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Chronic lymphocytic leukaemia cells activated in vitro reveal cellular changes that characterize B-prolymphocytic leukaemia and immunocytoma.

Abstract：

:Leukaemic blood lymphocytes from a patient in the terminal stage of chronic lymphocytic leukaemia (CLL) according to the Kiel classification were stimulated by lipopolysaccharide from Escherichia coli. During progression to blast transformation, stimulated cells lost receptors for mouse erythrocytes (MRBC), accumulated intracellular Ig (cIg), and expressed more surface membrane immunoglobulin (SmIg). In addition, transforming cells expressed receptors for the monoclonal antibody FMC7, known to distinguish between CLL cells and prolymphocytic leukaemia (B-PLL) cells. Thus, activation of the patient's CLL cells induced changes in the cellular phenotype so as to resemble B-PLL. Some clonal cells progressed further to a secretory stage of differentiation. Thus, in vitro stimulation induced cellular changes reminiscent of not only B-PLL but also immunocytoma. Further studies of this kind may elucidate the relationship between these lymphocytic malignancies.

journal_name

Scand J Immunol

journal_title

Scandinavian journal of immunology

authors

Robèrt KH,Juliusson G,Biberfeld P

doi

10.1111/j.1365-3083.1983.tb00805.x

subject

Has Abstract

pub_date

1983-05-01 00:00:00

pages

397-401

issue

5

eissn

0300-9475

issn

1365-3083

journal_volume

17

pub_type

杂志文章

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