解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Aging is a complex process that differentially impacts multiple cognitive, sensory, neuronal and molecular processes. Technological innovations now allow for parallel investigation of neuronal circuit function, structure and molecular composition in the brain of awake behaving adult mice. Thus, mice have become a crit...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2021.102358
更新日期:2021-01-23 00:00:00
abstract::As pivotal players in cellular metabolism, mitochondria have a double-faceted role in the final decision of cell fate. This is true for all cell types, but it is even more important and intriguing in the cancer setting. Mitochondria regulate cell fate in many diverse ways: through metabolism, by producing ATP and othe...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2020.102308
更新日期:2020-12-01 00:00:00
abstract::Calcium (Ca2+) signaling controls a wide range of cellular processes, including the hallmarks of cancer. The Ca2+ signaling system encompasses several types of proteins, such as receptors, channels, pumps, exchangers, buffers, and sensors, of which several are mutated or with altered expression in cancer cells. Since ...
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1016/j.ceca.2020.102285
更新日期:2020-11-01 00:00:00
abstract::There is growing evidence indicating that the pore structure of voltage-gated ion channels (VGICs) influences gating besides their conductance. Regarding low voltage-activated (LVA) Ca2+ channels, it has been demonstrated that substitutions of the pore aspartate (D) by a glutamate (D-to-E substitution) in domains III ...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2020.102214
更新日期:2020-07-01 00:00:00
abstract::Cellular Ca2+ signals are often constrained to cytosolic micro- or nano-domains where stochastic openings of Ca2+ channels cause large fluctuations in local Ca2+ concentration (Ca2+ 'noise'). With the advent of TIRF microscopy to image the fluorescence of Ca2+-sensitive probes from attoliter volumes it has become poss...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2019.102152
更新日期:2020-03-01 00:00:00
abstract::Palmitoylation (S-acylation) is the reversible conjugation of a fatty acid (usually C16 palmitate) to intracellular cysteine residues of proteins via a thioester linkage. Palmitoylation anchors intracellular regions of proteins to membranes because the palmitoylated cysteine is recruited to the lipid bilayer. NCX1 is ...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2019.102158
更新日期:2020-03-01 00:00:00
abstract::Ever since British Physician William Withering first described the use of foxglove extract for treatment of patients with congestive heart failure in 1785, cardiotonic steroids have been used clinically to treat heart failure and more recently atrial fibrillation. Due to their ability to bind and inhibit the ubiquitou...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2019.102156
更新日期:2020-03-01 00:00:00
abstract::Numerous lines of evidence indicate that nuclear calcium concentration ([Ca2+]n) may be controlled independently from cytosolic events by a local machinery. In particular, the perinuclear space between the inner nuclear membrane (INM) and the outer nuclear membrane (ONM) of the nuclear envelope (NE) likely serves as a...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2019.102143
更新日期:2020-03-01 00:00:00
abstract::Pituitary neuropeptide oxytocin is increasingly recognised as a cardiovascular hormone, in addition to its many regulatory roles in other organ systems. Studies in atrial and ventricular myocytes from the neonatal and adult rats have identified synthesis of oxytocin and the expression of oxytocin receptors in these ce...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2019.102099
更新日期:2019-12-01 00:00:00
abstract::Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca2+ mobilizing second messenger which triggers Ca2+ release in both sea urchin egg homogenates and in mammalian cells. The NAADP binding protein has not been identified and the regulation of NAADP mediated Ca2+ release remains controversial. To address...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2019.102060
更新日期:2019-11-01 00:00:00
abstract::Pancreatic islets produce pulses of insulin and other hormones that maintain normal glucose homeostasis. These micro-organs possess exquisite glucose-sensing capabilities, allowing for precise changes in pulsatile insulin secretion in response to small changes in glucose. When communication among these cells is disrup...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2019.102081
更新日期:2019-11-01 00:00:00
abstract::NMDA receptors (NMDARs) are glutamate-gated ion channels involved in excitatory synaptic transmission and in others physiological processes such as synaptic plasticity and development. The overload of Ca2+ ions through NMDARs, caused by an excessive activation of receptors, leads to excitotoxic neuronal cell death. Fo...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2019.04.001
更新日期:2019-06-01 00:00:00
abstract::MiR-204 is expressed in vascular smooth muscle cells (VSMC). However, its role in VSMC contraction is not known. We determined if miR-204 controls VSMC contractility and blood pressure through regulation of sarcoplasmic reticulum (SR) calcium (Ca2+) release. Systolic blood pressure (SBP) and vasoreactivity to VSMC con...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2019.03.006
更新日期:2019-06-01 00:00:00
abstract::TRPM family (Transient receptor potential channels, M for melastatin) is a group of intrinsic plasma membrane ion channels which are widely expressed throughout human body. It has been identified as a potent entry point of working desperate diseases out in a new way with newfangled ideas and safer technological means....
