Abstract:
:Ca2+ entry through voltage-gated Ca2+ channels (VGCC) triggers transmitter release. Direct recording of Ca2+ currents from the calyx of Held nerve terminal revealed that presynaptic VGCCs undergo various modulations via presynaptic G protein-coupled receptors (GPCRs), Ca2+-binding proteins and a developmental switch of their alpha1 subunits. Dynamic changes of presynaptic VGCCs alter synaptic efficacy, thereby contributing to a variety of modulations of the CNS function.
journal_name
Cell Calciumjournal_title
Cell calciumauthors
Takahashi Tdoi
10.1016/j.ceca.2005.01.018keywords:
subject
Has Abstractpub_date
2005-05-01 00:00:00pages
507-11issue
5eissn
0143-4160issn
1532-1991pii
S0143-4160(05)00035-7journal_volume
37pub_type
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