Abstract：
:Cellular senescence is a stable cell proliferation arrest induced by a variety of stresses including telomere shortening, oncogene activation and oxidative stress. This process plays a crucial role in many physiopathological contexts, especially during aging when cellular senescence favors development of age-related diseases, shortening lifespan. However, the molecular and cellular mechanisms controlling senescence are still a matter of active research. In the last decade, there has been emerging literature indicating a key involvement of calcium signaling in cellular senescence. In this review we will initially give an account of the direct evidence linking calcium and the regulation of senescence. We will then review our current knowledge on the role of calcium in some senescence-associated features and physiopathological conditions, which will shed light on additional ways in which calcium signaling is implicated in cellular senescence.
journal_name
Cell Calciumjournal_title
Cell calciumauthors
Martin N,Bernard Ddoi
10.1016/j.ceca.2017.04.001subject
Has Abstractpub_date
2018-03-01 00:00:00pages
16-23eissn
0143-4160issn
1532-1991pii
S0143-4160(17)30049-0journal_volume
70pub_type
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