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1016/j.ceca.2019.02.011
更新日期:2019-05-01 00:00:00
abstract::The non-selective second messenger-gated cation channel TRPC6 (transient receptor potential canonical 6) is activated by diacylglycerols (DAG) in a PKC-independent manner and plays important roles in a variety of physiological processes and diseases. In order to facilitate novel therapies, the development of potent in...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2018.12.009
更新日期:2019-03-01 00:00:00
abstract::Pacemaker cells residing in the sinoatrial node generate the regular heartbeat. Ca2+ signaling controls the heartbeat rate-directly, through the effect on membrane molecules (NCX exchange, K+ channel), and indirectly, through activation of calmodulin-AC-cAMP-PKA signaling. Thus, the physiological role of signaling in ...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2018.12.008
更新日期:2019-03-01 00:00:00
abstract::Calcium is a major intracellular signaling messenger in innate immune cells. Similar to other immune cell subsets, the majority of calcium entry into innate immune cells is induced by cell surface receptors that stimulate store-operated calcium entry through calcium-release activated calcium (CRAC) channels. Since the...
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1016/j.ceca.2019.01.003
更新日期:2019-03-01 00:00:00
abstract::Transient receptor potential cation channel, subtype melastatin 2 (TRPM2), is important for several physiological functions, such as immune response or temperature regulation. Recently, the structure of full-length TRPM2 from zebrafish was published (Huang et al., 2018) proposing a new activation mechanism - is it rea...
journal_title:Cell calcium
pub_type: 评论,杂志文章
doi:10.1016/j.ceca.2018.11.001
更新日期:2018-12-01 00:00:00
abstract::Middle East Respiratory Syndrome coronavirus (MERS-CoV) infections are associated with a significant mortality rate, and existing drugs show poor efficacy. Identifying novel targets/pathways required for MERS infectivity is therefore important for developing novel therapeutics. As an enveloped virus, translocation thr...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2018.08.003
更新日期:2018-11-01 00:00:00
abstract::Cellular calcium signaling events are transient. Hence they are observed in real time using fluorescence imaging or electrophysiological methods that require sophisticated instrumentation and specialized skills. For high throughput assays simple and inexpensive techniques are desirable. Many calcium channels that serv...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2018.05.009
更新日期:2018-09-01 00:00:00
abstract::K+-dependent Na+-Ca2+ exchangers (NCKXs) belong to Ca2+/cation antiporter gene superfamily. NCKX proteins play an important role in Ca2+ homeostasis and are bi-directional plasma membrane Ca2+-transporters which utilize the inward Na+ and outward K+ gradients to move Ca2+ ions into and out of the cytosol (4Na+:1Ca2+ +...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2018.06.002
更新日期:2018-09-01 00:00:00
abstract::Calcium release-activated calcium (CRAC) channels have been the target of drug discovery for many years. The identification of STIM and Orai proteins as key components of CRAC channels greatly facilitated this process because their co-expression in cell lines produced electrophysiological currents (ICRAC) much larger ...
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1016/j.ceca.2018.07.005
更新日期:2018-09-01 00:00:00
abstract::Stromal interaction molecule (STIM)-1 and -2 are multi-domain, single-pass transmembrane proteins involved in sensing changes in compartmentalized calcium (Ca2+) levels and transducing this cellular signal to Orai1 channel proteins. Our understanding of the molecular mechanisms underlying STIM signaling has been drama...
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1016/j.ceca.2018.04.006
更新日期:2018-07-01 00:00:00
abstract::Mitochondria from different organisms can undergo a sudden process of inner membrane unselective leakiness to molecules known as the mitochondrial permeability transition (MPT). This process has been studied for nearly four decades and several proteins have been claimed to constitute, or at least regulate the usually ...
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1016/j.ceca.2018.05.003
更新日期:2018-07-01 00:00:00
abstract::Although disturbance of cardiac Ca2+ regulation is involved in the pathophysiology of iron-overload cardiomyopathy, the obvious mechanisms involved in the dysregulation of iron-induced cardiac Ca2+ are unclear. Moreover, the roles of the iron chelator deferiprone and the T-type calcium channel blocker efonidipine on c...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2018.01.004
更新日期:2018-06-01 00:00:00
abstract::Hard end is a physiological disorder of pear fruit that is frequently observed in the 'Whangkeumbae' (Pyrus pyrifolia) variety, however, the mechanisms that are involved in its development are poorly understood. In this study, we explored the causes of hard end disorder in pear fruit in relation to calcium deficiency....
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2017.11.002
更新日期:2018-05-01 00:00:00
abstract::Cellular senescence is a stable cell proliferation arrest induced by a variety of stresses including telomere shortening, oncogene activation and oxidative stress. This process plays a crucial role in many physiopathological contexts, especially during aging when cellular senescence favors development of age-related d...
