halofugine on Th17 cells in concanavalin A-induced liver fibrosis.

    abstract：:Anti-inflammation strategy is one of the proposed therapeutic approaches to hepatic fibrosis. T helper (Th) 17 cells, which play a detrimental role in experimental murine models of inflammatory diseases, have been demonstrated to participate in the pathogenesis of liver damage. The inhibitory effect of halofuginone (H...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/sji.12144

    authors： Liang J,Zhang B,Shen RW,Liu JB,Gao MH,Geng X,Li Y,Li YY,Zhang W

    更新日期：2014-03-01 00:00:00

  • Monoclonal antibodies specific for variable and constant domains of murine lambda chains.

    abstract：:Rat monoclonal antibodies directed against the BALB/c myeloma protein M315 (alpha,lambda 2) are described. 9A8 (IgG1) binds the V domain of lambda 2 and cross-reacts with lambda 1 and lambda 3 chains. 2B6 (IgG2a) is directed to the C domain of lambda 2 and cross-reacts with C lambda 3. The antibodies bind isolated cha...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1989.tb01125.x

    authors： Bogen B

    更新日期：1989-03-01 00:00:00

  • Regulation of fatty acid synthesis in immune cells.

    abstract：:Metabolic reprogramming plays a critical role in the important cellular metabolic alterations that occur during the activation of immune cells to enable them to adapt to the extracellular environment. Here, we review recent studies on how substrate availability and metabolites mediate the signalling pathways that regu...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章,评审

    doi：10.1111/sji.12713

    authors： Qian X,Yang Z,Mao E,Chen E

    更新日期：2018-11-01 00:00:00

  • Mitogen-induced differentiation of human CLL lymphocytes to antibody-secreting cells.

    abstract：:Peripheral blood lymphocytes from nine patients with chronic lymphatic leukaemia (CLL) have been stimulated by photohaemagglutinin, pokeweed mitogen and Epstein-Barr virus. Our results provide proof that the leukaemic B cells in CLL are capable of responding to mitogenic signals by producing and secreting antibodies, ...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1979.tb01374.x

    authors： Robèrt KH,Bird AG,Möller E

    更新日期：1979-01-01 00:00:00

  • Kinetic analysis of interleukin 2 (IL-2) production and expression of IL-2 receptors by uraemic and normal lymphocytes.

    abstract：:The in vitro immune response of lymphocytes from uraemic patients was studied by comparing the in vitro kinetics of interleukin 2 (IL-2) production, the mitogen-induced proliferative response, and the expression of IL-2 receptors by T lymphocytes. The IL-2 production in 26 uraemic cell cultures decreased significantly...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1987.tb01043.x

    authors： Langhoff E,Hofmann B,Odum N,Ladefoged J,Platz P,Ryder LP,Svejgaard A

    更新日期：1987-01-01 00:00:00

  • Epstein-Barr virus-driven B Cell Proliferation with CD4+ T Cell Expansion: A Lymphomatoid Granulomatosis-like Disease Related to Hyperinterleukin-10 Secretion of Remarkably Favourable Outcome with Rituximab.

    abstract：:Granulomatous lymphomatosis is an Epstein-Barr virus (EBV)-driven B cell proliferation associated with an exuberant CD4(+) T cell reaction with usually histopathological pictures of angiocentrism. So far, the characteristics of CD4(+) T cells in granulomatous lymphomatosis and the mechanism leading to their expansion ...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/sji.12370

    authors： Cervera P,Guihot A,Gorochov G,Lassoued K,Coppo P

    更新日期：2015-12-01 00:00:00