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1016/j.ceca.2017.04.001
更新日期:2018-03-01 00:00:00
abstract::The endoplasmic reticulum (ER) and mitochondria cannot be considered as static structures, as they intimately communicate, forming very dynamic platforms termed mitochondria-associated membranes (MAMs). In particular, the ER transmits proper Ca2+ signals to mitochondria, which decode them into specific inputs to regul...
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1016/j.ceca.2017.05.003
更新日期:2018-01-01 00:00:00
abstract::The surface dynamics of neurotransmitter receptors and transporters, as well as ion channels, has been well-documented in neurons, revealing complex molecular behaviour and key physiological functions. However, our understanding of the membrane trafficking and dynamics of the signalling molecules located at the plasma...
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1016/j.ceca.2017.08.009
更新日期:2017-11-01 00:00:00
abstract::The lungs as the gateways of our body to the external environment are essential for gas exchange. They are also exposed to toxicants from two sides, the airways and the vasculature. Apart from naturally produced toxic agents, millions of human made chemicals were produced since the beginning of the industrial revoluti...
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1016/j.ceca.2017.04.005
更新日期:2017-11-01 00:00:00
abstract::The mammalian ryanodine receptor Ca2+ release channel (RyR) has a single conserved high affinity calmodulin (CaM) binding domain. However, the skeletal muscle RyR1 is activated and cardiac muscle RyR2 is inhibited by CaM at submicromolar Ca2+. This suggests isoform-specific domains are involved in RyR regulation by Ca...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2017.05.013
更新日期:2017-09-01 00:00:00
abstract::Neurons undergo dramatic changes in their gene expression profiles in response to synaptic stimulation. The coupling of neuronal excitation to gene transcription is well studied and is mediated by signaling pathways activated by cytoplasmic and nuclear calcium transients. Despite this, the minimum synaptic activity re...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2017.03.003
更新日期:2017-07-01 00:00:00
abstract::One of the largest challenges in cell biology is to map the lipid composition of the membranes of various organelles and define the exact location of processes that control the synthesis and distribution of lipids between cellular compartments. The critical role of phosphoinositides, low-abundant lipids with rapid met...
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1016/j.ceca.2016.12.008
更新日期:2017-06-01 00:00:00
abstract::Three decades ago, James W. Putney Jr. conceptualized the idea of store-operated calcium entry (SOCE) to explain how depletion of endoplasmic reticulum (ER) Ca2+ stores evokes Ca2+ influx across the plasma membrane. Since the publication of this highly influential idea, it is now established that SOCE is universal amo...
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1016/j.ceca.2016.12.006
更新日期:2017-05-01 00:00:00
abstract::Store-operated Ca2+ entry (SOCE), an important Ca2+ signaling pathway in non-excitable cells, regulates a variety of cellular functions. To study its physiological role, pharmacological tools, like 2-aminoethyl diphenylborinate (2-APB), are used to impact SOCE. 2-APB is one of the best characterized SOCE inhibitors. H...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2017.01.015
更新日期:2017-03-01 00:00:00
abstract::Fluorescence imaging of calcium ions (Ca(2+)) has become an essential technique for investigation of signaling pathways involving Ca(2+) as a second messenger. But, Ca(2+) signaling is involved in many biological phenomena, and therefore simultaneous visualization of Ca(2+) and other biomolecules (multicolor imaging) ...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2016.06.002
更新日期:2016-10-01 00:00:00
abstract::Cellular redox status is maintained by the balance between series of antioxidant systems and production of reactive oxygen/nitrogenous species. Cells utilize this redox balance to mediate diverse physiological functions. Transient receptor potential (TRP) channels are non-selective cation channels that act as biosenso...
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1016/j.ceca.2016.02.009
更新日期:2016-08-01 00:00:00
abstract::Calcium and redox signals are presently established as essential regulators of many cellular processes. Nevertheless, we are still far from fully understanding the physiological and pathological importance of these universal second messengers. It is becoming increasingly apparent that many cellular functions are not r...
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1016/j.ceca.2016.04.008
更新日期:2016-08-01 00:00:00
abstract::CatSper is a sperm-specific Ca(2+) channel that plays an essential role in the male fertility. However, its biophysical properties have been poorly characterized mainly due to its deficient heterologous expression. As other voltage-gated Ca(2+) channels (CaVs), CatSper possesses a conserved Ca(2+)-selective filter mot...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2016.03.011
更新日期:2016-07-01 00:00:00
abstract::Intracellular Ca(2+) signals are essential for stem cell differentiation due to their ability to control signaling pathways involved in this process. Arginine vasopression (AVP) is a neurohypophyseal hormone that increases intracellular Ca(2+) concentration during adipogenesis via V1a receptors, Gq-proteins and the PL...
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1016/j.ceca.2015.12.006
更新日期:2016-03-01 00:00:00